Methods of diagnosing and treating anxiety disorder

ABSTRACT

Methods and uses for diagnosing and treating anxiety disorders are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a Continuation of U.S. patent application Ser. No.15/258,977, filed Sep. 7, 2016, which claims priority to the followingfour United States Provisional Patent Applications, each filed on Sep.8, 2015: 62/215,628; 62/215,633; 62/215,636; and 62/215,673, each ofwhich is incorporated herein by reference in its entirety.

FIELD

This application relates to the treatment of anxiety disorders withnonselective activators of metabotropic glutamate receptors (mGluRs) andof diagnosis and treatment of anxiety disorders in subjects havinggenetic alterations, such as copy number variations (CNVs), in one ormore mGluR network genes.

BACKGROUND

Anxiety is a group of disorders characterized by excessive, irrationalfear and dread. Anxiety disorders include panic disorder,obsessive-compulsive disorder (OCD), post-traumatic stress disorder(PTSD), social anxiety disorder/social phobia, separation anxietydisorder, phobias, and generalized anxiety disorder.

Anxiety disorders are often classified by having a duration of at least6 months. The stress and fearfulness triggered by a stressful event maydevelop into an anxiety disorder over time if not treated.

Anxiety disorders affect approximately 40 million Americans each year,which is equivalent to about 18% of the population (see NationalInstitutes of Health (2009): Anxiety Disorders, Publication No. 093879). In many patients, anxiety disorders occur along with other mentalor physical illnesses or with alcohol or substance abuse. Anxietydisorders, such as panic disorder, can become disabling, with patientsdeveloping such intense fears of everyday situations that they becomehousebound.

Anxiety disorders can also result in exaggerated worry and tension thatinterferes with sleep and concentration and that leads to physicalsymptoms such as headaches, nausea, difficulty swallowing, andlightheadedness. Anxiety disorders can also lead to difficulty inperforming simple, everyday tasks and are often accompanied by substanceabuse or depression.

Presently, anxiety disorders may be diagnosed using a patient history,which may include a variety of rating scales (Ebell M H (2008) Am FamPhysician. 78(4):501-502). Standard scales may be used to evaluate theefficacy of treatment response and remission in pediatric anxiety, suchas the Pediatric Anxiety Rating Scale (PARS), which is a validatedclinician-rated measure of symptom severity and associated impairmentthat has been used for evaluation of therapies for generalized anxietydisorder, social phobia, and separation anxiety disorder (see Caporino NE (2013) J Am Acad Child Adolesc Psychiatry 52(1): 57-67). Rating scalesthat may be used in pediatric patients for associated or comorbidconditions include the Children's Depressive Rating Scale and Children'sYale-Brown Obsessive Compulsive Scale.

People with anxiety disorders may be treated with medications and/orpsychotherapy. However, medications to treat anxiety disorders, such asantidepressants, anti-anxiety medications, and beta-blockers, cannotcure the disorders, although they can be helpful in controlling somephysical symptoms.

Antidepressants have a long onset, so patients must be willing tocontinue medications until symptoms begin to improve.

Benzodiazepines are anti-anxiety medications that can work quickly, butoften patients develop tolerance to these medications and need toescalate dosing to see an effect. Beta-blockers can provide some relieffrom physical symptoms of anxiety and may be helpful for patients whoknow that they are going to do an activity that generates anxiety, butthey do not necessarily impact the underlying anxiety disorder. Becauseof the high prevalence of anxiety disorders and the limits of presentpharmacotherapy, new treatment options are needed.

Precision or personalized medicine is a concept relating to preventionand treatment strategies that take individual variability into account.Recently, a precision-medicine-based clinical trial was completedreporting successful treatment of ADHD in subjects having at least onegenetic alteration in a metabotropic glutamate receptor (mGluR) networkgene. In that study, subjects having a genetic alteration in an mGluRnetwork gene were successfully treated with fasoracetam (NFC-1), whichhas been shown in vitro to be a nonselective activator against allclasses of mGluRs (See Hirouchi M, et al. (2000) European Journal ofPharmacology 387:9-17). We herein describe that patients with anxietydisorders, including those patients that are characterized by geneticalterations in mGluR network genes, may also benefit from treatment withnonselective mGluR activators such as NFC-1.

SUMMARY

The inventors have studied the genotypes of over 900 patients diagnosedwith anxiety disorder and have found that these patients possess geneticalterations in one or more metabotropic glutamate receptor (mGluR)network genes at a significantly higher frequency than patientsdiagnosed with phobia, obsessive compulsive disorder (OCD), ordepression. The frequency of genetic alterations in mGluR network geneswas also substantially higher in this anxiety population than in controlpopulations that do not have other neuropsychological disorders.

Thus, provided herein are methods of treating anxiety disorder in asubject comprising administering an effective amount of a nonselectiveactivator of metabotropic glutamate receptors (mGluRs) to a subject,thereby treating anxiety disorder. In some embodiments the subject hasat least one genetic alteration in an mGluR network gene, such as a copynumber variation (CNV).

In some embodiments, a method of treating anxiety disorder in a subjectis provided comprising administering an effective amount of anonselective activator of metabotropic glutamate receptors (mGluRs) to asubject that has one symptom of anxiety and at least one geneticalteration in an mGluR network gene, thereby treating anxiety disorder.In another embodiment, a method of treating anxiety disorder in asubject is provided comprising administering an effective amount of anonselective activator of metabotropic glutamate receptors (mGluRs) to asubject that has one symptom of anxiety, thereby treating anxietydisorder. The symptom may be any symptom known to those of skill in theart, including the symptoms provided in the Diagnostic and StatisticalManual of Mental Disorders, Fifth Edition (DSM-5 2013), including, butnot limited to, fear and anxiety.

Also provided herein are methods of treating anxiety disorder comprisingadministering an effective amount of a nonselective activator ofmetabotropic glutamate receptors (mGluRs) to a subject that has at leastone genetic alteration in an mGluR network gene, such as a CNV, therebytreating anxiety disorder. In some embodiments, where the subject has aCNV in an mGluR network gene, the CNV is a duplication or deletion.

Also provided are methods of treating anxiety disorder in a subjectcomprising obtaining results from a genetic screen that determineswhether a subject has a genetic alteration in an mGluR network gene,and, if the results show that the subject has at least one geneticalteration in an mGluR network gene, treating the subject byadministering an effective amount of a nonselective activator of mGluRs.

In some embodiments of the above methods, the nonselective activator ofmGluRs is fasoracetam, such as fasoracetam monohydrate (NS-105 orNFC-1). In some embodiments the fasoracetam is administered at a dose of50 mg, 100 mg, 150 mg, 200 mg, 250 mg, 300 mg, 350 mg, or 400 mg,wherein the dose is administered once, twice, or three times daily. Insome embodiments, fasoracetam is administered at a dose of 50-400 mg,100-400 mg, or 200-400 mg, and administered once, twice, or three timesdaily. In some embodiments, the fasoracetam is administered at a dose of200-400 mg, such as 200 mg, 300 mg, or 400 mg, and administered twicedaily.

In some embodiments the method comprises considering results of a screento determine whether the subject has a genetic alteration such as a CNVin an mGluR network gene. In some embodiments of the above methods, thesubject has a CNV in at least 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mGluRnetwork genes. In some embodiments a CNV in an mGluR network gene isdetermined by obtaining a nucleic acid-comprising sample from thesubject and subjecting the sample to a screen that assesses CNVs in atleast 5, 6, 7, 8, 9, 10, 15, 20, 30, 40, 50, 60, 70, or all of Tier 1mGluR network genes. In some embodiments a CNV in an mGluR network geneis determined by obtaining a nucleic acid-comprising sample from thesubject and subjecting the sample to a screen that assesses CNVs in atleast 50, at least 100, at least 150, at least 175, or all of Tier 2mGluR network genes. In some embodiments a CNV in an mGluR network geneis determined by obtaining a nucleic acid sample from the subject andsubjecting the sample to a screen that assesses CNVs in at least 50, atleast 100, at least 200, at least 300, at least 400, at least 500, orall of Tier 3 mGluR network genes. In some embodiments the screen doesnot assess CNVs in one or more of GRM1, GRM2, GRM3, GRM4, GRM5, GRM6,GRM7, or GRM8. In certain embodiments the subject does not have a CNV inone or more of GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, or GRM8.

In some embodiments of the above methods, the anxiety disorder is one ormore of generalized anxiety disorder, phobia, social anxiety disorder,social phobia, panic disorder, panic attack, post-traumatic stressdisorders, separation anxiety disorder, selective mutism, agoraphobia,or an anxiety disorder induced by a substance/medication or due toanother medical condition. In some embodiments, the methods reduce atleast one symptom of anxiety disorder in the subject, such as fear,anxiety, separation anxiety, and/or panic attacks (e.g. frequency andseverity of attacks). In some embodiments, the methods reduce otherbehavioral symptoms such as inattentiveness, hyperactivity, and/orimpulsiveness. In some embodiments, the methods also comprise assessingsymptoms such as fear, anxiety, separation anxiety, panic attacks andtheir frequency or severity, as well as inattentiveness, hyperactivity,and/or impulsiveness during or after administration, for example, todetermine if one or more of those symptoms have been reduced in thesubject. In some methods, such assessment may be performed based on thePediatric Anxiety Rating Scale (PARS). In some embodiments, the methodsfurther comprise obtaining a clinical global impression of severity orimprovement for the subject during or after administration. In someembodiments, the methods may improve clinical global improvement scoresin the subject.

In some embodiments the subject is a pediatric or adolescent subject,such as between the ages of 5 and 17, 5 and 8, 8 and 17, 8 and 12, 12and 18, 13 and 18, or 12 and 17. In other embodiments the subject is anadult. In some embodiments, the subject has experienced symptoms ofanxiety for at least six months, while in other embodiments, anxietysymptoms have endured for less than six months yet anxiety disorder hasbeen diagnosed in the subject.

In some embodiments of the above methods, the nonselective activator ofmGluRs is administered in combination with another pharmaceutical ornon-pharmaceutical therapy. In some embodiments, the non-pharmaceuticaltherapy comprises brain stimulation, such as vagus nerve stimulation,repetitive transcranial magnetic stimulation, magnetic seizure therapy,or deep brain stimulation. In some embodiments, the activator isadministered in combination with an anxiolytic agent such asbenzodiazepine, an antidepressant, a pregabalin, or a beta-blocker.

Also provided herein are methods for diagnosing anxiety disorder in asubject comprising isolating a nucleic-acid comprising sample from asubject, analyzing the sample for the presence or absence of a geneticalteration in at least one mGluR network genes, and diagnosing anxietydisorder if the subject has at least one genetic alteration in a mGluRnetwork gene. Also provided are methods for diagnosing anxiety disorderin a subject comprising isolating a nucleic-acid comprising sample froma subject, isolating nucleic acid from the sample, analyzing the nucleicacid for the presence or absence of a genetic alteration in at least onemGluR network genes, and diagnosing anxiety disorder if the subject hasat least one genetic alteration in a mGluR network gene. Provided aswell are methods for identifying a subject as having anxiety disordercomprising obtaining a sample from a patient, optionally isolatingnucleic acid from the sample, optionally amplifying the nucleic acid,and analyzing the nucleic acid in the sample for the presence or absenceof a genetic alteration, such as a CNV, in at least one mGluR networkgene, wherein the subject is identified as having anxiety disorder if atleast one genetic alteration, such as a CNV, in an mGluR network gene isdetected. The invention also provides methods for diagnosing anxietydisorder in a subject comprising analyzing genetic information about oneor more mGluR network genes, comparing the subject's information to acontrol subject that does not have anxiety disorder, and diagnosinganxiety disorder if the genetic information suggests that the subjecthas at least one genetic alteration in a mGluR network gene.

Provided herein also are methods of confirming a diagnosis of anxietydisorder in a subject comprising: obtaining a nucleic acid-comprisingsample from a subject diagnosed with anxiety disorder by a method thatdoes not comprise detecting or analyzing genetic alterations in mGluRnetwork genes; optionally amplifying the nucleic acid in the sample; anddetermining whether the subject has at least one genetic alteration,such as a CNV, in an mGluR network gene, and confirming a diagnosis ofanxiety disorder if the subject has at least one genetic alteration in amGluR network gene.

In any of the above methods, the analysis for the presence or absence ofat least one genetic alteration in a mGluR network gene may comprisemicroarrays, whole genome sequencing, exome sequencing, targetedsequencing, FISH, comparative genomic hybridization, genome mapping, orother methods using next-generation sequencing, Sanger sequencing, PCR,or TaqMan technologies.

In some embodiments, the subject has CNVs in one, two, or more mGluRnetwork genes. In some embodiments, the methods comprise detecting CNVsin mGluR network genes by subjecting the sample to a screen thatassesses CNVs in at least 2, 3, 4, 5, 6, 7, 8, 9, or 10 mGluR networkgenes. In some embodiments, CNVs in mGluR network genes are determinedby subjecting the sample to a screen that assesses CNVs in at least 5,6, 7, 8, 9, 10, 15, 20, 30, 40, 50, 60, 70, or all of Tier 1 mGluRnetwork genes. In some embodiments, CNVs in mGluR network genes aredetermined by subjecting the sample to a screen that assesses CNVs in atleast 50, at least 100, at least 150, at least 175, or all of Tier 2mGluR network genes. In some embodiments, CNVs in mGluR network genesare determined by subjecting the sample to a screen that assesses CNVsin at least 50, at least 100, at least 200, at least 300, at least 400,at least 500, or all of Tier 3 mGluR network genes.

In some embodiments of the above methods, the anxiety disorder is one ormore of generalized anxiety disorder, phobia, social anxiety disorder,social phobia, panic disorder, panic attack, post-traumatic stressdisorders, separation anxiety disorder, selective mutism, agoraphobia,or an anxiety disorder induced by a substance/medication or due toanother medical condition. In some embodiments, the subject is apediatric or adolescent subject, such as a subject between the ages of 5and 17, 5 and 8, 8 and 17, 8 and 12, 12 and 18, 13 and 18, or 12 and 17.In other embodiments, the subject is an adult subject. In someembodiments, the subject has experienced symptoms of anxiety for atleast six months.

In some embodiments, the screening method for determining the presenceor absence of at least one mGluR network gene genetic alterationcomprises microarrays, whole genome sequencing, exome sequencing,targeted sequencing, FISH, comparative genomic hybridization, genomemapping, or other methods using next-generation sequencing, Sangersequencing, PCR, or TaqMan technologies.

In some embodiments, the subject is not assessed for genetic alterationsor CNVs in one or more of GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, andGRM8. In some embodiments, the subject does not have CNVs in one or moreof GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, and GRM8. In someembodiments, the subject does not have CNVs in any of GRM1, GRM2, GRM3,GRM4, GRM5, GRM6, GRM7, and GRM8.

In any of the methods and embodiments described in the precedingparagraphs of this Summary, in the claims, or in the DetailedDescription, the subject may have anxiety disorder as well as one ormore comorbid conditions such as attention-deficit hyperactivitydisorder (ADHD), oppositional defiant disorder (ODD), conduct disorder,Tourette's syndrome, phobia, obsessive compulsive disorder (OCD),difficulty controlling anger, disruptive behavior symptoms,dermatillomania, a developmental disorder, a movement disorder, a mooddisorder, or depression. In other cases, the subject does not have oneor more of ADHD, ODD, conduct disorder, Tourette's syndrome, phobia,obsessive compulsive disorder (OCD), difficulty controlling anger,disruptive behavior symptoms, dermatillomania, a developmental disorder,a movement disorder, a mood disorder, or depression. In yet other cases,the subject does not have any of ADHD, ODD, conduct disorder, Tourette'ssyndrome, phobia, obsessive compulsive disorder (OCD), difficultcontrolling anger, disruptive behavior symptoms, dermatillomania, adevelopmental disorder, a mood disorder, a movement disorder, ordepression. In some embodiments, the anxiety subject does not have OCD,phobia, or depression.

In any of the methods and embodiments described herein, symptoms ofinattentiveness, hyperactivity, and/or impulsiveness may be reduced inthe subject. For example, these symptoms may be lessened after 1 week oftreatment with the activator, such as after 2 weeks, after 3 weeks, orafter 4 weeks of treatment.

In some embodiments, the subject has co-morbid symptoms of ADHD and insome cases, the method reduces ADHD symptoms. In some embodiments, thesubject has OCD and in some cases, the method reduces OCD symptoms. Insome cases, the subject has co-morbid symptoms of dermatillomania, suchas excessive skin picking, and the method reduces those symptoms. Insome embodiments, the subject has one or more co-morbid developmentaldisorders, and in some cases, the method reduces the severity ofsymptoms related to the developmental disorders. For example, thesesymptoms may be lessened after 1 week of treatment with the activator,such as after 2 weeks, after 3 weeks, or after 4 weeks of treatment.

In some embodiments, the subject may have one or more of the followingchanges in symptoms after at least one, two, three, or four weeks oftreatment with the activator: (a) the subject has symptoms of angercontrol and the anger control symptoms are reduced; (b) the subject hassymptoms of disruptive behavior and the disruptive behavior symptoms arereduced; (c) the subject's CGI-I is reduced by at least 1 or by at least2; (d) the subject's CGI-I score after one, two, three, or four weeks oftreatment is 1 or 2; (e) the subject's CGI-S score after one, two,three, or four weeks of treatment is 1; (f) the subject has ADHD and thesubject's ADHD Rating Scale score is reduced by at least 25%, such as atleast 30%, at least 35%, or at least 40%; (g) the subject has symptomsof inattentiveness and the inattentiveness symptoms are reduced; (h) thesubject has symptoms of hyperactivity and the hyperactivity symptoms arereduced; (i) the subject has symptoms of impulsiveness and theimpulsiveness symptoms are reduced; (j) the subject has symptoms of ODDsuch as anger and irritability, argumentation and defiance, and/orvindictiveness and the ODD symptoms are reduced; (k) the subject hassymptoms of conduct disorder and the conduct disorder symptoms arereduced; (1) the subject has a movement disorder and the associatedsymptoms are reduced; (m) the subject has symptoms of OCD, and the OCDsymptoms are reduced; (n) the subject has symptoms of autism, and theautism symptoms are reduced; and (o) the subject has symptoms ofTourette's syndrome and the Tourette's syndrome symptoms are reduced. Inany of the methods and embodiments described herein, a subject may betreated when a clinician notes that the subject is more interested indoing things and/or becomes socially proactive.

In one embodiment, a method for diagnosing an mGluR-associated disorderis provided, wherein a subject is diagnosed with an mGluR-associateddisorder if at least one genetic alteration in an mGluR network gene isdetected.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows the number of samples from patients with anxiety,depression, obsessive-compulsive disorder (OCD), and phobias included ina genotyping study designed to assess genetic alterations in mGluRnetwork genes. Only those patient samples that were fully genotyped areincluded in the data analysis.

FIGS. 2-1 to 2-4 show the mGluR network genes included in the Tier 1gene set. These genes have 2 degrees of protein-protein interaction withmGluR genes (GRM1-8) based on the Cytoscape Human Interactome, which issoftware for integrating biomolecular interaction networks withhigh-throughput data (as described in Shannon P (2003) Genome Research13:2498-2504). The Tier 1 gene set includes 76 genes. The exact locationfor each gene in Tier 1 is listed in both the Human Genome version 18(hg18) and Human Genome version 19 (hg19). In addition, the exact genelocation plus 500 kilobase (i.e., the range from 500 kilobase before and500 kilobase after the gene of interest) is listed for hg19. The startsingle nucleotide polymorphism (StartSNP) (i.e., the SNP located 500kilobases before the gene of interest) and the EndSNP (i.e., the SNPlocated 500 kilobases after the gene of interest) are also listed. Genesof the mGluRs themselves are noted as “GRM.” The expanded regions (i.e.,500 kg up and down stream) frequently harbor regulatory elements and ifimpacted by a CNV, can have the same impact on the gene expression andfunction as a CNV residing in the gene sequence itself.

FIGS. 3-1 to 3-10 show the mGluR network genes included in the Tier 2gene set. These genes have 2 degrees of protein-protein interaction withmGluR genes (GRM1-8) based on the Cytoscape Human Interactome butexclude genes from Tier 1. The Tier 2 gene set includes 197 genes. Theexact location for each gene in Tier 2 is listed in both the HumanGenome version 18 (hg18) and Human Genome version 19 (hg19). Inaddition, the exact gene location plus 500 kilobase (i.e., the rangefrom 500 kilobase before and 500 kilobase after the gene of interest) islisted for hg19. The start single nucleotide polymorphism (StartSNP)(i.e., the SNP located 500 kilobases before the gene of interest) andthe EndSNP (i.e., the SNP located 500 kilobases after the gene ofinterest) in hg19 are also listed.

FIGS. 4-1 to 4-29 show genes within the Tier 3 gene set. Genes withreciprocal gene querying with 2 degrees of protein-protein interactionwith mGluR genes based on Cytoscape Human Interactome are included.Genes contained within Tiers 1 and 2 are excluded from Tier 3. The Tier3 gene set includes 599 genes. The exact location for each gene in Tier3 is listed in both the Human Genome version 18 (hg18) and Human Genomeversion 19 (hg19). In addition, the exact gene location plus 500kilobase (i.e., the range from 500 kilobase before and 500 kilobaseafter the gene of interest) is listed for hg19. The StartSNP (i.e., theSNP located 500 kilobases before the gene of interest) and the EndSNP(i.e., the SNP located 500 kilobases after the gene of interest) in hg19are also listed.

FIG. 5 shows the number of copy number variation (CNV) calls containingTier gene (mGluR network gene) within the samples from the 925 anxietypatients who were fully genotyped; the 95 depression patients who werefully genotyped; the 150 OCD patients that were fully genotyped; and the55 phobia patients that were fully genotyped. Note that some patientshad more than one CNV call that contained a mGluR network genes in aTier gene.

FIG. 6 shows the percentage of fully-genotyped patients with anxiety,depression, OCD, or phobia who had a CNV within Tier 1, Tiers 1+2, orTiers 1+2+3 mGluR network gene sets.

DESCRIPTION OF THE EMBODIMENTS

I. Definitions

A “mGluR” or metabotropic glutamate receptor refers to one of eightglutamate receptors expressed in neural tissue named mGluR1, mGluR2,mGluR3, mGluR4, mGluR5, mGluR6, mGluR7, and mGluR8. Their genes areabbreviated GRM1 to GRM8. The mGluR proteins are G-protein-coupledreceptors. They are typically placed into three sub-groups, Group Ireceptors including mGluR1 and mGluR5 are classed as slow excitatoryreceptors. Group II includes mGluR2 and mGluR3. Group III includesmGluR4, mGluR6, mGluR7, and mGluR8. Groups II and III are classed asslow inhibitory receptors. The mGluRs are distinguished from theionotropic GluRs or iGluRs, which are ion channel-associated glutamatereceptors and are classed as fast excitatory receptors.

A “mGluR network gene,” for purposes of this invention, comprises notonly the mGluR genes GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, and GRM8,but also each of the other genes listed herein in FIGS. 2-4 as well asthe regions of DNA that regulate the genes listed in FIGS. 2-4 . Inaddition, “mGluR network proteins” are the proteins encoded by the mGluRnetwork genes.

The mGluR network genes are grouped into three subsets: Tier 1, Tier2,and Tier 3. (See FIGS. 2-4 .) Tier 1 mGluR network genes, shown in FIG.2 , comprise 76 genes, including some GRM genes themselves as well as anumber of other genes. The Tier 2 mGluR network genes, shown in FIG. 3 ,comprise 197 genes, and exclude the Tier 1 genes.

Tiers 1 and 2 together are included in the “primary mGluR network.” The“primary network” of mGluR genes also includes the genes 4-Sep,LOC642393, and LOC653098, for a total of 276 genes. There are presentlytechnical difficulties in assessing the 4-Sep, LOC642393, and LOC653098genes. Thus, they are not included in the genes of Tiers 1 and 2,although they are included in the primary network of genes of thepresent invention. The genes of Tier 1 and Tier 2 differ in thatalterations in Tier 1 genes had been documented in previous genotypingstudies of subjects suffering from mental disorders.

Tier 3 mGluR network genes, shown in FIG. 4 , comprise 599 genes thatare in the distal part of the mGluR network based on the merged humaninteractome provided by the Cytoscape Software (Shannon P et al. (2003)Genome Research 13:2498-2504), and exclude the Tier 1 and Tier 2 genes.The Tier 3 genes are thus part of the “distal mGluR network.” Inaddition to the Tier 3 genes, the genes LOC285147, LOC147004, andLOC93444 are included in the “distal mGluR network,” although they werenot assessed in the present study and are not included in Tier 3 due totechnical difficulties in assessing genetic alterations in these genes.

A “genetic alteration” as used herein means any alteration in the DNA ofa gene, or in the DNA regulating a gene, that, for example, may resultin a gene product that is functionally changed as compared to a geneproduct produced from a non-altered DNA. A functional change may bediffering expression levels (up-regulation or down-regulation) or lossor change in one or more biological activities, for example. A geneticalteration includes without limitation, copy number variations (CNVs),single nucleotide variants (SNVs), also called single nucleotidepolymorphisms (SNPs) herein, frame shift mutations, or any other basepair substitutions, insertions, and deletions or duplications.

A “copy number variation” or “CNV” is a duplication or deletion of a DNAsegment encompassing a gene, genes, segment of a gene, or DNA regionregulating a gene, as compared to a reference genome. In someembodiments, a CNV is determined based on variation from a normaldiploid state. In some embodiments, a CNV represents a copy numberchange involving a DNA fragment that is 1 kilobase (kb) or larger. CNVsdescribed herein do not include those variants that arise from theinsertion/deletion of transposable elements (e.g., 6-kb KpnI repeats).The term CNV therefore encompasses terms such as large-scale copy numbervariants (LCVs; Iafrate et al. 2004), copy number polymorphisms (CNPs;Sebat et al. 2004), and intermediate-sized variants (ISVs; Tuzun et al.2005), but not retrotransposon insertions.

A “CNV deletion” or “deletion CNV” or similar terms refer to a CNV inwhich a gene, DNA segment regulating a gene, or gene segment is deleted.A “CNV duplication” or “duplication CNV” or similar terms refer to a CNVin which a gene, DNA segment regulating a gene, or gene segment ispresent in at least two, and possibly more than two, copies incomparison with the single copy found in a normal reference genome.

A “sample” refers to a sample from a subject that may be tested, forexample, for presence of a CNV in one or more mGluR network proteins, asdescribed herein. The sample may comprise cells, and it may comprisebody fluids, such as blood, serum, plasma, cerebral spinal fluid, urine,saliva, tears, pleural fluid, and the like.

“Anxiety disorders” are defined in the Diagnostic and Statistical Manualof Mental Disorders, Fifth Edition (DSM-5 2013) as a group of disordersthat share features of persistent, excessive fear and anxiety. Anxietydisorders typically have a duration of at least 6 months, although, insome embodiments herein the anxiety disorder is diagnosed after lessthan 6 months of duration. In children, anxiety disorders are typicallydiagnosed using one or more rating scales, such as, the PediatricAnxiety Rating Scale (PARS), the Children's Depressive Rating Scale, andthe Children's Yale-Brown Obsessive Compulsive Scale. We herein describenew methods for diagnosing and treating anxiety disorders.

Anxiety disorders include, but are not limited to, “generalized anxietydisorder,” “social anxiety disorder,” “social phobia,” “panic attack,”“panic disorder,” “post-traumatic stress disorder,” “agoraphobia,”“separation anxiety disorder,” “separation anxiety disorder,” “anxietydisorder induced by a substance/medication or due to another medicalcondition,” and “selective mutism,” among others.

“Generalized anxiety disorder” is excessive worry about a variety ofeveryday problems occurring more days than not for at least 6 months.“Social anxiety disorder” is a marked fear or anxiety about one or moresocial situations and is interchangeable with “social phobia”. “Panicattacks” are the abrupt onset of intense fear or discomfort associatedwith symptoms such as heart palpitations, sweating, dizziness, ornausea. “Panic disorder” is diagnosed in patients with recurrentunexpected panic attacks. “Post-traumatic stress disorder” (or “PTSD”)is a condition that can occur in people who have been exposed to anactual or threatened death, serious injury, or sexual violence, whereinthe individual experiences recurrent distressing memories, flashbacks,psychological distress, and/or physiological reactions to cues followingthe event. “Agoraphobia” is a condition wherein an individual has markedfear about situations such as being in public spaces, standing incrowds, or being outside of their home alone. “Separation anxietydisorder” is developmentally inappropriate and excessive fear or anxietyconcerning separation from those to whom the individual is attached.“Selective mutism” is a condition characterized by consistent failure tospeak in specific social situations in which there is an expectation tospeak (e.g., in school), despite having the ability to speak in othersituations.

Patients with an anxiety disorder may also have inattention,hyperactivity, anxiety, mood, and sleep disturbances.

The terms “subject” and “patient” are used interchangeably to refer to ahuman. The terms “pediatric subject” or “pediatric patient” are usedinterchangeably to refer to a human less than 18 years of age. An “adultpatient” refers to a human 18 years of age or older. An “adolescentpatient” or “adolescent subject” is a subject typically about 12 to 18,such as 12 to 17 or 13 to 18, years old.

In addition to definitions included in this sub-section, furtherdefinitions of terms are interspersed throughout the text.

II. Methods of Diagnosing Anxiety Disorders

In some embodiments, the invention comprises methods of diagnosinganxiety disorder in a subject comprising analyzing the geneticinformation of the subject to determine whether the subject has agenetic variation in at least one mGluR network gene, and diagnosing thesubject as having anxiety disorder if a genetic variation is found. Insome embodiments, a screen for the presence of mGluR network genevariations is one of two or more tests or evaluations that are performedto diagnose a subject. In some embodiments, the subject has anxietydisorder but does not have ADHD, ODD, conduct disorder, autism,Tourette's syndrome, phobia, obsessive compulsive disorder (OCD),difficulty controlling anger, disruptive behaviors, dermatillomania, adevelopmental disorder, a mood disorder, a movement disorder, ordepression. In some embodiments, the subject has anxiety disorder andalso one or more of ADHD, oppositional-defiant disorder (ODD), conductdisorder, autism, Tourette's syndrome, phobia, obsessive compulsivedisorder (OCD), difficulty controlling anger, disruptive behaviorsymptoms, dermatillomania, a developmental disorder, a mood disorder, amovement disorder, and depression. In some embodiments, the subject doesnot have any of ADHD, oppositional-defiant disorder (ODD), conductdisorder, autism, Tourette's syndrome, phobia, obsessive compulsivedisorder (OCD), difficulty controlling anger, disruptive behaviorsymptoms, dermatillomania, a developmental disorder, a mood disorder, amovement disorder, or depression. In some embodiments, the subject doesnot have any of OCD, phobia, or depression. A subject has anxiety ratherthan anxiety disorder if the symptoms of the disorder have been presentfor less than six months.

In other embodiments, the invention encompasses confirming a diagnosisof anxiety disorder in a subject. As used herein, “confirming adiagnosis of anxiety disorder” means re-diagnosing a subject who hasalready been diagnosed with anxiety disorder. In this one embodiment,the method of confirming a diagnosis of anxiety disorder comprisesanalyzing the genetic information of a subject that has been diagnosedas having anxiety disorder by a method that does not comprise analyzingmGluR network genes, to determine whether the subject has a geneticvariation in at least one mGluR network gene, and confirming thediagnosis of anxiety disorder if a genetic variation in at least onemGluR network gene is found. In some embodiments, a screen for thepresence of mGluR network gene variations is one of two or more tests orevaluations that are performed to confirm a diagnosis in a subject. Insome embodiments, the subject has anxiety disorder but does not have anyof ADHD, ODD, conduct disorder, autism, Tourette's syndrome, phobia,obsessive compulsive disorder (OCD), difficulty controlling anger,disruptive behavior symptoms, dermatillomania, a developmental disorder,a mood disorder, a movement disorder, or depression. In someembodiments, the subject has anxiety disorder and also one or more ofADHD, ODD, conduct disorder, autism, Tourette's syndrome, phobia,obsessive compulsive disorder (OCD), difficulty controlling anger,disruptive behavior symptoms, dermatillomania, a developmental disorder,a mood disorder, a movement disorder, and depression. A subject hasanxiety rather than anxiety disorder if the symptoms of the disorderhave been present for less than six months.

In another embodiment, the invention comprises confirming a diagnosis ofanxiety disorder in a subject who does not have ADHD, ODD, conductdisorder, autism, Tourette's syndrome, phobia, obsessive compulsivedisorder (OCD), difficulty controlling anger, disruptive behaviorsymptoms, dermatillomania, a developmental disorder, a mood disorder, amovement disorder, or depression, comprising analyzing the geneticinformation of a subject that has been diagnosed as having anxietydisorder by a method that does not comprise analyzing mGluR networkgenes, to determine whether the subject has a genetic variation in atleast one mGluR network gene, and confirming the diagnosis of anxietydisorder if a genetic variation in at least one mGluR network gene isfound.

In one embodiment, anxiety disorder is diagnosed and/or confirmed if atleast one CNV, SNV, frameshift mutation, or any other base pairsubstitution, insertion, deletion or duplication in an mGluR networkgene is detected. In other embodiments, anxiety disorder is diagnosedand/or confirmed if at least one CNV, SNV, frameshift mutation, or anyother base pair substitution, insertion, deletion, or duplication in aTier 1 mGluR network gene is detected. In another embodiment, anxietydisorder is diagnosed and/or confirmed if at least one CNV, SNV,frameshift mutation, or any other base pair substitution, insertion,deletion, or duplication in a Tier 2 mGluR network gene is detected. Instill other embodiments, anxiety disorder is diagnosed and/or confirmedif at least one CNV, SNV, frameshift mutation, or any other base pairsubstitution, insertion, deletion, or duplication in a Tier 3 mGluRnetwork gene is detected.

A diagnosis or confirmation of diagnosis of anxiety disorder may bebased or confirmed on finding a genetic alteration in a Tier 1, Tier 2,and/or Tier 3 mGluR network gene. The genetic alteration may be a CNV.The CNV may be a duplication or deletion of a region of DNA thatcontains some or all of the DNA encoding and controlling/regulating anmGluR network gene. In some embodiments, the diagnosis or confirmationof diagnosis of anxiety disorder is made in a patient who does not haveany of ADHD, ODD, conduct disorder, autism, Tourette's syndrome, phobia,obsessive compulsive disorder (OCD), difficulty controlling anger,disruptive behavior symptoms, dermatillomania, a developmental disorder,a mood disorder, a movement disorder, or depression. In someembodiments, the diagnosis or confirmation of diagnosis of anxietydisorder is made in a patient who has anxiety disorder and also one ormore of ADHD, ODD, conduct disorder, autism, Tourette's syndrome,phobia, obsessive compulsive disorder (OCD), difficulty controllinganger, disruptive behavior symptoms, dermatillomania, a developmentaldisorder, a mood disorder, a movement disorder, and depression.

In some embodiments, the diagnosis or confirmation of diagnosis ofanxiety disorder is based on a finding that the copy number of an mGluRnetwork gene deviates from the normal diploid state. In someembodiments, the diagnosis or confirmation of diagnosis of anxietydisorder is based on a copy number of zero or one, which indicates a CNVdeletion. In some embodiments, the diagnosis or confirmation ofdiagnosis of anxiety disorder is based on a copy number of three orgreater, which indicates a CNV duplication. In some embodiments, thediagnosis or confirmation of diagnosis of an anxiety disorder is made ina patient who does not have ADHD, ODD, conduct disorder, autism,Tourette's syndrome, phobia, obsessive compulsive disorder (OCD),difficulty controlling anger, disruptive behavior symptoms,dermatillomania, a developmental disorder, a mood disorder, a movementdisorder, or depression by the presence of a copy number of zero or one,or by a copy number of three or greater, or by any deviation from thediploid state.

In some embodiments, a more severe form of anxiety disorder is diagnosedor confirmed if at least two CNVs in mGluR network genes are detected.In one embodiment, a more severe form of anxiety disorder in a patientwho does not have ADHD, ODD, conduct disorder, autism, Tourette'ssyndrome, phobia, obsessive compulsive disorder (OCD), difficultycontrolling anger, disruptive behavior symptoms, dermatillomania, adevelopmental disorder, a mood disorder, a movement disorder, ordepression is diagnosed or confirmed if at least two CNVs in mGluRnetwork genes are detected. In one embodiment, a more severe form ofanxiety disorder in a patient who also has at least one of ADHD, ODD,conduct disorder, autism, Tourette's syndrome, phobia, obsessivecompulsive disorder (OCD), difficulty controlling anger, disruptivebehavior symptoms, dermatillomania, a developmental disorder, a mooddisorder, a movement disorder, or depression is diagnosed or confirmedif at least two CNVs in mGluR network genes are detected.

In one embodiment, a method of diagnosing and/or confirming anxietydisorder comprises obtaining a nucleic acid-containing sample from asubject; optionally amplifying the nucleic acid; optionally labeling thenucleic acid sample; applying the nucleic acid to a solid support thatcomprises one or more nucleic acids of mGluR network genes, wherein thenucleic acids optionally comprise SNVs of mGluR network genes; removingany unbound nucleic acid sample; and detecting any nucleic acid that hasbound to the nucleic acid on the solid support, wherein the subject isdiagnosed or confirmed as having anxiety disorder if bound nucleic acidsare detected. In one embodiment the method further comprises comparingany bound nucleic acids to a standard or control and diagnosing orconfirming anxiety disorder if the analysis finds that the test sampleis different from the control or standard. In another embodiment of thismethod, the patient with anxiety disorder does not have ADHD, ODD,conduct disorder, autism, Tourette's syndrome, phobia, obsessivecompulsive disorder (OCD), difficulty controlling anger, disruptivebehavior symptoms, dermatillomania, a developmental disorder, a mooddisorder, a movement disorder, or depression. In another embodiment, thepatient with anxiety disorder also has at least one of ADHD, ODD,conduct disorder, autism, Tourette's syndrome, phobia, obsessivecompulsive disorder (OCD), difficulty controlling anger, disruptivebehavior symptoms, dermatillomania, a developmental disorder, a mooddisorder, a movement disorder, or depression.

In each diagnostic, confirming, and treatment method of the invention,the anxiety disorder may be generalized anxiety disorder, phobia, socialanxiety disorder, social phobia, panic disorder, panic attack,post-traumatic stress disorders, separation anxiety disorder, selectivemutism, agoraphobia, or an anxiety disorder induced by asubstance/medication or due to another medical condition. In eachdiagnostic, confirming, and treatment method of the invention, thesubject may have an anxiety disorder but not have ADHD, ODD, conductdisorder, autism, Tourette's syndrome, phobia, obsessive compulsivedisorder (OCD), difficulty controlling anger, disruptive behaviorsymptoms, dermatillomania, a developmental disorder, a mood disorder, amovement disorder, or depression. In other diagnostic, confirming, andtreatment methods of the invention, the subject has anxiety disorder andone or more additional disorders such as ADHD, ODD, conduct disorder,autism, Tourette's syndrome, phobia, obsessive compulsive disorder(OCD), difficulty controlling anger, disruptive behavior symptoms,dermatillomania, a developmental disorder, a mood disorder, a movementdisorder, or depression.

III. Methods and Uses for Treating Anxiety Disorder

Encompassed herein are methods of treating anxiety disorder in a subjectcomprising administering an effective amount of a nonselective mGluRactivator. The term “treatment,” as used herein, includes anyadministration or application of a therapeutic for a disease or disorderin a subject, and includes inhibiting the disease, arresting itsdevelopment, relieving the symptoms of the disease, or preventingoccurrence or reoccurrence of the disease or symptoms of the disease.

The mGluR proteins are typically placed into three sub-groups, group Ireceptors including mGluR1 and mGluR5 are classed as slow excitatoryreceptors.

Group II includes mGluR2 and mGluR3. Group III includes mGluR4, mGluR6,mGluR7, and mGluR8. Groups II and III are classed as slow inhibitoryreceptors. The mGluRs are distinguished from the ionotropic GluRs oriGluRs, which are ion channel-associated glutamate receptors and areclassed as fast excitatory receptors.

A “nonselective activator of mGluRs” refers to a molecule that activatesmGluRs from more than one of the group I, II, and III categories. Thus,a nonselective activator of mGluRs may provide for a general stimulationof the mGluR networks. This is in contrast to specific mGluR activatorsthat may only significantly activate a single mGluR, such as mGluR5, forexample. Nonselective mGluR activators also include nonselective mGluRagonists.

In some embodiments, the nonselective mGluR activator is fasoracetam.Fasoracetam is a nootropic (i.e., cognitive-enhancing) drug that canstimulate both group I and group II/III mGluRs in in vitro studies. (SeeHirouchi M, et al. (2000) European Journal of Pharmacology 387:9-17.)Fasoracetam may stimulate adenylate cyclase activity through activationof group I mGluRs, while it may also inhibit adenylate cyclase activityby stimulating group II and III mGluRs. (Oka M, et al (1997) BrainResearch 754:121-130.) Fasoracetam has been observed to be highlybioavailable (79%-97%) with a half-life of 5-6.5 hours in prior humanstudies (see Malykh A G, et al. (2010) Drugs 70(3):287-312). Fasoracetamis a member of the racetam family of chemicals that share a five-carbonoxopyrrolidone ring.

The structure of fasoracetam is:

The term “fasoracetam” as used herein encompasses pharmaceuticallyacceptable hydrates and any solid state, amorphous, or crystalline formsof the fasoracetam molecule. For example, the term fasoracetam hereinincludes forms such as NFC-1: fasoracetam monohydrate. In addition toNFC-1, fasoracetam is also known as C-NS-105, NS105, and LAM-105.

NFC-1 has been previously studied in Phase I-III clinical trials indementia-related cognitive impairment but did not show sufficientefficacy in dementia in Phase III trials. These trials demonstrated thatNFC-1 was generally safe and well tolerated for those indications. PhaseIII data indicated that NFC-1 showed beneficial effects on psychiatricsymptoms in cerebral infarct patients and adult dementia patients withcerebrovascular diseases.

In each of the method of treatment embodiments, a metabotropic glutamatereceptor positive allosteric modulator, a metabotropic glutamatereceptor negative allosteric modulator, or a tachykinin-3/neurokinin-3receptor (TACR-3/NK3R) antagonist may be administered alone or incombination with a nonselective activator of mGluRs, for example, tosubjects having an alteration in a mGluR network gene. In someembodiments, the treatment agent comprises ADX63365, ADX50938, ADX71149,AMN082, a 1-(hetero)aryl-3-amino-pyrrolidine derivative, LY341495,ADX48621, GSK1144814, or SB223412.

Also encompassed herein are methods of treating anxiety disordercomprising administering fasoracetam to a subject that has a geneticalteration in at least one mGluR network gene. In some embodiments, thissubject has anxiety disorder but does not have ADHD, ODD, conductdisorder, autism, Tourette's syndrome, phobia, obsessive compulsivedisorder (OCD), difficulty controlling anger, disruptive behaviorsymptoms, dermatillomania, a developmental disorder, a mood disorder, amovement disorder, or depression, while in other embodiments, thesubject has anxiety disorder as well as at least one of ADHD, ODD,autism, conduct disorder, Tourette's syndrome, phobia, obsessivecompulsive disorder (OCD), difficulty controlling anger, disruptivebehavior symptoms, dermatillomania, a developmental disorder, a mooddisorder, a movement disorder, or depression.

In some embodiments, the treatment methods comprise identifying ordiagnosing a subject as having a genetic alteration in at least onemGluR network gene, and administering a nonselective mGluR activatorsuch as fasoracetam to the identified or diagnosed subject. In some ofthe embodiments, the subject has anxiety disorder, but does not haveADHD, ODD, conduct disorder, autism, Tourette's syndrome, phobia,obsessive compulsive disorder (OCD), difficulty controlling anger,disruptive behavior symptoms, dermatillomania, a developmental disorder,a mood disorder, a movement disorder, or depression. In otherembodiments, the subject has anxiety disorder, as well as one or moreneuropsychological disorders such as ADHD, ODD, conduct disorder,autism, Tourette's syndrome, phobia, obsessive compulsive disorder(OCD), difficulty controlling anger, disruptive behavior symptoms,dermatillomania, a developmental disorder, a mood disorder, a movementdisorder, and depression.

In each method of treating embodiment of the invention, the anxietydisorder may be generalized anxiety disorder, phobia, social anxietydisorder, social phobia, panic disorder, panic attack, post-traumaticstress disorders, separation anxiety disorder, selective mutism,agoraphobia, or an anxiety disorder induced by a substance/medication ordue to another medical condition. In each method of treating embodimentof the invention, the subject may have an anxiety disorder, but not oneor more neuropsychological disorders such as ADHD, ODD, conductdisorder, autism, Tourette's syndrome, phobia, obsessive compulsivedisorder (OCD), difficulty controlling anger, disruptive behaviorsymptoms, dermatillomania, a developmental disorder, a mood disorder, amovement disorder, and depression.

In each method of treating embodiment of the invention, the nonselectivemGluR activator may improve symptoms of inattention, hyperactivity,anxiety, mood, and sleep disturbances that may be seen in patients withan anxiety disorder.

In one embodiment, the nonselective mGluR activator is administered to asubject that has anxiety disorder and has been confirmed as having atleast one genetic alteration in an mGluR network gene. The geneticalteration may be in a Tier 1 mGluR network gene. The genetic alterationmay be in a Tier 2 mGluR network gene. The genetic alteration may be ina Tier 3 mGluR network gene. The genetic alteration may be more than onegenetic alteration, and the more than one alteration may be in one ofTiers 1, 2, or 3, or in any combination of Tiers.

Some embodiments include a method of treating anxiety disordercomprising obtaining genetic information about a subject's mGluR networkgenes, and administering a nonselective mGluR activator if the subjecthas at least one genetic alteration, such as a CNV, in an mGluR networkgene. Other embodiments encompass a method of treating anxiety disordercomprising obtaining genetic information about a subject's mGluR networkgenes, and administering a nonselective mGluR activator if the subjecthas least one genetic alteration, such as a CNV, in a Tier 1 mGluRnetwork gene.

Other embodiments include a method of treating anxiety disordercomprising obtaining genetic information about a subject's mGluR networkgenes, and administering a nonselective mGluR activator if the subjecthas at least one genetic alteration, such as a CNV, in a Tier 2 mGluRnetwork gene. Still other embodiments encompass a method of treatinganxiety disorder comprising obtaining genetic information about asubject's mGluR network genes, and administering a nonselective mGluRactivator if the subject has at least one genetic alteration, such as aCNV, in a Tier 3 mGluR network gene. Subjects having more than one CNVin any one Tier, or in a combination of any of the three Tiers, may betreated by administering a nonselective mGluR activator. In someembodiments, subjects having anxiety disorder, but not having ADHD, ODD,conduct disorder, autism, Tourette's syndrome, phobia, obsessivecompulsive disorder (OCD), difficulty controlling anger, disruptivebehavior symptoms, dermatillomania, a developmental disorder, a mooddisorder, a movement disorder, or depression, may be treated. In othermethod of treatment embodiments of the invention, the subject has one ormore neuropsychological disorders such as ADHD, ODD conduct disorder,autism, Tourette's syndrome, phobia, obsessive compulsive disorder(OCD), difficulty controlling anger, disruptive behavior symptoms,dermatillomania, a developmental disorder, a mood disorder, a movementdisorder, and depression in addition to anxiety disorder.

IV. Methods for Determining the Presence or Absence of GeneticAlterations

Any biological sample may be used to determine the presence or absenceof mGluR network gene alterations, including, but not limited to, blood,urine, serum, gastric lavage, CNS fluid, any type of cell (such as braincells, white blood cells, mononuclear cells) or body tissue. Anybiological sample whereby DNA can be extracted may be used to determinethe presence or absence of mGluR network gene alterations. Samples maybe freshly collected, or samples may have been previously collected forany use/purpose and stored until the time of testing for geneticalterations. DNA that was previously purified for a different purposemay also be used.

Various methods for determining genetic alterations are known, includingthe following:

A. Single Nucleotide Variant (SNV)/Single Nucleotide Polymorphism (SNP)Genotyping

Determining whether a patient has a genetic alteration, such as a CNV,in an mGluR network gene may be done by SNP/SNV Genotyping. A “singlenucleotide variant (SNV),” also called a “single nucleotide polymorphism(SNP)” herein, refers to a change in which a single base in the DNAdiffers from the usual base at that position. Millions of SNVs have beencataloged in the human genome. Some SNVs are normal variations in thegenome, while others are associated with disease. While specific SNVsmay be associated with disease states or susceptibility, high-densitySNV genotyping can also be undertaken, whereby sequencing information onSNVs is used to determine the unique genetic makeup of an individual.

In SNV genotyping, SNVs can be determined by hybridizing complementaryDNA probes to the SNV site. A wide range of platforms can be used withSNV genotyping tools to accommodate varying sample throughputs,multiplexing capabilities, and chemistries. In high-density SNV arrays,hundreds of thousands of probes are arrayed on a small chip, such thatmany SNVs can be interrogated simultaneously when target DNA isprocessed on the chip. By determining the amount of hybridization oftarget DNA in a sample to a probe (or redundant probes) on the array,specific SNV alleles can be determined. Use of arrays for SNV genotypingallows the large-scale interrogation of SNVs.

When analyzing CNVs, after SNVs have been analyzed, a computer programcan be used to manipulate the SNV data to arrive at CNV data. PennCNV ora similar program, can then be used to detect signal patterns across thegenome and identify consecutive genetic markers with copy numberchanges. (See Wang K, et al. (June 2008) Cold Spring Harb Protoc).PennCNV allows for kilobase-resolution detection of CNVs. (See Wang K,et al. (November 2007) Genome Res. 17(11):1665-74).

In CNV analysis, the SNV genotyping data is compared with the behaviorof normal diploid DNA. The software uses SNV genotyping data todetermine the signal intensity data and SNV allelic ratio distributionand to then use these data to determine when there is deviation from thenormal diploid condition of DNA that indicates a CNV. This is done inpart by using the log R Ratio (LRR), which is a normalized measure ofthe total signal intensity for the two alleles of the SNV (Wang 2008).If the software detects regions of contiguous SNVs with intensity (LRR)trending below 0, this indicates a CNV deletion. If the software insteaddetects regions of contiguous SNVs with intensity (LRR) trending above0, this indicates a CNV duplication. If no change in LRR is observedcompared to the behavior of diploid DNA, the sequence is in the normaldiploid state with no CNV present. The software also uses B allelefrequency (BAF), a normalized measure of the allelic intensity ratio oftwo alleles that changes when alleles are lost or gained as with a CNVdeletion or duplication. For example, a CNV deletion is indicated byboth a decrease in LRR values and a lack of heterozygotes in BAF values.In contrast, a CNV duplication is indicated by both an increase in LRRvalues and a splitting of the heterozygous genotype BAF clusters intotwo distinct clusters. The software automates the calculation of LRR andBAF to detect CNV deletions and duplications for whole-genome SNV data.The simultaneous analysis of intensity and genotype data accuratelydefines the normal diploid state and determines CNVs.

Array platforms such as those from Illumina, Affymetrix, and Agilent maybe used in SNV Genotyping. Custom arrays may also be designed and usedbased on the data described herein.

B. Comparative Genomic Hybridization

Comparative genomic hybridization (CGH) is another method that may beused to evaluate genetic alterations such as CNVs. CGH is a molecularcytogenetic method for analyzing genetic alterations such as CNVs incomparison to a reference sample using competitive fluorescence in situhybridization (FISH). DNA is isolated from a patient and a referencesource and independently labeled with fluorescent molecules (i.e.,fluorophores) after denaturation of the DNA. Hybridization of thefluorophores to the resultant samples are compared along the length ofeach chromosome to identify chromosomal differences between the twosources. A mismatch of colors indicates a gain or loss of material inthe test sample in a specific region, while a match of the colorsindicates no difference in genetic alterations such as copy numberbetween the test and reference samples at a particular region.

C. Comparative Genomic Hybridization

Whole genome sequencing, whole exome sequencing, or targeted sequencingmay also be used to analyze genetic alterations such as CNVs. Wholegenome sequencing (also known as full genome sequencing, complete genomesequencing, or entire genome sequencing) involves sequencing of the fullgenome of a species, including genes that do or do not code forproteins. Whole exome sequencing, in contrast, is sequencing of only theprotein-coding genes in the genome (approximately 1% of the genome).Targeted sequencing involves sequencing of only selected parts of thegenome.

A wide range of techniques would be known to those skilled in the art toperform whole genome, whole exome, or targeted sequencing with DNApurified from a subject. Similar techniques could be used for differenttypes of sequencing.

Techniques used for whole genome sequencing include nanopore technology,fluorophore technology, DNA nanoball technology, and pyrosequencing(i.e., sequencing by synthesis). In particular, next-generationsequencing (NGS) involves sequencing of millions of small fragments ofDNA in parallel followed by use of bioinformatics analyses to piecetogether sequencing data from the fragments.

As whole exome sequencing does not need to sequence as large an amountof DNA as whole genome sequencing, a wider range of techniques are maybe used. Methods for whole exome sequencing include polymerase chainreaction methods, NGS methods, molecular inversion probes, hybridcapture using microarrays, in-solution capture, and classical Sangersequencing. Targeted sequencing allows for providing sequence data forspecific genes rather than whole genomes and can use any of thetechniques used for other types of sequencing, including specializedmicroarrays containing materials for sequencing genes of interest.

D. Other Methods for Determining Genetic Alterations

Proprietary methodologies, such as those from BioNano or OpGen, usinggenome mapping technology can also be used to evaluate geneticalterations such as CNVs.

Standard molecular biology methodologies such as quantitative polymerasechain reaction (PCR), droplet PCR, and TaqMan probes (i.e., hydrolysisprobes designed to increase the specificity of quantitative PCR) can beused to assess genetic alterations such as CNVs. Fluorescent in situhybridization (FISH) probes may also be used to evaluate geneticalterations such as CNVs. The analysis of genetic alterations such asCNVs present in patients with anxiety is not limited by the precisemethods whereby the genetic alterations such as CNVs are determined.

V. Methods for Diagnosing Anxiety Based on CNV Data

In some embodiments, the genetic alteration is a SNV or CNV. The SNV(s)or CNV(s) associated with anxiety disorder are found in an mGluR networkgene, such as a gene listed in Tier1, Tier2, or Tier3 as shown in FIGS.2-4 or a set or panel of such genes.

In some embodiments, gene sets of mGluR network genes are used foranalyzing samples from patients with or suspected of having anxietydisorder. In some embodiments, the presence of CNV duplications ordeletions within these gene sets or panels is determined. In someembodiments, CNVs in the Tier 1 genes shown in FIG. 2 are determined. Insome embodiments a panel of at least 10, at least 20, at least 30, atleast 40, at least 50, at least 60, at least 70, or all 76 of the Tier 1genes is evaluated for the presence of CNVs. Within any such panel ofgenes, individual, specific Tier 1 genes may be excluded from theanalysis set. Any or all of GRM1-8 may be excluded from the panel, forexample.

In some embodiments, the Tier 2 genes as shown in FIG. 3 are analyzedfor the presence of genetic alterations such as CNVs. Tier 2 genes arethose that are tightly associated with mGluRs, but which are notcontained within Tier 1.

In some embodiments, the Tier 2 genes are evaluated together with Tier 1genes. In some embodiments, at least 100 Tier 2 genes are evaluated,while in some embodiments, at least 150, or 197 of the Tier 2 genes areevaluated. Individual, specific Tier 2 genes may be excluded from thegene set for evaluation in some embodiments.

In some embodiments, the 599 Tier 3 genes shown in FIG. 4 are evaluatedfor genetic alterations such as CNVs. In some embodiments, the Tier 3genes are evaluated together with Tier 1 and/or Tier 2 genes. In someembodiments, at least 100 Tier 3 genes are evaluated, while in someembodiments, at least 150, 200, 250, 300, 350, 400, 450, or 599 of theTier 3 genes are evaluated. Individual, specific Tier 3 genes may beexcluded from the gene set for evaluation in some embodiments.

VI. Methods of Administration and Combination Therapy

In some embodiments, the agent that modulates mGluR signaling isfasoracetam or fasoracetam monohydrate (also known as C-NS-105, NFC1,NS105, or LAM-105).

A. Dosing

In some embodiments, fasoracetam may be administered as fasoracetammonohydrate (NFC-1). In some embodiments, fasoracetam may beadministered by mouth (i.e., per os). In some embodiments, fasoracetammay be administered as capsules. In some embodiments, fasoracetamcapsules may contain 50, 60, 70, 80, 90, 100, 110, 120, 125, 130, 135,140, 145, 150, 155, 160, 165, 170, 175, 180, 185, 190, 195, or 200 mg offasoracetam monohydrate. In some embodiments, fasoracetam may be dosedonce daily or twice daily. In some embodiments, the daily dose offasoracetam may be 50 mg once-daily, 100 mg once-daily, 200 mgonce-daily, 400 mg once-daily, 50 mg twice-daily, 100 mg twice-daily,200 mg twice-daily, or 400 mg twice-daily. In some embodiments,fasoracetam dosing may be adjusted using a series of dose escalations.In some embodiments, pharmacokinetic data on drug level or clinicalresponse is used to determine changes in dosing. In some embodiments,dose escalation of fasoracetam is not used. In some embodiments,subjects are treated at a dose of fasoracetam expected to be clinicallyefficacious without a dose-escalation protocol.

B. Combination Therapies

In some embodiments, fasoracetam is used in combination with otheragents for the treatment of anxiety disorder. The other agent used incombination with fasoracetam may be an anxiolytic (such as barbiturates,pregabalin, or benzodiazepines, including chlordiazepoxide, clorazepate,diazepam, flurazepam, halazepam, prazepam, lorazepam, lormetazepam,oxazepam, temazepam, clonazepam, flunitrazepam, nimetazepam, nitrazepam,adinazolam, alprazolam, estazolam, triazolam, climazolam, loprazolam, ormidazolam), antidepressant (such as fluoxetine, escitalopram, bupropion,mirtazapine, amitriptyline, imipramine, venlafaxine, sertraline,paroxetine, or other compounds in the classes of tricyclicantidepressants, selective serotonin reuptake inhibitors, serotonin andnorepinephrine reuptake inhibitors, norepinephrine and dopamine reuptakeinhibitors, monoamine oxidase inhibitors, or other drugs approved forthe use of depression), or beta-blocker (such as acebutolol, atenolol,betaxolol, bisoprolol, esmolol, nebivolol, metoprolol, cartelol,penbutolol, pindolol, carvedilol, labetalol, levobunolol, metipranolol,nadolol, propranolol, sotalol, timolol, or other selective ornonselective blockers of beta-adrenergic receptors).

In some embodiments, fasoracetam may be used in combination with anon-pharmacologic treatment, such as psychotherapy or brain stimulationtherapies. In some embodiments, fasoracetam is used in combination withbrain stimulation, which may be vagus nerve stimulation, repetitivetranscranial magnetic stimulation, magnetic seizure therapy, deep brainstimulation, or any other therapies involving modulation of brainfunction by electricity, magnets, or implants.

VII. Articles of Manufacture

In some embodiments, the invention comprises articles of manufacturethat may be used in the methods and treatments described herein. In oneembodiment, the manufacture is a solid support or microarray for use indetecting genetic alterations in some or all of the mGluR network geneslisted in FIGS. 1-3 (i.e., Tiers 1-3). (See also Tables 1-3 hereinproviding start and stop locations for different mGluR network-relatedSNPs. This information may be useful in constructing a microarray.) Insome embodiments, genes contained in multiple Tiers are assessed withinthe same solid support or microarray. In some embodiments, certain mGluRnetwork genes are excluded. In some embodiments, the GRM genes areexcluded.

Thus, for example, in some embodiments in which mGluR network genes areassayed to determine if there is a genetic alteration in one or more ofthe genes, such as a CNV, a solid support or microarray, such as on achip, is used that contains appropriate probes for determining thepresence of genetic alterations in 10, 20, 30, 40, 50, 60, 70 or all ofthe Tier 1 genes. In certain embodiments, the detectable labels are notnaturally occurring. In some embodiments, the solid support ormicroarray may also include appropriate probes for determining thepresence of genetic alterations in at least 10, 20, 30, 50, 100, 150, orall of the Tier 2 genes. In some embodiments, it may further includeappropriate probes for determining the presence of genetic alterationsin at least 10, 20, 50, 100, 200, 300, 400, 500 or all of the Tier 3genes. For example, such a solid support, microarray, or chip may beused to determine the presence of genetic alterations such as CNVs orSNVs in the Tier 1, Tier 1+2, or Tier 1+2+3 mGluR gene networks as partof a method of treating an ADHD or 22q deletion and/or duplicationpatient.

In some embodiments, the manufacture is a set of probes for mGluRnetwork genes of interest from Tiers 1, 2, and/or 3. In some embodimentsthe probes are labelled. Similarly, sets of probes may be manufacturedfor determining the presence of genetic alterations in 10, 20, 30, 40,50, 60, 70 or all of the Tier 1 genes. In some embodiments, probes maybe manufactured for determining the presence of genetic alterations inat least 10, 20, 30, 50, 100, 150, or all of the Tier 2 genes. In someembodiments, probes may further include those for determining thepresence of genetic alterations in at least 10, 20, 50, 100, 200, 300,400, 500 or all of the Tier 3 genes. These various probe sets may beused in methods of determining the presence of genetic alterations, suchas CNVs and SNVs in the Tier 1, Tier 1+2, or Tier 1+2+3 mGluR genenetworks as part of a method of treating an ADHD or 22q deletion and/orduplication patient.

EXAMPLES Example 1. Enrichment of CNV Calls Containing mGluR NetworkGenes in Samples from Patients with Anxiety Disorders

A study of potential enrichment of mGluR network genes was undertaken inpatients who had anxiety, phobias, depression, and obsessive-compulsivedisorders (OCD). Given the critical role of mGluRs and their signalingnetworks, changes in copy number of mGluR network genes may provide newapproaches for diagnostics or treatments for psychiatric disorders.

Previously, a large-scale genome association study for copy-numbervariations enriched in patients with ADHD was performed as described inElia et al., Nature Genetics, 44(1): 78-84 (2012)). Elia's studyincluded about 2,493 patients with ADHD and about 9,222 controls, all ofwhom were of European ancestry and were between the ages of 6 and 18years of age. This study noted that the rate of CNVs that contained amGluR network gene was 1.2% in the control group, and that this rateincreased to 11.3% in ADHD patients.

Samples for the present study were selected based on ICP-9 codes fordiagnoses of children and adolescents from electronic health recordsthat were treated at the Children's Hospital of Philadelphia (CHOP). Allsubjects had been evaluated by a pediatric psychiatrist who had entereda diagnosis of anxiety, depression, obsessive-compulsive disorder (OCD),or phobia. FIG. 1 shows the number of patient samples analyzed in eachof the anxiety, depression, OCD and phobia groups. Certain patients foreach group were fully genotyped as shown in FIG. 1 . Data from fullygenotyped patients were used for analysis.

Single nucleotide variant (SNV)/single nucleotide polymorphism (SNP)genotype data were used to determine CNVs. SNV genotyping provides agenetic fingerprint of an individual using a large number of SNV markersto provide high-density SNV genotyping data (see Wang K, et al.(November 2007) Genome Res. 17(11):1665-74). HumanHap550 GenotypingBeadChip™ (Illumina) or Human610—Quad v1.0 BeadChip™ (Illumina) wereused in this study. For both chips, the same 520 SNVs were analyzed;therefore, data from these two chips are interchangeable. Standardmanufacturer protocols were used for all genotyping assays. Illuminareaders were used for all experiments.

SNV genotyping data from each fully genotyped patient sample wereanalyzed with the PennCNV software to determine the signal intensitydata and SNV allelic ratio distribution. These data were then used todetermine CNVs via simultaneous analysis of intensity and genotype data(as previously described in Wang 2008). Using this analysis, dataindicating a region of loss of contiguous SNVs lead to a call of a CNVdeletion. Data indicating a region of gain of contiguous SNVs lead to acall of a CNV duplication. A single individual may have multiple CNVdeletions/duplications or may not have any CNVs.

As discussed previously, three tiers of mGluR network genes weredeveloped. FIGS. 2-4 show the genes that are included in the three genesets—Tier 1 (76 genes) in FIG. 2 , Tier 2 (197 genes) in FIG. 3 , andTier 3 (599 genes) in FIG. 4 . Note that these gene sets werenon-inclusive, so a single gene was only contained in a single Tier.

FIG. 5 shows data on the number of CNV calls in each mGluR gene Tier forthe different patient groups. CNVs are either a duplication or deletion.The data indicate that a larger number of CNV calls were seen for eachgene set of mGluR network genes in the samples from patients withanxiety as compared to patients with depression, OCD, and phobia.

The percentage of patients who had a CNV call (either duplication ordeletion) in each gene set of mGluR network genes is shown in FIG. 6 .These data indicate that a substantially higher percentage of patientswith anxiety had a CNV call within each of the mGluR network gene setscompared with patients with depression, phobia, or OCD. The controlfrequency of patients with CNVs in mGluR network genes has previouslybeen estimated in a large study of over 9,000 controls of Europeanancestry to be 1.2% (see Elia), supporting the specificity of theenrichment of mGluR network genes within CNVs in patients with anxietydisorders. Based on data in the present study, the frequency of patientswith OCD, phobia, or depression for CNVs was less than 1.6% for the Tier1 gene set, while the frequency of patients with CNVs in patients withanxiety was 7.91% for Tier 1, 12.20% for Tier 1 and 2, and 26.65% forTiers 1, 2, and 3. See FIG. 6 .

As indicated in FIGS. 5-6 , there was a significant enrichment of mGluRnetwork gene alterations in the patients with anxiety. Therefore,diagnostics and treatments focused on modulation of mGluR gene networksmay be of particular use in patients with anxiety disorders.

Example 2. Analysis of mGluR Network Genes Contained within CNVs fromSamples of Patients with Anxiety Disorder

We next analyzed genotyping data from the 925 fully genotyped patientswith anxiety disorder to identify the genes associated with the CNVs.The mGluR network genes that are contained within CNVs from this groupof 925 patients are presented as examples of genes within the mGluRnetwork that are contained within CNVs either as duplications ordeletions.

Table 1 shows data of representative CNVs from patients with anxietywherein a Tier 1 mGluR network gene was located within, or in thevicinity of, a CNV in the patient's sample. CNVs can lead to structuralchanges that affect the transcription of genes located outside of, butin the vicinity of, the CNV. As such, mGluR network genes within one ofthe Tiers that were located within 500,000 base pairs of a CNV were alsoincluded in the analysis. When an mGluR network gene is contained withinthe listed CNV, this is noted with a “distance from gene” value of 0.When an mGluR network gene is contained in close proximity to a CNV butnot within it, this is presented with a “distance from gene” value ofgreater than 0.

Table 1 lists the chromosome wherein the CNV was located, with its startand stop location in relation to the Human Genome version 19 (hg19). Thenumber of SNVs located within the CNV is noted as “Num SNP,” and thelength of the CNV is noted in base pairs. The StartSNP and EndSNP of theCNV are also provided.

The “State, CN” column indicates the copy number resulting from the CNV.As normal human DNA (i.e. with no CNV) should be diploid and would havea “State, CN” of 2. CNVs with a “State, CN” of 0 or 1 indicate a copynumber deletion. In contrast, CNVs with a “State, CN” of three orgreater indicate a copy number duplication.

The confidence value indicates the relative confidence that the call ofthe CNV is correct. All CNVs included in this analysis had a positiveconfidence value, indicating a high likelihood that the CNV call iscorrect. A value of 15 or greater was seen for most CNVs and isconsidered extremely high confidence in the CNV call based on qPCR andTaqman genotyping validation.

In Table 1, the “mGluR gene” column lists the specific mGluR networkgene within Tier 1 contained within the listed CNV. Table 1 is sorted toshow all of the CNVs that included a given Tier 1 mGluR network gene.Some Tier 1 genes may be represented in multiple CNVs from differentpatients in the study, leading to multiple rows for those particularmGluR network genes. Some Tier 1 genes may not have been represented ina CNV from this particular patient population.

Table 2 shows data from specific CNVs that contained a Tier 1 or Tier 2mGluR network gene. The organization of Table 2 follows that of Table 1.The “mGluR gene” column lists the specific mGluR network gene withinTier 1 or Tier 2 contained within the listed CNV. Table 2 is sorted toshow all of the CNVs that included a given Tier 1 or Tier 2 mGluRnetwork gene. Some Tier 1 or Tier 2 genes may be represented in multipleCNVs from different patients in the study, leading to multiple rows forthose particular genes. Some Tier 1 or Tier 2 genes may not have beenrepresented in a CNV from this particular patient population.

Table 3 shows data from specific CNVs that contained a Tier 1, 2, or 3mGluR network gene. The organization of Table 3 follows that of Tables 1and 2. The “mGluR gene” column lists the specific mGluR network genewithin Tier 1, Tier 2, or Tier 3 contained within the listed CNV. Table3 is sorted to show all the CNVs that included a given Tier 1, 2, or 3mGluR network gene. Some Tier 1, 2, or 3 genes may be represented inmultiple CNVs from different patients in the study, leading to multiplerows for those particular mGluR network genes. Some Tier 1, 2, or 3genes may not have been represented in a CNV from this particularpatient population.

Together, the data in Tables 1-3 indicate that a wide variety of mGluRnetwork genes contained within each Tier are present in CNVs frompatients with anxiety. If a larger patient cohort with anxiety phenotypewas genotyped, all the genes in Tier-1, Tier-2, and Tier-3 would showenrichment for CNVs in patients with anxiety.

Example 3. Improvements in Anxiety/Mood in ADHD Patients GivenFasoracetam Monohydrate (NFC-1)

An open-label Phase 1b clinical trial was conducted to investigate thesafety, pharmacokinetics and efficacy of NFC-1 (fasoracetam monohydrate)in adolescent subjects between the ages of 12 and 17 previouslydiagnosed with ADHD who also had at least one genetic alteration in anmGluR network gene.

The study included 30 ADHD subjects who were between ages 12 and 17, ofany ancestry or race, and of weight within the 5th to 95th percentilefor their age, and otherwise judged to be in good medical health.Subjects were genotyped and included in the trial if they possess atleast one genetic alteration in the form of at least one copy numbervariation (deletion or duplication) in an mGluR network gene thatpotentially disrupts the function of the gene. Seventeen of the 30subjects have a CNV in a tier 1 mGluR network gene, while 7 subjectshave a CNV in a Tier 2 gene and 6 in a Tier 3 gene. At enrollment,several trial subjects showed evidence of co-morbid phenotypes such asanxiety and mood disorders, based on the results of items 19-47 of aparent-conducted Vanderbilt Scale.

Exclusion criteria comprised subjects suffering from a clinicallysignificant illness, either mental or physical, that, in theinvestigator's opinion, might confound the results of the study or thatmight prevent them from completing the study, subjects that are pregnantor nursing, subjects that test positive for illicit drugs of that have ahistory of drug abuse, subjects that consume alcoholic beverages, orsubjects for which the investigator is otherwise concerned regardingtheir compliance or suitability.

NFC-1 capsules of either 50 mg or 200 mg comprising fasoracetammonohydrate as active ingredient and placebo capsules comprisingmicrocellulose were used for the study. The design of the trial was aphone screening (1 day), enrollment phase (1 to 2 days), a wash-outphase for subjects currently on ADHD medications (1-14 days),pharmacokinetic (PK) assessment (2 days), followed by a dose-escalationphase (35 days) and a follow-up phone visit approximately four weeksafter the last dose, for a maximum of 127 days. All ADHD medicationswere discontinued during the wash-out phase prior to the study. Thewash-out period for stimulants was 2-3 days and that for atomoxetine ornoradrenergic agonists was 10-12 days. No new ADHD medications werestarted during the study.

A dose-escalation phase of the trial ran over a 5-week period, after theinitial wash-out period and the PK and initial safety assessments.During week 1, all subjects were administered placebo capsules twicedaily. After one week of placebo treatment, patients were started on 50mg bid NFC-1 for 1 week. If safety and responsiveness data from priordose level of fasoracetam indicated it was appropriate, subjects werethen escalated to the next higher dose (100, 200, or 400 mg). Subjectswho showed tolerance to the 50 mg bid dose as well as response to thedrug were to be maintained at that level for the remaining 3 weeks ofthe trial. Subjects who showed tolerance but lack of response or partialresponse to the 50 mg bid dose were to be moved up to the next higherdose of 100 mg during the following week. Subjects who showed toleranceat 100 mg but lack of response or partial response were to be moved upto the 200 mg dose the following week while those who showed bothtolerance and response at 100 mg were to be kept at 100 mg bid for theremainder of the trial. Similarly, subjects moved up to the 200 mg dosewho showed both tolerance and response were to be kept at 200 mg for thefinal week of the trial while those showing tolerance but lack ofresponse or partial response were moved to a 400 mg dose for the finalweek. Of the 30 trial subjects, 3 received a maximum dose of 100 mg, 9received a maximum dose of 200 mg, and the remaining 18 received amaximum dose of 400 mg.

Certain subjects in the study also displayed other co-morbid phenotypessuch as anxiety, depression, mood disorders, and sleep disturbances suchas insomnia, according to the information recorded in the enrollment andweek 1. At enrollment, two subjects had maximum scores of 3 on 2 of the3 Vanderbilt Scale items (nos. 41, 42, and 47) that are related toanxiety. At week 5, these subjects scored 3 on all 3 items.

Results of a BRIEF scale were also analyzed for changes in anxiety/moodscores in all 30 subjects. The BRIEF scale, performed by parents,requests information on the frequency of the following behaviors:

-   -   1. Over-reacts to small problems;    -   6. Upset with new situations;    -   7. Explosive-angry outbursts;    -   12. Upset by changes in plans;    -   13. Disturbed by change of teacher/class;    -   20. Easily tearful;    -   23. Resists change of routine, foods, plans;    -   25. Outbursts for little reason;    -   26. Mood changes frequently;    -   30. Trouble getting used to new situations;    -   45. Reacts more strongly to situations than other children;    -   50. Mood easily influenced by situation;    -   62. Angry or tearful outbursts are intense but end suddenly;    -   64. Small events trigger big reactions; and    -   70. Becomes upset too easily.

The answers to these questions are scored as “never,” “sometimes,” or“often.” The BRIEF test was administered at enrollment and again aftereach week of the dose escalation treatment from placebo week to week 5.All scores for all 30 subjects for each question above were added up forenrollment and week 5, giving 1 point for each “never” or “often” score.It was found that the total “never” score for all questions for allsubjects at enrollment was 125 and at week 5 was 191, showing a trendtoward improvement. Similarly, the total “often” score at enrollment was154 while the total “often” score at week 5 was 77, again showing atrend toward improvement in anxiety and mood symptoms in the ADHDsubjects.

Example 4. Treatment with Fasoracetam Monohydrate (NFC-1) of ADHDPatients with CNVs in mGluR Network Genes and Impact on ObsessiveCompulsive Symptoms

Among the 30 ADHD subjects tested in the open-label Phase Ib clinicaltrial described in Example 2, eight had symptoms of obsessivecompulsive-disorder (OCD). One of the subjects with tics also hadsymptoms of OCD. In all eight subjects, OCD symptoms improved duringtherapy with NFC-1.

One subject with OCD also had a history of ear scratching (i.edermatillomania), leading to a bleeding ulcer. The bleeding ulcer healedduring therapy with NFC-1, indicating that the subject's dermatillomaniasymptoms had reduced during NFC-1 therapy.

Example 5. Study of Phenotypes Associated with mGluR Network CNVs

A total of 1,000 ADHD patients aged 6-17 years were enrolled in a trialto consider phenotypes that may be associated with CNVs in Tier 1 or 2mGluR network genes. Study sites collected saliva for a DNA sample. EachDNA sample was then subjected to DNA extraction, genetic sequencing, andbiobanking of DNA.

Genetic sequencing results together with medical history were used toevaluate genotype (based on genetic sequencing) and phenotype (based oninterviews conducted by a clinician with the subject'sparent(s)/guardian(s)). Subjects had ADHD as defined by the Diagnosticand Statistical Manual of Mental Disorders, 5th Edition (DSM-V).

A single clinician posed a series of questions related to potentialbehavioral or health phenotypes to the parent(s) or legal guardian(s) ofthe subjects. For each individual phenotype, the parent/guardian wasasked: “Is this a current concern” and a Yes or No answer was collected.The clinician determined the frequency of Yes and No responses togenerate phenotype data.

The study found that prevalence of anger control as a current concernfor parents was 58.9% in ADHD subjects with a Tier 1 or 2 mGluR networkgene CNV but only 47.4% in ADHD subjects without such an mGluR networkgene CNV. This difference was statistically significant (odds ratio of1.59, P=0.003). This odds ratio of greater than 1 implies a higherprevalence of current anger control concerns in parents in ADHD subjectswho had a Tier 1 or 2 mGluR network gene CNV versus those without such aCNV.

The prevalence of disruptive behavior as a current concern for parentswas 57.1% in ADHD subjects with a Tier 1 or 2 mGluR network gene CNV and43.9% in ADHD subjects without such an mGluR network gene CNV. Thisdifference was also statistically significant (odds ratio of 1.70,P<0.001), indicating a higher prevalence of current disruptive behaviorconcerns in parents in ADHD subjects who also had an mGluR network genemutation versus those without a mutation.

Example 6: Copy Number Variation in mGluR Network Genes in ADHD Subjectswith Co-Morbid Disorders

Samples from 2707 known ADHD pediatric subjects (mean age of about10-10.5 years) were genotyped on 550/610 Illumina chips to determine ifthey have one or more CNVs in Tier 1 or Tier 2 genes. The 2707 subjectsincluded 759 females and 1778 males of African American or whiteethnicity (1063 and 1483, respectively). 430 of the 2707 subjects(16.9%) had at least one CNV in an mGluR Tier 1 or Tier 2 gene.

The 2707 subjects' records were also checked to determine if they hadco-morbid diagnoses according to the World Health OrganizationInternational Classification of Diseases 9th Edition (ICD-9). Of the2707 subjects, 1902 (about 70%) had comorbidities while 805 did not. Ofthose 1902 subjects with comorbidities, about 30% had more than onecomorbidity, and about 20% had two or more, while smaller percentageshad larger numbers of comorbidities.

The most prevalent comorbidities, each occurring in more than 100 of thesubjects, are listed in Table 4. The table lists the comorbidities byICD-9 code and provides the number of cases among the 2707 subjects(column titled “N”) and name for each co-morbid condition or disorder.

TABLE 4 ICD-9 Code N Name N_299.00 342 Autistic disorder, current oractive state N_299.80 267 Other specified pervasive developmentaldisorders, current or active state N_299.90 179 Unspecified pervasivedevelopmental disorder, current or active state N_300.00 407 Anxietystate unspecified N_311 244 Depressive disorder not elsewhere classifiedN_312.9 568 Unspecified disturbance of conduct N_313.81 313 Oppositionaldefiant disorder (ODD) N_314.9 120 Unspecified hyperkinetic syndrome ofchildhood N_315.2 320 Other specific developmental learning difficultiesN_315.31 189 Expressive language disorder N_315.32 157 Mixedreceptive-expressive language disorder N_315.39 327 Other developmentalspeech disorder N_315.4 116 Developmental coordination disorder N_315.5160 Mixed development disorder N_315.8 398 Other specified delays indevelopment N_315.9 479 Unspecified delay in development N_319 110Unspecified intellectual disabilities

The comorbidities in Table 4 tend to cluster into a few differentgroups: disorders related to anxiety, depression, or mood; prevalentdevelopmental disorders; less prevalent developmental disorders; andautism and related disorders.

The genotype data and the comorbidity data were then combined todetermine how many of the subjects with CNVs in Tier 1 or 2 mGluRnetwork genes also had comorbidities. It was found that 316 of thesubjects with such a CNV also had at least one comorbidity (about 18% ofthe CNV-positive subjects or about 12% of the total subjects) while 114of the subjects without a Tier 1 or 2 mGluR network gene CNV had atleast one comorbidity (about 15% of the CNV-negative subjects or about4% of the total subjects). This difference showed a P value of 0.118.Thus, comorbidities tended to be more common in CNV-positive than inCNV-negative subjects overall. When only subjects identifying as whiteethnicity are considered, there was a highly significant correlationbetween mGluR CNVs and ADHD comorbidities. Specifically, 218 of 1483subjects had at least one CNV in a Tier 1 or 2 mGluR network gene, and,of those 218 subjects, 169 also had a comorbidity whereas 49 did not.That difference showed a P value of 0.004.

The foregoing written specification is considered to be sufficient toenable one skilled in the art to practice the embodiments. The foregoingdescription and Examples detail certain embodiments and describes thebest mode contemplated by the inventors. It will be appreciated,however, that no matter how detailed the foregoing may appear in text,the embodiment may be practiced in many ways and should be construed inaccordance with the appended claims and any equivalents thereof.

As used herein, the term about refers to a numeric value, including, forexample, whole numbers, fractions, and percentages, whether or notexplicitly indicated. The term about generally refers to a range ofnumerical values (e.g., +/−5-10% of the recited range) that one ofordinary skill in the art would consider equivalent to the recited value(e.g., having the same function or result). When terms such as at leastand about precede a list of numerical values or ranges, the terms modifyall of the values or ranges provided in the list. In some instances, theterm about may include numerical values that are rounded to the nearestsignificant figure.

TABLE 1 Distance From Chr: Start-Stop(hg19) NumSNP Length State, CNStartSNP EndSNP Confidence Gene mGluR Gene chr11: 84128537-1209415837678 36813047 1 rs488925 rs4643089 29.271 0 ACAT1 chr11:98062720-121890280 5422 23827561 1 rs6589308 rs1944465 29.075 0 ACAT1chr11: 21723471-131521797 20508 109798327 1 rs11828478 rs2512898 27.5650 ACAT1 chr11: 42185849-126756938 15451 84571090 1 rs4375424 rs1075035636.99 0 ACAT1 chr11: 74545378-134940416 14496 60395039 3 rs512780rs11224228 527.758 0 ACAT1 chr17: 21685812-67308196 12365 45622385 1rs34864328 rs17686852 50.018 0 ACCN1 chr17: 32104675-32822032 239 7173584 rs6505377 rs213135 113.523 0 ACCN1 chr17: 26648492-58955084 583132306593 3 rs1981512 rs8068776 15.642 0 ACCN1 chr2: 34870277-24192962137755 207059345 3 rs13422005 rs10205276 46.946 0 ACTR2 chr2:38101137-241482099 36812 203380963 1 rs879321 rs7576043 52.099 0 ACTR2chr2: 12056323-227979775 39094 215923453 1 rs966391 rs1922020 31.384 0ACTR2 chr2: 41212010-82396211 9721 41184202 3 rs12614285 rs934310396.396 0 ACTR2 chr7: 8794418-119068130 23484 110273713 1 rs2189621rs6977904 70.867 0 ADCY1 chr7: 7724805-53845684 11772 46120880 3rs10263415 rs6948633 42.007 0 ADCY1 chr7: 8872727-156383359 27773147510633 1 rs917038 rs878717 32.336 0 ADCY1 chr7: 11855636-15614860826852 144292973 1 rs6947930 rs6945016 36.446 0 ADCY1 chr7:60392-84158180 19095 84097789 3 rs12670102 rs2715048 208.308 0 ADCY1chr11: 23168804-106781292 16332 83612489 1 rs11027007 rs7103285 49.747 0ADRBK1 chr11: 66898492-67136981 22 238490 1 rs11227699 rs3781941 17.9550 ADRBK1 chr11: 21723471-131521797 20508 109798327 1 rs11828478rs2512898 27.565 0 ADRBK1 chr11: 42185849-126756938 15451 84571090 1rs4375424 rs10750356 36.99 0 ADRBK1 chr11: 66933410-67046501 14 113092 1rs1253784 rs12274774 5.288 0 ADRBK1 chr16: 29441284-33923125 585 44818423 rs7206789 rs4043755 42.437 0 ALDOA chr16: 176743-50013967 832849837225 3 rs2562164 rs12597023 174.392 0 ALDOA chr21: 14601415-480849898249 33483575 3 rs2775537 rs2839378 41.154 0 APP chr21:14601415-48084989 8249 33483575 3 rs2775537 rs2839378 12047.211 0 APPchr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0APP chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs28393784787.438 0 APP chr21: 14768343-48084989 8193 33316647 3 rs2257224rs2839378 5021.076 0 APP chr21: 10708231-47970581 8807 37262351 3rs4044122 rs2255397 73.188 0 APP chr5: 49952847-89853069 7268 39900223 3rs12188654 rs42467 26.225 0 ARL15 chr5: 39526068-67275356 4441 277492891 rs16869031 rs999826 77.848 0 ARL15 chr5: 52884614-53418318 145 5337051 rs524289 rs9292039 31.471 0 ARL15 chr5: 4872310-180709915 35876175837606 3 rs816467 rs10071993 179.394 0 ARL15 chr17: 21685812-6730819612365 45622385 1 rs34864328 rs17686852 50.018 0 ATXN7L3 chr17:26648492-58955084 5831 32306593 3 rs1981512 rs8068776 15.642 0 ATXN7L3chr14: 26898958-104436931 17396 77537974 1 rs1245195 rs11851097 57.233 0BDKRB2 chr14: 80818058-105348552 5492 24530495 3 rs6574553 rs202841615.874 0 BDKRB2 chr14: 65405722-103799039 8979 38393318 3 rs11623705rs11628472 266.153 0 BDKRB2 chr8: 60424884-145286483 17030 84861600 3rs1401422 rs9720889 8.858 0 CA8 chr8: 60494752-60667231 25 172480 1rs12674637 rs6471803 14.25 434192 CA8 chr8: 23218101-146274708 23020123056608 1 rs7010362 rs7822726 38.828 0 CA8 chr8: 30757798-14275096920699 111993172 1 rs10101203 rs6421025 34.223 0 CA8 chr8:43235525-66712108 3632 23476584 3 rs10091311 rs7001138 58.838 0 CA8chr9: 139492789-140913833 196 1421045 1 rs28485548 cnvi0002661 28.211 0CACNA1B chr9: 139821068-141105225 163 1284158 3 rs3750512 rs1155936355.611 0 CACNA1B chr1: 79710545-188898319 17303 109187775 1 rs417181rs16829637 45.89 0 CACYBP chr1: 75098453-243531649 27360 168433197 1rs12117493 rs10927002 32.113 0 CACYBP chr1: 64114301-245591329 29842181477029 1 rs11208257 rs1173850 37.504 0 CACYBP chr1:174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0CACYBP chr1: 109645793-194560463 12025 84914671 3 cnvi0008281 rs1092161663.121 0 CACYBP chr14: 26898958-104436931 17396 77537974 1 rs1245195rs11851097 57.233 0 CALM1 chr14: 80818058-105348552 5492 24530495 3rs6574553 rs2028416 15.874 0 CALM1 chr14: 65405722-103799039 897938393318 3 rs11623705 rs11628472 266.153 0 CALM1 chr1:178626526-244159143 13064 65532618 3 rs2761477 rs479338 11.373 0 CHRM3chr1: 238655362-242087644 1078 3432283 3 rs2392861 rs4658565 806.215 0CHRM3 chr1: 75098453-243531649 27360 168433197 1 rs12117493 rs1092700232.113 0 CHRM3 chr1: 64114301-245591329 29842 181477029 1 rs11208257rs1173850 37.504 0 CHRM3 chr1: 174219398-247422297 15986 73202900 1rs16846809 rs4642922 35.258 0 CHRM3 chr1: 236848751-249219320 329312370570 3 rs819666 cnvi0018731 920.725 0 CHRM3 chr19: 31569338-537809663788 22211629 1 rs2867544 rs10407424 33.9 0 CIC chr19: 288246-5911062811009 58822383 3 rs10409452 cnvi0009466 100.582 0 CIC chr17:21685812-67308196 12365 45622385 1 rs34864328 rs17686852 50.018 0 CNPchr17: 26648492-58955084 5831 32306593 3 rs1981512 rs8068776 15.642 0CNP chr3: 1850547-2114929 103 264383 3 rs4543005 rs9880266 402.844 25621CNTN4 chr3: 1819843-1962536 66 142694 1 rs9875417 rs4685465 225.117178014 CNTN4 chr3: 234726-6328081 2293 6093356 3 rs7632811 rs1595039106.207 0 CNTN4 chr3: 179527-114630641 23879 114451115 3 rs4684741rs1587972 207.852 0 CNTN4 chr3: 1818056-1981567 55 163512 1 rs7624354rs1488757 186.651 158983 CNTN4 chr17: 21685812-67308196 12365 45622385 1rs34864328 rs17686852 50.018 0 CRHR1 chr17: 43657921-44064851 65 4069313 rs9898857 rs8079215 86.447 0 CRHR1 chr17: 43657921-44354796 88 6968763 rs9898857 rs2732700 21.196 0 CRHR1 chr17: 26648492-58955084 583132306593 3 rs1981512 rs8068776 15.642 0 CRHR1 chr2: 34870277-24192962137755 207059345 3 rs13422005 rs10205276 46.946 0 CTNNA2 chr2:77041264-194763754 21140 117722491 1 rs2102827 rs16835406 94.091 0CTNNA2 chr2: 38101137-241482099 36812 203380963 1 rs879321 rs757604352.099 0 CTNNA2 chr2: 12056323-227979775 39094 215923453 1 rs966391rs1922020 31.384 0 CTNNA2 chr2: 41212010-82396211 9721 41184202 3rs12614285 rs934310 396.396 0 CTNNA2 chr1: 178626526-244159143 1306465532618 3 rs2761477 rs479338 11.373 0 DISC1 chr1: 188850774-23542360710060 46572834 1 rs16829466 rs12409696 43.25 0 DISC1 chr1:191875752-235423607 9517 43547856 1 rs9427811 rs12409696 62.01 0 DISC1chr1: 231711489-231813134 28 101646 3 rs1765782 rs6541281 70.39 0 DISC1chr1: 231711489-231813134 22 101646 3 rs1765782 rs6541281 42.561 0 DISC1chr1: 75098453-243531649 27360 168433197 1 rs12117493 rs10927002 32.1130 DISC1 chr1: 64114301-245591329 29842 181477029 1 rs11208257 rs117385037.504 0 DISC1 chr1: 174219398-247422297 15986 73202900 1 rs16846809rs4642922 35.258 0 DISC1 chr1: 226536645-236803753 2600 10267109 3rs874583 rs10925178 100.109 0 DISC1 chr7: 78621315-155831817 1367877210503 3 rs1006818 rs6969015 123.319 0 DPP6 chr7: 153503148-15366215140 159004 3 rs2622200 rs4726357 86.109 0 DPP6 chr7: 153843805-15394655129 102747 3 rs9690764 rs9640345 36.97 0 DPP6 chr7: 153694399-15381165511 117257 3 rs10235799 rs3115192 13.736 0 DPP6 chr7: 8872727-15638335927773 147510633 1 rs917038 rs878717 32.336 0 DPP6 chr7:11855636-156148608 26852 144292973 1 rs6947930 rs6945016 36.446 0 DPP6chr7: 143807304-158827326 3603 15020023 3 rs10252253 rs2071624 54.584 0DPP6 chr12: 59512781-127744939 13469 68232159 3 rs908394 rs7966946 20.620 DYNLL1 chr12: 10020267-129866293 23654 119846027 1 rs1597097 rs217050445.428 0 DYNLL1 chr12: 112610714-133708729 5366 21098016 3 rs11066188rs11147249 695.45 0 DYNLL1 chr12: 50855195-133778796 17748 82923602 3rs4351895 rs7975069 159.589 0 DYNLL1 chr19: 43257015-55294329 −730912037315 3 rs7246152 rs2569676 21.402 0 FPR1 chr19: 31569338-537809663788 22211629 1 rs2867544 rs10407424 33.9 0 FPR1 chr19: 288246-5911062811009 58822383 3 rs10409452 cnvi0009466 100.582 0 FPR1 chr12:6562293-6711147 27 148855 1 rs2041385 rs1639122 19.307 0 GAPDH chr12:6485661-6711147 48 225487 1 rs3759324 rs1639122 18.66 0 GAPDH chr12:207886-50770291 11565 50562406 3 rs868249 rs4477515 43.892 0 GAPDHchr19: 266034-18061509 3100 17795476 3 rs2312724 rs7250332 19.51 0 GNA15chr19: 629303-4119012 709 3489710 1 rs2283575 rs350887 26.758 0 GNA15chr19: 288246-59110628 11009 58822383 3 rs10409452 cnvi0009466 100.582 0GNA15 chr3: 33409611-170735099 23775 137325489 1 rs3915062 rs1192403226.867 0 GNAI2 chr3: 13878889-149737330 24723 135858442 1 rs12634112rs2007869 55.663 0 GNAI2 chr3: 179527-114630641 23879 114451115 3rs4684741 rs1587972 207.852 0 GNAI2 chr16: 50219449-89544756 1032439325308 3 rs6500298 rs3803681 108.108 0 GNAO1 chr9: 2522475-14006834225719 137545868 3 rs10966757 rs4074426 93.386 0 GNAQ chr9:33180228-132003792 14691 98823565 1 rs7854765 rs9408988 28.69 0 GNAQchr9: 1989033-107532317 18263 105543285 1 rs7864828 rs10820726 39.824 0GNAQ chr9: 46587-94335290 17484 94288704 3 rs10814410 rs9409606 762.3930 GNAQ chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs283937841.154 0 GRIK1 chr21: 30057145-31992864 372 1935720 1 rs6516861rs1702405 41.668 0 GRIK1 chr21: 14601415-48084989 8249 33483575 3rs2775537 rs2839378 12047.211 0 GRIK1 chr21: 14595264-48084989 878133489726 3 rs2847443 rs2839378 1871.363 0 GRIK1 chr21: 14601415-480849898249 33483575 3 rs2775537 rs2839378 4787.438 0 GRIK1 chr21:14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 GRIK1chr21: 10708231-47970581 8807 37262351 3 rs4044122 rs2255397 73.188 0GRIK1 chr1: 1005806-105612342 19173 104606537 3 rs3934834 rs158463344.152 0 GRIK3 chr1: 2006108-109527861 22130 107521754 3 rs2254669rs839879 162.269 0 GRIK3 chr6: 73120320-165130872 18715 92010553 1rs9442780 rs10946016 76.383 0 GRM1 chr6: 73120320-165130872 1871592010553 1 rs9442780 rs10946016 76.383 0 GRM1 chr6: 94117546-16510367915579 70986134 1 rs3799792 rs9347902 34.066 0 GRM1 chr6:94117546-165103679 15579 70986134 1 rs3799792 rs9347902 34.066 0 GRM1chr6: 66609532-147053632 15315 80444101 3 rs9354335 rs4896886 44.941 0GRM1 chr6: 66609532-147053632 15315 80444101 3 rs9354335 rs489688644.941 0 GRM1 chr6: 66541198-162520133 19344 95978936 1 rs2000382rs6901071 27.509 0 GRM1 chr6: 66541198-162520133 19344 95978936 1rs2000382 rs6901071 27.509 0 GRM1 chr6: 64844594-169078546 21567104233953 1 rs4710465 rs601639 46.524 0 GRM1 chr6: 64844594-16907854621567 104233953 1 rs4710465 rs601639 46.524 0 GRM1 chr6:67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 GRM1chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0GRM1 chr6: 100082983-170909002 16393 70826020 3 rs594231 rs12213906261.313 0 GRM1 chr6: 100082983-170909002 16393 70826020 3 rs594231rs12213906 261.313 0 GRM1 chr7: 78621315-155831817 13678 77210503 3rs1006818 rs6969015 123.319 0 GRM3 chr7: 8794418-119068130 23484110273713 1 rs2189621 rs6977904 70.867 0 GRM3 chr7: 85117732-86026526122 908795 1 rs4728584 rs10242995 65.094 246704 GRM3 chr7:8872727-156383359 27773 147510633 1 rs917038 rs878717 32.336 0 GRM3chr7: 11855636-156148608 26852 144292973 1 rs6947930 rs6945016 36.446 0GRM3 chr7: 84302877-110993169 5183 26690293 3 rs4338048 rs10254893203.09 0 GRM3 chr11: 23168804-106781292 16332 83612489 1 rs11027007rs7103285 49.747 0 GRM5 chr11: 23168804-106781292 16332 83612489 1rs11027007 rs7103285 49.747 0 GRM5 chr11: 84128537-120941583 767836813047 1 rs488925 rs4643089 29.271 0 GRM5 chr11: 84128537-1209415837678 36813047 1 rs488925 rs4643089 29.271 0 GRM5 chr11:81251505-103234729 4842 21983225 3 rs7935238 rs1913462 26.176 0 GRM5chr11: 81251505-103234729 4842 21983225 3 rs7935238 rs1913462 26.176 0GRM5 chr11: 21723471-131521797 20508 109798327 1 rs11828478 rs251289827.565 0 GRM5 chr11: 21723471-131521797 20508 109798327 1 rs11828478rs2512898 27.565 0 GRM5 chr11: 42185849-126756938 15451 84571090 1rs4375424 rs10750356 36.99 0 GRM5 chr11: 42185849-126756938 1545184571090 1 rs4375424 rs10750356 36.99 0 GRM5 chr11: 74545378-13494041614496 60395039 3 rs512780 rs11224228 527.758 0 GRM5 chr11:74545378-134940416 14496 60395039 3 rs512780 rs11224228 527.758 0 GRM5chr3: 5824878-8781331 952 2956454 3 rs2470628 rs11916022 924.891 0 GRM7chr3: 5824878-8781331 952 2956454 3 rs2470628 rs11916022 924.891 0 GRM7chr3: 179527-114630641 23879 114451115 3 rs4684741 rs1587972 207.852 0GRM7 chr3: 179527-114630641 23879 114451115 3 rs4684741 rs1587972207.852 0 GRM7 chr7: 78621315-155831817 13678 77210503 3 rs1006818rs6969015 123.319 0 GRM8 chr7: 78621315-155831817 13678 77210503 3rs1006818 rs6969015 123.319 0 GRM8 chr7: 8872727-156383359 27773147510633 1 rs917038 rs878717 32.336 0 GRM8 chr7: 8872727-15638335927773 147510633 1 rs917038 rs878717 32.336 0 GRM8 chr7:11855636-156148608 26852 144292973 1 rs6947930 rs6945016 36.446 0 GRM8chr7: 11855636-156148608 26852 144292973 1 rs6947930 rs6945016 36.446 0GRM8 chr7: 125676925-125780682 24 103758 1 rs1419535 rs10267757 26.358297970 GRM8 chr7: 125676925-125780682 24 103758 1 rs1419535 rs1026775726.358 297970 GRM8 chr7: 120061880-143606234 4616 23544355 3 rs12531689rs10247493 18.96 0 GRM8 chr7: 120061880-143606234 4616 23544355 3rs12531689 rs10247493 18.96 0 GRM8 chr9: 2522475-140068342 25719137545868 3 rs10966757 rs4074426 93.386 0 GSN chr9: 33180228-13200379214691 98823565 1 rs7854765 rs9408988 28.69 0 GSN chr9:100158052-139077343 9815 38919292 3 rs1020884 rs4842126 470.601 0 GSNchr5: 49952847-89853069 7268 39900223 3 rs12188654 rs42467 26.225 0HOMER1 chr5: 57343495-171903310 21683 114559816 1 rs10940593 rs1004248261.169 0 HOMER1 chr5: 78520731-78765405 35 244675 1 rs4704546 rs771008912.78 0 HOMER1 chr5: 78542290-79057477 95 515188 1 rs10474578 rs25912638.26 0 HOMER1 chr5: 4872310-180709915 35876 175837606 3 rs816467rs10071993 179.394 0 HOMER1 chr13: 19584477-81204088 13265 61619612 3rs1334954 rs1176297 22.162 0 HTR2A chr13: 23742931-115064482 1982991321552 1 rs4770401 rs7999630 44.074 0 HTR2A chr13: 36707502-10365610413622 66948603 1 rs3827890 rs1952590 38.726 0 HTR2A chr13:47300055-47409034 48 108980 1 rs1539177 rs6314 25.525 0 HTR2A chr13:19121741-63373781 10326 44252041 3 rs9578050 rs9539575 82.761 0 HTR2Achr4: 68173959-185767176 20235 117593218 1 rs6552083 rs4862428 61.893 0LARP7 chr4: 63726348-173015421 19817 109289074 1 rs17082970 rs213100230.251 0 LARP7 chr4: 29179713-117038307 15513 87858595 1 rs1507441rs1068807 71.6 0 LARP7 chr4: 89603085-113991140 4018 24388056 3rs2972038 rs2279892 28.405 0 LARP7 chr4: 22401728-188608857 28456166207130 1 rs4697297 rs7687115 35.717 0 LARP7 chr4: 31222833-18054807624457 149325244 1 rs7662351 rs3849606 36.162 0 LARP7 chr4:113385223-113578609 25 193387 1 cnvi0012240 rs1129065 19.233 0 LARP7chr4: 69590353-190872778 23145 121282426 3 rs293433 rs12646565 315.633 0LARP7 chr22: 16871137-51184393 9245 34313257 3 rs131538 rs7284680 209.790 MAPK1 chr14: 26898958-104436931 17396 77537974 1 rs1245195 rs1185109757.233 0 MTHFD1 chr14: 64926097-65063315 19 137219 1 rs2281603rs10134770 14.377 0 MTHFD1 chr14: 19917123-65327288 10286 45410166 3rs2495197 rs9323455 270.291 0 MTHFD1 chr21: 14601415-48084989 824933483575 3 rs2775537 rs2839378 41.154 0 MX1 chr21: 14601415-480849898249 33483575 3 rs2775537 rs2839378 12047.211 0 MX1 chr21:14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 MX1chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0MX1 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs28393785021.076 0 MX1 chr21: 10708231-47970581 8807 37262351 3 rs4044122rs2255397 73.188 0 MX1 chr1: 1005806-105612342 19173 104606537 3rs3934834 rs1584633 44.152 0 NEGR1 chr1: 64114301-245591329 29842181477029 1 rs11208257 rs1173850 37.504 0 NEGR1 chr1: 72606418-7271774314 111326 1 rs1385919 rs1776012 17.335 0 NEGR1 chr1: 2006108-10952786122130 107521754 3 rs2254669 rs839879 162.269 0 NEGR1 chr5:49952847-89853069 7268 39900223 3 rs12188654 rs42467 26.225 0 NLN chr5:57343495-171903310 21683 114559816 1 rs10940593 rs10042482 61.169 0 NLNchr5: 39526068-67275356 4441 27749289 1 rs16869031 rs999826 77.848 0 NLNchr5: 4872310-180709915 35876 175837606 3 rs816467 rs10071993 179.394 0NLN chr2: 34870277-241929621 37755 207059345 3 rs13422005 rs1020527646.946 0 NMI chr2: 77041264-194763754 21140 117722491 1 rs2102827rs16835406 94.091 0 NMI chr2: 38101137-241482099 36812 203380963 1rs879321 rs7576043 52.099 0 NMI chr2: 12056323-227979775 39094 2159234531 rs966391 rs1922020 31.384 0 NMI chr2: 83383702-175194550 1629191810849 3 rs12469609 rs11891208 154.4 0 NMI chr21: 14601415-480849898249 33483575 3 rs2775537 rs2839378 41.154 0 PCBP3 chr21:44839153-47856106 674 3016954 1 rs2838302 rs2236616 38.158 0 PCBP3chr21: 47091361-47226895 18 135535 1 rs2838973 rs2839002 14.709 0 PCBP3chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 12047.211 0PCBP3 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs28393781871.363 0 PCBP3 chr21: 14601415-48084989 8249 33483575 3 rs2775537rs2839378 4787.438 0 PCBP3 chr21: 46381900-48098560 448 1716661 1rs8132265 cnvi0019195 712.68 0 PCBP3 chr21: 14768343-48084989 819333316647 3 rs2257224 rs2839378 5021.076 0 PCBP3 chr21: 10708231-479705818807 37262351 3 rs4044122 rs2255397 73.188 0 PCBP3 chr7:8794418-119068130 23484 110273713 1 rs2189621 rs6977904 70.867 0 PDE1Cchr7: 7724805-53845684 11772 46120880 3 rs10263415 rs6948633 42.007 0PDE1C chr7: 8872727-156383359 27773 147510633 1 rs917038 rs878717 32.3360 PDE1C chr7: 11855636-156148608 26852 144292973 1 rs6947930 rs694501636.446 0 PDE1C chr7: 60392-84158180 19095 84097789 3 rs12670102rs2715048 208.308 0 PDE1C chr19: 43257015-55294329 −7309 12037315 3rs7246152 rs2569676 21.402 0 PPP2R1A chr19: 52365654-54612628 5242246975 3 rs4514789 rs254262 59.657 0 PPP2R1A chr19: 31569338-537809663788 22211629 1 rs2867544 rs10407424 33.9 0 PPP2R1A chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466 100.582 0PPP2R1A chr17: 44458950-81047708 −8195 36588759 1 cnvi0016818 rs3568023135.591 0 PRPSAP1 chr17: 62662507-81047708 −11496 18385202 3 rs6504246rs35680231 56.048 0 PRPSAP1 chr17: 21685812-67308196 12365 45622385 1rs34864328 rs17686852 50.018 0 PSMD11 chr17: 26648492-58955084 583132306593 3 rs1981512 rs8068776 15.642 0 PSMD11 chr11: 211482-6691082613813 66699345 3 rs2293168 rs4375446 30.249 0 PSMD13 chr12:59512781-127744939 13469 68232159 3 rs908394 rs7966946 20.62 0 PXNchr12: 10020267-129866293 23654 119846027 1 rs1597097 rs2170504 45.428 0PXN chr12: 112610714-133708729 5366 21098016 3 rs11066188 rs11147249695.45 0 PXN chr12: 50855195-133778796 17748 82923602 3 rs4351895rs7975069 159.589 0 PXN chr17: 44458950-81047708 −8195 36588759 1cnvi0016818 rs35680231 35.591 0 QRICH2 chr17: 62662507-81047708 −1149618385202 3 rs6504246 rs35680231 56.048 0 QRICH2 chr22: 18907405-21465780610 2558376 3 rs9618419 rs11703181 1799.961 0 RANBP1 chr22:19601238-20241160 201 639923 3 rs8135473 rs1567871 11.687 0 RANBP1chr22: 18877787-21462353 613 2584567 1 rs2543958 rs140392 772.063 0RANBP1 chr22: 18877787-21462353 512 2584567 1 rs2543958 rs1403921596.687 0 RANBP1 chr22: 16871137-51184393 9245 34313257 3 rs131538rs7284680 209.79 0 RANBP1 chr13: 87746779-104646511 3908 16899733 3rs9301986 rs17414312 27.724 0 RAP2A chr13: 90018392-105190802 413615172411 1 rs7335222 rs11841281 42.954 0 RAP2A chr13: 23742931-11506448219829 91321552 1 rs4770401 rs7999630 44.074 0 RAP2A chr13:36707502-103656104 13622 66948603 1 rs3827890 rs1952590 38.726 0 RAP2Achr13: 65193124-115053155 12025 49860032 3 rs9598811 rs7327124 78.057 0RAP2A chr1: 1005806-105612342 19173 104606537 3 rs3934834 rs158463344.152 0 RCC1 chr1: 2006108-109527861 22130 107521754 3 rs2254669rs839879 162.269 0 RCC1 chr4: 179131-68998153 13495 68819023 3 rs7686948rs7687396 625.133 0 RGS12 chr2: 34870277-241929621 37755 207059345 3rs13422005 rs10205276 46.946 0 RIF1 chr2: 77041264-194763754 21140117722491 1 rs2102827 rs16835406 94.091 0 RIF1 chr2: 38101137-24148209936812 203380963 1 rs879321 rs7576043 52.099 0 RIF1 chr2:12056323-227979775 39094 215923453 1 rs966391 rs1922020 31.384 0 RIF1chr2: 83383702-175194550 16291 91810849 3 rs12469609 rs11891208 154.4 0RIF1 chr19: 43257015-55294329 −7309 12037315 3 rs7246152 rs256967621.402 0 RUVBL2 chr19: 31569338-53780966 3788 22211629 1 rs2867544rs10407424 33.9 0 RUVBL2 chr19: 288246-59110628 11009 58822383 3rs10409452 cnvi0009466 100.582 0 RUVBL2 chr19: 31569338-53780966 378822211629 1 rs2867544 rs10407424 33.9 0 RYR1 chr19: 288246-59110628 1100958822383 3 rs10409452 cnvi0009466 100.582 0 RYR1 chr1:178626526-244159143 13064 65532618 3 rs2761477 rs479338 11.373 0 RYR2chr1: 237570457-237675464 37 105008 1 rs4659495 rs2618721 15.007 0 RYR2chr1: 75098453-243531649 27360 168433197 1 rs12117493 rs10927002 32.1130 RYR2 chr1: 64114301-245591329 29842 181477029 1 rs11208257 rs117385037.504 0 RYR2 chr1: 174219398-247422297 15986 73202900 1 rs16846809rs4642922 35.258 0 RYR2 chr1: 237584925-237904870 86 319946 1 rs4593814rs10925504 31.95 0 RYR2 chr1: 236848751-249219320 3293 12370570 3rs819666 cnvi0018731 920.725 0 RYR2 chr1: 1005806-105612342 19173104606537 3 rs3934834 rs1584633 44.152 0 SDC3 chr1: 2006108-10952786122130 107521754 3 rs2254669 rs839879 162.269 0 SDC3 chr1:79710545-188898319 17303 109187775 1 rs417181 rs16829637 45.89 0 SELEchr1: 169556446-171300348 340 1743903 1 rs9332480 rs7541160 32.81 0 SELEchr1: 75098453-243531649 27360 168433197 1 rs12117493 rs10927002 32.1130 SELE chr1: 64114301-245591329 29842 181477029 1 rs11208257 rs117385037.504 0 SELE chr1: 109645793-194560463 12025 84914671 3 cnvi0008281rs10921616 63.121 0 SELE chr6: 2681610-31453618 81 28772009 3 rs1131896rs9267212 428.177 0 SERPINB9 chr6: 2585208-31281876 −2 28696669 1rs1634746 rs1634747 31.615 0 SERPINB9 chr6: 1171596-29899147 47 287275520 rs3128994 rs2394704 63.572 0 SERPINB9 chr6: 1175965-29899147 4328723183 0 rs1611522 rs2394704 52.089 0 SERPINB9 chr6: 1171596-2989522843 28723633 0 rs3128994 rs9259831 53.123 0 SERPINB9 chr6:1171596-29899147 47 28727552 0 rs3128994 rs2394704 80.695 0 SERPINB9chr6: 1177990-29899147 39 28721158 0 rs2428530 rs2394704 44.381 0SERPINB9 chr6: 2681610-31453618 81 28772009 3 rs1131896 rs9267212390.234 0 SERPINB9 chr6: 2584569-31286381 8 28701813 1 rs9391764rs9265057 34.598 0 SERPINB9 chr6: 1171596-29892436 39 28720841 1rs3128994 rs9259806 31.699 0 SERPINB9 chr6: 1171596-29895228 43 287236330 rs3128994 rs9259831 43.568 0 SERPINB9 chr6: 181089-30430875 180630249787 3 rs1535053 rs35792611 80.394 0 SERPINB9 chr21:14601415-48084989 8249 33483575 3 rs2775537 rs2839378 41.154 0 SETD4chr21: 36927793-37647438 142 719646 3 rs2205031 rs9980084 187.28 0 SETD4chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 12047.211 0SETD4 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs28393781871.363 0 SETD4 chr21: 14601415-48084989 8249 33483575 3 rs2775537rs2839378 4787.438 0 SETD4 chr21: 14768343-48084989 8193 33316647 3rs2257224 rs2839378 5021.076 0 SETD4 chr21: 10708231-47970581 880737262351 3 rs4044122 rs2255397 73.188 0 SETD4 chr5: 49952847-898530697268 39900223 3 rs12188654 rs42467 26.225 0 SGTB chr5:57343495-171903310 21683 114559816 1 rs10940593 rs10042482 61.169 0 SGTBchr5: 39526068-67275356 4441 27749289 1 rs16869031 rs999826 77.848 0SGTB chr5: 4872310-180709915 35876 175837606 3 rs816467 rs10071993179.394 0 SGTB chr19: 43257015-55294329 −7309 12037315 3 rs7246152rs2569676 21.402 0 SHANK1 chr19: 31569338-53780966 3788 22211629 1rs2867544 rs10407424 33.9 0 SHANK1 chr19: 288246-59110628 11009 588223833 rs10409452 cnvi0009466 100.582 0 SHANK1 chr19: 31569338-53780966 378822211629 1 rs2867544 rs10407424 33.9 0 SLC7A10 chr19: 288246-5911062811009 58822383 3 rs10409452 cnvi0009466 100.582 0 SLC7A10 chr15:29325866-56044189 5303 26718324 3 rs4779705 rs2414433 21.732 0 SORDchr15: 44763598-47394943 502 2631346 3 rs7172106 rs4095484 142.088 0SORD chr15: 43392075-66051345 4963 22659271 3 rs8028608 rs6494537 59.8420 SORD chr12: 8171838-32535863 5853 24364026 3 rs11609309 rs796318223.697 0 STRAP chr12: 10020267-129866293 23654 119846027 1 rs1597097rs2170504 45.428 0 STRAP chr12: 10113083-116370432 20594 106257350 1rs2012504 rs7958254 35.157 0 STRAP chr12: 207886-50770291 11565 505624063 rs868249 rs4477515 43.892 0 STRAP chr17: 75730493-79302149 880 35716573 rs7210773 rs2864474 14.319 0 TK1 chr17: 44458950-81047708 −819536588759 1 cnvi0016818 rs35680231 35.591 0 TK1 chr17: 62662507-81047708−11496 18385202 3 rs6504246 rs35680231 56.048 0 TK1 chr3:145967173-173899890 4912 27932718 3 rs9863647 rs7618997 46.396 0 TNIKchr3: 164955741-191742104 5741 26786364 1 rs2218152 rs9835019 52.438 0TNIK chr3: 83075971-196935657 21465 113859687 1 rs9872858 rs3472975144.35 0 TNIK chr3: 102240202-195550366 17318 93310165 1 rs1620217rs11711870 41.031 0 TNIK chr3: 166503411-190576461 4854 24073051 1rs11925936 rs1393054 31.414 0 TNIK chr3: 114889454-177826047 1270062936594 3 rs6795297 rs7628308 102.526 0 TNIK chr1: 1005806-10561234219173 104606537 3 rs3934834 rs1584633 44.152 0 USP24 chr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879 162.269 0 USP24chr3: 179527-114630641 23879 114451115 3 rs4684741 rs1587972 207.852 0VHL

TABLE 2 State, Distance mGluR Chr: Start-Stop(hg19) NumSNP Length CNStartSNP EndSNP Confidence From Gene Gene chr11: 42185849-12675693815451 84571090 1 rs4375424 rs10750356 36.99 0 ACAT1 chr11:21723471-131521797 20508 109798327 1 rs11828478 rs2512898 27.565 0 ACAT1chr11: 84128537-120941583 7678 36813047 1 rs488925 rs4643089 29.271 0ACAT1 chr11: 98062720-121890280 5422 23827561 1 rs6589308 rs194446529.075 0 ACAT1 chr11: 74545378-134940416 14496 60395039 3 rs512780rs11224228 527.758 0 ACAT1 chr6: 64844594-169078546 21567 104233953 1rs4710465 rs601639 46.524 0 ACAT2 chr6: 66541198-162520133 1934495978936 1 rs2000382 rs6901071 27.509 0 ACAT2 chr6: 73120320-16513087218715 92010553 1 rs9442780 rs10946016 76.383 0 ACAT2 chr6:94117546-165103679 15579 70986134 1 rs3799792 rs9347902 34.066 0 ACAT2chr6: 151495387-165969396 3761 14474010 3 rs9322304 rs1022180 22.826 0ACAT2 chr6: 100082983-170909002 16393 70826020 3 rs594231 rs12213906261.313 0 ACAT2 chr17: 32104675-32822032 239 717358 4 rs6505377 rs213135113.523 0 ACCN1 chr17: 21685812-67308196 12365 45622385 1 rs34864328rs17686852 50.018 0 ACCN1 chr17: 26648492-58955084 5831 32306593 3rs1981512 rs8068776 15.642 0 ACCN1 chr12: 10113083-116370432 20594106257350 1 rs2012504 rs7958254 35.157 0 ACCN2 chr12: 10020267-12986629323654 119846027 1 rs1597097 rs2170504 45.428 0 ACCN2 chr12:39967134-84174413 8879 44207280 1 rs11172661 rs11116039 39.568 0 ACCN2chr12: 207886-50770291 11565 50562406 3 rs868249 rs4477515 43.892 0ACCN2 chr2: 18856-41136833 9721 41117978 3 rs11901199 rs10187704 191.6380 ACP1 chr7: 60392-84158180 19095 84097789 3 rs12670102 rs2715048208.308 0 ACTB chr2: 12056323-227979775 39094 215923453 1 rs966391rs1922020 31.384 0 ACTR2 chr2: 38101137-241482099 36812 203380963 1rs879321 rs7576043 52.099 0 ACTR2 chr2: 34870277-241929621 37755207059345 3 rs13422005 rs10205276 46.946 0 ACTR2 chr2: 41212010-823962119721 41184202 3 rs12614285 rs934310 396.396 0 ACTR2 chr20:13712393-55093901 8218 41381509 1 rs6033810 rs6999 41.237 0 ADA chr20:4591715-58420336 11753 53828622 1 rs6139494 rs1416388 40.922 0 ADAchr20: 7869025-62424661 11941 54555637 3 rs2294306 rs6010652 9.732 0 ADAchr20: 236802-54845796 12646 54608995 3 rs448294 rs6064362 286.151 0 ADAchr7: 11855636-156148608 26852 144292973 1 rs6947930 rs6945016 36.446 0ADCY1 chr7: 8872727-156383359 27773 147510633 1 rs917038 rs878717 32.3360 ADCY1 chr7: 8794418-119068130 23484 110273713 1 rs2189621 rs697790470.867 0 ADCY1 chr7: 7724805-53845684 11772 46120880 3 rs10263415rs6948633 42.007 0 ADCY1 chr7: 60392-84158180 19095 84097789 3rs12670102 rs2715048 208.308 0 ADCY1 chr4: 179131-68998153 1349568819023 3 rs7686948 rs7687396 625.133 0 ADD1 chr2: 12056323-22797977539094 215923453 1 rs966391 rs1922020 31.384 0 ADD2 chr2:38101137-241482099 36812 203380963 1 rs879321 rs7576043 52.099 0 ADD2chr2: 34870277-241929621 37755 207059345 3 rs13422005 rs10205276 46.9460 ADD2 chr2: 41212010-82396211 9721 41184202 3 rs12614285 rs934310396.396 0 ADD2 chr1: 64114301-245591329 29842 181477029 1 rs11208257rs1173850 37.504 0 ADORA1 chr1: 75098453-243531649 27360 168433197 1rs12117493 rs10927002 32.113 0 ADORA1 chr1: 189128124-227340790 792738212667 1 rs7515205 rs12752546 167.428 0 ADORA1 chr1:178626526-244159143 13064 65532618 3 rs2761477 rs479338 11.373 0 ADORA1chr1: 188850774-235423607 10060 46572834 1 rs16829466 rs12409696 43.25 0ADORA1 chr1: 191875752-235423607 9517 43547856 1 rs9427811 rs1240969662.01 0 ADORA1 chr1: 174219398-247422297 15986 73202900 1 rs16846809rs4642922 35.258 0 ADORA1 chr1: 197187605-226404457 6316 29216853 3rs10922187 rs3008192 130.989 0 ADORA1 chr5: 84830796-171903310 1664287072515 1 rs300657 rs10042482 42.208 0 ADRA1B chr5: 57343495-17190331021683 114559816 1 rs10940593 rs10042482 61.169 0 ADRA1B chr5:4872310-180709915 35876 175837606 3 rs816467 rs10071993 179.394 0 ADRA1Bchr10: 7188484-134205354 26672 127016871 1 rs1977295 rs3923858 50.772 0ADRA2A chr10: 57671424-133349223 16243 75677800 1 rs11005106 rs430171037.114 0 ADRA2A chr10: 58385643-124973104 13625 66587462 1 rs7920235rs17663304 36.18 0 ADRA2A chr10: 55492162-117205017 13465 61712856 1rs6481032 rs1933664 62.56 0 ADRA2A chr10: 53602190-135522754 1916781920565 3 rs12247820 rs10909028 139.373 0 ADRA2A chr4: 179131-6899815313495 68819023 3 rs7686948 rs7687396 625.133 0 ADRA2C chr5:84830796-171903310 16642 87072515 1 rs300657 rs10042482 42.208 0 ADRB2chr5: 57343495-171903310 21683 114559816 1 rs10940593 rs10042482 61.1690 ADRB2 chr5: 98442871-150317237 9828 51874367 1 rs1447379 rs771079038.687 0 ADRB2 chr5: 4872310-180709915 35876 175837606 3 rs816467rs10071993 179.394 0 ADRB2 chr11: 42185849-126756938 15451 84571090 1rs4375424 rs10750356 36.99 0 ADRBK1 chr11: 21723471-131521797 20508109798327 1 rs11828478 rs2512898 27.565 0 ADRBK1 chr11:23168804-106781292 16332 83612489 1 rs11027007 rs7103285 49.747 0 ADRBK1chr11: 66898492-67136981 22 238490 1 rs11227699 rs3781941 17.955 0ADRBK1 chr11: 66933410-67046501 14 113092 1 rs1253784 rs12274774 5.288 0ADRBK1 chr16: 29441284-33923125 585 4481842 3 rs7206789 rs4043755 42.4370 ALDOA chr16: 176743-50013967 8328 49837225 3 rs2562164 rs12597023174.392 0 ALDOA chr9: 1989033-107532317 18263 105543285 1 rs7864828rs10820726 39.824 0 ANXA2 chr9: 33180228-132003792 14691 98823565 1rs7854765 rs9408988 28.69 0 ANXA2 chr15: 51688996-102398060 1103050709065 1 rs2459396 rs7181527 36.939 0 ANXA2 chr9: 2522475-14006834225719 137545868 3 rs10966757 rs4074426 93.386 0 ANXA2 chr15:53775670-96810867 9973 43035198 1 rs657495 rs2589238 49.204 0 ANXA2chr9: 46587-94335290 17484 94288704 3 rs10814410 rs9409606 762.393 0ANXA2 chr15: 43392075-66051345 4963 22659271 3 rs8028608 rs649453759.842 0 ANXA2 chr21: 14601415-48084989 8249 33483575 3 rs2775537rs2839378 12047.211 0 APP chr21: 14601415-48084989 8249 33483575 3rs2775537 rs2839378 41.154 0 APP chr21: 14595264-48084989 8781 334897263 rs2847443 rs2839378 1871.363 0 APP chr21: 14601415-48084989 824933483575 3 rs2775537 rs2839378 4787.438 0 APP chr21: 14768343-480849898193 33316647 3 rs2257224 rs2839378 5021.076 0 APP chr21:10708231-47970581 8807 37262351 3 rs4044122 rs2255397 73.188 0 APP chr9:1989033-107532317 18263 105543285 1 rs7864828 rs10820726 39.824 0 APTXchr9: 2522475-140068342 25719 137545868 3 rs10966757 rs4074426 93.386 0APTX chr9: 46587-94335290 17484 94288704 3 rs10814410 rs9409606 762.3930 APTX chr7: 11855636-156148608 26852 144292973 1 rs6947930 rs694501636.446 0 AQP1 chr7: 8872727-156383359 27773 147510633 1 rs917038rs878717 32.336 0 AQP1 chr7: 8794418-119068130 23484 110273713 1rs2189621 rs6977904 70.867 0 AQP1 chr7: 7724805-53845684 11772 461208803 rs10263415 rs6948633 42.007 0 AQP1 chr7: 60392-84158180 19095 840977893 rs12670102 rs2715048 208.308 0 AQP1 chr4: 31222833-180548076 24457149325244 1 rs7662351 rs3849606 36.162 0 ARHGAP24 chr4:22401728-188608857 28456 166207130 1 rs4697297 rs7687115 35.717 0ARHGAP24 chr4: 68173959-185767176 20235 117593218 1 rs6552083 rs486242861.893 0 ARHGAP24 chr4: 63726348-173015421 19817 109289074 1 rs17082970rs2131002 30.251 0 ARHGAP24 chr4: 29179713-117038307 15513 87858595 1rs1507441 rs1068807 71.6 0 ARHGAP24 chr4: 69590353-190872778 23145121282426 3 rs293433 rs12646565 315.633 0 ARHGAP24 chr5:39526068-67275356 4441 27749289 1 rs16869031 rs999826 77.848 0 ARL15chr5: 49952847-89853069 7268 39900223 3 rs12188654 rs42467 26.225 0ARL15 chr5: 52884614-53418318 145 533705 1 rs524289 rs9292039 31.471 0ARL15 chr5: 4872310-180709915 35876 175837606 3 rs816467 rs10071993179.394 0 ARL15 chr11: 42185849-126756938 15451 84571090 1 rs4375424rs10750356 36.99 0 ARRB1 chr11: 21723471-131521797 20508 109798327 1rs11828478 rs2512898 27.565 0 ARRB1 chr11: 23168804-106781292 1633283612489 1 rs11027007 rs7103285 49.747 0 ARRB1 chr11: 74545378-13494041614496 60395039 3 rs512780 rs11224228 527.758 0 ARRB1 chr17:108420-26610769 5548 26502350 3 rs12452527 rs658591 82.699 0 ARRB2chr17: 21685812-67308196 12365 45622385 1 rs34864328 rs17686852 50.018 0ATXN7L3 chr17: 26648492-58955084 5831 32306593 3 rs1981512 rs806877615.642 0 ATXN7L3 chr14: 26898958-104436931 17396 77537974 1 rs1245195rs11851097 57.233 0 BDKRB1 chr14: 80818058-105348552 5492 24530495 3rs6574553 rs2028416 15.874 0 BDKRB1 chr14: 65405722-103799039 897938393318 3 rs11623705 rs11628472 266.153 0 BDKRB1 chr14:26898958-104436931 17396 77537974 1 rs1245195 rs11851097 57.233 0 BDKRB2chr14: 80818058-105348552 5492 24530495 3 rs6574553 rs2028416 15.874 0BDKRB2 chr14: 65405722-103799039 8979 38393318 3 rs11623705 rs11628472266.153 0 BDKRB2 chr19: 629303-4119012 709 3489710 1 rs2283575 rs35088726.758 0 BTBD2 chr19: 266034-18061509 3100 17795476 3 rs2312724rs7250332 19.51 0 BTBD2 chr19: 1130986-2128054 143 997069 1 rs10413074rs1017084 25.799 0 BTBD2 chr19: 288246-59110628 11009 58822383 3rs10409452 cnvi0009466 100.582 0 BTBD2 chr1: 64114301-245591329 29842181477029 1 rs11208257 rs1173850 37.504 0 BTG2 chr1: 75098453-24353164927360 168433197 1 rs12117493 rs10927002 32.113 0 BTG2 chr1:189128124-227340790 7927 38212667 1 rs7515205 rs12752546 167.428 0 BTG2chr1: 178626526-244159143 13064 65532618 3 rs2761477 rs479338 11.373 0BTG2 chr1: 188850774-235423607 10060 46572834 1 rs16829466 rs1240969643.25 0 BTG2 chr1: 191875752-235423607 9517 43547856 1 rs9427811rs12409696 62.01 0 BTG2 chr1: 174219398-247422297 15986 73202900 1rs16846809 rs4642922 35.258 0 BTG2 chr1: 197187605-226404457 631629216853 3 rs10922187 rs3008192 130.989 0 BTG2 chr1: 64114301-24559132929842 181477029 1 rs11208257 rs1173850 37.504 0 C1orf116 chr1:75098453-243531649 27360 168433197 1 rs12117493 rs10927002 32.113 0C1orf116 chr1: 189128124-227340790 7927 38212667 1 rs7515205 rs12752546167.428 0 C1orf116 chr1: 178626526-244159143 13064 65532618 3 rs2761477rs479338 11.373 0 C1orf116 chr1: 188850774-235423607 10060 46572834 1rs16829466 rs12409696 43.25 0 C1orf116 chr1: 191875752-235423607 951743547856 1 rs9427811 rs12409696 62.01 0 C1orf116 chr1:174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0C1orf116 chr1: 197187605-226404457 6316 29216853 3 rs10922187 rs3008192130.989 0 C1orf116 chr7: 11855636-156148608 26852 144292973 1 rs6947930rs6945016 36.446 0 C7orf25 chr7: 8872727-156383359 27773 147510633 1rs917038 rs878717 32.336 0 C7orf25 chr7: 8794418-119068130 23484110273713 1 rs2189621 rs6977904 70.867 0 C7orf25 chr7: 7724805-5384568411772 46120880 3 rs10263415 rs6948633 42.007 0 C7orf25 chr7:60392-84158180 19095 84097789 3 rs12670102 rs2715048 208.308 0 C7orf25chr8: 30757798-142750969 20699 111993172 1 rs10101203 rs6421025 34.223 0CA8 chr8: 23218101-146274708 23020 123056608 1 rs7010362 rs782272638.828 0 CA8 chr8: 60424884-145286483 17030 84861600 3 rs1401422rs9720889 8.858 0 CA8 chr8: 60494752-60667231 25 172480 1 rs12674637rs6471803 14.25 434192 CA8 chr8: 43235525-66712108 3632 23476584 3rs10091311 rs7001138 58.838 0 CA8 chr9: 139492789-140913833 196 14210451 rs28485548 cnvi0002661 28.211 0 CACNA1B chr9: 139821068-141105225 1631284158 3 rs3750512 rs11559363 55.611 0 CACNA1B chr1: 64114301-24559132929842 181477029 1 rs11208257 rs1173850 37.504 0 CACYBP chr1:75098453-243531649 27360 168433197 1 rs12117493 rs10927002 32.113 0CACYBP chr1: 79710545-188898319 17303 109187775 1 rs417181 rs1682963745.89 0 CACYBP chr1: 174219398-247422297 15986 73202900 1 rs16846809rs4642922 35.258 0 CACYBP chr1: 109645793-194560463 12025 84914671 3cnvi0008281 rs10921616 63.121 0 CACYBP chr16: 64107047-82920737 454418813691 1 rs2319723 rs918661 28.887 0 CALB2 chr16: 59854720-892738837609 29419164 3 rs1373880 rs8046156 31.884 0 CALB2 chr16:50219449-89544756 10324 39325308 3 rs6500298 rs3803681 108.108 0 CALB2chr14: 26898958-104436931 17396 77537974 1 rs1245195 rs11851097 57.233 0CALM1 chr14: 80818058-105348552 5492 24530495 3 rs6574553 rs202841615.874 0 CALM1 chr14: 65405722-103799039 8979 38393318 3 rs11623705rs11628472 266.153 0 CALM1 chr2: 12056323-227979775 39094 215923453 1rs966391 rs1922020 31.384 0 CALM2 chr2: 38101137-241482099 36812203380963 1 rs879321 rs7576043 52.099 0 CALM2 chr2: 34870277-24192962137755 207059345 3 rs13422005 rs10205276 46.946 0 CALM2 chr2:41212010-82396211 9721 41184202 3 rs12614285 rs934310 396.396 0 CALM2chr19: 31569338-53780966 3788 22211629 1 rs2867544 rs10407424 33.9 0CALM3 chr14: 26898958-104436931 17396 77537974 1 rs1245195 rs1185109757.233 0 CALM3 chr14: 80818058-105348552 5492 24530495 3 rs6574553rs2028416 15.874 0 CALM3 chr19: 43257015-55294329 −7309 12037315 3rs7246152 rs2569676 21.402 0 CALM3 chr19: 288246-59110628 11009 588223833 rs10409452 cnvi0009466 100.582 0 CALM3 chr14: 65405722-103799039 897938393318 3 rs11623705 rs11628472 266.153 0 CALM3 chr3: 179527-11463064123879 114451115 3 rs4684741 rs1587972 207.852 0 CAMK1 chr7:11855636-156148608 26852 144292973 1 rs6947930 rs6945016 36.446 0 CAMK2Bchr7: 8872727-156383359 27773 147510633 1 rs917038 rs878717 32.336 0CAMK2B chr7: 8794418-119068130 23484 110273713 1 rs2189621 rs697790470.867 0 CAMK2B chr7: 7724805-53845684 11772 46120880 3 rs10263415rs6948633 42.007 0 CAMK2B chr7: 60392-84158180 19095 84097789 3rs12670102 rs2715048 208.308 0 CAMK2B chr5: 84830796-171903310 1664287072515 1 rs300657 rs10042482 42.208 0 CAMK4 chr5: 57343495-17190331021683 114559816 1 rs10940593 rs10042482 61.169 0 CAMK4 chr5:80735161-125293366 8499 44558206 1 rs1541830 rs327816 52.167 0 CAMK4chr5: 98442871-150317237 9828 51874367 1 rs1447379 rs7710790 38.687 0CAMK4 chr5: 108979318-132114847 4575 23135530 1 rs31595 rs30514 35.063 0CAMK4 chr5: 108284342-111242002 627 2957661 1 rs3797817 rs1713387044.164 0 CAMK4 chr5: 4872310-180709915 35876 175837606 3 rs816467rs10071993 179.394 0 CAMK4 chr5: 57343495-171903310 21683 114559816 1rs10940593 rs10042482 61.169 0 CCNB1 chr5: 49952847-89853069 726839900223 3 rs12188654 rs42467 26.225 0 CCNB1 chr5: 4872310-18070991535876 175837606 3 rs816467 rs10071993 179.394 0 CCNB1 chr1:1005806-105612342 19173 104606537 3 rs3934834 rs1584633 44.152 0 CDC42chr1: 2006108-109527861 22130 107521754 3 rs2254669 rs839879 162.269 0CDC42 chr20: 4591715-58420336 11753 53828622 1 rs6139494 rs141638840.922 0 CHGB chr20: 236802-54845796 12646 54608995 3 rs448294 rs6064362286.151 0 CHGB chr15: 29325866-56044189 5303 26718324 3 rs4779705rs2414433 21.732 0 CHP chr15: 32939946-43104406 2544 10164461 3rs12594777 rs13380301 32.942 0 CHP chr7: 11855636-156148608 26852144292973 1 rs6947930 rs6945016 36.446 0 CHRM2 chr7: 8872727-15638335927773 147510633 1 rs917038 rs878717 32.336 0 CHRM2 chr7:78621315-155831817 13678 77210503 3 rs1006818 rs6969015 123.319 0 CHRM2chr7: 120061880-143606234 4616 23544355 3 rs12531689 rs10247493 18.96 0CHRM2 chr1: 64114301-245591329 29842 181477029 1 rs11208257 rs117385037.504 0 CHRM3 chr1: 75098453-243531649 27360 168433197 1 rs12117493rs10927002 32.113 0 CHRM3 chr1: 178626526-244159143 13064 65532618 3rs2761477 rs479338 11.373 0 CHRM3 chr1: 238655362-242087644 1078 34322833 rs2392861 rs4658565 806.215 0 CHRM3 chr1: 174219398-247422297 1598673202900 1 rs16846809 rs4642922 35.258 0 CHRM3 chr1: 236848751-2492193203293 12370570 3 rs819666 cnvi0018731 920.725 0 CHRM3 chr19:31569338-53780966 3788 22211629 1 rs2867544 rs10407424 33.9 0 CIC chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466 100.582 0 CICchr17: 21685812-67308196 12365 45622385 1 rs34864328 rs17686852 50.018 0CNP chr17: 26648492-58955084 5831 32306593 3 rs1981512 rs8068776 15.6420 CNP chr6: 64844594-169078546 21567 104233953 1 rs4710465 rs60163946.524 0 CNR1 chr6: 66541198-162520133 19344 95978936 1 rs2000382rs6901071 27.509 0 CNR1 chr6: 73120320-165130872 18715 92010553 1rs9442780 rs10946016 76.383 0 CNR1 chr6: 66609532-147053632 1531580444101 3 rs9354335 rs4896886 44.941 0 CNR1 chr6: 26922906-9357835919746 66655454 1 rs9348738 rs9363009 27.061 0 CNR1 chr6:62697746-94090076 6391 31392331 1 rs6455128 rs3799807 108.85 0 CNR1chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0CNR1 chr6: 79198069-99893938 4062 20695870 3 rs1321584 rs4504482 200.9610 CNR1 chr3: 13878889-149737330 24723 135858442 1 rs12634112 rs200786955.663 0 COPB2 chr3: 102240202-195550366 17318 93310165 1 rs1620217rs11711870 41.031 0 COPB2 chr3: 83075971-196935657 21465 113859687 1rs9872858 rs34729751 44.35 0 COPB2 chr3: 33409611-170735099 23775137325489 1 rs3915062 rs11924032 26.867 0 COPB2 chr3:103140700-144883172 8539 41742473 1 rs4314176 rs6797159 44.122 0 COPB2chr3: 114889454-177826047 12700 62936594 3 rs6795297 rs7628308 102.526 0COPB2 chr17: 43657921-44354796 88 696876 3 rs9898857 rs2732700 21.196 0CRHR1 chr17: 21685812-67308196 12365 45622385 1 rs34864328 rs1768685250.018 0 CRHR1 chr17: 43657921-44064851 65 406931 3 rs9898857 rs807921586.447 0 CRHR1 chr17: 26648492-58955084 5831 32306593 3 rs1981512rs8068776 15.642 0 CRHR1 chr7: 11855636-156148608 26852 144292973 1rs6947930 rs6945016 36.446 0 CYCS chr7: 8872727-156383359 27773147510633 1 rs917038 rs878717 32.336 0 CYCS chr7: 8794418-11906813023484 110273713 1 rs2189621 rs6977904 70.867 0 CYCS chr7:7724805-53845684 11772 46120880 3 rs10263415 rs6948633 42.007 0 CYCSchr7: 60392-84158180 19095 84097789 3 rs12670102 rs2715048 208.308 0CYCS chr12: 10113083-116370432 20594 106257350 1 rs2012504 rs795825435.157 0 DCN chr12: 10020267-129866293 23654 119846027 1 rs1597097rs2170504 45.428 0 DCN chr12: 59512781-127744939 13469 68232159 3rs908394 rs7966946 20.62 0 DCN chr12: 84589672-93258498 1292 8668827 1rs1482434 rs11106721 43.425 0 DCN chr12: 50855195-133778796 1774882923602 3 rs4351895 rs7975069 159.589 0 DCN chr11: 42185849-12675693815451 84571090 1 rs4375424 rs10750356 36.99 0 DHCR7 chr11:21723471-131521797 20508 109798327 1 rs11828478 rs2512898 27.565 0 DHCR7chr11: 23168804-106781292 16332 83612489 1 rs11027007 rs7103285 49.747 0DHCR7 chr11: 67086298-74446791 1348 7360494 3 rs1944096 rs7103136173.017 0 DHCR7 chr1: 64114301-245591329 29842 181477029 1 rs11208257rs1173850 37.504 0 DISC1 chr1: 75098453-243531649 27360 168433197 1rs12117493 rs10927002 32.113 0 DISC1 chr1: 231711489-231813134 28 1016463 rs1765782 rs6541281 70.39 0 DISC1 chr1: 231711489-231813134 22 1016463 rs1765782 rs6541281 42.561 0 DISC1 chr1: 178626526-244159143 1306465532618 3 rs2761477 rs479338 11.373 0 DISC1 chr1: 188850774-23542360710060 46572834 1 rs16829466 rs12409696 43.25 0 DISC1 chr1:191875752-235423607 9517 43547856 1 rs9427811 rs12409696 62.01 0 DISC1chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0DISC1 chr1: 226536645-236803753 2600 10267109 3 rs874583 rs10925178100.109 0 DISC1 chr14: 26898958-104436931 17396 77537974 1 rs1245195rs11851097 57.233 0 DLST chr14: 65405722-103799039 8979 38393318 3rs11623705 rs11628472 266.153 0 DLST chr11: 42185849-126756938 1545184571090 1 rs4375424 rs10750356 36.99 0 DRD2 chr11: 21723471-13152179720508 109798327 1 rs11828478 rs2512898 27.565 0 DRD2 chr11:84128537-120941583 7678 36813047 1 rs488925 rs4643089 29.271 0 DRD2chr11: 98062720-121890280 5422 23827561 1 rs6589308 rs1944465 29.075 0DRD2 chr11: 74545378-134940416 14496 60395039 3 rs512780 rs11224228527.758 0 DRD2 chr3: 13878889-149737330 24723 135858442 1 rs12634112rs2007869 55.663 0 DRD3 chr3: 102240202-195550366 17318 93310165 1rs1620217 rs11711870 41.031 0 DRD3 chr3: 83075971-196935657 21465113859687 1 rs9872858 rs34729751 44.35 0 DRD3 chr3: 33409611-17073509923775 137325489 1 rs3915062 rs11924032 26.867 0 DRD3 chr3:103140700-144883172 8539 41742473 1 rs4314176 rs6797159 44.122 0 DRD3chr3: 179527-114630641 23879 114451115 3 rs4684741 rs1587972 207.852 0DRD3 chr20: 13712393-55093901 8218 41381509 1 rs6033810 rs6999 41.237 0DSTN chr20: 4591715-58420336 11753 53828622 1 rs6139494 rs1416388 40.9220 DSTN chr20: 7869025-62424661 11941 54555637 3 rs2294306 rs60106529.732 0 DSTN chr20: 236802-54845796 12646 54608995 3 rs448294 rs6064362286.151 0 DSTN chr12: 10020267-129866293 23654 119846027 1 rs1597097rs2170504 45.428 0 DYNLL1 chr12: 59512781-127744939 13469 68232159 3rs908394 rs7966946 20.62 0 DYNLL1 chr12: 112610714-133708729 536621098016 3 rs11066188 rs11147249 695.45 0 DYNLL1 chr12:50855195-133778796 17748 82923602 3 rs4351895 rs7975069 159.589 0 DYNLL1chr10: 53602190-135522754 19167 81920565 3 rs12247820 rs10909028 139.3730 ECHS1 chr7: 11855636-156148608 26852 144292973 1 rs6947930 rs694501636.446 0 EGFR chr7: 8872727-156383359 27773 147510633 1 rs917038rs878717 32.336 0 EGFR chr7: 8794418-119068130 23484 110273713 1rs2189621 rs6977904 70.867 0 EGFR chr7: 60392-84158180 19095 84097789 3rs12670102 rs2715048 208.308 0 EGFR chr17: 21685812-67308196 1236545622385 1 rs34864328 rs17686852 50.018 0 ERBB2 chr17: 26648492-589550845831 32306593 3 rs1981512 rs8068776 15.642 0 ERBB2 chr5:57343495-171903310 21683 114559816 1 rs10940593 rs10042482 61.169 0 F2Rchr5: 49952847-89853069 7268 39900223 3 rs12188654 rs42467 26.225 0 F2Rchr5: 4872310-180709915 35876 175837606 3 rs816467 rs10071993 179.394 0F2R chr5: 57343495-171903310 21683 114559816 1 rs10940593 rs1004248261.169 0 F2RL2 chr5: 49952847-89853069 7268 39900223 3 rs12188654rs42467 26.225 0 F2RL2 chr5: 4872310-180709915 35876 175837606 3rs816467 rs10071993 179.394 0 F2RL2 chr19: 266034-18061509 3100 177954763 rs2312724 rs7250332 19.51 0 F2RL3 chr19: 288246-59110628 1100958822383 3 rs10409452 cnvi0009466 100.582 0 F2RL3 chr1:64114301-245591329 29842 181477029 1 rs11208257 rs1173850 37.504 0 F3chr1: 75098453-243531649 27360 168433197 1 rs12117493 rs10927002 32.1130 F3 chr1: 79710545-188898319 17303 109187775 1 rs417181 rs1682963745.89 0 F3 chr1: 1005806-105612342 19173 104606537 3 rs3934834 rs158463344.152 0 F3 chr1: 2006108-109527861 22130 107521754 3 rs2254669 rs839879162.269 0 F3 chr14: 26898958-104436931 17396 77537974 1 rs1245195rs11851097 57.233 0 FKBP3 chr14: 19917123-65327288 10286 45410166 3rs2495197 rs9323455 270.291 0 FKBP3 chr19: 31569338-53780966 378822211629 1 rs2867544 rs10407424 33.9 0 FPR1 chr19: 43257015-55294329−7309 12037315 3 rs7246152 rs2569676 21.402 0 FPR1 chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466 100.582 0 FPR1chr7: 60392-84158180 19095 84097789 3 rs12670102 rs2715048 208.308 0FSCN1 chr15: 51688996-102398060 11030 50709065 1 rs2459396 rs718152736.939 0 FURIN chr15: 53775670-96810867 9973 43035198 1 rs657495rs2589238 49.204 0 FURIN chr15: 91345348-91492877 34 147530 3 rs16944840rs749938 0 0 FURIN chr15: 66108544-102427006 8615 36318463 3 cnvi0007613rs11632620 159.164 0 FURIN chr6: 64844594-169078546 21567 104233953 1rs4710465 rs601639 46.524 0 FYN chr6: 66541198-162520133 19344 959789361 rs2000382 rs6901071 27.509 0 FYN chr6: 73120320-165130872 1871592010553 1 rs9442780 rs10946016 76.383 0 FYN chr6: 66609532-14705363215315 80444101 3 rs9354335 rs4896886 44.941 0 FYN chr6:94117546-165103679 15579 70986134 1 rs3799792 rs9347902 34.066 0 FYNchr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0FYN chr6: 100082983-170909002 16393 70826020 3 rs594231 rs12213906261.313 0 FYN chr12: 6485661-6711147 48 225487 1 rs3759324 rs163912218.66 0 GAPDH chr12: 6562293-6711147 27 148855 1 rs2041385 rs163912219.307 0 GAPDH chr12: 207886-50770291 11565 50562406 3 rs868249rs4477515 43.892 0 GAPDH chr6: 26922906-93578359 19746 66655454 1rs9348738 rs9363009 27.061 0 GLP1R chr6: 31289284-56929863 1540225640580 3 rs9265170 cnvi0015437 25.647 0 GLP1R chr6: 32968276-7344974215442 40481467 3 rs2395300 rs4235869 415.87 0 GLP1R chr17:108420-26610769 5548 26502350 3 rs12452527 rs658591 82.699 0 GLP2Rchr19: 629303-4119012 709 3489710 1 rs2283575 rs350887 26.758 0 GNA15chr19: 266034-18061509 3100 17795476 3 rs2312724 rs7250332 19.51 0 GNA15chr19: 288246-59110628 11009 58822383 3 rs10409452 cnvi0009466 100.582 0GNA15 chr7: 11855636-156148608 26852 144292973 1 rs6947930 rs694501636.446 0 GNAI1 chr7: 8872727-156383359 27773 147510633 1 rs917038rs878717 32.336 0 GNAI1 chr7: 8794418-119068130 23484 110273713 1rs2189621 rs6977904 70.867 0 GNAI1 chr7: 78621315-155831817 1367877210503 3 rs1006818 rs6969015 123.319 0 GNAI1 chr7: 60392-8415818019095 84097789 3 rs12670102 rs2715048 208.308 0 GNAI1 chr3:13878889-149737330 24723 135858442 1 rs12634112 rs2007869 55.663 0 GNAI2chr3: 33409611-170735099 23775 137325489 1 rs3915062 rs11924032 26.867 0GNAI2 chr3: 179527-114630641 23879 114451115 3 rs4684741 rs1587972207.852 0 GNAI2 chr1: 64114301-245591329 29842 181477029 1 rs11208257rs1173850 37.504 0 GNAI3 chr1: 75098453-243531649 27360 168433197 1rs12117493 rs10927002 32.113 0 GNAI3 chr1: 79710545-188898319 17303109187775 1 rs417181 rs16829637 45.89 0 GNAI3 chr1: 109645793-19456046312025 84914671 3 cnvi0008281 rs10921616 63.121 0 GNAI3 chr16:50219449-89544756 10324 39325308 3 rs6500298 rs3803681 108.108 0 GNAO1chr9: 1989033-107532317 18263 105543285 1 rs7864828 rs10820726 39.824 0GNAQ chr9: 33180228-132003792 14691 98823565 1 rs7854765 rs9408988 28.690 GNAQ chr9: 2522475-140068342 25719 137545868 3 rs10966757 rs407442693.386 0 GNAQ chr9: 46587-94335290 17484 94288704 3 rs10814410 rs9409606762.393 0 GNAQ chr5: 4872310-180709915 35876 175837606 3 rs816467rs10071993 179.394 0 GNB2L1 chr10: 7188484-134205354 26672 127016871 1rs1977295 rs3923858 50.772 0 GOT1 chr10: 57671424-133349223 1624375677800 1 rs11005106 rs4301710 37.114 0 GOT1 chr10: 58385643-12497310413625 66587462 1 rs7920235 rs17663304 36.18 0 GOT1 chr10:55492162-117205017 13465 61712856 1 rs6481032 rs1933664 62.56 0 GOT1chr10: 53602190-135522754 19167 81920565 3 rs12247820 rs10909028 139.3730 GOT1 chr17: 108420-26610769 5548 26502350 3 rs12452527 rs658591 82.6990 GP1BA chr10: 7188484-134205354 26672 127016871 1 rs1977295 rs392385850.772 0 GPR26 chr10: 57671424-133349223 16243 75677800 1 rs11005106rs4301710 37.114 0 GPR26 chr10: 124668629-135157955 2949 10489327 3rs11248331 rs10776672 23.553 0 GPR26 chr10: 53602190-135522754 1916781920565 3 rs12247820 rs10909028 139.373 0 GPR26 chr17:44458950-81047708 −8195 36588759 1 cnvi0016818 rs35680231 35.591 0 GRB2chr17: 62662507-81047708 −11496 18385202 3 rs6504246 rs35680231 56.048 0GRB2 chr17: 21685812-67308196 12365 45622385 1 rs34864328 rs1768685250.018 0 GRB7 chr17: 26648492-58955084 5831 32306593 3 rs1981512rs8068776 15.642 0 GRB7 chr5: 84830796-171903310 16642 87072515 1rs300657 rs10042482 42.208 0 GRIA1 chr5: 57343495-171903310 21683114559816 1 rs10940593 rs10042482 61.169 0 GRIA1 chr5: 4872310-18070991535876 175837606 3 rs816467 rs10071993 179.394 0 GRIA1 chr21:14601415-48084989 8249 33483575 3 rs2775537 rs2839378 12047.211 0 GRIK1chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 41.154 0GRIK1 chr21: 30057145-31992864 372 1935720 1 rs6516861 rs1702405 41.6680 GRIK1 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs28393781871.363 0 GRIK1 chr21: 14601415-48084989 8249 33483575 3 rs2775537rs2839378 4787.438 0 GRIK1 chr21: 14768343-48084989 8193 33316647 3rs2257224 rs2839378 5021.076 0 GRIK1 chr21: 10708231-47970581 880737262351 3 rs4044122 rs2255397 73.188 0 GRIK1 chr1: 1005806-10561234219173 104606537 3 rs3934834 rs1584633 44.152 0 GRIK3 chr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879 162.269 0 GRIK3chr6: 64844594-169078546 21567 104233953 1 rs4710465 rs601639 46.524 0GRM1 chr6: 66541198-162520133 19344 95978936 1 rs2000382 rs690107127.509 0 GRM1 chr6: 73120320-165130872 18715 92010553 1 rs9442780rs10946016 76.383 0 GRM1 chr6: 66609532-147053632 15315 80444101 3rs9354335 rs4896886 44.941 0 GRM1 chr6: 94117546-165103679 1557970986134 1 rs3799792 rs9347902 34.066 0 GRM1 chr6: 67621368-14770918016188 80087813 1 rs6919455 rs7739314 52.498 0 GRM1 chr6:100082983-170909002 16393 70826020 3 rs594231 rs12213906 261.313 0 GRM1chr3: 13878889-149737330 24723 135858442 1 rs12634112 rs2007869 55.663 0GRM2 chr3: 33409611-170735099 23775 137325489 1 rs3915062 rs1192403226.867 0 GRM2 chr3: 179527-114630641 23879 114451115 3 rs4684741rs1587972 207.852 0 GRM2 chr7: 11855636-156148608 26852 144292973 1rs6947930 rs6945016 36.446 0 GRM3 chr7: 8872727-156383359 27773147510633 1 rs917038 rs878717 32.336 0 GRM3 chr7: 85117732-86026526 122908795 1 rs4728584 rs10242995 65.094 246704 GRM3 chr7: 8794418-11906813023484 110273713 1 rs2189621 rs6977904 70.867 0 GRM3 chr7:78621315-155831817 13678 77210503 3 rs1006818 rs6969015 123.319 0 GRM3chr7: 84302877-110993169 5183 26690293 3 rs4338048 rs10254893 203.09 0GRM3 chr6: 26922906-93578359 19746 66655454 1 rs9348738 rs9363009 27.0610 GRM4 chr6: 31289284-56929863 15402 25640580 3 rs9265170 cnvi001543725.647 0 GRM4 chr6: 32968276-73449742 15442 40481467 3 rs2395300rs4235869 415.87 0 GRM4 chr11: 42185849-126756938 15451 84571090 1rs4375424 rs10750356 36.99 0 GRM5 chr11: 21723471-131521797 20508109798327 1 rs11828478 rs2512898 27.565 0 GRM5 chr11: 23168804-10678129216332 83612489 1 rs11027007 rs7103285 49.747 0 GRM5 chr11:84128537-120941583 7678 36813047 1 rs488925 rs4643089 29.271 0 GRM5chr11: 81251505-103234729 4842 21983225 3 rs7935238 rs1913462 26.176 0GRM5 chr11: 74545378-134940416 14496 60395039 3 rs512780 rs11224228527.758 0 GRM5 chr5: 161172541-179954615 4271 18782075 3 rs4921415rs10059433 6.291 0 GRM6 chr5: 4872310-180709915 35876 175837606 3rs816467 rs10071993 179.394 0 GRM6 chr3: 5824878-8781331 952 2956454 3rs2470628 rs11916022 924.891 0 GRM7 chr3: 179527-114630641 23879114451115 3 rs4684741 rs1587972 207.852 0 GRM7 chr7: 11855636-15614860826852 144292973 1 rs6947930 rs6945016 36.446 0 GRM8 chr7:8872727-156383359 27773 147510633 1 rs917038 rs878717 32.336 0 GRM8chr7: 78621315-155831817 13678 77210503 3 rs1006818 rs6969015 123.319 0GRM8 chr7: 125676925-125780682 24 103758 1 rs1419535 rs10267757 26.358297970 GRM8 chr7: 120061880-143606234 4616 23544355 3 rs12531689rs10247493 18.96 0 GRM8 chr9: 33180228-132003792 14691 98823565 1rs7854765 rs9408988 28.69 0 GSN chr9: 2522475-140068342 25719 1375458683 rs10966757 rs4074426 93.386 0 GSN chr9: 100158052-139077343 981538919292 3 rs1020884 rs4842126 470.601 0 GSN chr1: 64114301-24559132929842 181477029 1 rs11208257 rs1173850 37.504 0 HBXIP chr1:75098453-243531649 27360 168433197 1 rs12117493 rs10927002 32.113 0HBXIP chr1: 79710545-188898319 17303 109187775 1 rs417181 rs1682963745.89 0 HBXIP chr1: 109645793-194560463 12025 84914671 3 cnvi0008281rs10921616 63.121 0 HBXIP chr5: 78520731-78765405 35 244675 1 rs4704546rs7710089 12.78 0 HOMER1 chr5: 57343495-171903310 21683 114559816 1rs10940593 rs10042482 61.169 0 HOMER1 chr5: 49952847-89853069 726839900223 3 rs12188654 rs42467 26.225 0 HOMER1 chr5: 78542290-79057477 95515188 1 rs10474578 rs259126 38.26 0 HOMER1 chr5: 4872310-18070991535876 175837606 3 rs816467 rs10071993 179.394 0 HOMER1 chr19:18622443-22202166 372 3579724 3 rs4808812 rs10412244 11.197 0 HOMER3chr19: 288246-59110628 11009 58822383 3 rs10409452 cnvi0009466 100.582 0HOMER3 chr6: 26922906-93578359 19746 66655454 1 rs9348738 rs936300927.061 0 HSP90AB1 chr6: 31289284-56929863 15402 25640580 3 rs9265170cnvi0015437 25.647 0 HSP90AB1 chr6: 32968276-73449742 15442 40481467 3rs2395300 rs4235869 415.87 0 HSP90AB1 chr13: 36707502-103656104 1362266948603 1 rs3827890 rs1952590 38.726 0 HTR2A chr13: 23742931-11506448219829 91321552 1 rs4770401 rs7999630 44.074 0 HTR2A chr13:19584477-81204088 13265 61619612 3 rs1334954 rs1176297 22.162 0 HTR2Achr13: 47300055-47409034 48 108980 1 rs1539177 rs6314 25.525 0 HTR2Achr13: 19121741-63373781 10326 44252041 3 rs9578050 rs9539575 82.761 0HTR2A chr3: 13878889-149737330 24723 135858442 1 rs12634112 rs200786955.663 0 IMPDH2 chr3: 33409611-170735099 23775 137325489 1 rs3915062rs11924032 26.867 0 IMPDH2 chr3: 48801929-49362892 29 560964 1 rs6766238rs1865741 15.852 0 IMPDH2 chr3: 179527-114630641 23879 114451115 3rs4684741 rs1587972 207.852 0 IMPDH2 chr5: 57343495-171903310 21683114559816 1 rs10940593 rs10042482 61.169 0 IQGAP2 chr5:49952847-89853069 7268 39900223 3 rs12188654 rs42467 26.225 0 IQGAP2chr5: 4872310-180709915 35876 175837606 3 rs816467 rs10071993 179.394 0IQGAP2 chr10: 7188484-134205354 26672 127016871 1 rs1977295 rs392385850.772 0 ITGB1 chr10: 734229-69155636 14859 68421408 3 rs1769236rs2394375 72.104 0 ITGB1 chr10: 88874-53366180 12853 53277307 3cnvi0015449 rs10998465 319.021 0 ITGB1 chr12: 10113083-116370432 20594106257350 1 rs2012504 rs7958254 35.157 0 ITGB7 chr12: 10020267-12986629323654 119846027 1 rs1597097 rs2170504 45.428 0 ITGB7 chr12:39967134-84174413 8879 44207280 1 rs11172661 rs11116039 39.568 0 ITGB7chr12: 50855195-133778796 17748 82923602 3 rs4351895 rs7975069 159.589 0ITGB7 chr3: 3748218-4590681 268 842464 1 rs901050 rs6802929 33.083 0ITPR1 chr3: 234726-6328081 2293 6093356 3 rs7632811 rs1595039 106.207 0ITPR1 chr3: 179527-114630641 23879 114451115 3 rs4684741 rs1587972207.852 0 ITPR1 chr1: 1005806-105612342 19173 104606537 3 rs3934834rs1584633 44.152 0 KIAA0090 chr1: 2006108-109527861 22130 107521754 3rs2254669 rs839879 162.269 0 KIAA0090 chr19: 288246-59110628 1100958822383 3 rs10409452 cnvi0009466 100.582 0 KIAA1683 chr6:64844594-169078546 21567 104233953 1 rs4710465 rs601639 46.524 0 LAMA4chr6: 66541198-162520133 19344 95978936 1 rs2000382 rs6901071 27.509 0LAMA4 chr6: 73120320-165130872 18715 92010553 1 rs9442780 rs1094601676.383 0 LAMA4 chr6: 66609532-147053632 15315 80444101 3 rs9354335rs4896886 44.941 0 LAMA4 chr6: 94117546-165103679 15579 70986134 1rs3799792 rs9347902 34.066 0 LAMA4 chr6: 67621368-147709180 1618880087813 1 rs6919455 rs7739314 52.498 0 LAMA4 chr6: 100082983-17090900216393 70826020 3 rs594231 rs12213906 261.313 0 LAMA4 chr4:22401728-188608857 28456 166207130 1 rs4697297 rs7687115 35.717 0 LRP2BPchr4: 162592024-189861553 6129 27269530 1 rs5005966 rs6853039 63.501 0LRP2BP chr4: 163766726-189931630 5627 26164905 3 rs10033012 rs1001886825.326 0 LRP2BP chr4: 69590353-190872778 23145 121282426 3 rs293433rs12646565 315.633 0 LRP2BP chr17: 44458950-81047708 −8195 36588759 1cnvi0016818 rs35680231 35.591 0 LRRC59 chr17: 21685812-67308196 1236545622385 1 rs34864328 rs17686852 50.018 0 LRRC59 chr17:26648492-58955084 5831 32306593 3 rs1981512 rs8068776 15.642 0 LRRC59chr6: 31337633-32449411 1650 1111779 1 rs9266433 rs1964995 124.395 0 LTAchr6: 31281438-32874796 −7311 1593359 1 cnvi0006173 rs9469310 36.913 0LTA chr6: 26922906-93578359 19746 66655454 1 rs9348738 rs9363009 27.0610 LTA chr6: 3760708-31957364 8062 28196657 3 rs2187825 cnvi000638039.016 0 LTA chr6: 31289284-32512613 10001 1223330 3 rs9265170rs35571839 45.035 0 LTA chr6: 31281438-32449411 −7879 1167974 1cnvi0006173 rs1964995 24.023 0 LTA chr6: 31281438-32354428 −8033 10729911 cnvi0006173 rs4424066 37.329 0 LTA chr6: 31289284-31960770 9811 6714873 rs9265170 cnvi0006385 29.628 0 LTA chr6: 26430981-31878433 −80015447453 1 rs2893848 rs519417 55.651 0 LTA chr6: 29253756-32671521 22673417766 1 rs9468508 rs9275439 51.553 0 LTA chr6: 31289284-56929863 1540225640580 3 rs9265170 cnvi0015437 25.647 0 LTA chr6: 30475431-32449411−7687 1973981 3 cnvi0005997 rs1964995 153.275 0 LTA chr4:179131-68998153 13495 68819023 3 rs7686948 rs7687396 625.133 0 LYARchr8: 30757798-142750969 20699 111993172 1 rs10101203 rs6421025 34.223 0LYN chr8: 56843930-57035027 38 191098 1 rs10091244 rs4386955 14.478 0LYN chr8: 23218101-146274708 23020 123056608 1 rs7010362 rs782272638.828 0 LYN chr8: 56706994-56851419 31 144426 3 rs2316972 rs11263271.58 0 LYN chr8: 43235525-66712108 3632 23476584 3 rs10091311 rs700113858.838 0 LYN chr3: 13878889-149737330 24723 135858442 1 rs12634112rs2007869 55.663 0 MAP4 chr3: 33409611-170735099 23775 137325489 1rs3915062 rs11924032 26.867 0 MAP4 chr3: 179527-114630641 23879114451115 3 rs4684741 rs1587972 207.852 0 MAP4 chr22: 16871137-511843939245 34313257 3 rs131538 rs7284680 209.79 0 MAPK1 chr17:43657921-44354796 88 696876 3 rs9898857 rs2732700 21.196 0 MAPT chr17:21685812-67308196 12365 45622385 1 rs34864328 rs17686852 50.018 0 MAPTchr17: 43657921-44064851 65 406931 3 rs9898857 rs8079215 86.447 0 MAPTchr17: 26648492-58955084 5831 32306593 3 rs1981512 rs8068776 15.642 0MAPT chr19: 31569338-53780966 3788 22211629 1 rs2867544 rs10407424 33.90 MARK4 chr19: 43257015-55294329 −7309 12037315 3 rs7246152 rs256967621.402 0 MARK4 chr19: 288246-59110628 11009 58822383 3 rs10409452cnvi0009466 100.582 0 MARK4 chr18: 25388300-75954881 11539 50566582 1rs11083228 rs1876021 39.235 0 MC4R chr18: 26162481-67193217 925541030737 1 rs12458903 rs9961907 31.327 0 MC4R chr18: 1583633-5814204211490 56558410 3 rs9945988 rs1560399 3.736 0 MC4R chr18:26550830-63713914 8241 37163085 1 rs16945738 rs2715304 17.922 0 MC4Rchr18: 46516210-68441007 5088 21924798 1 rs7229153 rs1282652 51.891 0MC4R chr18: 44788908-78015180 8492 33226273 3 rs9944807 rs12960632 579.20 MC4R chr6: 26922906-93578359 19746 66655454 1 rs9348738 rs936300927.061 0 MRPL14 chr6: 31289284-56929863 15402 25640580 3 rs9265170cnvi0015437 25.647 0 MRPL14 chr6: 32968276-73449742 15442 40481467 3rs2395300 rs4235869 415.87 0 MRPL14 chr10: 7188484-134205354 26672127016871 1 rs1977295 rs3923858 50.772 0 MRPS16 chr10:57671424-133349223 16243 75677800 1 rs11005106 rs4301710 37.114 0 MRPS16chr10: 58385643-124973104 13625 66587462 1 rs7920235 rs17663304 36.18 0MRPS16 chr10: 55492162-117205017 13465 61712856 1 rs6481032 rs193366462.56 0 MRPS16 chr10: 53602190-135522754 19167 81920565 3 rs12247820rs10909028 139.373 0 MRPS16 chr14: 26898958-104436931 17396 77537974 1rs1245195 rs11851097 57.233 0 MTHFD1 chr14: 64926097-65063315 19 1372191 rs2281603 rs10134770 14.377 0 MTHFD1 chr14: 19917123-65327288 1028645410166 3 rs2495197 rs9323455 270.291 0 MTHFD1 chr4: 22401728-18860885728456 166207130 1 rs4697297 rs7687115 35.717 0 MTNR1A chr4:162592024-189861553 6129 27269530 1 rs5005966 rs6853039 63.501 0 MTNR1Achr4: 163766726-189931630 5627 26164905 3 rs10033012 rs10018868 25.326 0MTNR1A chr4: 69590353-190872778 23145 121282426 3 rs293433 rs12646565315.633 0 MTNR1A chr11: 42185849-126756938 15451 84571090 1 rs4375424rs10750356 36.99 0 MTNR1B chr11: 21723471-131521797 20508 109798327 1rs11828478 rs2512898 27.565 0 MTNR1B chr11: 23168804-106781292 1633283612489 1 rs11027007 rs7103285 49.747 0 MTNR1B chr11:84128537-120941583 7678 36813047 1 rs488925 rs4643089 29.271 0 MTNR1Bchr11: 81251505-103234729 4842 21983225 3 rs7935238 rs1913462 26.176 0MTNR1B chr11: 74545378-134940416 14496 60395039 3 rs512780 rs11224228527.758 0 MTNR1B chr21: 14601415-48084989 8249 33483575 3 rs2775537rs2839378 12047.211 0 MX1 chr21: 14601415-48084989 8249 33483575 3rs2775537 rs2839378 41.154 0 MX1 chr21: 14595264-48084989 8781 334897263 rs2847443 rs2839378 1871.363 0 MX1 chr21: 14601415-48084989 824933483575 3 rs2775537 rs2839378 4787.438 0 MX1 chr21: 14768343-480849898193 33316647 3 rs2257224 rs2839378 5021.076 0 MX1 chr21:10708231-47970581 8807 37262351 3 rs4044122 rs2255397 73.188 0 MX1 chr8:30757798-142750969 20699 111993172 1 rs10101203 rs6421025 34.223 0 MYCchr8: 23218101-146274708 23020 123056608 1 rs7010362 rs7822726 38.828 0MYC chr8: 60424884-145286483 17030 84861600 3 rs1401422 rs9720889 8.8580 MYC chr8: 66822030-144791126 16557 77969097 3 rs6472235 rs10100154251.068 0 MYC chr6: 64844594-169078546 21567 104233953 1 rs4710465rs601639 46.524 0 MYO6 chr6: 66541198-162520133 19344 95978936 1rs2000382 rs6901071 27.509 0 MYO6 chr6: 73120320-165130872 1871592010553 1 rs9442780 rs10946016 76.383 0 MYO6 chr6: 66609532-14705363215315 80444101 3 rs9354335 rs4896886 44.941 0 MYO6 chr6:26922906-93578359 19746 66655454 1 rs9348738 rs9363009 27.061 0 MYO6chr6: 62697746-94090076 6391 31392331 1 rs6455128 rs3799807 108.85 0MYO6 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs773931452.498 0 MYO6 chr6: 75600804-78928379 602 3327576 3 rs7743423 rs141605549.19 0 MYO6 chr9: 1989033-107532317 18263 105543285 1 rs7864828rs10820726 39.824 0 NANS chr9: 33180228-132003792 14691 98823565 1rs7854765 rs9408988 28.69 0 NANS chr9: 2522475-140068342 25719 1375458683 rs10966757 rs4074426 93.386 0 NANS chr9: 100158052-139077343 981538919292 3 rs1020884 rs4842126 470.601 0 NANS chr3: 13878889-14973733024723 135858442 1 rs12634112 rs2007869 55.663 0 NCK1 chr3:102240202-195550366 17318 93310165 1 rs1620217 rs11711870 41.031 0 NCK1chr3: 83075971-196935657 21465 113859687 1 rs9872858 rs34729751 44.35 0NCK1 chr3: 33409611-170735099 23775 137325489 1 rs3915062 rs1192403226.867 0 NCK1 chr3: 103140700-144883172 8539 41742473 1 rs4314176rs6797159 44.122 0 NCK1 chr3: 114889454-177826047 12700 62936594 3rs6795297 rs7628308 102.526 0 NCK1 chr14: 26898958-104436931 1739677537974 1 rs1245195 rs11851097 57.233 0 NFKBIA chr14: 26018408-444863433682 18467936 3 rs10138454 rs9323093 17.669 0 NFKBIA chr14:35433187-35884639 78 451453 3 rs2273154 rs1012919 170.85 0 NFKBIA chr14:35760062-35886955 27 126894 4 rs17536892 rs2415290 5.425 0 NFKBIA chr14:19917123-65327288 10286 45410166 3 rs2495197 rs9323455 270.291 0 NFKBIAchr2: 12056323-227979775 39094 215923453 1 rs966391 rs1922020 31.384 0NMI chr2: 38101137-241482099 36812 203380963 1 rs879321 rs7576043 52.0990 NMI chr2: 34870277-241929621 37755 207059345 3 rs13422005 rs1020527646.946 0 NMI chr2: 77041264-194763754 21140 117722491 1 rs2102827rs16835406 94.091 0 NMI chr2: 83383702-175194550 16291 91810849 3rs12469609 rs11891208 154.4 0 NMI chr4: 31222833-180548076 24457149325244 1 rs7662351 rs3849606 36.162 0 NPY2R chr4: 22401728-18860885728456 166207130 1 rs4697297 rs7687115 35.717 0 NPY2R chr4:68173959-185767176 20235 117593218 1 rs6552083 rs4862428 61.893 0 NPY2Rchr4: 63726348-173015421 19817 109289074 1 rs17082970 rs2131002 30.251 0NPY2R chr4: 126374899-162380016 6166 36005118 1 rs4834042 rs1704109233.404 0 NPY2R chr4: 137206602-158430547 3577 21223946 3 rs1597600rs12507865 83.533 0 NPY2R chr4: 155739051-165849854 1997 10110804 1rs7691720 rs10005938 26.215 0 NPY2R chr4: 69590353-190872778 23145121282426 3 rs293433 rs12646565 315.633 0 NPY2R chr1: 1005806-10561234219173 104606537 3 rs3934834 rs1584633 44.152 0 NUDC chr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879 162.269 0 NUDCchr1: 1005806-105612342 19173 104606537 3 rs3934834 rs1584633 44.152 0OPRD1 chr1: 2006108-109527861 22130 107521754 3 rs2254669 rs839879162.269 0 OPRD1 chr19: 31569338-53780966 3788 22211629 1 rs2867544rs10407424 33.9 0 PAFAH1B3 chr19: 288246-59110628 11009 58822383 3rs10409452 cnvi0009466 100.582 0 PAFAH1B3 chr2: 12056323-227979775 39094215923453 1 rs966391 rs1922020 31.384 0 PCBP1 chr2: 38101137-24148209936812 203380963 1 rs879321 rs7576043 52.099 0 PCBP1 chr2:34870277-241929621 37755 207059345 3 rs13422005 rs10205276 46.946 0PCBP1 chr2: 69979290-70389900 49 410611 3 rs10177224 rs11677137 16.309 0PCBP1 chr2: 41212010-82396211 9721 41184202 3 rs12614285 rs934310396.396 0 PCBP1 chr21: 14601415-48084989 8249 33483575 3 rs2775537rs2839378 12047.211 0 PCBP3 chr21: 47091361-47226895 18 135535 1rs2838973 rs2839002 14.709 0 PCBP3 chr21: 14601415-48084989 824933483575 3 rs2775537 rs2839378 41.154 0 PCBP3 chr21: 44839153-47856106674 3016954 1 rs2838302 rs2236616 38.158 0 PCBP3 chr21:14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 PCBP3chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0PCBP3 chr21: 46381900-48098560 448 1716661 1 rs8132265 cnvi0019195712.68 0 PCBP3 chr21: 14768343-48084989 8193 33316647 3 rs2257224rs2839378 5021.076 0 PCBP3 chr21: 10708231-47970581 8807 37262351 3rs4044122 rs2255397 73.188 0 PCBP3 chr5: 84830796-171903310 1664287072515 1 rs300657 rs10042482 42.208 0 PCDHA4 chr5: 57343495-17190331021683 114559816 1 rs10940593 rs10042482 61.169 0 PCDHA4 chr5:98442871-150317237 9828 51874367 1 rs1447379 rs7710790 38.687 0 PCDHA4chr5: 4872310-180709915 35876 175837606 3 rs816467 rs10071993 179.394 0PCDHA4 chr6: 64844594-169078546 21567 104233953 1 rs4710465 rs60163946.524 0 PCMT1 chr6: 66541198-162520133 19344 95978936 1 rs2000382rs6901071 27.509 0 PCMT1 chr6: 73120320-165130872 18715 92010553 1rs9442780 rs10946016 76.383 0 PCMT1 chr6: 94117546-165103679 1557970986134 1 rs3799792 rs9347902 34.066 0 PCMT1 chr6: 100082983-17090900216393 70826020 3 rs594231 rs12213906 261.313 0 PCMT1 chr19:31569338-53780966 3788 22211629 1 rs2867544 rs10407424 33.9 0 PDCD5chr19: 288246-59110628 11009 58822383 3 rs10409452 cnvi0009466 100.582 0PDCD5 chr12: 10113083-116370432 20594 106257350 1 rs2012504 rs795825435.157 0 PDE1B chr12: 10020267-129866293 23654 119846027 1 rs1597097rs2170504 45.428 0 PDE1B chr12: 39967134-84174413 8879 44207280 1rs11172661 rs11116039 39.568 0 PDE1B chr12: 50855195-133778796 1774882923602 3 rs4351895 rs7975069 159.589 0 PDE1B chr7: 11855636-15614860826852 144292973 1 rs6947930 rs6945016 36.446 0 PDE1C chr7:8872727-156383359 27773 147510633 1 rs917038 rs878717 32.336 0 PDE1Cchr7: 8794418-119068130 23484 110273713 1 rs2189621 rs6977904 70.867 0PDE1C chr7: 7724805-53845684 11772 46120880 3 rs10263415 rs694863342.007 0 PDE1C chr7: 60392-84158180 19095 84097789 3 rs12670102rs2715048 208.308 0 PDE1C chr17: 44458950-81047708 −8195 36588759 1cnvi0016818 rs35680231 35.591 0 PDE6G chr17: 62662507-81047708 −1149618385202 3 rs6504246 rs35680231 56.048 0 PDE6G chr1: 64114301-24559132929842 181477029 1 rs11208257 rs1173850 37.504 0 PGM1 chr1:1005806-105612342 19173 104606537 3 rs3934834 rs1584633 44.152 0 PGM1chr1: 2006108-109527861 22130 107521754 3 rs2254669 rs839879 162.269 0PGM1 chr16: 176743-50013967 8328 49837225 3 rs2562164 rs12597023 174.3920 PHKB chr16: 29441284-33923125 585 4481842 3 rs7206789 rs4043755 42.4370 PHKG2 chr16: 176743-50013967 8328 49837225 3 rs2562164 rs12597023174.392 0 PHKG2 chr22: 16871137-51184393 9245 34313257 3 rs131538rs7284680 209.79 0 PICK1 chr3: 166503411-190576461 4854 24073051 1rs11925936 rs1393054 31.414 0 PIK3CA chr3: 102240202-195550366 1731893310165 1 rs1620217 rs11711870 41.031 0 PIK3CA chr3: 83075971-19693565721465 113859687 1 rs9872858 rs34729751 44.35 0 PIK3CA chr3:164955741-191742104 5741 26786364 1 rs2218152 rs9835019 52.438 0 PIK3CAchr3: 177912894-197551411 4129 19638518 3 rs9290640 rs1273562 185.507 0PIK3CA chr5: 57343495-171903310 21683 114559816 1 rs10940593 rs1004248261.169 0 PIK3R1 chr5: 49952847-89853069 7268 39900223 3 rs12188654rs42467 26.225 0 PIK3R1 chr5: 4872310-180709915 35876 175837606 3rs816467 rs10071993 179.394 0 PIK3R1 chr6: 26922906-93578359 1974666655454 1 rs9348738 rs9363009 27.061 0 PLA2G7 chr6: 31289284-5692986315402 25640580 3 rs9265170 cnvi0015437 25.647 0 PLA2G7 chr6:32968276-73449742 15442 40481467 3 rs2395300 rs4235869 415.87 0 PLA2G7chr20: 4591715-58420336 11753 53828622 1 rs6139494 rs1416388 40.922 0PLCB1 chr20: 7869025-62424661 11941 54555637 3 rs2294306 rs6010652 9.7320 PLCB1 chr20: 236802-54845796 12646 54608995 3 rs448294 rs6064362286.151 0 PLCB1 chr11: 42185849-126756938 15451 84571090 1 rs4375424rs10750356 36.99 0 PLCB3 chr11: 21723471-131521797 20508 109798327 1rs11828478 rs2512898 27.565 0 PLCB3 chr11: 23168804-106781292 1633283612489 1 rs11027007 rs7103285 49.747 0 PLCB3 chr11: 211482-6691082613813 66699345 3 rs2293168 rs4375446 30.249 0 PLCB3 chr16:64107047-82920737 4544 18813691 1 rs2319723 rs918661 28.887 0 PLCG2chr16: 59854720-89273883 7609 29419164 3 rs1373880 rs8046156 31.884 0PLCG2 chr16: 50219449-89544756 10324 39325308 3 rs6500298 rs3803681108.108 0 PLCG2 chr1: 1005806-105612342 19173 104606537 3 rs3934834rs1584633 44.152 0 PPIH chr1: 2006108-109527861 22130 107521754 3rs2254669 rs839879 162.269 0 PPIH chr19: 31569338-53780966 3788 222116291 rs2867544 rs10407424 33.9 0 PPP2R1A chr19: 43257015-55294329 −730912037315 3 rs7246152 rs2569676 21.402 0 PPP2R1A chr19: 52365654-54612628524 2246975 3 rs4514789 rs254262 59.657 0 PPP2R1A chr19: 288246-5911062811009 58822383 3 rs10409452 cnvi0009466 100.582 0 PPP2R1A chr1:1005806-105612342 19173 104606537 3 rs3934834 rs1584633 44.152 0 PRDX1chr1: 2006108-109527861 22130 107521754 3 rs2254669 rs839879 162.269 0PRDX1 chr17: 44458950-81047708 −8195 36588759 1 cnvi0016818 rs3568023135.591 0 PRKCA chr17: 21685812-67308196 12365 45622385 1 rs34864328rs17686852 50.018 0 PRKCA chr17: 59314257-66170047 1135 6855791 1rs758467 rs4558468 71.379 0 PRKCA chr17: 61016209-66240093 890 5223885 1rs1588368 rs11658645 37.309 0 PRKCA chr17: 62662507-81047708 −1149618385202 3 rs6504246 rs35680231 56.048 0 PRKCA chr10: 7188484-13420535426672 127016871 1 rs1977295 rs3923858 50.772 0 PRLHR chr10:57671424-133349223 16243 75677800 1 rs11005106 rs4301710 37.114 0 PRLHRchr10: 58385643-124973104 13625 66587462 1 rs7920235 rs17663304 36.18 0PRLHR chr10: 53602190-135522754 19167 81920565 3 rs12247820 rs10909028139.373 0 PRLHR chr19: 31569338-53780966 3788 22211629 1 rs2867544rs10407424 33.9 0 PRMT1 chr19: 43257015-55294329 −7309 12037315 3rs7246152 rs2569676 21.402 0 PRMT1 chr19: 288246-59110628 11009 588223833 rs10409452 cnvi0009466 100.582 0 PRMT1 chr17: 44458950-81047708 −819536588759 1 cnvi0016818 rs35680231 35.591 0 PRPSAP1 chr17:62662507-81047708 −11496 18385202 3 rs6504246 rs35680231 56.048 0PRPSAP1 chr9: 1989033-107532317 18263 105543285 1 rs7864828 rs1082072639.824 0 PSAT1 chr9: 33180228-132003792 14691 98823565 1 rs7854765rs9408988 28.69 0 PSAT1 chr9: 2522475-140068342 25719 137545868 3rs10966757 rs4074426 93.386 0 PSAT1 chr9: 46587-94335290 17484 942887043 rs10814410 rs9409606 762.393 0 PSAT1 chr14: 26898958-104436931 1739677537974 1 rs1245195 rs11851097 57.233 0 PSEN1 chr14: 65405722-1037990398979 38393318 3 rs11623705 rs11628472 266.153 0 PSEN1 chr11:345515-17408630 4247 17063116 3 rs11246094 rs5215 30.474 0 PSMA1 chr11:211482-66910826 13813 66699345 3 rs2293168 rs4375446 30.249 0 PSMA1chr14: 90716051-90836365 22 120315 1 rs11159958 rs11626241 15.241 0PSMC1 chr14: 26898958-104436931 17396 77537974 1 rs1245195 rs1185109757.233 0 PSMC1 chr14: 80818058-105348552 5492 24530495 3 rs6574553rs2028416 15.874 0 PSMC1 chr14: 65405722-103799039 8979 38393318 3rs11623705 rs11628472 266.153 0 PSMC1 chr2: 38101137-241482099 36812203380963 1 rs879321 rs7576043 52.099 0 PSMD1 chr2: 34870277-24192962137755 207059345 3 rs13422005 rs10205276 46.946 0 PSMD1 chr2:231927569-232035793 10 108225 1 rs3815844 rs2032953 14.229 0 PSMD1 chr2:193255360-242529978 10289 49274619 3 rs1351905 cnvi0010399 93.244 0PSMD1 chr17: 21685812-67308196 12365 45622385 1 rs34864328 rs1768685250.018 0 PSMD11 chr17: 26648492-58955084 5831 32306593 3 rs1981512rs8068776 15.642 0 PSMD11 chr11: 211482-66910826 13813 66699345 3rs2293168 rs4375446 30.249 0 PSMD13 chr3: 13878889-149737330 24723135858442 1 rs12634112 rs2007869 55.663 0 PSMD6 chr3: 33409611-17073509923775 137325489 1 rs3915062 rs11924032 26.867 0 PSMD6 chr3:179527-114630641 23879 114451115 3 rs4684741 rs1587972 207.852 0 PSMD6chr14: 22513116-32242747 1997 9729632 1 rs4982546 rs17098165 31.673 0PSME1 chr14: 22349686-25012115 755 2662430 1 rs994827 rs7142675 27.602 0PSME1 chr14: 19917123-65327288 10286 45410166 3 rs2495197 rs9323455270.291 0 PSME1 chr12: 10020267-129866293 23654 119846027 1 rs1597097rs2170504 45.428 0 PXN chr12: 59512781-127744939 13469 68232159 3rs908394 rs7966946 20.62 0 PXN chr12: 112610714-133708729 5366 210980163 rs11066188 rs11147249 695.45 0 PXN chr12: 50855195-133778796 1774882923602 3 rs4351895 rs7975069 159.589 0 PXN chr14: 26898958-10443693117396 77537974 1 rs1245195 rs11851097 57.233 0 PYGL chr14:19917123-65327288 10286 45410166 3 rs2495197 rs9323455 270.291 0 PYGLchr11: 42185849-126756938 15451 84571090 1 rs4375424 rs10750356 36.99 0PYGM chr11: 21723471-131521797 20508 109798327 1 rs11828478 rs251289827.565 0 PYGM chr11: 23168804-106781292 16332 83612489 1 rs11027007rs7103285 49.747 0 PYGM chr11: 211482-66910826 13813 66699345 3rs2293168 rs4375446 30.249 0 PYGM chr17: 44458950-81047708 −819536588759 1 cnvi0016818 rs35680231 35.591 0 QRICH2 chr17:62662507-81047708 −11496 18385202 3 rs6504246 rs35680231 56.048 0 QRICH2chr7: 11855636-156148608 26852 144292973 1 rs6947930 rs6945016 36.446 0RALA chr7: 8872727-156383359 27773 147510633 1 rs917038 rs878717 32.3360 RALA chr7: 8794418-119068130 23484 110273713 1 rs2189621 rs697790470.867 0 RALA chr7: 7724805-53845684 11772 46120880 3 rs10263415rs6948633 42.007 0 RALA chr7: 60392-84158180 19095 84097789 3 rs12670102rs2715048 208.308 0 RALA chr22: 18877787-21462353 613 2584567 1rs2543958 rs140392 772.063 0 RANBP1 chr22: 18907405-21465780 610 25583763 rs9618419 rs11703181 1799.961 0 RANBP1 chr22: 19601238-20241160 201639923 3 rs8135473 rs1567871 11.687 0 RANBP1 chr22: 19613784-21462353380 1848570 3 rs5993743 rs140392 153.49 0 RANBP1 chr22:18877787-21462353 512 2584567 1 rs2543958 rs140392 1596.687 0 RANBP1chr22: 16871137-51184393 9245 34313257 3 rs131538 rs7284680 209.79 0RANBP1 chr13: 36707502-103656104 13622 66948603 1 rs3827890 rs195259038.726 0 RAP2A chr13: 23742931-115064482 19829 91321552 1 rs4770401rs7999630 44.074 0 RAP2A chr13: 87746779-104646511 3908 16899733 3rs9301986 rs17414312 27.724 0 RAP2A chr13: 90018392-105190802 413615172411 1 rs7335222 rs11841281 42.954 0 RAP2A chr13: 65193124-11505315512025 49860032 3 rs9598811 rs7327124 78.057 0 RAP2A chr1:1005806-105612342 19173 104606537 3 rs3934834 rs1584633 44.152 0 RCC1chr1: 2006108-109527861 22130 107521754 3 rs2254669 rs839879 162.269 0RCC1 chr1: 1005806-105612342 19173 104606537 3 rs3934834 rs158463344.152 0 RCC2 chr1: 2006108-109527861 22130 107521754 3 rs2254669rs839879 162.269 0 RCC2 chr4: 179131-68998153 13495 68819023 3 rs7686948rs7687396 625.133 0 RGS12 chr1: 64114301-245591329 29842 181477029 1rs11208257 rs1173850 37.504 0 RGS2 chr1: 75098453-243531649 27360168433197 1 rs12117493 rs10927002 32.113 0 RGS2 chr1:189128124-227340790 7927 38212667 1 rs7515205 rs12752546 167.428 0 RGS2chr1: 178626526-244159143 13064 65532618 3 rs2761477 rs479338 11.373 0RGS2 chr1: 188850774-235423607 10060 46572834 1 rs16829466 rs1240969643.25 0 RGS2 chr1: 191875752-235423607 9517 43547856 1 rs9427811rs12409696 62.01 0 RGS2 chr1: 174219398-247422297 15986 73202900 1rs16846809 rs4642922 35.258 0 RGS2 chr1: 109645793-194560463 1202584914671 3 cnvi0008281 rs10921616 63.121 0 RGS2 chr3: 13878889-14973733024723 135858442 1 rs12634112 rs2007869 55.663 0 RHOA chr3:33409611-170735099 23775 137325489 1 rs3915062 rs11924032 26.867 0 RHOAchr3: 179527-114630641 23879 114451115 3 rs4684741 rs1587972 207.852 0RHOA chr2: 12056323-227979775 39094 215923453 1 rs966391 rs192202031.384 0 RIF1 chr2: 38101137-241482099 36812 203380963 1 rs879321rs7576043 52.099 0 RIF1 chr2: 34870277-241929621 37755 207059345 3rs13422005 rs10205276 46.946 0 RIF1 chr2: 77041264-194763754 21140117722491 1 rs2102827 rs16835406 94.091 0 RIF1 chr2: 83383702-17519455016291 91810849 3 rs12469609 rs11891208 154.4 0 RIF1 chr1:1005806-105612342 19173 104606537 3 rs3934834 rs1584633 44.152 0 RPA2chr1: 2006108-109527861 22130 107521754 3 rs2254669 rs839879 162.269 0RPA2 chr11: 345515-17408630 4247 17063116 3 rs11246094 rs5215 30.474 0RPLP2 chr11: 211482-66910826 13813 66699345 3 rs2293168 rs4375446 30.2490 RPLP2 chr20: 13712393-55093901 8218 41381509 1 rs6033810 rs6999 41.2370 RPN2 chr20: 4591715-58420336 11753 53828622 1 rs6139494 rs141638840.922 0 RPN2 chr20: 7869025-62424661 11941 54555637 3 rs2294306rs6010652 9.732 0 RPN2 chr20: 236802-54845796 12646 54608995 3 rs448294rs6064362 286.151 0 RPN2 chr5: 84830796-171903310 16642 87072515 1rs300657 rs10042482 42.208 0 RPS14 chr5: 57343495-171903310 21683114559816 1 rs10940593 rs10042482 61.169 0 RPS14 chr5:98442871-150317237 9828 51874367 1 rs1447379 rs7710790 38.687 0 RPS14chr5: 4872310-180709915 35876 175837606 3 rs816467 rs10071993 179.394 0RPS14 chr11: 3906740-4201641 55 294902 1 rs11600857 rs2044138 27.361 0RRM1 chr11: 345515-17408630 4247 17063116 3 rs11246094 rs5215 30.474 0RRM1 chr11: 211482-66910826 13813 66699345 3 rs2293168 rs4375446 30.2490 RRM1 chr19: 31569338-53780966 3788 22211629 1 rs2867544 rs1040742433.9 0 RUVBL2 chr19: 43257015-55294329 −7309 12037315 3 rs7246152rs2569676 21.402 0 RUVBL2 chr19: 288246-59110628 11009 58822383 3rs10409452 cnvi0009466 100.582 0 RUVBL2 chr19: 31569338-53780966 378822211629 1 rs2867544 rs10407424 33.9 0 RYR1 chr19: 288246-59110628 1100958822383 3 rs10409452 cnvi0009466 100.582 0 RYR1 chr1:64114301-245591329 29842 181477029 1 rs11208257 rs1173850 37.504 0 RYR2chr1: 75098453-243531649 27360 168433197 1 rs12117493 rs10927002 32.1130 RYR2 chr1: 178626526-244159143 13064 65532618 3 rs2761477 rs47933811.373 0 RYR2 chr1: 237570457-237675464 37 105008 1 rs4659495 rs261872115.007 0 RYR2 chr1: 174219398-247422297 15986 73202900 1 rs16846809rs4642922 35.258 0 RYR2 chr1: 237584925-237904870 86 319946 1 rs4593814rs10925504 31.95 0 RYR2 chr1: 236848751-249219320 3293 12370570 3rs819666 cnvi0018731 920.725 0 RYR2 chr1: 64114301-245591329 29842181477029 1 rs11208257 rs1173850 37.504 0 S100A6 chr1:75098453-243531649 27360 168433197 1 rs12117493 rs10927002 32.113 0S100A6 chr1: 79710545-188898319 17303 109187775 1 rs417181 rs1682963745.89 0 S100A6 chr1: 109645793-194560463 12025 84914671 3 cnvi0008281rs10921616 63.121 0 S100A6 chr13: 23742931-115064482 19829 91321552 1rs4770401 rs7999630 44.074 0 SACS chr13: 19584477-81204088 1326561619612 3 rs1334954 rs1176297 22.162 0 SACS chr13: 19121741-6337378110326 44252041 3 rs9578050 rs9539575 82.761 0 SACS chr1:64114301-245591329 29842 181477029 1 rs11208257 rs1173850 37.504 0 SARSchr1: 75098453-243531649 27360 168433197 1 rs12117493 rs10927002 32.1130 SARS chr1: 79710545-188898319 17303 109187775 1 rs417181 rs1682963745.89 0 SARS chr1: 109645793-194560463 12025 84914671 3 cnvi0008281rs10921616 63.121 0 SARS chr2: 12056323-227979775 39094 215923453 1rs966391 rs1922020 31.384 0 SCTR chr2: 38101137-241482099 36812203380963 1 rs879321 rs7576043 52.099 0 SCTR chr2: 34870277-24192962137755 207059345 3 rs13422005 rs10205276 46.946 0 SCTR chr2:77041264-194763754 21140 117722491 1 rs2102827 rs16835406 94.091 0 SCTRchr2: 83383702-175194550 16291 91810849 3 rs12469609 rs11891208 154.4 0SCTR chr1: 1005806-105612342 19173 104606537 3 rs3934834 rs158463344.152 0 SDC3 chr1: 2006108-109527861 22130 107521754 3 rs2254669rs839879 162.269 0 SDC3 chr1: 64114301-245591329 29842 181477029 1rs11208257 rs1173850 37.504 0 SELE chr1: 75098453-243531649 27360168433197 1 rs12117493 rs10927002 32.113 0 SELE chr1: 79710545-18889831917303 109187775 1 rs417181 rs16829637 45.89 0 SELE chr1:169556446-171300348 340 1743903 1 rs9332480 rs7541160 32.81 0 SELE chr1:109645793-194560463 12025 84914671 3 cnvi0008281 rs10921616 63.121 0SELE chr6: 2681610-31453618 81 28772009 3 rs1131896 rs9267212 428.177 0SERPINB9 chr6: 1171596-29899147 47 28727552 0 rs3128994 rs2394704 80.6950 SERPINB9 chr6: 1171596-29899147 47 28727552 0 rs3128994 rs239470463.572 0 SERPINB9 chr6: 1171596-29895228 43 28723633 0 rs3128994rs9259831 53.123 0 SERPINB9 chr6: 1175965-29899147 43 28723183 0rs1611522 rs2394704 52.089 0 SERPINB9 chr6: 1177990-29899147 39 287211580 rs2428530 rs2394704 44.381 0 SERPINB9 chr6: 2585208-31281876 −228696669 1 rs1634746 rs1634747 31.615 0 SERPINB9 chr6: 2681610-3145361881 28772009 3 rs1131896 rs9267212 390.234 0 SERPINB9 chr6:2584569-31286381 8 28701813 1 rs9391764 rs9265057 34.598 0 SERPINB9chr6: 1171596-29892436 39 28720841 1 rs3128994 rs9259806 31.699 0SERPINB9 chr6: 1171596-29895228 43 28723633 0 rs3128994 rs9259831 43.5680 SERPINB9 chr6: 181089-30430875 1806 30249787 3 rs1535053 rs3579261180.394 0 SERPINB9 chr9: 33180228-132003792 14691 98823565 1 rs7854765rs9408988 28.69 0 SET chr9: 2522475-140068342 25719 137545868 3rs10966757 rs4074426 93.386 0 SET chr9: 100158052-139077343 981538919292 3 rs1020884 rs4842126 470.601 0 SET chr21: 14601415-480849898249 33483575 3 rs2775537 rs2839378 12047.211 0 SETD4 chr21:14601415-48084989 8249 33483575 3 rs2775537 rs2839378 41.154 0 SETD4chr21: 36927793-37647438 142 719646 3 rs2205031 rs9980084 187.28 0 SETD4chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0SETD4 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs28393784787.438 0 SETD4 chr21: 14768343-48084989 8193 33316647 3 rs2257224rs2839378 5021.076 0 SETD4 chr21: 10708231-47970581 8807 37262351 3rs4044122 rs2255397 73.188 0 SETD4 chr2: 12056323-227979775 39094215923453 1 rs966391 rs1922020 31.384 0 SF3B14 chr2: 18856-41136833 972141117978 3 rs11901199 rs10187704 191.638 0 SF3B14 chr19:31569338-53780966 3788 22211629 1 rs2867544 rs10407424 33.9 0 SHANK1chr19: 43257015-55294329 −7309 12037315 3 rs7246152 rs2569676 21.402 0SHANK1 chr19: 288246-59110628 11009 58822383 3 rs10409452 cnvi0009466100.582 0 SHANK1 chr17: 108420-26610769 5548 26502350 3 rs12452527rs658591 82.699 0 SHBG chr16: 176743-50013967 8328 49837225 3 rs2562164rs12597023 174.392 0 SIAH1 chr1: 1005806-105612342 19173 104606537 3rs3934834 rs1584633 44.152 0 SLC2A1 chr1: 2006108-109527861 22130107521754 3 rs2254669 rs839879 162.269 0 SLC2A1 chr5: 141659-190100084662 18868350 3 rs11741126 rs4642370 50.124 0 SLC6A3 chr5:506051-4746181 1345 4240131 3 rs6864158 rs7716294 447.942 0 SLC6A3 chr4:31222833-180548076 24457 149325244 1 rs7662351 rs3849606 36.162 0 SNCAchr4: 22401728-188608857 28456 166207130 1 rs4697297 rs7687115 35.717 0SNCA chr4: 68173959-185767176 20235 117593218 1 rs6552083 rs486242861.893 0 SNCA chr4: 63726348-173015421 19817 109289074 1 rs17082970rs2131002 30.251 0 SNCA chr4: 29179713-117038307 15513 87858595 1rs1507441 rs1068807 71.6 0 SNCA chr4: 89603085-113991140 4018 24388056 3rs2972038 rs2279892 28.405 0 SNCA chr4: 90618264-90784528 33 166265 1rs17286290 rs2736994 16.242 0 SNCA chr4: 69590353-190872778 23145121282426 3 rs293433 rs12646565 315.633 0 SNCA chr20: 13712393-550939018218 41381509 1 rs6033810 rs6999 41.237 0 SNRPB2 chr20: 4591715-5842033611753 53828622 1 rs6139494 rs1416388 40.922 0 SNRPB2 chr20:7869025-62424661 11941 54555637 3 rs2294306 rs6010652 9.732 0 SNRPB2chr20: 236802-54845796 12646 54608995 3 rs448294 rs6064362 286.151 0SNRPB2 chr18: 25388300-75954881 11539 50566582 1 rs11083228 rs187602139.235 0 SOCS6 chr18: 46516210-68441007 5088 21924798 1 rs7229153rs1282652 51.891 0 SOCS6 chr18: 64480206-70125971 1534 5645766 3rs10516001 rs1347013 65.248 0 SOCS6 chr18: 65585580-69281510 10743695931 1 rs11875790 rs8090683 111.579 0 SOCS6 chr18: 62041997-760474933846 14005497 1 rs1421538 rs8085865 33.212 0 SOCS6 chr18:44788908-78015180 8492 33226273 3 rs9944807 rs12960632 579.2 0 SOCS6chr17: 21685812-67308196 12365 45622385 1 rs34864328 rs17686852 50.018 0SOCS7 chr17: 26648492-58955084 5831 32306593 3 rs1981512 rs806877615.642 0 SOCS7 chr15: 44763598-47394943 502 2631346 3 rs7172106rs4095484 142.088 0 SORD chr15: 29325866-56044189 5303 26718324 3rs4779705 rs2414433 21.732 0 SORD chr15: 43392075-66051345 4963 226592713 rs8028608 rs6494537 59.842 0 SORD chr20: 13712393-55093901 821841381509 1 rs6033810 rs6999 41.237 0 SRC chr20: 4591715-58420336 1175353828622 1 rs6139494 rs1416388 40.922 0 SRC chr20: 7869025-6242466111941 54555637 3 rs2294306 rs6010652 9.732 0 SRC chr20:35942718-36175566 43 232849 3 rs6104528 rs4810841 2.708 0 SRC chr20:236802-54845796 12646 54608995 3 rs448294 rs6064362 286.151 0 SRC chr20:13712393-55093901 8218 41381509 1 rs6033810 rs6999 41.237 0 STAU1 chr20:4591715-58420336 11753 53828622 1 rs6139494 rs1416388 40.922 0 STAU1chr20: 7869025-62424661 11941 54555637 3 rs2294306 rs6010652 9.732 0STAU1 chr20: 236802-54845796 12646 54608995 3 rs448294 rs6064362 286.1510 STAU1 chr12: 10113083-116370432 20594 106257350 1 rs2012504 rs795825435.157 0 STRAP chr12: 10020267-129866293 23654 119846027 1 rs1597097rs2170504 45.428 0 STRAP chr12: 8171838-32535863 5853 24364026 3rs11609309 rs7963182 23.697 0 STRAP chr12: 207886-50770291 1156550562406 3 rs868249 rs4477515 43.892 0 STRAP chr1: 1005806-10561234219173 104606537 3 rs3934834 rs1584633 44.152 0 STX12 chr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879 162.269 0 STX12chr9: 1989033-107532317 18263 105543285 1 rs7864828 rs10820726 39.824 0SYK chr9: 33180228-132003792 14691 98823565 1 rs7854765 rs9408988 28.690 SYK chr9: 2522475-140068342 25719 137545868 3 rs10966757 rs407442693.386 0 SYK chr9: 46587-94335290 17484 94288704 3 rs10814410 rs9409606762.393 0 SYK chr5: 57343495-171903310 21683 114559816 1 rs10940593rs10042482 61.169 0 TBCA chr5: 49952847-89853069 7268 39900223 3rs12188654 rs42467 26.225 0 TBCA chr5: 4872310-180709915 35876 1758376063 rs816467 rs10071993 179.394 0 TBCA chr19: 629303-4119012 709 3489710 1rs2283575 rs350887 26.758 0 TBXA2R chr19: 266034-18061509 3100 177954763 rs2312724 rs7250332 19.51 0 TBXA2R chr19: 288246-59110628 1100958822383 3 rs10409452 cnvi0009466 100.582 0 TBXA2R chr6:64844594-169078546 21567 104233953 1 rs4710465 rs601639 46.524 0 TCP1chr6: 66541198-162520133 19344 95978936 1 rs2000382 rs6901071 27.509 0TCP1 chr6: 73120320-165130872 18715 92010553 1 rs9442780 rs1094601676.383 0 TCP1 chr6: 94117546-165103679 15579 70986134 1 rs3799792rs9347902 34.066 0 TCP1 chr6: 151495387-165969396 3761 14474010 3rs9322304 rs1022180 22.826 0 TCP1 chr6: 100082983-170909002 1639370826020 3 rs594231 rs12213906 261.313 0 TCP1 chr6: 26922906-9357835919746 66655454 1 rs9348738 rs9363009 27.061 0 TEAD3 chr6:31289284-56929863 15402 25640580 3 rs9265170 cnvi0015437 25.647 0 TEAD3chr6: 32968276-73449742 15442 40481467 3 rs2395300 rs4235869 415.87 0TEAD3 chr10: 7188484-134205354 26672 127016871 1 rs1977295 rs392385850.772 0 TFAM chr10: 57671424-133349223 16243 75677800 1 rs11005106rs4301710 37.114 0 TFAM chr10: 734229-69155636 14859 68421408 3rs1769236 rs2394375 72.104 0 TFAM chr10: 58385643-124973104 1362566587462 1 rs7920235 rs17663304 36.18 0 TFAM chr10: 55492162-11720501713465 61712856 1 rs6481032 rs1933664 62.56 0 TFAM chr10:53602190-135522754 19167 81920565 3 rs12247820 rs10909028 139.373 0 TFAMchr20: 13712393-55093901 8218 41381509 1 rs6033810 rs6999 41.237 0 TGM2chr20: 4591715-58420336 11753 53828622 1 rs6139494 rs1416388 40.922 0TGM2 chr20: 7869025-62424661 11941 54555637 3 rs2294306 rs6010652 9.7320 TGM2 chr20: 236802-54845796 12646 54608995 3 rs448294 rs6064362286.151 0 TGM2 chr15: 29325866-56044189 5303 26718324 3 rs4779705rs2414433 21.732 0 TJP1 chr15: 29659013-30239328 126 580316 1 rs4779618rs12905328 41.602 0 TJP1 chr15: 20058438-32544679 2394 12486242 3rs12591240 cnvi0018163 296.82 0 TJP1 chr15: 22267462-32461463 223210194002 3 rs4123826 rs286103 218.215 0 TJP1 chr17: 44458950-81047708−8195 36588759 1 cnvi0016818 rs35680231 35.591 0 TK1 chr17:75730493-79302149 880 3571657 3 rs7210773 rs2864474 14.319 0 TK1 chr17:62662507-81047708 −11496 18385202 3 rs6504246 rs35680231 56.048 0 TK1chr4: 31222833-180548076 24457 149325244 1 rs7662351 rs3849606 36.162 0TLR10 chr4: 22401728-188608857 28456 166207130 1 rs4697297 rs768711535.717 0 TLR10 chr4: 29179713-117038307 15513 87858595 1 rs1507441rs1068807 71.6 0 TLR10 chr4: 179131-68998153 13495 68819023 3 rs7686948rs7687396 625.133 0 TLR10 chr3: 166503411-190576461 4854 24073051 1rs11925936 rs1393054 31.414 0 TNIK chr3: 102240202-195550366 1731893310165 1 rs1620217 rs11711870 41.031 0 TNIK chr3: 83075971-19693565721465 113859687 1 rs9872858 rs34729751 44.35 0 TNIK chr3:145967173-173899890 4912 27932718 3 rs9863647 rs7618997 46.396 0 TNIKchr3: 164955741-191742104 5741 26786364 1 rs2218152 rs9835019 52.438 0TNIK chr3: 114889454-177826047 12700 62936594 3 rs6795297 rs7628308102.526 0 TNIK chr12: 207886-50770291 11565 50562406 3 rs868249rs4477515 43.892 0 TPI1 chr9: 139492789-140913833 196 1421045 1rs28485548 cnvi0002661 28.211 0 TRAF2 chr9: 139492789-140212642 109719854 3 rs28485548 rs13295516 12.464 0 TRAF2 chr9: 2522475-14006834225719 137545868 3 rs10966757 rs4074426 93.386 0 TRAF2 chr9:139725120-140176250 50 451131 1 rs2811750 rs28576426 24.435 0 TRAF2chr11: 42185849-126756938 15451 84571090 1 rs4375424 rs10750356 36.99 0TRMT112 chr11: 21723471-131521797 20508 109798327 1 rs11828478 rs251289827.565 0 TRMT112 chr11: 23168804-106781292 16332 83612489 1 rs11027007rs7103285 49.747 0 TRMT112 chr11: 211482-66910826 13813 66699345 3rs2293168 rs4375446 30.249 0 TRMT112 chr12: 10113083-116370432 20594106257350 1 rs2012504 rs7958254 35.157 0 TUBA1A chr12:10020267-129866293 23654 119846027 1 rs1597097 rs2170504 45.428 0 TUBA1Achr12: 39967134-84174413 8879 44207280 1 rs11172661 rs11116039 39.568 0TUBA1A chr12: 207886-50770291 11565 50562406 3 rs868249 rs4477515 43.8920 TUBA1A chr12: 10113083-116370432 20594 106257350 1 rs2012504 rs795825435.157 0 TUBA1B chr12: 10020267-129866293 23654 119846027 1 rs1597097rs2170504 45.428 0 TUBA1B chr12: 39967134-84174413 8879 44207280 1rs11172661 rs11116039 39.568 0 TUBA1B chr12: 207886-50770291 1156550562406 3 rs868249 rs4477515 43.892 0 TUBA1B chr6: 10123365-31221039−3135 21097675 1 rs2181334 rs4416711 318.459 0 TUBB chr6:26922906-93578359 19746 66655454 1 rs9348738 rs9363009 27.061 0 TUBBchr6: 2681610-31453618 81 28772009 3 rs1131896 rs9267212 428.177 0 TUBBchr6: 2585208-31281876 −2 28696669 1 rs1634746 rs1634747 31.615 0 TUBBchr6: 3760708-31957364 8062 28196657 3 rs2187825 cnvi0006380 39.016 0TUBB chr6: 19044000-31286381 −6774 12242382 1 rs6922929 rs9265057 31.3840 TUBB chr6: 24697388-31341340 −8293 6643953 1 rs2092404 rs926651538.794 0 TUBB chr6: 26430981-31878433 −8001 5447453 1 rs2893848 rs51941755.651 0 TUBB chr6: 2681610-31453618 81 28772009 3 rs1131896 rs9267212390.234 0 TUBB chr6: 2584569-31286381 8 28701813 1 rs9391764 rs926505734.598 0 TUBB chr6: 29253756-32671521 2267 3417766 1 rs9468508 rs927543951.553 0 TUBB chr6: 19044000-31286381 −6774 12242382 0 rs6922929rs9265057 33.119 0 TUBB chr6: 30475431-32449411 −7687 1973981 3cnvi0005997 rs1964995 153.275 0 TUBB chr17: 21685812-67308196 1236545622385 1 rs34864328 rs17686852 50.018 0 TUBG1 chr17: 26648492-589550845831 32306593 3 rs1981512 rs8068776 15.642 0 TUBG1 chr9:33180228-132003792 14691 98823565 1 rs7854765 rs9408988 28.69 0 TXNchr9: 2522475-140068342 25719 137545868 3 rs10966757 rs4074426 93.386 0TXN chr9: 100158052-139077343 9815 38919292 3 rs1020884 rs4842126470.601 0 TXN chr18: 10274-30780701 6393 30770428 3 cnvi0008694 rs271534338.777 0 TYMS chr1: 64114301-245591329 29842 181477029 1 rs11208257rs1173850 37.504 0 UBQLN4 chr1: 75098453-243531649 27360 168433197 1rs12117493 rs10927002 32.113 0 UBQLN4 chr1: 79710545-188898319 17303109187775 1 rs417181 rs16829637 45.89 0 UBQLN4 chr1: 109645793-19456046312025 84914671 3 cnvi0008281 rs10921616 63.121 0 UBQLN4 chr4:31222833-180548076 24457 149325244 1 rs7662351 rs3849606 36.162 0 UCHL1chr4: 22401728-188608857 28456 166207130 1 rs4697297 rs7687115 35.717 0UCHL1 chr4: 29179713-117038307 15513 87858595 1 rs1507441 rs1068807 71.60 UCHL1 chr4: 39472311-63464732 3456 23992422 3 rs2687975 rs4403080120.672 0 UCHL1 chr4: 179131-68998153 13495 68819023 3 rs7686948rs7687396 625.133 0 UCHL1 chr3: 179527-114630641 23879 114451115 3rs4684741 rs1587972 207.852 0 VHL chr3: 13878889-149737330 24723135858442 1 rs12634112 rs2007869 55.663 0 VIPR1 chr3: 33409611-17073509923775 137325489 1 rs3915062 rs11924032 26.867 0 VIPR1 chr3:179527-114630641 23879 114451115 3 rs4684741 rs1587972 207.852 0 VIPR1chr2: 18856-41136833 9721 41117978 3 rs11901199 rs10187704 191.638 0YWHAQ chr2: 12056323-227979775 39094 215923453 1 rs966391 rs192202031.384 0 ZAP70 chr2: 38101137-241482099 36812 203380963 1 rs879321rs7576043 52.099 0 ZAP70 chr2: 34870277-241929621 37755 207059345 3rs13422005 rs10205276 46.946 0 ZAP70 chr2: 77041264-194763754 21140117722491 1 rs2102827 rs16835406 94.091 0 ZAP70 chr2: 83383702-17519455016291 91810849 3 rs12469609 rs11891208 154.4 0 ZAP70

TABLE 3 Distance Chr:Start-Stop(hg19) NumSNP Length State, CN StartSNPEndSNP Confidence From Gene mGluR Gene chr17:44458950-81047708 −819536588759 1 cnvi0016818 rs35680231 35.591 0 ABI3 chr17:21685812-6730819612365 45622385 1 rs34864328 rs17686852 50.018 0 ABI3chr17:26648492-58955084 5831 32306593 3 rs1981512 rs8068776 15.642 0ABI3 chr11:42185849-126756938 15451 84571090 1 rs4375424 rs1075035636.99 0 ACAT1 chr11:84128537-120941583 7678 36813047 1 rs488925rs4643089 29.271 0 ACAT1 chr11:21723471-131521797 20508 109798327 1rs11828478 rs2512898 27.565 0 ACAT1 chr11:98062720-121890280 542223827561 1 rs6589308 rs1944465 29.075 0 ACAT1 chr11:74545378-13494041614496 60395039 3 rs512780 rs11224228 527.758 0 ACAT1chr6:64844594-169078546 21567 104233953 1 rs4710465 rs601639 46.524 0ACAT2 chr6:151495387-165969396 3761 14474010 3 rs9322304 rs102218022.826 0 ACAT2 chr6:73120320-165130872 18715 92010553 1 rs9442780rs10946016 76.383 0 ACAT2 chr6:66541198-162520133 19344 95978936 1rs2000382 rs6901071 27.509 0 ACAT2 chr6:94117546-165103679 1557970986134 1 rs3799792 rs9347902 34.066 0 ACAT2 chr6:100082983-17090900216393 70826020 3 rs594231 rs12213906 261.313 0 ACAT2chr17:32104675-32822032 239 717358 4 rs6505377 rs213135 113.523 0 ACCN1chr17:21685812-67308196 12365 45622385 1 rs34864328 rs17686852 50.018 0ACCN1 chr17:26648492-58955084 5831 32306593 3 rs1981512 rs8068776 15.6420 ACCN1 chr12:10113083-116370432 20594 106257350 1 rs2012504 rs795825435.157 0 ACCN2 chr12:10020267-129866293 23654 119846027 1 rs1597097rs2170504 45.428 0 ACCN2 chr12:39967134-84174413 8879 44207280 1rs11172661 rs11116039 39.568 0 ACCN2 chr12:207886-50770291 1156550562406 3 rs868249 rs4477515 43.892 0 ACCN2 chr2:18856-41136833 972141117978 3 rs11901199 rs10187704 191.638 0 ACP1 chr1:64114301-24559132929842 181477029 1 rs11208257 rs1173850 37.504 0 ACTA1chr1:178626526-244159143 13064 65532618 3 rs2761477 rs479338 11.373 0ACTA1 chr1:75098453-243531649 27360 168433197 1 rs12117493 rs1092700232.113 0 ACTA1 chr1:188850774-235423607 10060 46572834 1 rs16829466rs12409696 43.25 0 ACTA1 chr1:191875752-235423607 9517 43547856 1rs9427811 rs12409696 62.01 0 ACTA1 chr1:174219398-247422297 1598673202900 1 rs16846809 rs4642922 35.258 0 ACTA1 chr1:226536645-2368037532600 10267109 3 rs874583 rs10925178 100.109 0 ACTA1 chr7:60392-8415818019095 84097789 3 rs12670102 rs2715048 208.308 0 ACTBchr1:64114301-245591329 29842 181477029 1 rs11208257 rs1173850 37.504 0ACTN2 chr1:178626526-244159143 13064 65532618 3 rs2761477 rs47933811.373 0 ACTN2 chr1:75098453-243531649 27360 168433197 1 rs12117493rs10927002 32.113 0 ACTN2 chr1:174219398-247422297 15986 73202900 1rs16846809 rs4642922 35.258 0 ACTN2 chr1:236848751-249219320 329312370570 3 rs819666 cnvi0018731 920.725 0 ACTN2 chr2:12056323-22797977539094 215923453 1 rs966391 rs1922020 31.384 0 ACTR2chr2:34870277-241929621 37755 207059345 3 rs13422005 rs10205276 46.946 0ACTR2 chr2:38101137-241482099 36812 203380963 1 rs879321 rs757604352.099 0 ACTR2 chr2:41212010-82396211 9721 41184202 3 rs12614285rs934310 396.396 0 ACTR2 chr20:13712393-55093901 8218 41381509 1rs6033810 rs6999 41.237 0 ADA chr20:7869025-62424661 11941 54555637 3rs2294306 rs6010652 9.732 0 ADA chr20:4591715-58420336 11753 53828622 1rs6139494 rs1416388 40.922 0 ADA chr20:236802-54845796 12646 54608995 3rs448294 rs6064362 286.151 0 ADA chr7:11855636-156148608 26852 1442929731 rs6947930 rs6945016 36.446 0 ADCY1 chr7:7724805-53845684 1177246120880 3 rs10263415 rs6948633 42.007 0 ADCY1 chr7:8872727-15638335927773 147510633 1 rs917038 rs878717 32.336 0 ADCY1chr7:8794418-119068130 23484 110273713 1 rs2189621 rs6977904 70.867 0ADCY1 chr7:60392-84158180 19095 84097789 3 rs12670102 rs2715048 208.3080 ADCY1 chr3:13878889-149737330 24723 135858442 1 rs12634112 rs200786955.663 0 ADCY5 chr3:33409611-170735099 23775 137325489 1 rs3915062rs11924032 26.867 0 ADCY5 chr3:102240202-195550366 17318 93310165 1rs1620217 rs11711870 41.031 0 ADCY5 chr3:103140700-144883172 853941742473 1 rs4314176 rs6797159 44.122 0 ADCY5 chr3:83075971-19693565721465 113859687 1 rs9872858 rs34729751 44.35 0 ADCY5chr3:114889454-177826047 12700 62936594 3 rs6795297 rs7628308 102.526 0ADCY5 chr8:30757798-142750969 20699 111993172 1 rs10101203 rs642102534.223 0 ADCY8 chr8:60424884-145286483 17030 84861600 3 rs1401422rs9720889 8.858 0 ADCY8 chr8:130808973-134279601 923 3470629 3 rs7823788rs2976574 37.758 0 ADCY8 chr8:23218101-146274708 23020 123056608 1rs7010362 rs7822726 38.828 0 ADCY8 chr8:66822030-144791126 1655777969097 3 rs6472235 rs10100154 251.068 0 ADCY8 chr7:11855636-15614860826852 144292973 1 rs6947930 rs6945016 36.446 0 ADCYAP1R1chr7:7724805-53845684 11772 46120880 3 rs10263415 rs6948633 42.007 0ADCYAP1R1 chr7:8872727-156383359 27773 147510633 1 rs917038 rs87871732.336 0 ADCYAP1R1 chr7:8794418-119068130 23484 110273713 1 rs2189621rs6977904 70.867 0 ADCYAP1R1 chr7:60392-84158180 19095 84097789 3rs12670102 rs2715048 208.308 0 ADCYAP1R1 chr4:179131-68998153 1349568819023 3 rs7686948 rs7687396 625.133 0 ADD1 chr2:12056323-22797977539094 215923453 1 rs966391 rs1922020 31.384 0 ADD2chr2:34870277-241929621 37755 207059345 3 rs13422005 rs10205276 46.946 0ADD2 chr2:38101137-241482099 36812 203380963 1 rs879321 rs7576043 52.0990 ADD2 chr2:41212010-82396211 9721 41184202 3 rs12614285 rs934310396.396 0 ADD2 chr10:7188484-134205354 26672 127016871 1 rs1977295rs3923858 50.772 0 ADD3 chr10:58385643-124973104 13625 66587462 1rs7920235 rs17663304 36.18 0 ADD3 chr10:57671424-133349223 1624375677800 1 rs11005106 rs4301710 37.114 0 ADD3 chr10:55492162-11720501713465 61712856 1 rs6481032 rs1933664 62.56 0 ADD3chr10:53602190-135522754 19167 81920565 3 rs12247820 rs10909028 139.3730 ADD3 chr1:64114301-245591329 29842 181477029 1 rs11208257 rs117385037.504 0 ADORA1 chr1:178626526-244159143 13064 65532618 3 rs2761477rs479338 11.373 0 ADORA1 chr1:75098453-243531649 27360 168433197 1rs12117493 rs10927002 32.113 0 ADORA1 chr1:188850774-235423607 1006046572834 1 rs16829466 rs12409696 43.25 0 ADORA1 chr1:191875752-2354236079517 43547856 1 rs9427811 rs12409696 62.01 0 ADORA1chr1:189128124-227340790 7927 38212667 1 rs7515205 rs12752546 167.428 0ADORA1 chr1:174219398-247422297 15986 73202900 1 rs16846809 rs464292235.258 0 ADORA1 chr1:197187605-226404457 6316 29216853 3 rs10922187rs3008192 130.989 0 ADORA1 chr5:84830796-171903310 16642 87072515 1rs300657 rs10042482 42.208 0 ADRA1B chr5:57343495-171903310 21683114559816 1 rs10940593 rs10042482 61.169 0 ADRA1B chr5:4872310-18070991535876 175837606 3 rs816467 rs10071993 179.394 0 ADRA1Bchr10:7188484-134205354 26672 127016871 1 rs1977295 rs3923858 50.772 0ADRA2A chr10:58385643-124973104 13625 66587462 1 rs7920235 rs1766330436.18 0 ADRA2A chr10:57671424-133349223 16243 75677800 1 rs11005106rs4301710 37.114 0 ADRA2A chr10:55492162-117205017 13465 61712856 1rs6481032 rs1933664 62.56 0 ADRA2A chr10:53602190-135522754 1916781920565 3 rs12247820 rs10909028 139.373 0 ADRA2A chr4:179131-6899815313495 68819023 3 rs7686948 rs7687396 625.133 0 ADRA2Cchr5:84830796-171903310 16642 87072515 1 rs300657 rs10042482 42.208 0ADRB2 chr5:57343495-171903310 21683 114559816 1 rs10940593 rs1004248261.169 0 ADRB2 chr5:98442871-150317237 9828 51874367 1 rs1447379rs7710790 38.687 0 ADRB2 chr5:4872310-180709915 35876 175837606 3rs816467 rs10071993 179.394 0 ADRB2 chr11:42185849-126756938 1545184571090 1 rs4375424 rs10750356 36.99 0 ADRBK1 chr11:66898492-6713698122 238490 1 rs11227699 rs3781941 17.955 0 ADRBK1chr11:21723471-131521797 20508 109798327 1 rs11828478 rs2512898 27.565 0ADRBK1 chr11:23168804-106781292 16332 83612489 1 rs11027007 rs710328549.747 0 ADRBK1 chr11:66933410-67046501 14 113092 1 rs1253784 rs122747745.288 0 ADRBK1 chr4:6487726-29802167 5076 23314442 3 rs13117055rs16882325 48.087 0 AFAP1 chr4:179131-68998153 13495 68819023 3rs7686948 rs7687396 625.133 0 AFAP1 chr3:13878889-149737330 24723135858442 1 rs12634112 rs2007869 55.663 0 AGTR1 chr3:145967173-1738998904912 27932718 3 rs9863647 rs7618997 46.396 0 AGTR1chr3:33409611-170735099 23775 137325489 1 rs3915062 rs11924032 26.867 0AGTR1 chr3:102240202-195550366 17318 93310165 1 rs1620217 rs1171187041.031 0 AGTR1 chr3:83075971-196935657 21465 113859687 1 rs9872858rs34729751 44.35 0 AGTR1 chr3:148403438-148598058 101 194621 1 rs201944rs6762776 28.127 0 AGTR1 chr3:114889454-177826047 12700 62936594 3rs6795297 rs7628308 102.526 0 AGTR1 chr1:64114301-245591329 29842181477029 1 rs11208257 rs1173850 37.504 0 AHCYL1 chr1:75098453-24353164927360 168433197 1 rs12117493 rs10927002 32.113 0 AHCYL1chr1:79710545-188898319 17303 109187775 1 rs417181 rs16829637 45.89 0AHCYL1 chr1:109645793-194560463 12025 84914671 3 cnvi0008281 rs1092161663.121 0 AHCYL1 chr6:64844594-169078546 21567 104233953 1 rs4710465rs601639 46.524 0 AKAP12 chr6:151495387-165969396 3761 14474010 3rs9322304 rs1022180 22.826 0 AKAP12 chr6:73120320-165130872 1871592010553 1 rs9442780 rs10946016 76.383 0 AKAP12 chr6:66541198-16252013319344 95978936 1 rs2000382 rs6901071 27.509 0 AKAP12chr6:94117546-165103679 15579 70986134 1 rs3799792 rs9347902 34.066 0AKAP12 chr6:100082983-170909002 16393 70826020 3 rs594231 rs12213906261.313 0 AKAP12 chr15:86103176-86282934 60 179759 1 rs16941432rs11630179 16.029 0 AKAP13 chr15:51688996-102398060 11030 50709065 1rs2459396 rs7181527 36.939 0 AKAP13 chr15:53775670-96810867 997343035198 1 rs657495 rs2589238 49.204 0 AKAP13 chr15:85877017-86143504 76266488 3 rs6497007 rs1551971 67.92 0 AKAP13 chr15:85607670-86109582 80501913 1 rs11073917 rs8034125 17.186 0 AKAP13 chr15:66108544-1024270068615 36318463 3 cnvi0007613 rs11632620 159.164 0 AKAP13chr14:26898958-104436931 17396 77537974 1 rs1245195 rs11851097 57.233 0AKAP5 chr14:64926097-65063315 19 137219 1 rs2281603 rs10134770 14.377 0AKAP5 chr14:19917123-65327288 10286 45410166 3 rs2495197 rs9323455270.291 0 AKAP5 chr7:11855636-156148608 26852 144292973 1 rs6947930rs6945016 36.446 0 AKAP9 chr7:78621315-155831817 13678 77210503 3rs1006818 rs6969015 123.319 0 AKAP9 chr7:8872727-156383359 27773147510633 1 rs917038 rs878717 32.336 0 AKAP9 chr7:8794418-11906813023484 110273713 1 rs2189621 rs6977904 70.867 0 AKAP9chr7:84302877-110993169 5183 26690293 3 rs4338048 rs10254893 203.09 0AKAP9 chr10:734229-69155636 14859 68421408 3 rs1769236 rs2394375 72.1040 AKR1C3 chr10:88874-53366180 12853 53277307 3 cnvi0015449 rs10998465319.021 0 AKR1C3 chr14:105154105-105277209 16 123105 1 rs3809456rs4983559 17.771 0 AKT1 chr14:105163532-105277209 15 113678 1 rs7140154rs4983559 13.231 0 AKT1 chr14:80818058-105348552 5492 24530495 3rs6574553 rs2028416 15.874 0 AKT1 chr14:104921616-105268228 55 346613 1rs11622864 rs4983387 29.892 0 AKT1 chr14:105163532-106766841 179 16033103 rs7140154 rs8010546 35.65 0 AKT1 chr14:103847274-107188715 464 33414423 rs8020912 rs4280141 104.64 0 AKT1 chr16:29441284-33923125 585 44818423 rs7206789 rs4043755 42.437 0 ALDOA chr16:176743-50013967 8328 498372253 rs2562164 rs12597023 174.392 0 ALDOA chr4:31222833-180548076 24457149325244 1 rs7662351 rs3849606 36.162 0 ANK2 chr4:89603085-1139911404018 24388056 3 rs2972038 rs2279892 28.405 0 ANK2chr4:68173959-185767176 20235 117593218 1 rs6552083 rs4862428 61.893 0ANK2 chr4:22401728-188608857 28456 166207130 1 rs4697297 rs768711535.717 0 ANK2 chr4:63726348-173015421 19817 109289074 1 rs17082970rs2131002 30.251 0 ANK2 chr4:29179713-117038307 15513 87858595 1rs1507441 rs1068807 71.6 0 ANK2 chr4:69590353-190872778 23145 1212824263 rs293433 rs12646565 315.633 0 ANK2 chr19:266034-18061509 3100 177954763 rs2312724 rs7250332 19.51 0 ANKRD24 chr19:288246-59110628 1100958822383 3 rs10409452 cnvi0009466 100.582 0 ANKRD24chr9:1989033-107532317 18263 105543285 1 rs7864828 rs10820726 39.824 0ANXA2 chr9:2522475-140068342 25719 137545868 3 rs10966757 rs407442693.386 0 ANXA2 chr9:33180228-132003792 14691 98823565 1 rs7854765rs9408988 28.69 0 ANXA2 chr15:51688996-102398060 11030 50709065 1rs2459396 rs7181527 36.939 0 ANXA2 chr15:53775670-96810867 9973 430351981 rs657495 rs2589238 49.204 0 ANXA2 chr9:46587-94335290 17484 94288704 3rs10814410 rs9409606 762.393 0 ANXA2 chr15:43392075-66051345 496322659271 3 rs8028608 rs6494537 59.842 0 ANXA2 chr5:84830796-17190331016642 87072515 1 rs300657 rs10042482 42.208 0 ANXA6chr5:57343495-171903310 21683 114559816 1 rs10940593 rs10042482 61.169 0ANXA6 chr5:4872310-180709915 35876 175837606 3 rs816467 rs10071993179.394 0 ANXA6 chr10:7188484-134205354 26672 127016871 1 rs1977295rs3923858 50.772 0 ANXA7 chr10:58385643-124973104 13625 66587462 1rs7920235 rs17663304 36.18 0 ANXA7 chr10:57671424-133349223 1624375677800 1 rs11005106 rs4301710 37.114 0 ANXA7 chr10:55492162-11720501713465 61712856 1 rs6481032 rs1933664 62.56 0 ANXA7chr10:53602190-135522754 19167 81920565 3 rs12247820 rs10909028 139.3730 ANXA7 chr11:21723471-131521797 20508 109798327 1 rs11828478 rs251289827.565 0 APLP2 chr11:74545378-134940416 14496 60395039 3 rs512780rs11224228 527.758 0 APLP2 chr21:14601415-48084989 8249 33483575 3rs2775537 rs2839378 12047.211 0 APP chr21:14601415-48084989 824933483575 3 rs2775537 rs2839378 41.154 0 APP chr21:14768343-48084989 819333316647 3 rs2257224 rs2839378 5021.076 0 APP chr21:14601415-480849898249 33483575 3 rs2775537 rs2839378 4787.438 0 APPchr21:14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0APP chr21:10708231-47970581 8807 37262351 3 rs4044122 rs2255397 73.188 0APP chr9:1989033-107532317 18263 105543285 1 rs7864828 rs10820726 39.8240 APTX chr9:2522475-140068342 25719 137545868 3 rs10966757 rs407442693.386 0 APTX chr9:46587-94335290 17484 94288704 3 rs10814410 rs9409606762.393 0 APTX chr7:11855636-156148608 26852 144292973 1 rs6947930rs6945016 36.446 0 AQP1 chr7:7724805-53845684 11772 46120880 3rs10263415 rs6948633 42.007 0 AQP1 chr7:8872727-156383359 27773147510633 1 rs917038 rs878717 32.336 0 AQP1 chr7:8794418-119068130 23484110273713 1 rs2189621 rs6977904 70.867 0 AQP1 chr7:60392-84158180 1909584097789 3 rs12670102 rs2715048 208.308 0 AQP1 chr1:64114301-24559132929842 181477029 1 rs11208257 rs1173850 37.504 0 ARF1chr1:178626526-244159143 13064 65532618 3 rs2761477 rs479338 11.373 0ARF1 chr1:75098453-243531649 27360 168433197 1 rs12117493 rs1092700232.113 0 ARF1 chr1:188850774-235423607 10060 46572834 1 rs16829466rs12409696 43.25 0 ARF1 chr1:191875752-235423607 9517 43547856 1rs9427811 rs12409696 62.01 0 ARF1 chr1:174219398-247422297 1598673202900 1 rs16846809 rs4642922 35.258 0 ARF1 chr1:226536645-2368037532600 10267109 3 rs874583 rs10925178 100.109 0 ARF1chr12:10113083-116370432 20594 106257350 1 rs2012504 rs7958254 35.157 0ARF3 chr12:10020267-129866293 23654 119846027 1 rs1597097 rs217050445.428 0 ARF3 chr12:39967134-84174413 8879 44207280 1 rs11172661rs11116039 39.568 0 ARF3 chr12:207886-50770291 11565 50562406 3 rs868249rs4477515 43.892 0 ARF3 chr11:42185849-126756938 15451 84571090 1rs4375424 rs10750356 36.99 0 ARHGAP1 chr11:21723471-131521797 20508109798327 1 rs11828478 rs2512898 27.565 0 ARHGAP1chr11:23168804-106781292 16332 83612489 1 rs11027007 rs7103285 49.747 0ARHGAP1 chr11:46370767-47132132 68 761366 1 rs876701 rs7108434 27.248 0ARHGAP1 chr11:211482-66910826 13813 66699345 3 rs2293168 rs437544630.249 0 ARHGAP1 chr4:31222833-180548076 24457 149325244 1 rs7662351rs3849606 36.162 0 ARHGAP24 chr4:68173959-185767176 20235 117593218 1rs6552083 rs4862428 61.893 0 ARHGAP24 chr4:22401728-188608857 28456166207130 1 rs4697297 rs7687115 35.717 0 ARHGAP24chr4:63726348-173015421 19817 109289074 1 rs17082970 rs2131002 30.251 0ARHGAP24 chr4:29179713-117038307 15513 87858595 1 rs1507441 rs106880771.6 0 ARHGAP24 chr4:69590353-190872778 23145 121282426 3 rs293433rs12646565 315.633 0 ARHGAP24 chr19:31569338-53780966 3788 22211629 1rs2867544 rs10407424 33.9 0 ARHGEF1 chr19:288246-59110628 11009 588223833 rs10409452 cnvi0009466 100.582 0 ARHGEF1 chr5:39526068-67275356 444127749289 1 rs16869031 rs999826 77.848 0 ARL15 chr5:49952847-898530697268 39900223 3 rs12188654 rs42467 26.225 0 ARL15 chr5:52884614-53418318145 533705 1 rs524289 rs9292039 31.471 0 ARL15 chr5:4872310-18070991535876 175837606 3 rs816467 rs10071993 179.394 0 ARL15chr10:7188484-134205354 26672 127016871 1 rs1977295 rs3923858 50.772 0ARL3 chr10:58385643-124973104 13625 66587462 1 rs7920235 rs1766330436.18 0 ARL3 chr10:57671424-133349223 16243 75677800 1 rs11005106rs4301710 37.114 0 ARL3 chr10:55492162-117205017 13465 61712856 1rs6481032 rs1933664 62.56 0 ARL3 chr10:53602190-135522754 19167 819205653 rs12247820 rs10909028 139.373 0 ARL3 chr3:234726-6328081 2293 60933563 rs7632811 rs1595039 106.207 0 ARL8B chr3:179527-114630641 23879114451115 3 rs4684741 rs1587972 207.852 0 ARL8B chr11:42185849-12675693815451 84571090 1 rs4375424 rs10750356 36.99 0 ARRB1chr11:21723471-131521797 20508 109798327 1 rs11828478 rs2512898 27.565 0ARRB1 chr11:23168804-106781292 16332 83612489 1 rs11027007 rs710328549.747 0 ARRB1 chr11:74545378-134940416 14496 60395039 3 rs512780rs11224228 527.758 0 ARRB1 chr17:108420-26610769 5548 26502350 3rs12452527 rs658591 82.699 0 ARRB2 chr11:345515-17408630 4247 17063116 3rs11246094 rs5215 30.474 0 ASCL2 chr11:211482-66910826 13813 66699345 3rs2293168 rs4375446 30.249 0 ASCL2 chr1:64114301-245591329 29842181477029 1 rs11208257 rs1173850 37.504 0 ATF3 chr1:178626526-24415914313064 65532618 3 rs2761477 rs479338 11.373 0 ATF3chr1:75098453-243531649 27360 168433197 1 rs12117493 rs10927002 32.113 0ATF3 chr1:188850774-235423607 10060 46572834 1 rs16829466 rs1240969643.25 0 ATF3 chr1:191875752-235423607 9517 43547856 1 rs9427811rs12409696 62.01 0 ATF3 chr1:189128124-227340790 7927 38212667 1rs7515205 rs12752546 167.428 0 ATF3 chr1:174219398-247422297 1598673202900 1 rs16846809 rs4642922 35.258 0 ATF3 chr1:197187605-2264044576316 29216853 3 rs10922187 rs3008192 130.989 0 ATF3chr12:207886-50770291 11565 50562406 3 rs868249 rs4477515 43.892 0 ATN1chr1:64114301-245591329 29842 181477029 1 rs11208257 rs1173850 37.504 0ATP1B1 chr1:75098453-243531649 27360 168433197 1 rs12117493 rs1092700232.113 0 ATP1B1 chr1:79710545-188898319 17303 109187775 1 rs417181rs16829637 45.89 0 ATP1B1 chr1:109645793-194560463 12025 84914671 3cnvi0008281 rs10921616 63.121 0 ATP1B1 chr12:10113083-116370432 20594106257350 1 rs2012504 rs7958254 35.157 0 ATP2B1 chr12:59512781-12774493913469 68232159 3 rs908394 rs7966946 20.62 0 ATP2B1chr12:10020267-129866293 23654 119846027 1 rs1597097 rs2170504 45.428 0ATP2B1 chr12:84589672-93258498 1292 8668827 1 rs1482434 rs1110672143.425 0 ATP2B1 chr12:50855195-133778796 17748 82923602 3 rs4351895rs7975069 159.589 0 ATP2B1 chr3:179527-114630641 23879 114451115 3rs4684741 rs1587972 207.852 0 ATP2B2 chr6:10123365-31221039 −313521097675 1 rs2181334 rs4416711 318.459 0 ATXN1 chr6:2681610-31453618 8128772009 3 rs1131896 rs9267212 428.177 0 ATXN1 chr6:3760708-319573648062 28196657 3 rs2187825 cnvi0006380 39.016 0 ATXN1chr6:1171596-29895228 43 28723633 0 rs3128994 rs9259831 53.123 0 ATXN1chr6:1171596-29899147 47 28727552 0 rs3128994 rs2394704 80.695 0 ATXN1chr6:1177990-29899147 39 28721158 0 rs2428530 rs2394704 44.381 0 ATXN1chr6:1175965-29899147 43 28723183 0 rs1611522 rs2394704 52.089 0 ATXN1chr6:2585208-31281876 −2 28696669 1 rs1634746 rs1634747 31.615 0 ATXN1chr6:1171596-29899147 47 28727552 0 rs3128994 rs2394704 63.572 0 ATXN1chr6:2584569-31286381 8 28701813 1 rs9391764 rs9265057 34.598 0 ATXN1chr6:2681610-31453618 81 28772009 3 rs1131896 rs9267212 390.234 0 ATXN1chr6:1171596-29892436 39 28720841 1 rs3128994 rs9259806 31.699 0 ATXN1chr6:1171596-29895228 43 28723633 0 rs3128994 rs9259831 43.568 0 ATXN1chr6:181089-30430875 1806 30249787 3 rs1535053 rs35792611 80.394 0 ATXN1chr14:80818058-105348552 5492 24530495 3 rs6574553 rs2028416 15.874 0ATXN3 chr14:92416364-92538953 29 122590 1 rs2498852 rs7144492 16.714 0ATXN3 chr14:26898958-104436931 17396 77537974 1 rs1245195 rs1185109757.233 0 ATXN3 chr14:65405722-103799039 8979 38393318 3 rs11623705rs11628472 266.153 0 ATXN3 chr3:13878889-149737330 24723 135858442 1rs12634112 rs2007869 55.663 0 ATXN7 chr3:33409611-170735099 23775137325489 1 rs3915062 rs11924032 26.867 0 ATXN7 chr3:179527-11463064123879 114451115 3 rs4684741 rs1587972 207.852 0 ATXN7chr17:21685812-67308196 12365 45622385 1 rs34864328 rs17686852 50.018 0ATXN7L3 chr17:26648492-58955084 5831 32306593 3 rs1981512 rs806877615.642 0 ATXN7L3 chr12:63576379-63675857 23 99479 1 rs7302283 rs476307512.637 29789 AVPR1A chr12:10113083-116370432 20594 106257350 1 rs2012504rs7958254 35.157 0 AVPR1A chr12:59512781-127744939 13469 68232159 3rs908394 rs7966946 20.62 0 AVPR1A chr12:10020267-129866293 23654119846027 1 rs1597097 rs2170504 45.428 0 AVPR1A chr12:39967134-841744138879 44207280 1 rs11172661 rs11116039 39.568 0 AVPR1Achr12:50855195-133778796 17748 82923602 3 rs4351895 rs7975069 159.589 0AVPR1A chr9:33141752-33260632 23 118881 3 rs2770807 rs706121 26.37 0B4GALT1 chr9:1989033-107532317 18263 105543285 1 rs7864828 rs1082072639.824 0 B4GALT1 chr9:2522475-140068342 25719 137545868 3 rs10966757rs4074426 93.386 0 B4GALT1 chr9:46587-94335290 17484 94288704 3rs10814410 rs9409606 762.393 0 B4GALT1 chr4:31222833-180548076 24457149325244 1 rs7662351 rs3849606 36.162 0 BANK1 chr4:89603085-1139911404018 24388056 3 rs2972038 rs2279892 28.405 0 BANK1chr4:68173959-185767176 20235 117593218 1 rs6552083 rs4862428 61.893 0BANK1 chr4:102178963-102407109 19 228147 1 rs2850965 rs1863575 20.006 0BANK1 chr4:22401728-188608857 28456 166207130 1 rs4697297 rs768711535.717 0 BANK1 chr4:102974061-104493370 290 1519310 3 rs10516490rs2588907 29.673 0 BANK1 chr4:102715888-102961880 45 245993 1 rs4522865rs6821429 17.305 0 BANK1 chr4:63726348-173015421 19817 109289074 1rs17082970 rs2131002 30.251 0 BANK1 chr4:29179713-117038307 1551387858595 1 rs1507441 rs1068807 71.6 0 BANK1 chr4:69590353-19087277823145 121282426 3 rs293433 rs12646565 315.633 0 BANK1chr16:59854720-89273883 7609 29419164 3 rs1373880 rs8046156 31.884 0BCAR1 chr16:64107047-82920737 4544 18813691 1 rs2319723 rs918661 28.8870 BCAR1 chr16:50219449-89544756 10324 39325308 3 rs6500298 rs3803681108.108 0 BCAR1 chr18:25388300-75954881 11539 50566582 1 rs11083228rs1876021 39.235 0 BCL2 chr18:46516210-68441007 5088 21924798 1rs7229153 rs1282652 51.891 0 BCL2 chr18:26550830-63713914 8241 371630851 rs16945738 rs2715304 17.922 0 BCL2 chr18:26162481-67193217 925541030737 1 rs12458903 rs9961907 31.327 0 BCL2 chr18:44788908-780151808492 33226273 3 rs9944807 rs12960632 579.2 0 BCL2chr14:80818058-105348552 5492 24530495 3 rs6574553 rs2028416 15.874 0BDKRB1 chr14:26898958-104436931 17396 77537974 1 rs1245195 rs1185109757.233 0 BDKRB1 chr14:65405722-103799039 8979 38393318 3 rs11623705rs11628472 266.153 0 BDKRB1 chr14:80818058-105348552 5492 24530495 3rs6574553 rs2028416 15.874 0 BDKRB2 chr14:26898958-104436931 1739677537974 1 rs1245195 rs11851097 57.233 0 BDKRB2 chr14:65405722-1037990398979 38393318 3 rs11623705 rs11628472 266.153 0 BDKRB2chr10:7188484-134205354 26672 127016871 1 rs1977295 rs3923858 50.772 0BMI1 chr10:734229-69155636 14859 68421408 3 rs1769236 rs2394375 72.104 0BMI1 chr10:88874-53366180 12853 53277307 3 cnvi0015449 rs10998465319.021 0 BMI1 chr2:12056323-227979775 39094 215923453 1 rs966391rs1922020 31.384 0 BMPR2 chr2:34870277-241929621 37755 207059345 3rs13422005 rs10205276 46.946 0 BMPR2 chr2:203285157-203545198 26 2600421 rs6747299 rs6709463 22.241 0 BMPR2 chr2:38101137-241482099 36812203380963 1 rs879321 rs7576043 52.099 0 BMPR2 chr2:185050218-2127521934583 27701976 1 rs1526196 rs6727114 45.31 0 BMPR2chr2:193255360-242529978 10289 49274619 3 rs1351905 cnvi0010399 93.244 0BMPR2 chr3:13878889-149737330 24723 135858442 1 rs12634112 rs200786955.663 0 BOC chr3:33409611-170735099 23775 137325489 1 rs3915062rs11924032 26.867 0 BOC chr3:102240202-195550366 17318 93310165 1rs1620217 rs11711870 41.031 0 BOC chr3:103140700-144883172 8539 417424731 rs4314176 rs6797159 44.122 0 BOC chr3:83075971-196935657 21465113859687 1 rs9872858 rs34729751 44.35 0 BOC chr3:179527-114630641 23879114451115 3 rs4684741 rs1587972 207.852 0 BOC chr7:11855636-15614860826852 144292973 1 rs6947930 rs6945016 36.446 0 BPGMchr7:78621315-155831817 13678 77210503 3 rs1006818 rs6969015 123.319 0BPGM chr7:8872727-156383359 27773 147510633 1 rs917038 rs878717 32.336 0BPGM chr7:120061880-143606234 4616 23544355 3 rs12531689 rs1024749318.96 0 BPGM chr17:21685812-67308196 12365 45622385 1 rs34864328rs17686852 50.018 0 BRCA1 chr17:26648492-58955084 5831 32306593 3rs1981512 rs8068776 15.642 0 BRCA1 chr13:19584477-81204088 1326561619612 3 rs1334954 rs1176297 22.162 0 BRCA2 chr13:23742931-11506448219829 91321552 1 rs4770401 rs7999630 44.074 0 BRCA2chr13:19121741-63373781 10326 44252041 3 rs9578050 rs9539575 82.761 0BRCA2 chr16:50219449-89544756 10324 39325308 3 rs6500298 rs3803681108.108 0 BRD7 chr8:30757798-142750969 20699 111993172 1 rs10101203rs6421025 34.223 0 BRF2 chr8:23218101-146274708 23020 123056608 1rs7010362 rs7822726 38.828 0 BRF2 chr8:25304020-43159151 3371 17855132 3rs10503771 cnvi0018779 263.504 0 BRF2 chr11:42185849-126756938 1545184571090 1 rs4375424 rs10750356 36.99 0 BRMS1 chr11:21723471-13152179720508 109798327 1 rs11828478 rs2512898 27.565 0 BRMS1chr11:23168804-106781292 16332 83612489 1 rs11027007 rs7103285 49.747 0BRMS1 chr11:211482-66910826 13813 66699345 3 rs2293168 rs4375446 30.2490 BRMS1 chr19:1130986-2128054 143 997069 1 rs10413074 rs1017084 25.799 0BTBD2 chr19:266034-18061509 3100 17795476 3 rs2312724 rs7250332 19.51 0BTBD2 chr19:629303-4119012 709 3489710 1 rs2283575 rs350887 26.758 0BTBD2 chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466100.582 0 BTBD2 chr1:64114301-245591329 29842 181477029 1 rs11208257rs1173850 37.504 0 BTG2 chr1:178626526-244159143 13064 65532618 3rs2761477 rs479338 11.373 0 BTG2 chr1:75098453-243531649 27360 1684331971 rs12117493 rs10927002 32.113 0 BTG2 chr1:188850774-235423607 1006046572834 1 rs16829466 rs12409696 43.25 0 BTG2 chr1:191875752-2354236079517 43547856 1 rs9427811 rs12409696 62.01 0 BTG2chr1:189128124-227340790 7927 38212667 1 rs7515205 rs12752546 167.428 0BTG2 chr1:174219398-247422297 15986 73202900 1 rs16846809 rs464292235.258 0 BTG2 chr1:197187605-226404457 6316 29216853 3 rs10922187rs3008192 130.989 0 BTG2 chr1:64114301-245591329 29842 181477029 1rs11208257 rs1173850 37.504 0 C1orf116 chr1:178626526-244159143 1306465532618 3 rs2761477 rs479338 11.373 0 C1orf116 chr1:75098453-24353164927360 168433197 1 rs12117493 rs10927002 32.113 0 C1orf116chr1:188850774-235423607 10060 46572834 1 rs16829466 rs12409696 43.25 0C1orf116 chr1:191875752-235423607 9517 43547856 1 rs9427811 rs1240969662.01 0 C1orf116 chr1:189128124-227340790 7927 38212667 1 rs7515205rs12752546 167.428 0 C1orf116 chr1:174219398-247422297 15986 73202900 1rs16846809 rs4642922 35.258 0 C1orf116 chr1:197187605-226404457 631629216853 3 rs10922187 rs3008192 130.989 0 C1orf116 chr17:5233817-539803330 164217 1 rs12600505 rs9913432 15.632 0 C1QBP chr17:108420-266107695548 26502350 3 rs12452527 rs658591 82.699 0 C1QBPchr20:7869025-62424661 11941 54555637 3 rs2294306 rs6010652 9.732 0C20orf20 chr20:54870769-62912463 2390 8041695 3 rs6069696 rs6062363249.708 0 C20orf20 chr20:13712393-55093901 8218 41381509 1 rs6033810rs6999 41.237 0 C20orf24 chr20:7869025-62424661 11941 54555637 3rs2294306 rs6010652 9.732 0 C20orf24 chr20:4591715-58420336 1175353828622 1 rs6139494 rs1416388 40.922 0 C20orf24 chr20:236802-5484579612646 54608995 3 rs448294 rs6064362 286.151 0 C20orf24chr4:31222833-180548076 24457 149325244 1 rs7662351 rs3849606 36.162 0C4orf17 chr4:89603085-113991140 4018 24388056 3 rs2972038 rs227989228.405 0 C4orf17 chr4:68173959-185767176 20235 117593218 1 rs6552083rs4862428 61.893 0 C4orf17 chr4:22401728-188608857 28456 166207130 1rs4697297 rs7687115 35.717 0 C4orf17 chr4:63726348-173015421 19817109289074 1 rs17082970 rs2131002 30.251 0 C4orf17chr4:29179713-117038307 15513 87858595 1 rs1507441 rs1068807 71.6 0C4orf17 chr4:69590353-190872778 23145 121282426 3 rs293433 rs12646565315.633 0 C4orf17 chr5:161172541-179954615 4271 18782075 3 rs4921415rs10059433 6.291 0 C5orf25 chr5:4872310-180709915 35876 175837606 3rs816467 rs10071993 179.394 0 C5orf25 chr7:11855636-156148608 26852144292973 1 rs6947930 rs6945016 36.446 0 C7orf25 chr7:7724805-5384568411772 46120880 3 rs10263415 rs6948633 42.007 0 C7orf25chr7:8872727-156383359 27773 147510633 1 rs917038 rs878717 32.336 0C7orf25 chr7:8794418-119068130 23484 110273713 1 rs2189621 rs697790470.867 0 C7orf25 chr7:60392-84158180 19095 84097789 3 rs12670102rs2715048 208.308 0 C7orf25 chr9:1989033-107532317 18263 105543285 1rs7864828 rs10820726 39.824 0 C9orf25 chr9:2522475-140068342 25719137545868 3 rs10966757 rs4074426 93.386 0 C9orf25chr9:33180228-132003792 14691 98823565 1 rs7854765 rs9408988 28.69 0C9orf25 chr9:46587-94335290 17484 94288704 3 rs10814410 rs9409606762.393 0 C9orf25 chr8:30757798-142750969 20699 111993172 1 rs10101203rs6421025 34.223 0 CA8 chr8:60424884-145286483 17030 84861600 3rs1401422 rs9720889 8.858 0 CA8 chr8:23218101-146274708 23020 1230566081 rs7010362 rs7822726 38.828 0 CA8 chr8:60494752-60667231 25 172480 1rs12674637 rs6471803 14.25 434192 CA8 chr8:43235525-66712108 363223476584 3 rs10091311 rs7001138 58.838 0 CA8 chr22:16871137-511843939245 34313257 3 rs131538 rs7284680 209.79 0 CABIN1chr12:59512781-127744939 13469 68232159 3 rs908394 rs7966946 20.62 0CABP1 chr12:10020267-129866293 23654 119846027 1 rs1597097 rs217050445.428 0 CABP1 chr12:112610714-133708729 5366 21098016 3 rs11066188rs11147249 695.45 0 CABP1 chr12:50855195-133778796 17748 82923602 3rs4351895 rs7975069 159.589 0 CABP1 chr9:139492789-140913833 196 14210451 rs28485548 cnvi0002661 28.211 0 CACNA1B chr9:139821068-141105225 1631284158 3 rs3750512 rs11559363 55.611 0 CACNA1B chr12:207886-5077029111565 50562406 3 rs868249 rs4477515 43.892 0 CACNA1Cchr1:64114301-245591329 29842 181477029 1 rs11208257 rs1173850 37.504 0CACYBP chr1:75098453-243531649 27360 168433197 1 rs12117493 rs1092700232.113 0 CACYBP chr1:79710545-188898319 17303 109187775 1 rs417181rs16829637 45.89 0 CACYBP chr1:174219398-247422297 15986 73202900 1rs16846809 rs4642922 35.258 0 CACYBP chr1:109645793-194560463 1202584914671 3 cnvi0008281 rs10921616 63.121 0 CACYBPchr16:59854720-89273883 7609 29419164 3 rs1373880 rs8046156 31.884 0CALB2 chr16:64107047-82920737 4544 18813691 1 rs2319723 rs918661 28.8870 CALB2 chr16:50219449-89544756 10324 39325308 3 rs6500298 rs3803681108.108 0 CALB2 chr7:11855636-156148608 26852 144292973 1 rs6947930rs6945016 36.446 0 CALCR chr7:78621315-155831817 13678 77210503 3rs1006818 rs6969015 123.319 0 CALCR chr7:8872727-156383359 27773147510633 1 rs917038 rs878717 32.336 0 CALCR chr7:8794418-11906813023484 110273713 1 rs2189621 rs6977904 70.867 0 CALCRchr7:84302877-110993169 5183 26690293 3 rs4338048 rs10254893 203.09 0CALCR chr7:11855636-156148608 26852 144292973 1 rs6947930 rs694501636.446 0 CALD1 chr7:78621315-155831817 13678 77210503 3 rs1006818rs6969015 123.319 0 CALD1 chr7:8872727-156383359 27773 147510633 1rs917038 rs878717 32.336 0 CALD1 chr7:120061880-143606234 4616 235443553 rs12531689 rs10247493 18.96 0 CALD1 chr14:80818058-105348552 549224530495 3 rs6574553 rs2028416 15.874 0 CALM1 chr14:26898958-10443693117396 77537974 1 rs1245195 rs11851097 57.233 0 CALM1chr14:65405722-103799039 8979 38393318 3 rs11623705 rs11628472 266.153 0CALM1 chr2:12056323-227979775 39094 215923453 1 rs966391 rs192202031.384 0 CALM2 chr2:34870277-241929621 37755 207059345 3 rs13422005rs10205276 46.946 0 CALM2 chr2:38101137-241482099 36812 203380963 1rs879321 rs7576043 52.099 0 CALM2 chr2:41212010-82396211 9721 41184202 3rs12614285 rs934310 396.396 0 CALM2 chr19:31569338-53780966 378822211629 1 rs2867544 rs10407424 33.9 0 CALM3 chr14:80818058-1053485525492 24530495 3 rs6574553 rs2028416 15.874 0 CALM3chr19:43257015-55294329 −7309 12037315 3 rs7246152 rs2569676 21.402 0CALM3 chr14:26898958-104436931 17396 77537974 1 rs1245195 rs1185109757.233 0 CALM3 chr19:288246-59110628 11009 58822383 3 rs10409452cnvi0009466 100.582 0 CALM3 chr14:65405722-103799039 8979 38393318 3rs11623705 rs11628472 266.153 0 CALM3 chr3:179527-114630641 23879114451115 3 rs4684741 rs1587972 207.852 0 CAMK1 chr5:84830796-17190331016642 87072515 1 rs300657 rs10042482 42.208 0 CAMK2Achr5:149480879-149638360 72 157482 3 rs13362413 rs4958445 6.487 0 CAMK2Achr5:57343495-171903310 21683 114559816 1 rs10940593 rs10042482 61.169 0CAMK2A chr5:98442871-150317237 9828 51874367 1 rs1447379 rs771079038.687 0 CAMK2A chr5:4872310-180709915 35876 175837606 3 rs816467rs10071993 179.394 0 CAMK2A chr7:11855636-156148608 26852 144292973 1rs6947930 rs6945016 36.446 0 CAMK2B chr7:7724805-53845684 11772 461208803 rs10263415 rs6948633 42.007 0 CAMK2B chr7:8872727-156383359 27773147510633 1 rs917038 rs878717 32.336 0 CAMK2B chr7:8794418-11906813023484 110273713 1 rs2189621 rs6977904 70.867 0 CAMK2Bchr7:60392-84158180 19095 84097789 3 rs12670102 rs2715048 208.308 0CAMK2B chr10:7188484-134205354 26672 127016871 1 rs1977295 rs392385850.772 0 CAMK2G chr10:58385643-124973104 13625 66587462 1 rs7920235rs17663304 36.18 0 CAMK2G chr10:57671424-133349223 16243 75677800 1rs11005106 rs4301710 37.114 0 CAMK2G chr10:55492162-117205017 1346561712856 1 rs6481032 rs1933664 62.56 0 CAMK2G chr10:53602190-13552275419167 81920565 3 rs12247820 rs10909028 139.373 0 CAMK2Gchr5:84830796-171903310 16642 87072515 1 rs300657 rs10042482 42.208 0CAMK4 chr5:108979318-132114847 4575 23135530 1 rs31595 rs30514 35.063 0CAMK4 chr5:57343495-171903310 21683 114559816 1 rs10940593 rs1004248261.169 0 CAMK4 chr5:98442871-150317237 9828 51874367 1 rs1447379rs7710790 38.687 0 CAMK4 chr5:80735161-125293366 8499 44558206 1rs1541830 rs327816 52.167 0 CAMK4 chr5:108284342-111242002 627 2957661 1rs3797817 rs17133870 44.164 0 CAMK4 chr5:4872310-180709915 35876175837606 3 rs816467 rs10071993 179.394 0 CAMK4 chr17:3760621-3910613 44149993 3 rs218722 rs1105936 4.306 0 CAMKK1 chr17:108420-26610769 554826502350 3 rs12452527 rs658591 82.699 0 CAMKK1 chr12:59512781-12774493913469 68232159 3 rs908394 rs7966946 20.62 0 CAMKK2chr12:10020267-129866293 23654 119846027 1 rs1597097 rs2170504 45.428 0CAMKK2 chr12:112610714-133708729 5366 21098016 3 rs11066188 rs11147249695.45 0 CAMKK2 chr12:50855195-133778796 17748 82923602 3 rs4351895rs7975069 159.589 0 CAMKK2 chr1:64114301-245591329 29842 181477029 1rs11208257 rs1173850 37.504 0 CAPN2 chr1:178626526-244159143 1306465532618 3 rs2761477 rs479338 11.373 0 CAPN2 chr1:75098453-24353164927360 168433197 1 rs12117493 rs10927002 32.113 0 CAPN2chr1:188850774-235423607 10060 46572834 1 rs16829466 rs12409696 43.25 0CAPN2 chr1:191875752-235423607 9517 43547856 1 rs9427811 rs1240969662.01 0 CAPN2 chr1:189128124-227340790 7927 38212667 1 rs7515205rs12752546 167.428 0 CAPN2 chr1:174219398-247422297 15986 73202900 1rs16846809 rs4642922 35.258 0 CAPN2 chr1:197187605-226404457 631629216853 3 rs10922187 rs3008192 130.989 0 CAPN2 chr4:163766726-1899316305627 26164905 3 rs10033012 rs10018868 25.326 0 CASP3chr4:68173959-185767176 20235 117593218 1 rs6552083 rs4862428 61.893 0CASP3 chr4:22401728-188608857 28456 166207130 1 rs4697297 rs768711535.717 0 CASP3 chr4:162592024-189861553 6129 27269530 1 rs5005966rs6853039 63.501 0 CASP3 chr4:69590353-190872778 23145 121282426 3rs293433 rs12646565 315.633 0 CASP3 chr4:31222833-180548076 24457149325244 1 rs7662351 rs3849606 36.162 0 CASP6 chr4:89603085-1139911404018 24388056 3 rs2972038 rs2279892 28.405 0 CASP6chr4:68173959-185767176 20235 117593218 1 rs6552083 rs4862428 61.893 0CASP6 chr4:22401728-188608857 28456 166207130 1 rs4697297 rs768711535.717 0 CASP6 chr4:63726348-173015421 19817 109289074 1 rs17082970rs2131002 30.251 0 CASP6 chr4:29179713-117038307 15513 87858595 1rs1507441 rs1068807 71.6 0 CASP6 chr4:69590353-190872778 23145 1212824263 rs293433 rs12646565 315.633 0 CASP6 chr10:7188484-134205354 26672127016871 1 rs1977295 rs3923858 50.772 0 CASP7 chr10:58385643-12497310413625 66587462 1 rs7920235 rs17663304 36.18 0 CASP7chr10:57671424-133349223 16243 75677800 1 rs11005106 rs4301710 37.114 0CASP7 chr10:55492162-117205017 13465 61712856 1 rs6481032 rs193366462.56 0 CASP7 chr10:53602190-135522754 19167 81920565 3 rs12247820rs10909028 139.373 0 CASP7 chr2:12056323-227979775 39094 215923453 1rs966391 rs1922020 31.384 0 CASP8 chr2:34870277-241929621 37755207059345 3 rs13422005 rs10205276 46.946 0 CASP8chr2:201924078-202178089 27 254012 3 rs6737556 rs12986657 7.613 0 CASP8chr2:38101137-241482099 36812 203380963 1 rs879321 rs7576043 52.099 0CASP8 chr2:185050218-212752193 4583 27701976 1 rs1526196 rs6727114 45.310 CASP8 chr2:201988238-202111380 11 123143 1 rs7583529 rs3769825 18.6120 CASP8 chr2:193255360-242529978 10289 49274619 3 rs1351905 cnvi001039993.244 0 CASP8 chr3:13878889-149737330 24723 135858442 1 rs12634112rs2007869 55.663 0 CASR chr3:33409611-170735099 23775 137325489 1rs3915062 rs11924032 26.867 0 CASR chr3:102240202-195550366 1731893310165 1 rs1620217 rs11711870 41.031 0 CASR chr3:103140700-1448831728539 41742473 1 rs4314176 rs6797159 44.122 0 CASRchr3:83075971-196935657 21465 113859687 1 rs9872858 rs34729751 44.35 0CASR chr3:114889454-177826047 12700 62936594 3 rs6795297 rs7628308102.526 0 CASR chr7:11855636-156148608 26852 144292973 1 rs6947930rs6945016 36.446 0 CAV1 chr7:78621315-155831817 13678 77210503 3rs1006818 rs6969015 123.319 0 CAV1 chr7:8872727-156383359 27773147510633 1 rs917038 rs878717 32.336 0 CAV1 chr7:8794418-119068130 23484110273713 1 rs2189621 rs6977904 70.867 0 CAV1 chr7:109628488-1257179142698 16089427 1 cnvi0014315 rs1582264 33.443 0 CAV1chr7:111385084-118923413 1217 7538330 3 rs718845 rs11978545 371.267 0CAV1 chr11:42185849-126756938 15451 84571090 1 rs4375424 rs1075035636.99 0 CBL chr11:84128537-120941583 7678 36813047 1 rs488925 rs464308929.271 0 CBL chr11:21723471-131521797 20508 109798327 1 rs11828478rs2512898 27.565 0 CBL chr11:98062720-121890280 5422 23827561 1rs6589308 rs1944465 29.075 0 CBL chr11:74545378-134940416 14496 603950393 rs512780 rs11224228 527.758 0 CBL chr17:44458950-81047708 −819536588759 1 cnvi0016818 rs35680231 35.591 0 CBX1 chr17:21685812-6730819612365 45622385 1 rs34864328 rs17686852 50.018 0 CBX1chr17:26648492-58955084 5831 32306593 3 rs1981512 rs8068776 15.642 0CBX1 chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466100.582 0 CCDC106 chr5:49952847-89853069 7268 39900223 3 rs12188654rs42467 26.225 0 CCNB1 chr5:57343495-171903310 21683 114559816 1rs10940593 rs10042482 61.169 0 CCNB1 chr5:4872310-180709915 35876175837606 3 rs816467 rs10071993 179.394 0 CCNB1 chr11:42185849-12675693815451 84571090 1 rs4375424 rs10750356 36.99 0 CCND1chr11:21723471-131521797 20508 109798327 1 rs11828478 rs2512898 27.565 0CCND1 chr11:23168804-106781292 16332 83612489 1 rs11027007 rs710328549.747 0 CCND1 chr11:67086298-74446791 1348 7360494 3 rs1944096rs7103136 173.017 0 CCND1 chr19:288246-59110628 11009 58822383 3rs10409452 cnvi0009466 100.582 0 CCNE1 chr3:13878889-149737330 24723135858442 1 rs12634112 rs2007869 55.663 0 CCR4 chr3:179527-11463064123879 114451115 3 rs4684741 rs1587972 207.852 0 CCR4chr3:13878889-149737330 24723 135858442 1 rs12634112 rs2007869 55.663 0CCR5 chr3:33409611-170735099 23775 137325489 1 rs3915062 rs1192403226.867 0 CCR5 chr3:179527-114630641 23879 114451115 3 rs4684741rs1587972 207.852 0 CCR5 chr12:7383187-8099302 149 716116 1 rs7962099rs1473164 74.227 0 CD163 chr12:7631883-8692843 157 1060961 1 rs6488336rs10841856 50.943 0 CD163 chr12:207886-50770291 11565 50562406 3rs868249 rs4477515 43.892 0 CD163 chr11:42185849-126756938 1545184571090 1 rs4375424 rs10750356 36.99 0 CD5 chr11:21723471-13152179720508 109798327 1 rs11828478 rs2512898 27.565 0 CD5chr11:23168804-106781292 16332 83612489 1 rs11027007 rs7103285 49.747 0CD5 chr11:211482-66910826 13813 66699345 3 rs2293168 rs4375446 30.249 0CD5 chr12:207886-50770291 11565 50562406 3 rs868249 rs4477515 43.892 0CD9 chr1:1005806-105612342 19173 104606537 3 rs3934834 rs1584633 44.1520 CDC42 chr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879162.269 0 CDC42 chr1:1005806-105612342 19173 104606537 3 rs3934834rs1584633 44.152 0 CDKN2C chr1:2006108-109527861 22130 107521754 3rs2254669 rs839879 162.269 0 CDKN2C chr5:84830796-171903310 1664287072515 1 rs300657 rs10042482 42.208 0 CETN3 chr5:49952847-898530697268 39900223 3 rs12188654 rs42467 26.225 0 CETN3chr5:57343495-171903310 21683 114559816 1 rs10940593 rs10042482 61.169 0CETN3 chr5:84160703-104650005 3339 20489303 1 rs6860783 rs560688 92.9140 CETN3 chr5:80735161-125293366 8499 44558206 1 rs1541830 rs32781652.167 0 CETN3 chr5:4872310-180709915 35876 175837606 3 rs816467rs10071993 179.394 0 CETN3 chr7:11855636-156148608 26852 144292973 1rs6947930 rs6945016 36.446 0 CFTR chr7:78621315-155831817 13678 772105033 rs1006818 rs6969015 123.319 0 CFTR chr7:8872727-156383359 27773147510633 1 rs917038 rs878717 32.336 0 CFTR chr7:8794418-119068130 23484110273713 1 rs2189621 rs6977904 70.867 0 CFTR chr7:109628488-1257179142698 16089427 1 cnvi0014315 rs1582264 33.443 0 CFTRchr7:117170774-118611141 254 1440368 1 rs1429566 rs12531411 29.859 0CFTR chr7:111385084-118923413 1217 7538330 3 rs718845 rs11978545 371.2670 CFTR chr10:7188484-134205354 26672 127016871 1 rs1977295 rs392385850.772 0 CHAT chr10:734229-69155636 14859 68421408 3 rs1769236 rs239437572.104 0 CHAT chr10:46928388-52437780 1060 5509393 3 rs7915055 rs3001866425.826 0 CHAT chr10:88874-53366180 12853 53277307 3 cnvi0015449rs10998465 319.021 0 CHAT chr17:108420-26610769 5548 26502350 3rs12452527 rs658591 82.699 0 CHD3 chr20:4591715-58420336 11753 538286221 rs6139494 rs1416388 40.922 0 CHGB chr20:236802-54845796 12646 546089953 rs448294 rs6064362 286.151 0 CHGB chr15:29325866-56044189 530326718324 3 rs4779705 rs2414433 21.732 0 CHP chr15:32939946-43104406 254410164461 3 rs12594777 rs13380301 32.942 0 CHP chr7:11855636-15614860826852 144292973 1 rs6947930 rs6945016 36.446 0 CHRM2chr7:78621315-155831817 13678 77210503 3 rs1006818 rs6969015 123.319 0CHRM2 chr7:8872727-156383359 27773 147510633 1 rs917038 rs878717 32.3360 CHRM2 chr7:120061880-143606234 4616 23544355 3 rs12531689 rs1024749318.96 0 CHRM2 chr1:64114301-245591329 29842 181477029 1 rs11208257rs1173850 37.504 0 CHRM3 chr1:178626526-244159143 13064 65532618 3rs2761477 rs479338 11.373 0 CHRM3 chr1:75098453-243531649 27360168433197 1 rs12117493 rs10927002 32.113 0 CHRM3chr1:238655362-242087644 1078 3432283 3 rs2392861 rs4658565 806.215 0CHRM3 chr1:174219398-247422297 15986 73202900 1 rs16846809 rs464292235.258 0 CHRM3 chr1:236848751-249219320 3293 12370570 3 rs819666cnvi0018731 920.725 0 CHRM3 chr10:7188484-134205354 26672 127016871 1rs1977295 rs3923858 50.772 0 CHUK chr10:58385643-124973104 1362566587462 1 rs7920235 rs17663304 36.18 0 CHUK chr10:57671424-13334922316243 75677800 1 rs11005106 rs4301710 37.114 0 CHUKchr10:55492162-117205017 13465 61712856 1 rs6481032 rs1933664 62.56 0CHUK chr10:53602190-135522754 19167 81920565 3 rs12247820 rs10909028139.373 0 CHUK chr19:31569338-53780966 3788 22211629 1 rs2867544rs10407424 33.9 0 CIC chr19:288246-59110628 11009 58822383 3 rs10409452cnvi0009466 100.582 0 CIC chr3:13878889-149737330 24723 135858442 1rs12634112 rs2007869 55.663 0 CISH chr3:33409611-170735099 23775137325489 1 rs3915062 rs11924032 26.867 0 CISH chr3:179527-11463064123879 114451115 3 rs4684741 rs1587972 207.852 0 CISHchr5:49952847-89853069 7268 39900223 3 rs12188654 rs42467 26.225 0 CKMT2chr5:57343495-171903310 21683 114559816 1 rs10940593 rs10042482 61.169 0CKMT2 chr5:4872310-180709915 35876 175837606 3 rs816467 rs10071993179.394 0 CKMT2 chr5:161172541-179954615 4271 18782075 3 rs4921415rs10059433 6.291 0 CLTB chr5:4872310-180709915 35876 175837606 3rs816467 rs10071993 179.394 0 CLTB chr8:2365648-32608792 10334 302431453 rs2100623 rs3757934 31.188 0 CLU chr8:23218101-146274708 23020123056608 1 rs7010362 rs7822726 38.828 0 CLU chr8:25304020-43159151 337117855132 3 rs10503771 cnvi0018779 263.504 0 CLU chr16:59854720-892738837609 29419164 3 rs1373880 rs8046156 31.884 0 CMIPchr16:64107047-82920737 4544 18813691 1 rs2319723 rs918661 28.887 0 CMIPchr16:50219449-89544756 10324 39325308 3 rs6500298 rs3803681 108.108 0CMIP chr19:266034-18061509 3100 17795476 3 rs2312724 rs7250332 19.51 0CNN1 chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466100.582 0 CNN1 chr17:21685812-67308196 12365 45622385 1 rs34864328rs17686852 50.018 0 CNP chr17:26648492-58955084 5831 32306593 3rs1981512 rs8068776 15.642 0 CNP chr6:64844594-169078546 21567 1042339531 rs4710465 rs601639 46.524 0 CNR1 chr6:66609532-147053632 1531580444101 3 rs9354335 rs4896886 44.941 0 CNR1 chr6:73120320-16513087218715 92010553 1 rs9442780 rs10946016 76.383 0 CNR1chr6:26922906-93578359 19746 66655454 1 rs9348738 rs9363009 27.061 0CNR1 chr6:66541198-162520133 19344 95978936 1 rs2000382 rs6901071 27.5090 CNR1 chr6:62697746-94090076 6391 31392331 1 rs6455128 rs3799807 108.850 CNR1 chr6:67621368-147709180 16188 80087813 1 rs6919455 rs773931452.498 0 CNR1 chr6:79198069-99893938 4062 20695870 3 rs1321584 rs4504482200.961 0 CNR1 chr1:1005806-105612342 19173 104606537 3 rs3934834rs1584633 44.152 0 CNR2 chr1:2006108-109527861 22130 107521754 3rs2254669 rs839879 162.269 0 CNR2 chr17:54276856-55773806 409 1496951 1rs9911321 rs1544508 34.437 0 COIL chr17:44458950-81047708 −8195 365887591 cnvi0016818 rs35680231 35.591 0 COIL chr17:21685812-67308196 1236545622385 1 rs34864328 rs17686852 50.018 0 COIL chr17:26648492-589550845831 32306593 3 rs1981512 rs8068776 15.642 0 COILchr3:13878889-149737330 24723 135858442 1 rs12634112 rs2007869 55.663 0COPB2 chr3:33409611-170735099 23775 137325489 1 rs3915062 rs1192403226.867 0 COPB2 chr3:102240202-195550366 17318 93310165 1 rs1620217rs11711870 41.031 0 COPB2 chr3:103140700-144883172 8539 41742473 1rs4314176 rs6797159 44.122 0 COPB2 chr3:83075971-196935657 21465113859687 1 rs9872858 rs34729751 44.35 0 COPB2 chr3:114889454-17782604712700 62936594 3 rs6795297 rs7628308 102.526 0 COPB2chr11:42185849-126756938 15451 84571090 1 rs4375424 rs10750356 36.99 0CORO1B chr11:21723471-131521797 20508 109798327 1 rs11828478 rs251289827.565 0 CORO1B chr11:23168804-106781292 16332 83612489 1 rs11027007rs7103285 49.747 0 CORO1B chr11:67186000-67288594 13 102595 1 rs1790733rs2276118 16.171 0 CORO1B chr11:67086298-74446791 1348 7360494 3rs1944096 rs7103136 173.017 0 CORO1B chr3:13878889-149737330 24723135858442 1 rs12634112 rs2007869 55.663 0 COX17 chr3:33409611-17073509923775 137325489 1 rs3915062 rs11924032 26.867 0 COX17chr3:102240202-195550366 17318 93310165 1 rs1620217 rs11711870 41.031 0COX17 chr3:103140700-144883172 8539 41742473 1 rs4314176 rs679715944.122 0 COX17 chr3:83075971-196935657 21465 113859687 1 rs9872858rs34729751 44.35 0 COX17 chr3:114889454-177826047 12700 62936594 3rs6795297 rs7628308 102.526 0 COX17 chr4:31222833-180548076 24457149325244 1 rs7662351 rs3849606 36.162 0 CPE chr4:163766726-1899316305627 26164905 3 rs10033012 rs10018868 25.326 0 CPEchr4:68173959-185767176 20235 117593218 1 rs6552083 rs4862428 61.893 0CPE chr4:22401728-188608857 28456 166207130 1 rs4697297 rs7687115 35.7170 CPE chr4:63726348-173015421 19817 109289074 1 rs17082970 rs213100230.251 0 CPE chr4:162592024-189861553 6129 27269530 1 rs5005966rs6853039 63.501 0 CPE chr4:69590353-190872778 23145 121282426 3rs293433 rs12646565 315.633 0 CPE chr12:10113083-116370432 20594106257350 1 rs2012504 rs7958254 35.157 0 CRADD chr12:59512781-12774493913469 68232159 3 rs908394 rs7966946 20.62 0 CRADDchr12:10020267-129866293 23654 119846027 1 rs1597097 rs2170504 45.428 0CRADD chr12:50855195-133778796 17748 82923602 3 rs4351895 rs7975069159.589 0 CRADD chr10:7188484-134205354 26672 127016871 1 rs1977295rs3923858 50.772 0 CREM chr10:734229-69155636 14859 68421408 3 rs1769236rs2394375 72.104 0 CREM chr10:88874-53366180 12853 53277307 3cnvi0015449 rs10998465 319.021 0 CREM chr17:43657921-44354796 88 6968763 rs9898857 rs2732700 21.196 0 CRHR1 chr17:43657921-44064851 65 406931 3rs9898857 rs8079215 86.447 0 CRHR1 chr17:21685812-67308196 1236545622385 1 rs34864328 rs17686852 50.018 0 CRHR1 chr17:26648492-589550845831 32306593 3 rs1981512 rs8068776 15.642 0 CRHR1chr2:46812338-46995893 51 183556 1 rs1376406 rs13424717 14.574 0 CRIPTchr2:12056323-227979775 39094 215923453 1 rs966391 rs1922020 31.384 0CRIPT chr2:34870277-241929621 37755 207059345 3 rs13422005 rs1020527646.946 0 CRIPT chr2:38101137-241482099 36812 203380963 1 rs879321rs7576043 52.099 0 CRIPT chr2:41212010-82396211 9721 41184202 3rs12614285 rs934310 396.396 0 CRIPT chr11:345515-17408630 4247 170631163 rs11246094 rs5215 30.474 0 CSNK2A1 chr11:211482-66910826 1381366699345 3 rs2293168 rs4375446 30.249 0 CSNK2A1 chr20:236802-5484579612646 54608995 3 rs448294 rs6064362 286.151 0 CSNK2A1chr16:50219449-89544756 10324 39325308 3 rs6500298 rs3803681 108.108 0CSNK2A2 chr6:26922906-93578359 19746 66655454 1 rs9348738 rs936300927.061 0 CSNK2B chr6:31289284-32512613 10001 1223330 3 rs9265170rs35571839 45.035 0 CSNK2B chr6:3760708-31957364 8062 28196657 3rs2187825 cnvi0006380 39.016 0 CSNK2B chr6:31281438-32449411 −78791167974 1 cnvi0006173 rs1964995 24.023 0 CSNK2B chr6:31337633-324494111650 1111779 1 rs9266433 rs1964995 124.395 0 CSNK2Bchr6:31281438-32354428 −8033 1072991 1 cnvi0006173 rs4424066 37.329 0CSNK2B chr6:31289284-31960770 9811 671487 3 rs9265170 cnvi0006385 29.6280 CSNK2B chr6:31281438-32874796 −7311 1593359 1 cnvi0006173 rs946931036.913 0 CSNK2B chr6:26430981-31878433 −8001 5447453 1 rs2893848rs519417 55.651 0 CSNK2B chr6:29253756-32671521 2267 3417766 1 rs9468508rs9275439 51.553 0 CSNK2B chr6:31289284-56929863 15402 25640580 3rs9265170 cnvi0015437 25.647 0 CSNK2B chr6:30475431-32449411 −76871973981 3 cnvi0005997 rs1964995 153.275 0 CSNK2B chr3:13878889-14973733024723 135858442 1 rs12634112 rs2007869 55.663 0 CTNNB1chr3:33409611-170735099 23775 137325489 1 rs3915062 rs11924032 26.867 0CTNNB1 chr3:179527-114630641 23879 114451115 3 rs4684741 rs1587972207.852 0 CTNNB1 chr7:11855636-156148608 26852 144292973 1 rs6947930rs6945016 36.446 0 CYCS chr7:7724805-53845684 11772 46120880 3rs10263415 rs6948633 42.007 0 CYCS chr7:8872727-156383359 27773147510633 1 rs917038 rs878717 32.336 0 CYCS chr7:8794418-119068130 23484110273713 1 rs2189621 rs6977904 70.867 0 CYCS chr7:60392-84158180 1909584097789 3 rs12670102 rs2715048 208.308 0 CYCS chr19:266034-180615093100 17795476 3 rs2312724 rs7250332 19.51 0 DAPK3 chr19:629303-4119012709 3489710 1 rs2283575 rs350887 26.758 0 DAPK3 chr19:288246-5911062811009 58822383 3 rs10409452 cnvi0009466 100.582 0 DAPK3chr5:161172541-179954615 4271 18782075 3 rs4921415 rs10059433 6.291 0DBN1 chr5:4872310-180709915 35876 175837606 3 rs816467 rs10071993179.394 0 DBN1 chr12:10113083-116370432 20594 106257350 1 rs2012504rs7958254 35.157 0 DCN chr12:59512781-127744939 13469 68232159 3rs908394 rs7966946 20.62 0 DCN chr12:10020267-129866293 23654 1198460271 rs1597097 rs2170504 45.428 0 DCN chr12:84589672-93258498 1292 86688271 rs1482434 rs11106721 43.425 0 DCN chr12:50855195-133778796 1774882923602 3 rs4351895 rs7975069 159.589 0 DCN chr10:7188484-13420535426672 127016871 1 rs1977295 rs3923858 50.772 0 DDIT4chr10:58385643-124973104 13625 66587462 1 rs7920235 rs17663304 36.18 0DDIT4 chr10:57671424-133349223 16243 75677800 1 rs11005106 rs430171037.114 0 DDIT4 chr10:55492162-117205017 13465 61712856 1 rs6481032rs1933664 62.56 0 DDIT4 chr10:53602190-135522754 19167 81920565 3rs12247820 rs10909028 139.373 0 DDIT4 chr17:44458950-81047708 −819536588759 1 cnvi0016818 rs35680231 35.591 0 DDX5 chr17:21685812-6730819612365 45622385 1 rs34864328 rs17686852 50.018 0 DDX5chr17:61016209-66240093 890 5223885 1 rs1588368 rs11658645 37.309 0 DDX5chr17:59314257-66170047 1135 6855791 1 rs758467 rs4558468 71.379 0 DDX5chr17:59205829-62530143 453 3324315 3 rs7222210 rs9897203 107.455 0 DDX5chr8:2365648-32608792 10334 30243145 3 rs2100623 rs3757934 31.188 0DEFB1 chr8:6721326-6829085 67 107760 3 rs2738050 rs2738113 19.653 0DEFB1 chr8:62041-25061807 9818 24999767 3 rs4710857 rs1510758 96.736 0DEFB1 chr2:34870277-241929621 37755 207059345 3 rs13422005 rs1020527646.946 0 DGKD chr2:38101137-241482099 36812 203380963 1 rs879321rs7576043 52.099 0 DGKD chr2:193255360-242529978 10289 49274619 3rs1351905 cnvi0010399 93.244 0 DGKD chr11:42185849-126756938 1545184571090 1 rs4375424 rs10750356 36.99 0 DGKZ chr11:21723471-13152179720508 109798327 1 rs11828478 rs2512898 27.565 0 DGKZchr11:23168804-106781292 16332 83612489 1 rs11027007 rs7103285 49.747 0DGKZ chr11:46370767-47132132 68 761366 1 rs876701 rs7108434 27.248 0DGKZ chr11:211482-66910826 13813 66699345 3 rs2293168 rs4375446 30.249 0DGKZ chr11:42185849-126756938 15451 84571090 1 rs4375424 rs1075035636.99 0 DHCR7 chr11:21723471-131521797 20508 109798327 1 rs11828478rs2512898 27.565 0 DHCR7 chr11:23168804-106781292 16332 83612489 1rs11027007 rs7103285 49.747 0 DHCR7 chr11:67086298-74446791 1348 73604943 rs1944096 rs7103136 173.017 0 DHCR7 chr9:1989033-107532317 18263105543285 1 rs7864828 rs10820726 39.824 0 DIRAS2 chr9:2522475-14006834225719 137545868 3 rs10966757 rs4074426 93.386 0 DIRAS2chr9:33180228-132003792 14691 98823565 1 rs7854765 rs9408988 28.69 0DIRAS2 chr9:46587-94335290 17484 94288704 3 rs10814410 rs9409606 762.3930 DIRAS2 chr1:231711489-231813134 22 101646 3 rs1765782 rs6541281 42.5610 DISC1 chr1:64114301-245591329 29842 181477029 1 rs11208257 rs117385037.504 0 DISC1 chr1:178626526-244159143 13064 65532618 3 rs2761477rs479338 11.373 0 DISC1 chr1:75098453-243531649 27360 168433197 1rs12117493 rs10927002 32.113 0 DISC1 chr1:231711489-231813134 28 1016463 rs1765782 rs6541281 70.39 0 DISC1 chr1:188850774-235423607 1006046572834 1 rs16829466 rs12409696 43.25 0 DISC1 chr1:191875752-2354236079517 43547856 1 rs9427811 rs12409696 62.01 0 DISC1chr1:174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0DISC1 chr1:226536645-236803753 2600 10267109 3 rs874583 rs10925178100.109 0 DISC1 chr3:196793858-196910082 10 116225 1 rs6795358 rs986165812.924 0 DLG1 chr3:196793858-196993693 16 199836 1 rs6795358 rs40628414.667 0 DLG1 chr3:196910082-197026927 10 116846 1 rs9861658 rs33821712.736 0 DLG1 chr3:196793858-196963612 17 169755 1 rs6795358 rs33818623.577 0 DLG1 chr3:196793858-196935657 12 141800 1 rs6795358 rs3472975116.088 0 DLG1 chr3:83075971-196935657 21465 113859687 1 rs9872858rs34729751 44.35 0 DLG1 chr3:196793858-196935657 12 141800 1 rs6795358rs34729751 14.018 0 DLG1 chr3:196838486-197019935 12 181450 1 rs1356612rs1741949 16.796 0 DLG1 chr3:196793858-196963612 17 169755 1 rs6795358rs338186 15.023 0 DLG1 chr3:177912894-197551411 4129 19638518 3rs9290640 rs1273562 185.507 0 DLG1 chr17:108420-26610769 5548 26502350 3rs12452527 rs658591 82.699 0 DLG4 chr14:26898958-104436931 1739677537974 1 rs1245195 rs11851097 57.233 0 DLST chr14:65405722-1037990398979 38393318 3 rs11623705 rs11628472 266.153 0 DLSTchr9:2522475-140068342 25719 137545868 3 rs10966757 rs4074426 93.386 0DNM1 chr9:33180228-132003792 14691 98823565 1 rs7854765 rs9408988 28.690 DNM1 chr9:100158052-139077343 9815 38919292 3 rs1020884 rs4842126470.601 0 DNM1 chr1:64114301-245591329 29842 181477029 1 rs11208257rs1173850 37.504 0 DNM3 chr1:172367677-172511969 31 144293 4 rs10911684rs12087284 11.699 0 DNM3 chr1:75098453-243531649 27360 168433197 1rs12117493 rs10927002 32.113 0 DNM3 chr1:79710545-188898319 17303109187775 1 rs417181 rs16829637 45.89 0 DNM3 chr1:109645793-19456046312025 84914671 3 cnvi0008281 rs10921616 63.121 0 DNM3chr8:2365648-32608792 10334 30243145 3 rs2100623 rs3757934 31.188 0DPYSL2 chr8:23218101-146274708 23020 123056608 1 rs7010362 rs782272638.828 0 DPYSL2 chr8:25304020-43159151 3371 17855132 3 rs10503771cnvi0018779 263.504 0 DPYSL2 chr5:161172541-179954615 4271 18782075 3rs4921415 rs10059433 6.291 0 DRD1 chr5:4872310-180709915 35876 1758376063 rs816467 rs10071993 179.394 0 DRD1 chr11:42185849-126756938 1545184571090 1 rs4375424 rs10750356 36.99 0 DRD2 chr11:84128537-1209415837678 36813047 1 rs488925 rs4643089 29.271 0 DRD2chr11:21723471-131521797 20508 109798327 1 rs11828478 rs2512898 27.565 0DRD2 chr11:98062720-121890280 5422 23827561 1 rs6589308 rs1944465 29.0750 DRD2 chr11:74545378-134940416 14496 60395039 3 rs512780 rs11224228527.758 0 DRD2 chr3:13878889-149737330 24723 135858442 1 rs12634112rs2007869 55.663 0 DRD3 chr3:33409611-170735099 23775 137325489 1rs3915062 rs11924032 26.867 0 DRD3 chr3:102240202-195550366 1731893310165 1 rs1620217 rs11711870 41.031 0 DRD3 chr3:103140700-1448831728539 41742473 1 rs4314176 rs6797159 44.122 0 DRD3chr3:83075971-196935657 21465 113859687 1 rs9872858 rs34729751 44.35 0DRD3 chr3:179527-114630641 23879 114451115 3 rs4684741 rs1587972 207.8520 DRD3 chr6:49184770-63747049 1854 14562280 3 rs2496363 rs1539022 8.9740 DST chr6:26922906-93578359 19746 66655454 1 rs9348738 rs9363009 27.0610 DST chr6:31289284-56929863 15402 25640580 3 rs9265170 cnvi001543725.647 0 DST chr6:32968276-73449742 15442 40481467 3 rs2395300 rs4235869415.87 0 DST chr20:13712393-55093901 8218 41381509 1 rs6033810 rs699941.237 0 DSTN chr20:7869025-62424661 11941 54555637 3 rs2294306rs6010652 9.732 0 DSTN chr20:4591715-58420336 11753 53828622 1 rs6139494rs1416388 40.922 0 DSTN chr20:236802-54845796 12646 54608995 3 rs448294rs6064362 286.151 0 DSTN chr1:1005806-105612342 19173 104606537 3rs3934834 rs1584633 44.152 0 DVL1 chr1:536794-1682374 159 1145581 3rs4649701 rs4648812 64.942 0 DVL1 chr1:1229770-2378046 167 1148277 1rs6669227 rs34241773 44.903 0 DVL1 chr1:1201632-2182470 109 980839 1rs12402622 rs260512 27.748 0 DVL1 chr1:1254841-3342804 386 2087964 1rs10907179 rs870171 39.259 0 DVL1 chr1:1162435-1277903 19 115469 3rs3766186 rs34411680 14.65 0 DVL1 chr17:108420-26610769 5548 26502350 3rs12452527 rs658591 82.699 0 DVL2 chr3:166503411-190576461 4854 240730511 rs11925936 rs1393054 31.414 0 DVL3 chr3:102240202-195550366 1731893310165 1 rs1620217 rs11711870 41.031 0 DVL3 chr3:164955741-1917421045741 26786364 1 rs2218152 rs9835019 52.438 0 DVL3chr3:83075971-196935657 21465 113859687 1 rs9872858 rs34729751 44.35 0DVL3 chr3:177912894-197551411 4129 19638518 3 rs9290640 rs1273562185.507 0 DVL3 chr12:59512781-127744939 13469 68232159 3 rs908394rs7966946 20.62 0 DYNLL1 chr12:10020267-129866293 23654 119846027 1rs1597097 rs2170504 45.428 0 DYNLL1 chr12:112610714-133708729 536621098016 3 rs11066188 rs11147249 695.45 0 DYNLL1chr12:50855195-133778796 17748 82923602 3 rs4351895 rs7975069 159.589 0DYNLL1 chr10:53602190-135522754 19167 81920565 3 rs12247820 rs10909028139.373 0 ECHS1 chr9:2522475-140068342 25719 137545868 3 rs10966757rs4074426 93.386 0 EDF1 chr9:139492789-140913833 196 1421045 1rs28485548 cnvi0002661 28.211 0 EDF1 chr9:139492789-140212642 109 7198543 rs28485548 rs13295516 12.464 0 EDF1 chr9:139725120-140176250 50 4511311 rs2811750 rs28576426 24.435 0 EDF1 chr8:144656754-145255867 71 5991141 rs4606077 rs7015323 34.761 0 EEF1D chr8:60424884-145286483 1703084861600 3 rs1401422 rs9720889 8.858 0 EEF1D chr8:23218101-14627470823020 123056608 1 rs7010362 rs7822726 38.828 0 EEF1Dchr8:66822030-144791126 16557 77969097 3 rs6472235 rs10100154 251.068 0EEF1D chr19:266034-18061509 3100 17795476 3 rs2312724 rs7250332 19.51 0EEF2 chr19:629303-4119012 709 3489710 1 rs2283575 rs350887 26.758 0 EEF2chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466 100.582 0EEF2 chr13:23742931-115064482 19829 91321552 1 rs4770401 rs799963044.074 0 EFNB2 chr13:65193124-115053155 12025 49860032 3 rs9598811rs7327124 78.057 0 EFNB2 chr7:11855636-156148608 26852 144292973 1rs6947930 rs6945016 36.446 0 EGFR chr7:8872727-156383359 27773 1475106331 rs917038 rs878717 32.336 0 EGFR chr7:8794418-119068130 23484 1102737131 rs2189621 rs6977904 70.867 0 EGFR chr7:60392-84158180 19095 84097789 3rs12670102 rs2715048 208.308 0 EGFR chr3:13878889-149737330 24723135858442 1 rs12634112 rs2007869 55.663 0 EIF1B chr3:33409611-17073509923775 137325489 1 rs3915062 rs11924032 26.867 0 EIF1Bchr3:179527-114630641 23879 114451115 3 rs4684741 rs1587972 207.852 0EIF1B chr12:207886-50770291 11565 50562406 3 rs868249 rs4477515 43.892 0ENO2 chr1:1005806-105612342 19173 104606537 3 rs3934834 rs1584633 44.1520 EPB41 chr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879162.269 0 EPB41 chr20:13712393-55093901 8218 41381509 1 rs6033810 rs699941.237 0 EPB41L1 chr20:7869025-62424661 11941 54555637 3 rs2294306rs6010652 9.732 0 EPB41L1 chr20:4591715-58420336 11753 53828622 1rs6139494 rs1416388 40.922 0 EPB41L1 chr20:236802-54845796 1264654608995 3 rs448294 rs6064362 286.151 0 EPB41L1 chr6:64844594-16907854621567 104233953 1 rs4710465 rs601639 46.524 0 EPB41L2chr6:66609532-147053632 15315 80444101 3 rs9354335 rs4896886 44.941 0EPB41L2 chr6:73120320-165130872 18715 92010553 1 rs9442780 rs1094601676.383 0 EPB41L2 chr6:66541198-162520133 19344 95978936 1 rs2000382rs6901071 27.509 0 EPB41L2 chr6:94117546-165103679 15579 70986134 1rs3799792 rs9347902 34.066 0 EPB41L2 chr6:67621368-147709180 1618880087813 1 rs6919455 rs7739314 52.498 0 EPB41L2 chr6:100082983-17090900216393 70826020 3 rs594231 rs12213906 261.313 0 EPB41L2chr1:1005806-105612342 19173 104606537 3 rs3934834 rs1584633 44.152 0EPHB2 chr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879162.269 0 EPHB2 chr17:21685812-67308196 12365 45622385 1 rs34864328rs17686852 50.018 0 ERBB2 chr17:26648492-58955084 5831 32306593 3rs1981512 rs8068776 15.642 0 ERBB2 chr6:64844594-169078546 21567104233953 1 rs4710465 rs601639 46.524 0 ESR1 chr6:151495387-1659693963761 14474010 3 rs9322304 rs1022180 22.826 0 ESR1chr6:73120320-165130872 18715 92010553 1 rs9442780 rs10946016 76.383 0ESR1 chr6:66541198-162520133 19344 95978936 1 rs2000382 rs6901071 27.5090 ESR1 chr6:94117546-165103679 15579 70986134 1 rs3799792 rs934790234.066 0 ESR1 chr6:100082983-170909002 16393 70826020 3 rs594231rs12213906 261.313 0 ESR1 chr14:64655161-64792340 27 137180 1 rs1255986rs3020443 16.892 0 ESR2 chr14:26898958-104436931 17396 77537974 1rs1245195 rs11851097 57.233 0 ESR2 chr14:19917123-65327288 1028645410166 3 rs2495197 rs9323455 270.291 0 ESR2 chr1:64114301-24559132929842 181477029 1 rs11208257 rs1173850 37.504 0 ESRRGchr1:178626526-244159143 13064 65532618 3 rs2761477 rs479338 11.373 0ESRRG chr1:75098453-243531649 27360 168433197 1 rs12117493 rs1092700232.113 0 ESRRG chr1:188850774-235423607 10060 46572834 1 rs16829466rs12409696 43.25 0 ESRRG chr1:191875752-235423607 9517 43547856 1rs9427811 rs12409696 62.01 0 ESRRG chr1:189128124-227340790 792738212667 1 rs7515205 rs12752546 167.428 0 ESRRG chr1:174219398-24742229715986 73202900 1 rs16846809 rs4642922 35.258 0 ESRRGchr1:197187605-226404457 6316 29216853 3 rs10922187 rs3008192 130.989 0ESRRG chr19:31569338-53780966 3788 22211629 1 rs2867544 rs10407424 33.90 ETHE1 chr19:43257015-55294329 −7309 12037315 3 rs7246152 rs256967621.402 0 ETHE1 chr19:288246-59110628 11009 58822383 3 rs10409452cnvi0009466 100.582 0 ETHE1 chr22:16871137-51184393 9245 34313257 3rs131538 rs7284680 209.79 0 EWSR1 chr1:64114301-245591329 29842181477029 1 rs11208257 rs1173850 37.504 0 F11R chr1:75098453-24353164927360 168433197 1 rs12117493 rs10927002 32.113 0 F11Rchr1:79710545-188898319 17303 109187775 1 rs417181 rs16829637 45.89 0F11R chr1:109645793-194560463 12025 84914671 3 cnvi0008281 rs1092161663.121 0 F11R chr5:49952847-89853069 7268 39900223 3 rs12188654 rs4246726.225 0 F2R chr5:57343495-171903310 21683 114559816 1 rs10940593rs10042482 61.169 0 F2R chr5:4872310-180709915 35876 175837606 3rs816467 rs10071993 179.394 0 F2R chr5:49952847-89853069 7268 39900223 3rs12188654 rs42467 26.225 0 F2RL2 chr5:57343495-171903310 21683114559816 1 rs10940593 rs10042482 61.169 0 F2RL2 chr5:4872310-18070991535876 175837606 3 rs816467 rs10071993 179.394 0 F2RL2chr19:266034-18061509 3100 17795476 3 rs2312724 rs7250332 19.51 0 F2RL3chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466 100.582 0F2RL3 chr1:64114301-245591329 29842 181477029 1 rs11208257 rs117385037.504 0 F3 chr1:1005806-105612342 19173 104606537 3 rs3934834 rs158463344.152 0 F3 chr1:75098453-243531649 27360 168433197 1 rs12117493rs10927002 32.113 0 F3 chr1:79710545-188898319 17303 109187775 1rs417181 rs16829637 45.89 0 F3 chr1:2006108-109527861 22130 107521754 3rs2254669 rs839879 162.269 0 F3 chr11:42185849-126756938 15451 845710901 rs4375424 rs10750356 36.99 0 FADD chr11:21723471-131521797 20508109798327 1 rs11828478 rs2512898 27.565 0 FADD chr11:23168804-10678129216332 83612489 1 rs11027007 rs7103285 49.747 0 FADDchr11:67086298-74446791 1348 7360494 3 rs1944096 rs7103136 173.017 0FADD chr10:7188484-134205354 26672 127016871 1 rs1977295 rs392385850.772 0 FAS chr10:58385643-124973104 13625 66587462 1 rs7920235rs17663304 36.18 0 FAS chr10:57671424-133349223 16243 75677800 1rs11005106 rs4301710 37.114 0 FAS chr10:55492162-117205017 1346561712856 1 rs6481032 rs1933664 62.56 0 FAS chr10:53602190-13552275419167 81920565 3 rs12247820 rs10909028 139.373 0 FASchr1:1005806-105612342 19173 104606537 3 rs3934834 rs1584633 44.152 0FBLIM1 chr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879162.269 0 FBLIM1 chr5:84830796-171903310 16642 87072515 1 rs300657rs10042482 42.208 0 FER chr5:108343438-108490168 32 146731 1 rs11958129rs11952637 17.906 0 FER chr5:57343495-171903310 21683 114559816 1rs10940593 rs10042482 61.169 0 FER chr5:98442871-150317237 9828 518743671 rs1447379 rs7710790 38.687 0 FER chr5:108410880-108517282 20 106403 1rs17161593 rs7715602 19.545 0 FER chr5:108295480-108436014 26 140535 1rs7734092 rs3816024 16.128 0 FER chr5:80735161-125293366 8499 44558206 1rs1541830 rs327816 52.167 0 FER chr5:108284342-111242002 627 2957661 1rs3797817 rs17133870 44.164 0 FER chr5:108029900-108145817 30 115918 1rs10050689 rs2900037 16.489 0 FER chr5:104968250-109596993 929 4628744 3rs10079505 rs4367336 15.741 0 FER chr5:4872310-180709915 35876 1758376063 rs816467 rs10071993 179.394 0 FER chr11:42185849-126756938 1545184571090 1 rs4375424 rs10750356 36.99 0 FEZ1 chr11:21723471-13152179720508 109798327 1 rs11828478 rs2512898 27.565 0 FEZ1chr11:74545378-134940416 14496 60395039 3 rs512780 rs11224228 527.758 0FEZ1 chr2:12056323-227979775 39094 215923453 1 rs966391 rs1922020 31.3840 FEZ2 chr2:34870277-241929621 37755 207059345 3 rs13422005 rs1020527646.946 0 FEZ2 chr2:18856-41136833 9721 41117978 3 rs11901199 rs10187704191.638 0 FEZ2 chr19:31569338-53780966 3788 22211629 1 rs2867544rs10407424 33.9 0 FFAR1 chr19:288246-59110628 11009 58822383 3rs10409452 cnvi0009466 100.582 0 FFAR1 chr19:31569338-53780966 378822211629 1 rs2867544 rs10407424 33.9 0 FFAR2 chr19:288246-59110628 1100958822383 3 rs10409452 cnvi0009466 100.582 0 FFAR2 chr20:236802-5484579612646 54608995 3 rs448294 rs6064362 286.151 0 FKBP1Achr14:26898958-104436931 17396 77537974 1 rs1245195 rs11851097 57.233 0FKBP3 chr14:19917123-65327288 10286 45410166 3 rs2495197 rs9323455270.291 0 FKBP3 chr12:10113083-116370432 20594 106257350 1 rs2012504rs7958254 35.157 0 FLJ41278 chr12:59512781-127744939 13469 68232159 3rs908394 rs7966946 20.62 0 FLJ41278 chr12:10020267-129866293 23654119846027 1 rs1597097 rs2170504 45.428 0 FLJ41278chr12:39967134-84174413 8879 44207280 1 rs11172661 rs11116039 39.568 0FLJ41278 chr12:50855195-133778796 17748 82923602 3 rs4351895 rs7975069159.589 0 FLJ41278 chr3:13878889-149737330 24723 135858442 1 rs12634112rs2007869 55.663 0 FLNB chr3:33409611-170735099 23775 137325489 1rs3915062 rs11924032 26.867 0 FLNB chr3:179527-114630641 23879 1144511153 rs4684741 rs1587972 207.852 0 FLNB chr19:31569338-53780966 378822211629 1 rs2867544 rs10407424 33.9 0 FPR1 chr19:43257015-55294329−7309 12037315 3 rs7246152 rs2569676 21.402 0 FPR1 chr19:288246-5911062811009 58822383 3 rs10409452 cnvi0009466 100.582 0 FPR1chr12:10113083-116370432 20594 106257350 1 rs2012504 rs7958254 35.157 0FRS2 chr12:59512781-127744939 13469 68232159 3 rs908394 rs7966946 20.620 FRS2 chr12:10020267-129866293 23654 119846027 1 rs1597097 rs217050445.428 0 FRS2 chr12:39967134-84174413 8879 44207280 1 rs11172661rs11116039 39.568 0 FRS2 chr12:69888884-69992465 15 103582 3 rs221103rs710764 16.735 0 FRS2 chr12:50855195-133778796 17748 82923602 3rs4351895 rs7975069 159.589 0 FRS2 chr7:60392-84158180 19095 84097789 3rs12670102 rs2715048 208.308 0 FSCN1 chr2:12056323-227979775 39094215923453 1 rs966391 rs1922020 31.384 0 FSHR chr2:34870277-24192962137755 207059345 3 rs13422005 rs10205276 46.946 0 FSHRchr2:38101137-241482099 36812 203380963 1 rs879321 rs7576043 52.099 0FSHR chr2:49646785-49758675 35 111891 1 rs10172488 rs6728261 127.406265119 FSHR chr2:49639121-49752589 40 113469 1 rs817060 rs4971621119.056 257455 FSHR chr2:41212010-82396211 9721 41184202 3 rs12614285rs934310 396.396 0 FSHR chr15:91345348-91492877 34 147530 3 rs16944840rs749938 0 0 FURIN chr15:51688996-102398060 11030 50709065 1 rs2459396rs7181527 36.939 0 FURIN chr15:53775670-96810867 9973 43035198 1rs657495 rs2589238 49.204 0 FURIN chr15:66108544-102427006 8615 363184633 cnvi0007613 rs11632620 159.164 0 FURIN chr9:1989033-107532317 18263105543285 1 rs7864828 rs10820726 39.824 0 FXN chr9:2522475-14006834225719 137545868 3 rs10966757 rs4074426 93.386 0 FXNchr9:33180228-132003792 14691 98823565 1 rs7854765 rs9408988 28.69 0 FXNchr9:46587-94335290 17484 94288704 3 rs10814410 rs9409606 762.393 0 FXNchr3:166503411-190576461 4854 24073051 1 rs11925936 rs1393054 31.414 0FXR1 chr3:102240202-195550366 17318 93310165 1 rs1620217 rs1171187041.031 0 FXR1 chr3:164955741-191742104 5741 26786364 1 rs2218152rs9835019 52.438 0 FXR1 chr3:83075971-196935657 21465 113859687 1rs9872858 rs34729751 44.35 0 FXR1 chr3:177912894-197551411 4129 196385183 rs9290640 rs1273562 185.507 0 FXR1 chr6:64844594-169078546 21567104233953 1 rs4710465 rs601639 46.524 0 FYN chr6:66609532-14705363215315 80444101 3 rs9354335 rs4896886 44.941 0 FYNchr6:73120320-165130872 18715 92010553 1 rs9442780 rs10946016 76.383 0FYN chr6:66541198-162520133 19344 95978936 1 rs2000382 rs6901071 27.5090 FYN chr6:94117546-165103679 15579 70986134 1 rs3799792 rs934790234.066 0 FYN chr6:67621368-147709180 16188 80087813 1 rs6919455rs7739314 52.498 0 FYN chr6:100082983-170909002 16393 70826020 3rs594231 rs12213906 261.313 0 FYN chr6:64844594-169078546 21567104233953 1 rs4710465 rs601639 46.524 0 GABRR1 chr6:66609532-14705363215315 80444101 3 rs9354335 rs4896886 44.941 0 GABRR1chr6:73120320-165130872 18715 92010553 1 rs9442780 rs10946016 76.383 0GABRR1 chr6:26922906-93578359 19746 66655454 1 rs9348738 rs936300927.061 0 GABRR1 chr6:66541198-162520133 19344 95978936 1 rs2000382rs6901071 27.509 0 GABRR1 chr6:62697746-94090076 6391 31392331 1rs6455128 rs3799807 108.85 0 GABRR1 chr6:67621368-147709180 1618880087813 1 rs6919455 rs7739314 52.498 0 GABRR1 chr6:79198069-998939384062 20695870 3 rs1321584 rs4504482 200.961 0 GABRR1chr6:64844594-169078546 21567 104233953 1 rs4710465 rs601639 46.524 0GABRR2 chr6:66609532-147053632 15315 80444101 3 rs9354335 rs489688644.941 0 GABRR2 chr6:73120320-165130872 18715 92010553 1 rs9442780rs10946016 76.383 0 GABRR2 chr6:26922906-93578359 19746 66655454 1rs9348738 rs9363009 27.061 0 GABRR2 chr6:66541198-162520133 1934495978936 1 rs2000382 rs6901071 27.509 0 GABRR2 chr6:62697746-940900766391 31392331 1 rs6455128 rs3799807 108.85 0 GABRR2chr6:67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0GABRR2 chr6:79198069-99893938 4062 20695870 3 rs1321584 rs4504482200.961 0 GABRR2 chr17:44458950-81047708 −8195 36588759 1 cnvi0016818rs35680231 35.591 0 GALR2 chr17:62662507-81047708 −11496 18385202 3rs6504246 rs35680231 56.048 0 GALR2 chr3:13878889-149737330 24723135858442 1 rs12634112 rs2007869 55.663 0 GAP43 chr3:33409611-17073509923775 137325489 1 rs3915062 rs11924032 26.867 0 GAP43chr3:102240202-195550366 17318 93310165 1 rs1620217 rs11711870 41.031 0GAP43 chr3:103140700-144883172 8539 41742473 1 rs4314176 rs679715944.122 0 GAP43 chr3:83075971-196935657 21465 113859687 1 rs9872858rs34729751 44.35 0 GAP43 chr3:114889454-177826047 12700 62936594 3rs6795297 rs7628308 102.526 0 GAP43 chr12:6485661-6711147 48 225487 1rs3759324 rs1639122 18.66 0 GAPDH chr12:6562293-6711147 27 148855 1rs2041385 rs1639122 19.307 0 GAPDH chr12:207886-50770291 11565 505624063 rs868249 rs4477515 43.892 0 GAPDH chr4:31222833-180548076 24457149325244 1 rs7662351 rs3849606 36.162 0 GC chr4:71849697-72861878 1671012182 3 rs6446977 rs11722798 16.573 0 GC chr4:68173959-185767176 20235117593218 1 rs6552083 rs4862428 61.893 0 GC chr4:22401728-18860885728456 166207130 1 rs4697297 rs7687115 35.717 0 GCchr4:63726348-173015421 19817 109289074 1 rs17082970 rs2131002 30.251 0GC chr4:29179713-117038307 15513 87858595 1 rs1507441 rs1068807 71.6 0GC chr4:69590353-190872778 23145 121282426 3 rs293433 rs12646565 315.6330 GC chr17:21685812-67308196 12365 45622385 1 rs34864328 rs1768685250.018 0 GFAP chr17:26648492-58955084 5831 32306593 3 rs1981512rs8068776 15.642 0 GFAP chr1:64114301-245591329 29842 181477029 1rs11208257 rs1173850 37.504 0 GFI1 chr1:1005806-105612342 19173104606537 3 rs3934834 rs1584633 44.152 0 GFI1 chr1:75098453-24353164927360 168433197 1 rs12117493 rs10927002 32.113 0 GFI1chr1:79710545-188898319 17303 109187775 1 rs417181 rs16829637 45.89 0GFI1 chr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879 162.2690 GFI1 chr9:2522475-140068342 25719 137545868 3 rs10966757 rs407442693.386 0 GFI1B chr9:100158052-139077343 9815 38919292 3 rs1020884rs4842126 470.601 0 GFI1B chr2:12056323-227979775 39094 215923453 1rs966391 rs1922020 31.384 0 GFPT1 chr2:34870277-241929621 37755207059345 3 rs13422005 rs10205276 46.946 0 GFPT1 chr2:38101137-24148209936812 203380963 1 rs879321 rs7576043 52.099 0 GFPT1chr2:41212010-82396211 9721 41184202 3 rs12614285 rs934310 396.396 0GFPT1 chr17:44458950-81047708 −8195 36588759 1 cnvi0016818 rs3568023135.591 0 GH1 chr17:21685812-67308196 12365 45622385 1 rs34864328rs17686852 50.018 0 GH1 chr17:61016209-66240093 890 5223885 1 rs1588368rs11658645 37.309 0 GH1 chr17:59314257-66170047 1135 6855791 1 rs758467rs4558468 71.379 0 GH1 chr17:59205829-62530143 453 3324315 3 rs7222210rs9897203 107.455 0 GH1 chr17:21685812-67308196 12365 45622385 1rs34864328 rs17686852 50.018 0 GIT1 chr17:26648492-58955084 583132306593 3 rs1981512 rs8068776 15.642 0 GIT1 chr12:10113083-11637043220594 106257350 1 rs2012504 rs7958254 35.157 0 GIT2chr12:59512781-127744939 13469 68232159 3 rs908394 rs7966946 20.62 0GIT2 chr12:10020267-129866293 23654 119846027 1 rs1597097 rs217050445.428 0 GIT2 chr12:50855195-133778796 17748 82923602 3 rs4351895rs7975069 159.589 0 GIT2 chr6:64844594-169078546 21567 104233953 1rs4710465 rs601639 46.524 0 GJA1 chr6:66609532-147053632 15315 804441013 rs9354335 rs4896886 44.941 0 GJA1 chr6:73120320-165130872 1871592010553 1 rs9442780 rs10946016 76.383 0 GJA1 chr6:66541198-16252013319344 95978936 1 rs2000382 rs6901071 27.509 0 GJA1chr6:94117546-165103679 15579 70986134 1 rs3799792 rs9347902 34.066 0GJA1 chr6:67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.4980 GJA1 chr6:100082983-170909002 16393 70826020 3 rs594231 rs12213906261.313 0 GJA1 chr6:26922906-93578359 19746 66655454 1 rs9348738rs9363009 27.061 0 GLP1R chr6:31289284-56929863 15402 25640580 3rs9265170 cnvi0015437 25.647 0 GLP1R chr6:32968276-73449742 1544240481467 3 rs2395300 rs4235869 415.87 0 GLP1R chr17:108420-26610769 554826502350 3 rs12452527 rs658591 82.699 0 GLP2R chr14:26898958-10443693117396 77537974 1 rs1245195 rs11851097 57.233 0 GMFBchr14:19917123-65327288 10286 45410166 3 rs2495197 rs9323455 270.291 0GMFB chr7:60392-84158180 19095 84097789 3 rs12670102 rs2715048 208.308 0GNA12 chr19:266034-18061509 3100 17795476 3 rs2312724 rs7250332 19.51 0GNA15 chr19:629303-4119012 709 3489710 1 rs2283575 rs350887 26.758 0GNA15 chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466100.582 0 GNA15 chr7:11855636-156148608 26852 144292973 1 rs6947930rs6945016 36.446 0 GNAI1 chr7:78621315-155831817 13678 77210503 3rs1006818 rs6969015 123.319 0 GNAI1 chr7:8872727-156383359 27773147510633 1 rs917038 rs878717 32.336 0 GNAI1 chr7:8794418-11906813023484 110273713 1 rs2189621 rs6977904 70.867 0 GNAI1 chr7:60392-8415818019095 84097789 3 rs12670102 rs2715048 208.308 0 GNAI1chr3:13878889-149737330 24723 135858442 1 rs12634112 rs2007869 55.663 0GNAI2 chr3:33409611-170735099 23775 137325489 1 rs3915062 rs1192403226.867 0 GNAI2 chr3:179527-114630641 23879 114451115 3 rs4684741rs1587972 207.852 0 GNAI2 chr1:64114301-245591329 29842 181477029 1rs11208257 rs1173850 37.504 0 GNAI3 chr1:75098453-243531649 27360168433197 1 rs12117493 rs10927002 32.113 0 GNAI3 chr1:79710545-18889831917303 109187775 1 rs417181 rs16829637 45.89 0 GNAI3chr1:109645793-194560463 12025 84914671 3 cnvi0008281 rs10921616 63.1210 GNAI3 chr16:50219449-89544756 10324 39325308 3 rs6500298 rs3803681108.108 0 GNAO1 chr9:1989033-107532317 18263 105543285 1 rs7864828rs10820726 39.824 0 GNAQ chr9:2522475-140068342 25719 137545868 3rs10966757 rs4074426 93.386 0 GNAQ chr9:33180228-132003792 1469198823565 1 rs7854765 rs9408988 28.69 0 GNAQ chr9:46587-94335290 1748494288704 3 rs10814410 rs9409606 762.393 0 GNAQ chr20:7869025-6242466111941 54555637 3 rs2294306 rs6010652 9.732 0 GNAS chr20:4591715-5842033611753 53828622 1 rs6139494 rs1416388 40.922 0 GNASchr20:54870769-62912463 2390 8041695 3 rs6069696 rs6062363 249.708 0GNAS chr22:22998337-23649242 126 650906 1 rs6003181 rs131693 276.751 0GNAZ chr22:16871137-51184393 9245 34313257 3 rs131538 rs7284680 209.79 0GNAZ chr5:4872310-180709915 35876 175837606 3 rs816467 rs10071993179.394 0 GNB2L1 chr10:7188484-134205354 26672 127016871 1 rs1977295rs3923858 50.772 0 GOT1 chr10:58385643-124973104 13625 66587462 1rs7920235 rs17663304 36.18 0 GOT1 chr10:57671424-133349223 1624375677800 1 rs11005106 rs4301710 37.114 0 GOT1 chr10:55492162-11720501713465 61712856 1 rs6481032 rs1933664 62.56 0 GOT1chr10:53602190-135522754 19167 81920565 3 rs12247820 rs10909028 139.3730 GOT1 chr17:108420-26610769 5548 26502350 3 rs12452527 rs658591 82.6990 GP1BA chr4:31222833-180548076 24457 149325244 1 rs7662351 rs384960636.162 0 GPM6A chr4:163766726-189931630 5627 26164905 3 rs10033012rs10018868 25.326 0 GPM6A chr4:68173959-185767176 20235 117593218 1rs6552083 rs4862428 61.893 0 GPM6A chr4:22401728-188608857 28456166207130 1 rs4697297 rs7687115 35.717 0 GPM6A chr4:162592024-1898615536129 27269530 1 rs5005966 rs6853039 63.501 0 GPM6Achr4:69590353-190872778 23145 121282426 3 rs293433 rs12646565 315.633 0GPM6A chr10:7188484-134205354 26672 127016871 1 rs1977295 rs392385850.772 0 GPR26 chr10:124668629-135157955 2949 10489327 3 rs11248331rs10776672 23.553 0 GPR26 chr10:57671424-133349223 16243 75677800 1rs11005106 rs4301710 37.114 0 GPR26 chr10:53602190-135522754 1916781920565 3 rs12247820 rs10909028 139.373 0 GPR26 chr1:64114301-24559132929842 181477029 1 rs11208257 rs1173850 37.504 0 GPSM2chr1:75098453-243531649 27360 168433197 1 rs12117493 rs10927002 32.113 0GPSM2 chr1:79710545-188898319 17303 109187775 1 rs417181 rs1682963745.89 0 GPSM2 chr1:2006108-109527861 22130 107521754 3 rs2254669rs839879 162.269 0 GPSM2 chr2:12056323-227979775 39094 215923453 1rs966391 rs1922020 31.384 0 GRB14 chr2:34870277-241929621 37755207059345 3 rs13422005 rs10205276 46.946 0 GRB14 chr2:38101137-24148209936812 203380963 1 rs879321 rs7576043 52.099 0 GRB14chr2:77041264-194763754 21140 117722491 1 rs2102827 rs16835406 94.091 0GRB14 chr2:83383702-175194550 16291 91810849 3 rs12469609 rs11891208154.4 0 GRB14 chr17:44458950-81047708 −8195 36588759 1 cnvi0016818rs35680231 35.591 0 GRB2 chr17:62662507-81047708 −11496 18385202 3rs6504246 rs35680231 56.048 0 GRB2 chr17:21685812-67308196 1236545622385 1 rs34864328 rs17686852 50.018 0 GRB7 chr17:26648492-589550845831 32306593 3 rs1981512 rs8068776 15.642 0 GRB7chr5:84830796-171903310 16642 87072515 1 rs300657 rs10042482 42.208 0GRIA1 chr5:57343495-171903310 21683 114559816 1 rs10940593 rs1004248261.169 0 GRIA1 chr5:4872310-180709915 35876 175837606 3 rs816467rs10071993 179.394 0 GRIA1 chr4:31222833-180548076 24457 149325244 1rs7662351 rs3849606 36.162 0 GRIA2 chr4:137206602-158430547 357721223946 3 rs1597600 rs12507865 83.533 0 GRIA2 chr4:68173959-18576717620235 117593218 1 rs6552083 rs4862428 61.893 0 GRIA2chr4:22401728-188608857 28456 166207130 1 rs4697297 rs7687115 35.717 0GRIA2 chr4:63726348-173015421 19817 109289074 1 rs17082970 rs213100230.251 0 GRIA2 chr4:126374899-162380016 6166 36005118 1 rs4834042rs17041092 33.404 0 GRIA2 chr4:155739051-165849854 1997 10110804 1rs7691720 rs10005938 26.215 0 GRIA2 chr4:69590353-190872778 23145121282426 3 rs293433 rs12646565 315.633 0 GRIA2 chr11:42185849-12675693815451 84571090 1 rs4375424 rs10750356 36.99 0 GRIA4chr11:84128537-120941583 7678 36813047 1 rs488925 rs4643089 29.271 0GRIA4 chr11:21723471-131521797 20508 109798327 1 rs11828478 rs251289827.565 0 GRIA4 chr11:98062720-121890280 5422 23827561 1 rs6589308rs1944465 29.075 0 GRIA4 chr11:23168804-106781292 16332 83612489 1rs11027007 rs7103285 49.747 0 GRIA4 chr11:74545378-134940416 1449660395039 3 rs512780 rs11224228 527.758 0 GRIA4 chr21:14601415-480849898249 33483575 3 rs2775537 rs2839378 12047.211 0 GRIK1chr21:14601415-48084989 8249 33483575 3 rs2775537 rs2839378 41.154 0GRIK1 chr21:30057145-31992864 372 1935720 1 rs6516861 rs1702405 41.668 0GRIK1 chr21:14768343-48084989 8193 33316647 3 rs2257224 rs28393785021.076 0 GRIK1 chr21:14601415-48084989 8249 33483575 3 rs2775537rs2839378 4787.438 0 GRIK1 chr21:14595264-48084989 8781 33489726 3rs2847443 rs2839378 1871.363 0 GRIK1 chr21:10708231-47970581 880737262351 3 rs4044122 rs2255397 73.188 0 GRIK1 chr1:1005806-10561234219173 104606537 3 rs3934834 rs1584633 44.152 0 GRIK3chr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879 162.269 0GRIK3 chr9:139929435-140068342 13 138908 1 rs12337910 rs4074426 9.973 0GRIN1 chr9:2522475-140068342 25719 137545868 3 rs10966757 rs407442693.386 0 GRIN1 chr9:139492789-140913833 196 1421045 1 rs28485548cnvi0002661 28.211 0 GRIN1 chr9:139492789-140212642 109 719854 3rs28485548 rs13295516 12.464 0 GRIN1 chr9:139926402-140277524 42 3511231 200006 rs7390551 31.315 0 GRIN1 chr9:140018138-140153851 12 135714 3rs4880094 rs28457075 17.073 0 GRIN1 chr9:139725120-140176250 50 451131 1rs2811750 rs28576426 24.435 0 GRIN1 chr9:140018138-140392494 38 374357 1rs4880094 rs4962232 27.672 0 GRIN1 chr9:139821068-141105225 163 12841583 rs3750512 rs11559363 55.611 0 GRIN1 chr16:176743-50013967 832849837225 3 rs2562164 rs12597023 174.392 0 GRIN2Achr12:10113083-116370432 20594 106257350 1 rs2012504 rs7958254 35.157 0GRIN2B chr12:8171838-32535863 5853 24364026 3 rs11609309 rs796318223.697 0 GRIN2B chr12:10020267-129866293 23654 119846027 1 rs1597097rs2170504 45.428 0 GRIN2B chr12:207886-50770291 11565 50562406 3rs868249 rs4477515 43.892 0 GRIN2B chr13:23742931-115064482 1982991321552 1 rs4770401 rs7999630 44.074 0 GRK1 chr13:65193124-11505315512025 49860032 3 rs9598811 rs7327124 78.057 0 GRK1 chr4:179131-6899815313495 68819023 3 rs7686948 rs7687396 625.133 0 GRK4chr6:64844594-169078546 21567 104233953 1 rs4710465 rs601639 46.524 0GRM1 chr6:66609532-147053632 15315 80444101 3 rs9354335 rs4896886 44.9410 GRM1 chr6:73120320-165130872 18715 92010553 1 rs9442780 rs1094601676.383 0 GRM1 chr6:66541198-162520133 19344 95978936 1 rs2000382rs6901071 27.509 0 GRM1 chr6:94117546-165103679 15579 70986134 1rs3799792 rs9347902 34.066 0 GRM1 chr6:67621368-147709180 16188 800878131 rs6919455 rs7739314 52.498 0 GRM1 chr6:100082983-170909002 1639370826020 3 rs594231 rs12213906 261.313 0 GRM1 chr3:13878889-14973733024723 135858442 1 rs12634112 rs2007869 55.663 0 GRM2chr3:33409611-170735099 23775 137325489 1 rs3915062 rs11924032 26.867 0GRM2 chr3:179527-114630641 23879 114451115 3 rs4684741 rs1587972 207.8520 GRM2 chr7:11855636-156148608 26852 144292973 1 rs6947930 rs694501636.446 0 GRM3 chr7:78621315-155831817 13678 77210503 3 rs1006818rs6969015 123.319 0 GRM3 chr7:8872727-156383359 27773 147510633 1rs917038 rs878717 32.336 0 GRM3 chr7:8794418-119068130 23484 110273713 1rs2189621 rs6977904 70.867 0 GRM3 chr7:85117732-86026526 122 908795 1rs4728584 rs10242995 65.094 246704 GRM3 chr7:84302877-110993169 518326690293 3 rs4338048 rs10254893 203.09 0 GRM3 chr6:26922906-9357835919746 66655454 1 rs9348738 rs9363009 27.061 0 GRM4chr6:31289284-56929863 15402 25640580 3 rs9265170 cnvi0015437 25.647 0GRM4 chr6:32968276-73449742 15442 40481467 3 rs2395300 rs4235869 415.870 GRM4 chr11:42185849-126756938 15451 84571090 1 rs4375424 rs1075035636.99 0 GRM5 chr11:81251505-103234729 4842 21983225 3 rs7935238rs1913462 26.176 0 GRM5 chr11:84128537-120941583 7678 36813047 1rs488925 rs4643089 29.271 0 GRM5 chr11:21723471-131521797 20508109798327 1 rs11828478 rs2512898 27.565 0 GRM5 chr11:23168804-10678129216332 83612489 1 rs11027007 rs7103285 49.747 0 GRM5chr11:74545378-134940416 14496 60395039 3 rs512780 rs11224228 527.758 0GRM5 chr5:161172541-179954615 4271 18782075 3 rs4921415 rs10059433 6.2910 GRM6 chr5:4872310-180709915 35876 175837606 3 rs816467 rs10071993179.394 0 GRM6 chr3:5824878-8781331 952 2956454 3 rs2470628 rs11916022924.891 0 GRM7 chr3:179527-114630641 23879 114451115 3 rs4684741rs1587972 207.852 0 GRM7 chr7:11855636-156148608 26852 144292973 1rs6947930 rs6945016 36.446 0 GRM8 chr7:78621315-155831817 13678 772105033 rs1006818 rs6969015 123.319 0 GRM8 chr7:8872727-156383359 27773147510633 1 rs917038 rs878717 32.336 0 GRM8 chr7:125676925-125780682 24103758 1 rs1419535 rs10267757 26.358 297970 GRM8chr7:120061880-143606234 4616 23544355 3 rs12531689 rs10247493 18.96 0GRM8 chr19:31569338-53780966 3788 22211629 1 rs2867544 rs10407424 33.9 0GSK3A chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466100.582 0 GSK3A chr3:13878889-149737330 24723 135858442 1 rs12634112rs2007869 55.663 0 GSK3B chr3:33409611-170735099 23775 137325489 1rs3915062 rs11924032 26.867 0 GSK3B chr3:102240202-195550366 1731893310165 1 rs1620217 rs11711870 41.031 0 GSK3B chr3:103140700-1448831728539 41742473 1 rs4314176 rs6797159 44.122 0 GSK3Bchr3:83075971-196935657 21465 113859687 1 rs9872858 rs34729751 44.35 0GSK3B chr3:114889454-177826047 12700 62936594 3 rs6795297 rs7628308102.526 0 GSK3B chr9:2522475-140068342 25719 137545868 3 rs10966757rs4074426 93.386 0 GSN chr9:33180228-132003792 14691 98823565 1rs7854765 rs9408988 28.69 0 GSN chr9:100158052-139077343 9815 38919292 3rs1020884 rs4842126 470.601 0 GSN chr1:64114301-245591329 29842181477029 1 rs11208257 rs1173850 37.504 0 GSTM4 chr1:75098453-24353164927360 168433197 1 rs12117493 rs10927002 32.113 0 GSTM4chr1:79710545-188898319 17303 109187775 1 rs417181 rs16829637 45.89 0GSTM4 chr1:109645793-194560463 12025 84914671 3 cnvi0008281 rs1092161663.121 0 GSTM4 chr9:1989033-107532317 18263 105543285 1 rs7864828rs10820726 39.824 0 HABP4 chr9:2522475-140068342 25719 137545868 3rs10966757 rs4074426 93.386 0 HABP4 chr9:99171631-99360461 19 188831 1rs10820564 rs6477568 18.889 0 HABP4 chr9:33180228-132003792 1469198823565 1 rs7854765 rs9408988 28.69 0 HABP4 chr9:94405452-99509624 9475104173 3 rs10992024 rs10114863 116.934 0 HABP4 chr5:84830796-17190331016642 87072515 1 rs300657 rs10042482 42.208 0 HAND1chr5:153684038-153925210 100 241173 3 rs6580069 rs2253311 14.734 0 HAND1chr5:57343495-171903310 21683 114559816 1 rs10940593 rs10042482 61.169 0HAND1 chr5:4872310-180709915 35876 175837606 3 rs816467 rs10071993179.394 0 HAND1 chr4:31222833-180548076 24457 149325244 1 rs7662351rs3849606 36.162 0 HAND2 chr4:163766726-189931630 5627 26164905 3rs10033012 rs10018868 25.326 0 HAND2 chr4:68173959-185767176 20235117593218 1 rs6552083 rs4862428 61.893 0 HAND2 chr4:22401728-18860885728456 166207130 1 rs4697297 rs7687115 35.717 0 HAND2chr4:162592024-189861553 6129 27269530 1 rs5005966 rs6853039 63.501 0HAND2 chr4:69590353-190872778 23145 121282426 3 rs293433 rs12646565315.633 0 HAND2 chr5:84830796-171903310 16642 87072515 1 rs300657rs10042482 42.208 0 HARS chr5:57343495-171903310 21683 114559816 1rs10940593 rs10042482 61.169 0 HARS chr5:98442871-150317237 982851874367 1 rs1447379 rs7710790 38.687 0 HARS chr5:4872310-18070991535876 175837606 3 rs816467 rs10071993 179.394 0 HARSchr1:64114301-245591329 29842 181477029 1 rs11208257 rs1173850 37.504 0HBXIP chr1:75098453-243531649 27360 168433197 1 rs12117493 rs1092700232.113 0 HBXIP chr1:79710545-188898319 17303 109187775 1 rs417181rs16829637 45.89 0 HBXIP chr1:109645793-194560463 12025 84914671 3cnvi0008281 rs10921616 63.121 0 HBXIP chr3:102240202-195550366 1731893310165 1 rs1620217 rs11711870 41.031 0 HES1 chr3:192603329-196181269617 3577941 3 rs6805010 rs7648887 385.598 0 HES1chr3:193664994-193931852 58 266859 1 rs1986907 rs4613405 104.029 0 HES1chr3:83075971-196935657 21465 113859687 1 rs9872858 rs34729751 44.35 0HES1 chr3:177912894-197551411 4129 19638518 3 rs9290640 rs1273562185.507 0 HES1 chr6:10123365-31221039 −3135 21097675 1 rs2181334rs4416711 318.459 0 HLA-A chr6:26922906-93578359 19746 66655454 1rs9348738 rs9363009 27.061 0 HLA-A chr6:2681610-31453618 81 28772009 3rs1131896 rs9267212 428.177 0 HLA-A chr6:3760708-31957364 8062 281966573 rs2187825 cnvi0006380 39.016 0 HLA-A chr6:19044000-31286381 −677412242382 1 rs6922929 rs9265057 31.384 0 HLA-A chr6:2585208-31281876 −228696669 1 rs1634746 rs1634747 31.615 0 HLA-A chr6:24697388-31341340−8293 6643953 1 rs2092404 rs9266515 38.794 0 HLA-Achr6:29177102-30253339 1364 1076238 1 rs1883329 rs1132547 42.696 0 HLA-Achr6:29812471-29937541 221 125071 1 rs7452613 rs11752303 122.513 0 HLA-Achr6:26430981-31878433 −8001 5447453 1 rs2893848 rs519417 55.651 0 HLA-Achr6:2584569-31286381 8 28701813 1 rs9391764 rs9265057 34.598 0 HLA-Achr6:2681610-31453618 81 28772009 3 rs1131896 rs9267212 390.234 0 HLA-Achr6:29253756-32671521 2267 3417766 1 rs9468508 rs9275439 51.553 0 HLA-Achr6:19044000-31286381 −6774 12242382 0 rs6922929 rs9265057 33.119 0HLA-A chr6:181089-30430875 1806 30249787 3 rs1535053 rs35792611 80.394 0HLA-A chr6:26922906-93578359 19746 66655454 1 rs9348738 rs9363009 27.0610 HLA-C chr6:30792235-31321211 404 528977 1 rs4713391 rs2596501 72.355 0HLA-C chr6:2681610-31453618 81 28772009 3 rs1131896 rs9267212 428.177 0HLA-C chr6:3760708-31957364 8062 28196657 3 rs2187825 cnvi0006380 39.0160 HLA-C chr6:19044000-31286381 −6774 12242382 1 rs6922929 rs926505731.384 0 HLA-C chr6:2585208-31281876 −2 28696669 1 rs1634746 rs163474731.615 0 HLA-C chr6:24697388-31341340 −8293 6643953 1 rs2092404rs9266515 38.794 0 HLA-C chr6:26430981-31878433 −8001 5447453 1rs2893848 rs519417 55.651 0 HLA-C chr6:2584569-31286381 8 28701813 1rs9391764 rs9265057 34.598 0 HLA-C chr6:2681610-31453618 81 28772009 3rs1131896 rs9267212 390.234 0 HLA-C chr6:29253756-32671521 2267 34177661 rs9468508 rs9275439 51.553 0 HLA-C chr6:19044000-31286381 −677412242382 0 rs6922929 rs9265057 33.119 0 HLA-C chr6:30475431-32449411−7687 1973981 3 cnvi0005997 rs1964995 153.275 0 HLA-Cchr6:26922906-93578359 19746 66655454 1 rs9348738 rs9363009 27.061 0HLA-DQA2 chr6:32496748-33038766 −7385 542019 1 rs34955825 rs230122035.189 0 HLA-DQA2 chr6:32496748-32895580 −7661 398833 1 rs34955825rs9501239 61.369 0 HLA-DQA2 chr6:32505531-32874796 −7700 369266 1cnvi0006586 rs9469310 29.88 0 HLA-DQA2 chr6:31281438-32874796 −73111593359 1 cnvi0006173 rs9469310 36.913 0 HLA-DQA2 chr6:32496748-32895580−7661 398833 1 rs34955825 rs9501239 49.158 0 HLA-DQA2chr6:32505531-32895580 −7668 390050 1 cnvi0006586 rs9501239 48.21 0HLA-DQA2 chr6:31289284-56929863 15402 25640580 3 rs9265170 cnvi001543725.647 0 HLA-DQA2 chr6:32524224-32814659 −7820 290436 3 rs28594633rs4711312 142.044 0 HLA-DQA2 chr13:19584477-81204088 13265 61619612 3rs1334954 rs1176297 22.162 0 HMGB1 chr13:23742931-115064482 1982991321552 1 rs4770401 rs7999630 44.074 0 HMGB1 chr13:19121741-6337378110326 44252041 3 rs9578050 rs9539575 82.761 0 HMGB1chr21:14601415-48084989 8249 33483575 3 rs2775537 rs2839378 12047.211 0HMGN1 chr21:14601415-48084989 8249 33483575 3 rs2775537 rs2839378 41.1540 HMGN1 chr21:14768343-48084989 8193 33316647 3 rs2257224 rs28393785021.076 0 HMGN1 chr21:14601415-48084989 8249 33483575 3 rs2775537rs2839378 4787.438 0 HMGN1 chr21:14595264-48084989 8781 33489726 3rs2847443 rs2839378 1871.363 0 HMGN1 chr21:10708231-47970581 880737262351 3 rs4044122 rs2255397 73.188 0 HMGN1 chr1:1005806-10561234219173 104606537 3 rs3934834 rs1584633 44.152 0 HMGN2chr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879 162.269 0HMGN2 chr5:84830796-171903310 16642 87072515 1 rs300657 rs1004248242.208 0 HMMR chr5:161172541-179954615 4271 18782075 3 rs4921415rs10059433 6.291 0 HMMR chr5:57343495-171903310 21683 114559816 1rs10940593 rs10042482 61.169 0 HMMR chr5:4872310-180709915 35876175837606 3 rs816467 rs10071993 179.394 0 HMMR chr16:2941320-71720681303 4230749 3 rs1034709 rs1600230 22.392 0 HMOX2 chr16:176743-500139678328 49837225 3 rs2562164 rs12597023 174.392 0 HMOX2chr5:161172541-179954615 4271 18782075 3 rs4921415 rs10059433 6.291 0HMP19 chr5:4872310-180709915 35876 175837606 3 rs816467 rs10071993179.394 0 HMP19 chr5:78520731-78765405 35 244675 1 rs4704546 rs771008912.78 0 HOMER1 chr5:49952847-89853069 7268 39900223 3 rs12188654 rs4246726.225 0 HOMER1 chr5:57343495-171903310 21683 114559816 1 rs10940593rs10042482 61.169 0 HOMER1 chr5:78542290-79057477 95 515188 1 rs10474578rs259126 38.26 0 HOMER1 chr5:4872310-180709915 35876 175837606 3rs816467 rs10071993 179.394 0 HOMER1 chr15:51688996-102398060 1103050709065 1 rs2459396 rs7181527 36.939 0 HOMER2 chr15:53775670-968108679973 43035198 1 rs657495 rs2589238 49.204 0 HOMER2chr15:66108544-102427006 8615 36318463 3 cnvi0007613 rs11632620 159.1640 HOMER2 chr19:18622443-22202166 372 3579724 3 rs4808812 rs1041224411.197 0 HOMER3 chr19:288246-59110628 11009 58822383 3 rs10409452cnvi0009466 100.582 0 HOMER3 chr18:1583633-58142042 11490 56558410 3rs9945988 rs1560399 3.736 0 HRH4 chr18:10274-30780701 6393 30770428 3cnvi0008694 rs271534 338.777 0 HRH4 chr14:80818058-105348552 549224530495 3 rs6574553 rs2028416 15.874 0 HSP90AA1chr14:26898958-104436931 17396 77537974 1 rs1245195 rs11851097 57.233 0HSP90AA1 chr14:65405722-103799039 8979 38393318 3 rs11623705 rs11628472266.153 0 HSP90AA1 chr6:26922906-93578359 19746 66655454 1 rs9348738rs9363009 27.061 0 HSP90AB1 chr6:31289284-56929863 15402 25640580 3rs9265170 cnvi0015437 25.647 0 HSP90AB1 chr6:32968276-73449742 1544240481467 3 rs2395300 rs4235869 415.87 0 HSP90AB1 chr6:26922906-9357835919746 66655454 1 rs9348738 rs9363009 27.061 0 HSPA1Achr6:31289284-32512613 10001 1223330 3 rs9265170 rs35571839 45.035 0HSPA1A chr6:3760708-31957364 8062 28196657 3 rs2187825 cnvi000638039.016 0 HSPA1A chr6:31281438-32449411 −7879 1167974 1 cnvi0006173rs1964995 24.023 0 HSPA1A chr6:31337633-32449411 1650 1111779 1rs9266433 rs1964995 124.395 0 HSPA1A chr6:31281438-32354428 −80331072991 1 cnvi0006173 rs4424066 37.329 0 HSPA1A chr6:31289284-319607709811 671487 3 rs9265170 cnvi0006385 29.628 0 HSPA1Achr6:31281438-32874796 −7311 1593359 1 cnvi0006173 rs9469310 36.913 0HSPA1A chr6:26430981-31878433 −8001 5447453 1 rs2893848 rs519417 55.6510 HSPA1A chr6:29253756-32671521 2267 3417766 1 rs9468508 rs927543951.553 0 HSPA1A chr6:31289284-56929863 15402 25640580 3 rs9265170cnvi0015437 25.647 0 HSPA1A chr6:30475431-32449411 −7687 1973981 3cnvi0005997 rs1964995 153.275 0 HSPA1A chr6:26922906-93578359 1974666655454 1 rs9348738 rs9363009 27.061 0 HSPA1B chr6:31289284-3251261310001 1223330 3 rs9265170 rs35571839 45.035 0 HSPA1Bchr6:3760708-31957364 8062 28196657 3 rs2187825 cnvi0006380 39.016 0HSPA1B chr6:31281438-32449411 −7879 1167974 1 cnvi0006173 rs196499524.023 0 HSPA1B chr6:31337633-32449411 1650 1111779 1 rs9266433rs1964995 124.395 0 HSPA1B chr6:31281438-32354428 −8033 1072991 1cnvi0006173 rs4424066 37.329 0 HSPA1B chr6:31289284-31960770 9811 6714873 rs9265170 cnvi0006385 29.628 0 HSPA1B chr6:31281438-32874796 −73111593359 1 cnvi0006173 rs9469310 36.913 0 HSPA1B chr6:26430981-31878433−8001 5447453 1 rs2893848 rs519417 55.651 0 HSPA1Bchr6:29253756-32671521 2267 3417766 1 rs9468508 rs9275439 51.553 0HSPA1B chr6:31289284-56929863 15402 25640580 3 rs9265170 cnvi001543725.647 0 HSPA1B chr6:30475431-32449411 −7687 1973981 3 cnvi0005997rs1964995 153.275 0 HSPA1B chr5:84830796-171903310 16642 87072515 1rs300657 rs10042482 42.208 0 HSPA4 chr5:57343495-171903310 21683114559816 1 rs10940593 rs10042482 61.169 0 HSPA4 chr5:98442871-1503172379828 51874367 1 rs1447379 rs7710790 38.687 0 HSPA4chr5:4872310-180709915 35876 175837606 3 rs816467 rs10071993 179.394 0HSPA4 chr7:11855636-156148608 26852 144292973 1 rs6947930 rs694501636.446 0 HSPB1 chr7:8872727-156383359 27773 147510633 1 rs917038rs878717 32.336 0 HSPB1 chr7:8794418-119068130 23484 110273713 1rs2189621 rs6977904 70.867 0 HSPB1 chr7:60392-84158180 19095 84097789 3rs12670102 rs2715048 208.308 0 HSPB1 chr5:39526068-67275356 444127749289 1 rs16869031 rs999826 77.848 0 HSPB3 chr5:49952847-898530697268 39900223 3 rs12188654 rs42467 26.225 0 HSPB3 chr5:4872310-18070991535876 175837606 3 rs816467 rs10071993 179.394 0 HSPB3chr12:59512781-127744939 13469 68232159 3 rs908394 rs7966946 20.62 0HSPB8 chr12:10020267-129866293 23654 119846027 1 rs1597097 rs217050445.428 0 HSPB8 chr12:112610714-133708729 5366 21098016 3 rs11066188rs11147249 695.45 0 HSPB8 chr12:50855195-133778796 17748 82923602 3rs4351895 rs7975069 159.589 0 HSPB8 chr19:288246-59110628 11009 588223833 rs10409452 cnvi0009466 100.582 0 HSPBP1 chr2:12056323-227979775 39094215923453 1 rs966391 rs1922020 31.384 0 HSPE1 chr2:34870277-24192962137755 207059345 3 rs13422005 rs10205276 46.946 0 HSPE1chr2:38101137-241482099 36812 203380963 1 rs879321 rs7576043 52.099 0HSPE1 chr2:185050218-212752193 4583 27701976 1 rs1526196 rs6727114 45.310 HSPE1 chr2:193255360-242529978 10289 49274619 3 rs1351905 cnvi001039993.244 0 HSPE1 chr13:19584477-81204088 13265 61619612 3 rs1334954rs1176297 22.162 0 HSPH1 chr13:23742931-115064482 19829 91321552 1rs4770401 rs7999630 44.074 0 HSPH1 chr13:19121741-63373781 1032644252041 3 rs9578050 rs9539575 82.761 0 HSPH1 chr13:36707502-10365610413622 66948603 1 rs3827890 rs1952590 38.726 0 HTR2Achr13:19584477-81204088 13265 61619612 3 rs1334954 rs1176297 22.162 0HTR2A chr13:23742931-115064482 19829 91321552 1 rs4770401 rs799963044.074 0 HTR2A chr13:47300055-47409034 48 108980 1 rs1539177 rs631425.525 0 HTR2A chr13:19121741-63373781 10326 44252041 3 rs9578050rs9539575 82.761 0 HTR2A chr2:231927569-232035793 10 108225 1 rs3815844rs2032953 14.229 0 HTR2B chr2:34870277-241929621 37755 207059345 3rs13422005 rs10205276 46.946 0 HTR2B chr2:38101137-241482099 36812203380963 1 rs879321 rs7576043 52.099 0 HTR2B chr2:193255360-24252997810289 49274619 3 rs1351905 cnvi0010399 93.244 0 HTR2Bchr1:1005806-105612342 19173 104606537 3 rs3934834 rs1584633 44.152 0HTR6 chr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879 162.2690 HTR6 chr8:30757798-142750969 20699 111993172 1 rs10101203 rs642102534.223 0 IKBKB chr8:41983076-50280013 418 8296938 1 rs12544318rs12677656 39.988 0 IKBKB chr8:23218101-146274708 23020 123056608 1rs7010362 rs7822726 38.828 0 IKBKB chr8:25304020-43159151 3371 178551323 rs10503771 cnvi0018779 263.504 0 IKBKB chr1:64114301-245591329 29842181477029 1 rs11208257 rs1173850 37.504 0 IKBKE chr1:178626526-24415914313064 65532618 3 rs2761477 rs479338 11.373 0 IKBKEchr1:75098453-243531649 27360 168433197 1 rs12117493 rs10927002 32.113 0IKBKE chr1:188850774-235423607 10060 46572834 1 rs16829466 rs1240969643.25 0 IKBKE chr1:191875752-235423607 9517 43547856 1 rs9427811rs12409696 62.01 0 IKBKE chr1:189128124-227340790 7927 38212667 1rs7515205 rs12752546 167.428 0 IKBKE chr1:174219398-247422297 1598673202900 1 rs16846809 rs4642922 35.258 0 IKBKE chr1:197187605-2264044576316 29216853 3 rs10922187 rs3008192 130.989 0 IKBKEchr16:176743-50013967 8328 49837225 3 rs2562164 rs12597023 174.392 0IL4R chr3:234726-6328081 2293 6093356 3 rs7632811 rs1595039 106.207 0IL5RA chr3:179527-114630641 23879 114451115 3 rs4684741 rs1587972207.852 0 IL5RA chr3:48801929-49362892 29 560964 1 rs6766238 rs186574115.852 0 IMPDH2 chr3:13878889-149737330 24723 135858442 1 rs12634112rs2007869 55.663 0 IMPDH2 chr3:33409611-170735099 23775 137325489 1rs3915062 rs11924032 26.867 0 IMPDH2 chr3:179527-114630641 23879114451115 3 rs4684741 rs1587972 207.852 0 IMPDH2 chr19:266034-180615093100 17795476 3 rs2312724 rs7250332 19.51 0 INSR chr19:288246-5911062811009 58822383 3 rs10409452 cnvi0009466 100.582 0 INSRchr3:120658659-121614175 112 955517 1 rs7618583 rs1881998 31.134 0 IQCB1chr3:13878889-149737330 24723 135858442 1 rs12634112 rs2007869 55.663 0IQCB1 chr3:33409611-170735099 23775 137325489 1 rs3915062 rs1192403226.867 0 IQCB1 chr3:102240202-195550366 17318 93310165 1 rs1620217rs11711870 41.031 0 IQCB1 chr3:121453361-121631841 22 178481 1 rs9841861rs1523519 24.376 0 IQCB1 chr3:121459589-121614175 21 154587 1 rs12498138rs1881998 18.424 0 IQCB1 chr3:103140700-144883172 8539 41742473 1rs4314176 rs6797159 44.122 0 IQCB1 chr3:83075971-196935657 21465113859687 1 rs9872858 rs34729751 44.35 0 IQCB1 chr3:121526849-12167040523 143557 1 rs6770719 rs9871743 13.308 0 IQCB1 chr3:121453361-12156498915 111629 1 rs9841861 rs6767409 18.746 0 IQCB1 chr3:121526849-12164816825 121320 1 rs6770719 rs1143672 14.896 0 IQCB1 chr3:114889454-17782604712700 62936594 3 rs6795297 rs7628308 102.526 0 IQCB1chr15:90962971-91108674 28 145704 3 rs17176602 rs8031453 41.934 0 IQGAP1chr15:51688996-102398060 11030 50709065 1 rs2459396 rs7181527 36.939 0IQGAP1 chr15:53775670-96810867 9973 43035198 1 rs657495 rs2589238 49.2040 IQGAP1 chr15:66108544-102427006 8615 36318463 3 cnvi0007613 rs11632620159.164 0 IQGAP1 chr5:49952847-89853069 7268 39900223 3 rs12188654rs42467 26.225 0 IQGAP2 chr5:57343495-171903310 21683 114559816 1rs10940593 rs10042482 61.169 0 IQGAP2 chr5:4872310-180709915 35876175837606 3 rs816467 rs10071993 179.394 0 IQGAP2 chr2:12056323-22797977539094 215923453 1 rs966391 rs1922020 31.384 0 IRS1chr2:34870277-241929621 37755 207059345 3 rs13422005 rs10205276 46.946 0IRS1 chr2:38101137-241482099 36812 203380963 1 rs879321 rs7576043 52.0990 IRS1 chr2:193255360-242529978 10289 49274619 3 rs1351905 cnvi001039993.244 0 IRS1 chr10:7188484-134205354 26672 127016871 1 rs1977295rs3923858 50.772 0 ITGB1 chr10:734229-69155636 14859 68421408 3rs1769236 rs2394375 72.104 0 ITGB1 chr10:88874-53366180 12853 53277307 3cnvi0015449 rs10998465 319.021 0 ITGB1 chr21:44839153-47856106 6743016954 1 rs2838302 rs2236616 38.158 0 ITGB2 chr21:14601415-480849898249 33483575 3 rs2775537 rs2839378 12047.211 0 ITGB2chr21:14601415-48084989 8249 33483575 3 rs2775537 rs2839378 41.154 0ITGB2 chr21:14768343-48084989 8193 33316647 3 rs2257224 rs28393785021.076 0 ITGB2 chr21:14601415-48084989 8249 33483575 3 rs2775537rs2839378 4787.438 0 ITGB2 chr21:14595264-48084989 8781 33489726 3rs2847443 rs2839378 1871.363 0 ITGB2 chr21:10708231-47970581 880737262351 3 rs4044122 rs2255397 73.188 0 ITGB2 chr1:1005806-10561234219173 104606537 3 rs3934834 rs1584633 44.152 0 ITGB3BPchr1:63914117-64047615 16 133499 1 rs3009577 rs10127824 22.702 0 ITGB3BPchr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879 162.269 0ITGB3BP chr17:73600891-73844748 34 243858 1 rs1624922 rs2290771 19.222 0ITGB4 chr17:44458950-81047708 −8195 36588759 1 cnvi0016818 rs3568023135.591 0 ITGB4 chr17:62662507-81047708 −11496 18385202 3 rs6504246rs35680231 56.048 0 ITGB4 chr3:13878889-149737330 24723 135858442 1rs12634112 rs2007869 55.663 0 ITGB5 chr3:33409611-170735099 23775137325489 1 rs3915062 rs11924032 26.867 0 ITGB5 chr3:102240202-19555036617318 93310165 1 rs1620217 rs11711870 41.031 0 ITGB5chr3:103140700-144883172 8539 41742473 1 rs4314176 rs6797159 44.122 0ITGB5 chr3:83075971-196935657 21465 113859687 1 rs9872858 rs3472975144.35 0 ITGB5 chr3:114889454-177826047 12700 62936594 3 rs6795297rs7628308 102.526 0 ITGB5 chr12:10113083-116370432 20594 106257350 1rs2012504 rs7958254 35.157 0 ITGB7 chr12:10020267-129866293 23654119846027 1 rs1597097 rs2170504 45.428 0 ITGB7 chr12:39967134-841744138879 44207280 1 rs11172661 rs11116039 39.568 0 ITGB7chr12:50855195-133778796 17748 82923602 3 rs4351895 rs7975069 159.589 0ITGB7 chr15:29325866-56044189 5303 26718324 3 rs4779705 rs2414433 21.7320 ITPKA chr15:32939946-43104406 2544 10164461 3 rs12594777 rs1338030132.942 0 ITPKA chr1:64114301-245591329 29842 181477029 1 rs11208257rs1173850 37.504 0 ITPKB chr1:178626526-244159143 13064 65532618 3rs2761477 rs479338 11.373 0 ITPKB chr1:75098453-243531649 27360168433197 1 rs12117493 rs10927002 32.113 0 ITPKBchr1:188850774-235423607 10060 46572834 1 rs16829466 rs12409696 43.25 0ITPKB chr1:191875752-235423607 9517 43547856 1 rs9427811 rs1240969662.01 0 ITPKB chr1:189128124-227340790 7927 38212667 1 rs7515205rs12752546 167.428 0 ITPKB chr1:174219398-247422297 15986 73202900 1rs16846809 rs4642922 35.258 0 ITPKB chr1:226423572-227452700 215 10291291 rs6605032 rs1969230 24.875 0 ITPKB chr1:226536645-236803753 260010267109 3 rs874583 rs10925178 100.109 0 ITPKB chr3:3748218-4590681 268842464 1 rs901050 rs6802929 33.083 0 ITPR1 chr3:234726-6328081 22936093356 3 rs7632811 rs1595039 106.207 0 ITPR1 chr3:179527-11463064123879 114451115 3 rs4684741 rs1587972 207.852 0 ITPR1chr6:26922906-93578359 19746 66655454 1 rs9348738 rs9363009 27.061 0ITPR3 chr6:31289284-56929863 15402 25640580 3 rs9265170 cnvi001543725.647 0 ITPR3 chr6:32968276-73449742 15442 40481467 3 rs2395300rs4235869 415.87 0 ITPR3 chr1:64114301-245591329 29842 181477029 1rs11208257 rs1173850 37.504 0 JAK1 chr1:1005806-105612342 19173104606537 3 rs3934834 rs1584633 44.152 0 JAK1 chr1:2006108-10952786122130 107521754 3 rs2254669 rs839879 162.269 0 JAK1chr21:14601415-48084989 8249 33483575 3 rs2775537 rs2839378 12047.211 0KCNE1 chr21:14601415-48084989 8249 33483575 3 rs2775537 rs2839378 41.1540 KCNE1 chr21:14768343-48084989 8193 33316647 3 rs2257224 rs28393785021.076 0 KCNE1 chr21:14601415-48084989 8249 33483575 3 rs2775537rs2839378 4787.438 0 KCNE1 chr21:14595264-48084989 8781 33489726 3rs2847443 rs2839378 1871.363 0 KCNE1 chr21:10708231-47970581 880737262351 3 rs4044122 rs2255397 73.188 0 KCNE1 chr2:12056323-22797977539094 215923453 1 rs966391 rs1922020 31.384 0 KCNE4chr2:34870277-241929621 37755 207059345 3 rs13422005 rs10205276 46.946 0KCNE4 chr2:38101137-241482099 36812 203380963 1 rs879321 rs757604352.099 0 KCNE4 chr2:193255360-242529978 10289 49274619 3 rs1351905cnvi0010399 93.244 0 KCNE4 chr7:11855636-156148608 26852 144292973 1rs6947930 rs6945016 36.446 0 KCNH2 chr7:78621315-155831817 1367877210503 3 rs1006818 rs6969015 123.319 0 KCNH2 chr7:8872727-15638335927773 147510633 1 rs917038 rs878717 32.336 0 KCNH2chr7:143807304-158827326 3603 15020023 3 rs10252253 rs2071624 54.584 0KCNH2 chr17:44458950-81047708 −8195 36588759 1 cnvi0016818 rs3568023135.591 0 KCNJ2 chr17:62662507-81047708 −11496 18385202 3 rs6504246rs35680231 56.048 0 KCNJ2 chr5:84830796-171903310 16642 87072515 1rs300657 rs10042482 42.208 0 KCNN2 chr5:108979318-132114847 457523135530 1 rs31595 rs30514 35.063 0 KCNN2 chr5:57343495-171903310 21683114559816 1 rs10940593 rs10042482 61.169 0 KCNN2 chr5:98442871-1503172379828 51874367 1 rs1447379 rs7710790 38.687 0 KCNN2chr5:80735161-125293366 8499 44558206 1 rs1541830 rs327816 52.167 0KCNN2 chr5:4872310-180709915 35876 175837606 3 rs816467 rs10071993179.394 0 KCNN2 chr19:31569338-53780966 3788 22211629 1 rs2867544rs10407424 33.9 0 KCNN4 chr19:43257015-55294329 −7309 12037315 3rs7246152 rs2569676 21.402 0 KCNN4 chr19:288246-59110628 11009 588223833 rs10409452 cnvi0009466 100.582 0 KCNN4 chr20:61852629-62212928 57360300 1 rs6010873 rs310672 29.152 0 KCNQ2 chr20:61867454-62198348 53330895 1 rs6011691 rs438363 35.319 0 KCNQ2 chr20:7869025-62424661 1194154555637 3 rs2294306 rs6010652 9.732 0 KCNQ2 chr20:54870769-629124632390 8041695 3 rs6069696 rs6062363 249.708 0 KCNQ2chr8:30757798-142750969 20699 111993172 1 rs10101203 rs6421025 34.223 0KCNQ3 chr8:60424884-145286483 17030 84861600 3 rs1401422 rs9720889 8.8580 KCNQ3 chr8:130808973-134279601 923 3470629 3 rs7823788 rs297657437.758 0 KCNQ3 chr8:23218101-146274708 23020 123056608 1 rs7010362rs7822726 38.828 0 KCNQ3 chr8:66822030-144791126 16557 77969097 3rs6472235 rs10100154 251.068 0 KCNQ3 chr6:64844594-169078546 21567104233953 1 rs4710465 rs601639 46.524 0 KCNQ5 chr6:66609532-14705363215315 80444101 3 rs9354335 rs4896886 44.941 0 KCNQ5chr6:73120320-165130872 18715 92010553 1 rs9442780 rs10946016 76.383 0KCNQ5 chr6:26922906-93578359 19746 66655454 1 rs9348738 rs9363009 27.0610 KCNQ5 chr6:66541198-162520133 19344 95978936 1 rs2000382 rs690107127.509 0 KCNQ5 chr6:62697746-94090076 6391 31392331 1 rs6455128rs3799807 108.85 0 KCNQ5 chr6:67621368-147709180 16188 80087813 1rs6919455 rs7739314 52.498 0 KCNQ5 chr6:73376868-73489110 34 112243 1rs12194741 rs7740606 24.362 0 KCNQ5 chr6:32968276-73449742 1544240481467 3 rs2395300 rs4235869 415.87 0 KCNQ5 chr6:73478625-75558759 4482080135 3 rs7775641 rs9293982 54.62 0 KCNQ5 chr4:31222833-18054807624457 149325244 1 rs7662351 rs3849606 36.162 0 KDRchr4:39472311-63464732 3456 23992422 3 rs2687975 rs4403080 120.672 0 KDRchr4:22401728-188608857 28456 166207130 1 rs4697297 rs7687115 35.717 0KDR chr4:29179713-117038307 15513 87858595 1 rs1507441 rs1068807 71.6 0KDR chr4:179131-68998153 13495 68819023 3 rs7686948 rs7687396 625.133 0KDR chr1:1005806-105612342 19173 104606537 3 rs3934834 rs1584633 44.1520 KIAA0090 chr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879162.269 0 KIAA0090 chr11:42185849-126756938 15451 84571090 1 rs4375424rs10750356 36.99 0 KIAA1377 chr11:81251505-103234729 4842 21983225 3rs7935238 rs1913462 26.176 0 KIAA1377 chr11:84128537-120941583 767836813047 1 rs488925 rs4643089 29.271 0 KIAA1377 chr11:21723471-13152179720508 109798327 1 rs11828478 rs2512898 27.565 0 KIAA1377chr11:98062720-121890280 5422 23827561 1 rs6589308 rs1944465 29.075 0KIAA1377 chr11:23168804-106781292 16332 83612489 1 rs11027007 rs710328549.747 0 KIAA1377 chr11:74545378-134940416 14496 60395039 3 rs512780rs11224228 527.758 0 KIAA1377 chr7:11855636-156148608 26852 144292973 1rs6947930 rs6945016 36.446 0 KIAA1549 chr7:78621315-155831817 1367877210503 3 rs1006818 rs6969015 123.319 0 KIAA1549 chr7:8872727-15638335927773 147510633 1 rs917038 rs878717 32.336 0 KIAA1549chr7:120061880-143606234 4616 23544355 3 rs12531689 rs10247493 18.96 0KIAA1549 chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466100.582 0 KIAA1683 chr5:84830796-171903310 16642 87072515 1 rs300657rs10042482 42.208 0 KIF3A chr5:108979318-132114847 4575 23135530 1rs31595 rs30514 35.063 0 KIF3A chr5:57343495-171903310 21683 114559816 1rs10940593 rs10042482 61.169 0 KIF3A chr5:98442871-150317237 982851874367 1 rs1447379 rs7710790 38.687 0 KIF3A chr5:4872310-18070991535876 175837606 3 rs816467 rs10071993 179.394 0 KIF3Achr4:31222833-180548076 24457 149325244 1 rs7662351 rs3849606 36.162 0KIT chr4:39472311-63464732 3456 23992422 3 rs2687975 rs4403080 120.672 0KIT chr4:22401728-188608857 28456 166207130 1 rs4697297 rs7687115 35.7170 KIT chr4:29179713-117038307 15513 87858595 1 rs1507441 rs1068807 71.60 KIT chr4:179131-68998153 13495 68819023 3 rs7686948 rs7687396 625.1330 KIT chr1:64114301-245591329 29842 181477029 1 rs11208257 rs117385037.504 0 KLHL20 chr1:75098453-243531649 27360 168433197 1 rs12117493rs10927002 32.113 0 KLHL20 chr1:79710545-188898319 17303 109187775 1rs417181 rs16829637 45.89 0 KLHL20 chr1:109645793-194560463 1202584914671 3 cnvi0008281 rs10921616 63.121 0 KLHL20chr5:84830796-171903310 16642 87072515 1 rs300657 rs10042482 42.208 0KLHL3 chr5:57343495-171903310 21683 114559816 1 rs10940593 rs1004248261.169 0 KLHL3 chr5:98442871-150317237 9828 51874367 1 rs1447379rs7710790 38.687 0 KLHL3 chr5:4872310-180709915 35876 175837606 3rs816467 rs10071993 179.394 0 KLHL3 chr19:31569338-53780966 378822211629 1 rs2867544 rs10407424 33.9 0 KLK10 chr19:43257015-55294329−7309 12037315 3 rs7246152 rs2569676 21.402 0 KLK10chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466 100.582 0KLK10 chr12:25264259-25401822 40 137564 1 rs17387019 rs4368021 16.172 0KRAS chr12:10113083-116370432 20594 106257350 1 rs2012504 rs795825435.157 0 KRAS chr12:8171838-32535863 5853 24364026 3 rs11609309rs7963182 23.697 0 KRAS chr12:10020267-129866293 23654 119846027 1rs1597097 rs2170504 45.428 0 KRAS chr12:25264259-25397282 37 133024 1rs17387019 rs17389103 24.756 0 KRAS chr12:207886-50770291 11565 505624063 rs868249 rs4477515 43.892 0 KRAS chr17:21685812-67308196 1236545622385 1 rs34864328 rs17686852 50.018 0 KRT10 chr17:38899411-3934729680 447886 1 rs7220877 rs7214006 23.174 0 KRT10 chr17:26648492-589550845831 32306593 3 rs1981512 rs8068776 15.642 0 KRT10chr12:10113083-116370432 20594 106257350 1 rs2012504 rs7958254 35.157 0KRT18 chr12:10020267-129866293 23654 119846027 1 rs1597097 rs217050445.428 0 KRT18 chr12:39967134-84174413 8879 44207280 1 rs11172661rs11116039 39.568 0 KRT18 chr12:50855195-133778796 17748 82923602 3rs4351895 rs7975069 159.589 0 KRT18 chr6:64844594-169078546 21567104233953 1 rs4710465 rs601639 46.524 0 LAMA4 chr6:66609532-14705363215315 80444101 3 rs9354335 rs4896886 44.941 0 LAMA4chr6:73120320-165130872 18715 92010553 1 rs9442780 rs10946016 76.383 0LAMA4 chr6:66541198-162520133 19344 95978936 1 rs2000382 rs690107127.509 0 LAMA4 chr6:94117546-165103679 15579 70986134 1 rs3799792rs9347902 34.066 0 LAMA4 chr6:67621368-147709180 16188 80087813 1rs6919455 rs7739314 52.498 0 LAMA4 chr6:100082983-170909002 1639370826020 3 rs594231 rs12213906 261.313 0 LAMA4 chr1:1005806-10561234219173 104606537 3 rs3934834 rs1584633 44.152 0 LCKchr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879 162.269 0LCK chr22:16871137-51184393 9245 34313257 3 rs131538 rs7284680 209.79 0LGALS2 chr1:64114301-245591329 29842 181477029 1 rs11208257 rs117385037.504 0 LMNA chr1:75098453-243531649 27360 168433197 1 rs12117493rs10927002 32.113 0 LMNA chr1:79710545-188898319 17303 109187775 1rs417181 rs16829637 45.89 0 LMNA chr1:109645793-194560463 12025 849146713 cnvi0008281 rs10921616 63.121 0 LMNA chr5:84830796-171903310 1664287072515 1 rs300657 rs10042482 42.208 0 LMNB1 chr5:108979318-1321148474575 23135530 1 rs31595 rs30514 35.063 0 LMNB1 chr5:57343495-17190331021683 114559816 1 rs10940593 rs10042482 61.169 0 LMNB1chr5:98442871-150317237 9828 51874367 1 rs1447379 rs7710790 38.687 0LMNB1 chr5:4872310-180709915 35876 175837606 3 rs816467 rs10071993179.394 0 LMNB1 chr8:60424884-145286483 17030 84861600 3 rs1401422rs9720889 8.858 0 LOC100133669 chr8:23218101-146274708 23020 123056608 1rs7010362 rs7822726 38.828 0 LOC100133669 chr8:66822030-144791126 1655777969097 3 rs6472235 rs10100154 251.068 0 LOC100133669chr6:64844594-169078546 21567 104233953 1 rs4710465 rs601639 46.524 0LOC154092 chr6:66609532-147053632 15315 80444101 3 rs9354335 rs489688644.941 0 LOC154092 chr6:73120320-165130872 18715 92010553 1 rs9442780rs10946016 76.383 0 LOC154092 chr6:66541198-162520133 19344 95978936 1rs2000382 rs6901071 27.509 0 LOC154092 chr6:94117546-165103679 1557970986134 1 rs3799792 rs9347902 34.066 0 LOC154092chr6:67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0LOC154092 chr6:100082983-170909002 16393 70826020 3 rs594231 rs12213906261.313 0 LOC154092 chr18:1583633-58142042 11490 56558410 3 rs9945988rs1560399 3.736 0 LOC339290 chr18:10274-30780701 6393 30770428 3cnvi0008694 rs271534 338.777 0 LOC339290 chr8:2365648-32608792 1033430243145 3 rs2100623 rs3757934 31.188 0 LOC340357 chr8:11876689-150511581245 3174470 1 rs10096955 rs7840505 32.747 0 LOC340357chr8:62041-25061807 9818 24999767 3 rs4710857 rs1510758 96.736 0LOC340357 chr17:44458950-81047708 −8195 36588759 1 cnvi0016818rs35680231 35.591 0 LOC400604 chr17:21685812-67308196 12365 45622385 1rs34864328 rs17686852 50.018 0 LOC400604 chr17:26648492-58955084 583132306593 3 rs1981512 rs8068776 15.642 0 LOC400604chr4:163766726-189931630 5627 26164905 3 rs10033012 rs10018868 25.326 0LRP2BP chr4:22401728-188608857 28456 166207130 1 rs4697297 rs768711535.717 0 LRP2BP chr4:162592024-189861553 6129 27269530 1 rs5005966rs6853039 63.501 0 LRP2BP chr4:69590353-190872778 23145 121282426 3rs293433 rs12646565 315.633 0 LRP2BP chr17:44458950-81047708 −819536588759 1 cnvi0016818 rs35680231 35.591 0 LRRC59chr17:21685812-67308196 12365 45622385 1 rs34864328 rs17686852 50.018 0LRRC59 chr17:26648492-58955084 5831 32306593 3 rs1981512 rs806877615.642 0 LRRC59 chr6:26922906-93578359 19746 66655454 1 rs9348738rs9363009 27.061 0 LTA chr6:31289284-32512613 10001 1223330 3 rs9265170rs35571839 45.035 0 LTA chr6:3760708-31957364 8062 28196657 3 rs2187825cnvi0006380 39.016 0 LTA chr6:31281438-32449411 −7879 1167974 1cnvi0006173 rs1964995 24.023 0 LTA chr6:31337633-32449411 1650 1111779 1rs9266433 rs1964995 124.395 0 LTA chr6:31281438-32354428 −8033 1072991 1cnvi0006173 rs4424066 37.329 0 LTA chr6:31289284-31960770 9811 671487 3rs9265170 cnvi0006385 29.628 0 LTA chr6:31281438-32874796 −7311 15933591 cnvi0006173 rs9469310 36.913 0 LTA chr6:26430981-31878433 −80015447453 1 rs2893848 rs519417 55.651 0 LTA chr6:29253756-32671521 22673417766 1 rs9468508 rs9275439 51.553 0 LTA chr6:31289284-56929863 1540225640580 3 rs9265170 cnvi0015437 25.647 0 LTA chr6:30475431-32449411−7687 1973981 3 cnvi0005997 rs1964995 153.275 0 LTAchr14:22513116-32242747 1997 9729632 1 rs4982546 rs17098165 31.673 0LTB4R chr14:22349686-25012115 755 2662430 1 rs994827 rs7142675 27.602 0LTB4R chr14:19917123-65327288 10286 45410166 3 rs2495197 rs9323455270.291 0 LTB4R chr3:13878889-149737330 24723 135858442 1 rs12634112rs2007869 55.663 0 LTF chr3:33409611-170735099 23775 137325489 1rs3915062 rs11924032 26.867 0 LTF chr3:179527-114630641 23879 1144511153 rs4684741 rs1587972 207.852 0 LTF chr3:157117977-158675961 280 15579851 rs1840673 rs1112930 71.366 0 LXN chr3:145967173-173899890 491227932718 3 rs9863647 rs7618997 46.396 0 LXN chr3:33409611-17073509923775 137325489 1 rs3915062 rs11924032 26.867 0 LXNchr3:102240202-195550366 17318 93310165 1 rs1620217 rs11711870 41.031 0LXN chr3:83075971-196935657 21465 113859687 1 rs9872858 rs34729751 44.350 LXN chr3:114889454-177896047 12700 62936594 3 rs6795297 rs7628308102.526 0 LXN chr4:179131-68998153 13495 68819023 3 rs7686948 rs7687396625.133 0 LYAR chr8:56843930-57035027 38 191098 1 rs10091244 rs438695514.478 0 LYN chr8:30757798-142750969 20699 111993172 1 rs10101203rs6421025 34.223 0 LYN chr8:56706994-56851419 31 144426 3 rs2316972rs1126327 1.58 0 LYN chr8:23218101-146274708 23020 123056608 1 rs7010362rs7822726 38.828 0 LYN chr8:43235525-66712108 3632 23476584 3 rs10091311rs7001138 58.838 0 LYN chr1:64114301-245591329 29842 181477029 1rs11208257 rs1173850 37.504 0 LYST chr1:178626526-244159143 1306465532618 3 rs2761477 rs479338 11.373 0 LYST chr1:236039174-236265665 54226492 4 rs17714318 rs16833290 11.648 0 LYST chr1:75098453-24353164927360 168433197 1 rs12117493 rs10927002 32.113 0 LYSTchr1:235832555-236429953 113 597399 1 rs11810173 rs1254188 31.543 0 LYSTchr1:174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0LYST chr1:226536645-236803753 2600 10267109 3 rs874583 rs10925178100.109 0 LYST chr6:26922906-93578359 19746 66655454 1 rs9348738rs9363009 27.061 0 MAD2L1BP chr6:31289284-56929863 15402 25640580 3rs9265170 cnvi0015437 25.647 0 MAD2L1BP chr6:32968276-73449742 1544240481467 3 rs2395300 rs4235869 415.87 0 MAD2L1BP chr15:29325866-560441895303 26718324 3 rs4779705 rs2414433 21.732 0 MAP1Achr15:43614724-43836478 29 221755 1 rs488756 rs2251844 14.185 0 MAP1Achr15:43392075-66051345 4963 22659271 3 rs8028608 rs6494537 59.842 0MAP1A chr20:13712393-55093901 8218 41381509 1 rs6033810 rs6999 41.237 0MAP1LC3A chr20:7869025-62424661 11941 54555637 3 rs2294306 rs60106529.732 0 MAP1LC3A chr20:4591715-58420336 11753 53828622 1 rs6139494rs1416388 40.922 0 MAP1LC3A chr20:236802-54845796 12646 54608995 3rs448294 rs6064362 286.151 0 MAP1LC3A chr15:51688996-102398060 1103050709065 1 rs2459396 rs7181527 36.939 0 MAP2K1 chr15:53775670-968108679973 43035198 1 rs657495 rs2589238 49.204 0 MAP2K1chr15:66108544-102427006 8615 36318463 3 cnvi0007613 rs11632620 159.1640 MAP2K1 chr17:108420-26610769 5548 26502350 3 rs12452527 rs65859182.699 0 MAP2K4 chr15:51688996-102398060 11030 50709065 1 rs2459396rs7181527 36.939 0 MAP2K5 chr15:67505066-68012403 39 507338 1 rs7169664rs4502166 30.191 0 MAP2K5 chr15:53775670-96810867 9973 43035198 1rs657495 rs2589238 49.204 0 MAP2K5 chr15:66108544-102427006 861536318463 3 cnvi0007613 rs11632620 159.164 0 MAP2K5chr19:31569338-53780966 3788 22211629 1 rs2867544 rs10407424 33.9 0MAP3K10 chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466100.582 0 MAP3K10 chr17:44458950-81047708 −8195 36588759 1 cnvi0016818rs35680231 35.591 0 MAP3K3 chr17:21685812-67308196 12365 45622385 1rs34864328 rs17686852 50.018 0 MAP3K3 chr17:61016209-66240093 8905223885 1 rs1588368 rs11658645 37.309 0 MAP3K3 chr17:59314257-661700471135 6855791 1 rs758467 rs4558468 71.379 0 MAP3K3chr17:59205829-62530143 453 3324315 3 rs7222210 rs9897203 107.455 0MAP3K3 chr6:64844594-169078546 21567 104233953 1 rs4710465 rs60163946.524 0 MAP3K7 chr6:66609532-147053632 15315 80444101 3 rs9354335rs4896886 44.941 0 MAP3K7 chr6:73120320-165130872 18715 92010553 1rs9442780 rs10946016 76.383 0 MAP3K7 chr6:26922906-93578359 1974666655454 1 rs9348738 rs9363009 27.061 0 MAP3K7 chr6:66541198-16252013319344 95978936 1 rs2000382 rs6901071 27.509 0 MAP3K7chr6:62697746-94090076 6391 31392331 1 rs6455128 rs3799807 108.85 0MAP3K7 chr6:67621368-147709180 16188 80087813 1 rs6919455 rs773931452.498 0 MAP3K7 chr6:79198069-99893938 4062 20695870 3 rs1321584rs4504482 200.961 0 MAP3K7 chr10:7188484-134205354 26672 127016871 1rs1977295 rs3923858 50.772 0 MAP3K8 chr10:734229-69155636 14859 684214083 rs1769236 rs2394375 72.104 0 MAP3K8 chr10:88874-53366180 1285353277307 3 cnvi0015449 rs10998465 319.021 0 MAP3K8chr3:13878889-149737330 24723 135858442 1 rs12634112 rs2007869 55.663 0MAP4 chr3:33409611-170735099 23775 137325489 1 rs3915062 rs1192403226.867 0 MAP4 chr3:179527-114630641 23879 114451115 3 rs4684741rs1587972 207.852 0 MAP4 chr11:42185849-126756938 15451 84571090 1rs4375424 rs10750356 36.99 0 MAP6 chr11:21723471-131521797 20508109798327 1 rs11828478 rs2512898 27.565 0 MAP6 chr11:23168804-10678129216332 83612489 1 rs11027007 rs7103285 49.747 0 MAP6chr11:74545378-134940416 14496 60395039 3 rs512780 rs11224228 527.758 0MAP6 chr22:16871137-51184393 9245 34313257 3 rs131538 rs7284680 209.79 0MAPK1 chr6:26922906-93578359 19746 66655454 1 rs9348738 rs9363009 27.0610 MAPK14 chr6:31289284-56929863 15402 25640580 3 rs9265170 cnvi001543725.647 0 MAPK14 chr6:32968276-73449742 15442 40481467 3 rs2395300rs4235869 415.87 0 MAPK14 chr16:29441284-33923125 585 4481842 3rs7206789 rs4043755 42.437 0 MAPK3 chr16:176743-50013967 8328 49837225 3rs2562164 rs12597023 174.392 0 MAPK3 chr17:43657921-44354796 88 696876 3rs9898857 rs2732700 21.196 0 MAPT chr17:43657921-44064851 65 406931 3rs9898857 rs8079215 86.447 0 MAPT chr17:21685812-67308196 12365 456223851 rs34864328 rs17686852 50.018 0 MAPT chr17:26648492-58955084 583132306593 3 rs1981512 rs8068776 15.642 0 MAPT chr6:64844594-16907854621567 104233953 1 rs4710465 rs601639 46.524 0 MARCKSchr6:66609532-147053632 15315 80444101 3 rs9354335 rs4896886 44.941 0MARCKS chr6:73120320-165130872 18715 92010553 1 rs9442780 rs1094601676.383 0 MARCKS chr6:66541198-162520133 19344 95978936 1 rs2000382rs6901071 27.509 0 MARCKS chr6:94117546-165103679 15579 70986134 1rs3799792 rs9347902 34.066 0 MARCKS chr6:67621368-147709180 1618880087813 1 rs6919455 rs7739314 52.498 0 MARCKS chr6:100082983-17090900216393 70826020 3 rs594231 rs12213906 261.313 0 MARCKSchr19:31569338-53780966 3788 22211629 1 rs2867544 rs10407424 33.9 0MARK4 chr19:43257015-55294329 −7309 12037315 3 rs7246152 rs256967621.402 0 MARK4 chr19:288246-59110628 11009 58822383 3 rs10409452cnvi0009466 100.582 0 MARK4 chr18:25388300-75954881 11539 50566582 1rs11083228 rs1876021 39.235 0 MBP chr18:62041997-76047493 3846 140054971 rs1421538 rs8085865 33.212 0 MBP chr18:44788908-78015180 8492 332262733 rs9944807 rs12960632 579.2 0 MBP chr18:25388300-75954881 1153950566582 1 rs11083228 rs1876021 39.235 0 MC4R chr18:1583633-5814204211490 56558410 3 rs9945988 rs1560399 3.736 0 MC4Rchr18:46516210-68441007 5088 21924798 1 rs7229153 rs1282652 51.891 0MC4R chr18:26550830-63713914 8241 37163085 1 rs16945738 rs2715304 17.9220 MC4R chr18:26162481-67193217 9255 41030737 1 rs12458903 rs996190731.327 0 MC4R chr18:44788908-78015180 8492 33226273 3 rs9944807rs12960632 579.2 0 MC4R chr5:84830796-171903310 16642 87072515 1rs300657 rs10042482 42.208 0 MCC chr5:108979318-132114847 4575 231355301 rs31595 rs30514 35.063 0 MCC chr5:57343495-171903310 21683 114559816 1rs10940593 rs10042482 61.169 0 MCC chr5:98442871-150317237 9828 518743671 rs1447379 rs7710790 38.687 0 MCC chr5:80735161-125293366 8499 445582061 rs1541830 rs327816 52.167 0 MCC chr5:4872310-180709915 35876 1758376063 rs816467 rs10071993 179.394 0 MCC chr10:7188484-134205354 26672127016871 1 rs1977295 rs3923858 50.772 0 MGMT chr10:124668629-1351579552949 10489327 3 rs11248331 rs10776672 23.553 0 MGMTchr10:57671424-133349223 16243 75677800 1 rs11005106 rs4301710 37.114 0MGMT chr10:53602190-135522754 19167 81920565 3 rs12247820 rs10909028139.373 0 MGMT chr12:10113083-116370432 20594 106257350 1 rs2012504rs7958254 35.157 0 MIP chr12:10020267-129866293 23654 119846027 1rs1597097 rs2170504 45.428 0 MIP chr12:39967134-84174413 8879 44207280 1rs11172661 rs11116039 39.568 0 MIP chr12:50855195-133778796 1774882923602 3 rs4351895 rs7975069 159.589 0 MIP chr12:207886-50770291 1156550562406 3 rs868249 rs4477515 43.892 0 MLF2 chr9:20322932-20430468 22107537 1 rs7048991 rs6475430 13.942 0 MLLT3 chr9:1989033-107532317 18263105543285 1 rs7864828 rs10820726 39.824 0 MLLT3 chr9:2522475-14006834225719 137545868 3 rs10966757 rs4074426 93.386 0 MLLT3chr9:12078499-29930098 5275 17851600 1 rs4449884 rs10813203 117.912 0MLLT3 chr9:46587-94335290 17484 94288704 3 rs10814410 rs9409606 762.3930 MLLT3 chr14:61278684-61530401 23 251718 1 rs2020892 rs4902024 17.437 0MNAT1 chr14:26898958-104436931 17396 77537974 1 rs1245195 rs1185109757.233 0 MNAT1 chr14:60826810-61530401 106 703592 1 rs17097373 rs490202440.432 0 MNAT1 chr14:19917123-65327288 10286 45410166 3 rs2495197rs9323455 270.291 0 MNAT1 chr16:59854720-89273883 7609 29419164 3rs1373880 rs8046156 31.884 0 MPHOSPH6 chr16:64107047-82920737 454418813691 1 rs2319723 rs918661 28.887 0 MPHOSPH6 chr16:50219449-8954475610324 39325308 3 rs6500298 rs3803681 108.108 0 MPHOSPH6chr6:26922906-93578359 19746 66655454 1 rs9348738 rs9363009 27.061 0MRPL14 chr6:31289284-56929863 15402 25640580 3 rs9265170 cnvi001543725.647 0 MRPL14 chr6:32968276-73449742 15442 40481467 3 rs2395300rs4235869 415.87 0 MRPL14 chr19:31569338-53780966 3788 22211629 1rs2867544 rs10407424 33.9 0 MRPS12 chr19:288246-59110628 11009 588223833 rs10409452 cnvi0009466 100.582 0 MRPS12 chr10:7188484-134205354 26672127016871 1 rs1977295 rs3923858 50.772 0 MRPS16 chr10:58385643-12497310413625 66587462 1 rs7920235 rs17663304 36.18 0 MRPS16chr10:57671424-133349223 16243 75677800 1 rs11005106 rs4301710 37.114 0MRPS16 chr10:55492162-117205017 13465 61712856 1 rs6481032 rs193366462.56 0 MRPS16 chr10:53602190-135522754 19167 81920565 3 rs12247820rs10909028 139.373 0 MRPS16 chr21:14601415-48084989 8249 33483575 3rs2775537 rs2839378 12047.211 0 MRPS6 chr21:14601415-48084989 824933483575 3 rs2775537 rs2839378 41.154 0 MRPS6 chr21:14768343-480849898193 33316647 3 rs2257224 rs2839378 5021.076 0 MRPS6chr21:14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0MRPS6 chr21:14595264-48084989 8781 33489726 3 rs2847443 rs28393781871.363 0 MRPS6 chr21:10708231-47970581 8807 37262351 3 rs4044122rs2255397 73.188 0 MRPS6 chr11:345515-17408630 4247 17063116 3rs11246094 rs5215 30.474 0 MRVI1 chr11:10323478-10713432 111 389955 3rs4399321 rs4910170 17.647 0 MRVI1 chr11:211482-66910826 13813 666993453 rs2293168 rs4375446 30.249 0 MRVI1 chr14:26898958-104436931 1739677537974 1 rs1245195 rs11851097 57.233 0 MTHFD1 chr14:64926097-6506331519 137219 1 rs2281603 rs10134770 14.377 0 MTHFD1 chr14:19917123-6532728810286 45410166 3 rs2495197 rs9323455 270.291 0 MTHFD1chr4:163766726-189931630 5627 26164905 3 rs10033012 rs10018868 25.326 0MTNR1A chr4:22401728-188608857 28456 166207130 1 rs4697297 rs768711535.717 0 MTNR1A chr4:162592024-189861553 6129 27269530 1 rs5005966rs6853039 63.501 0 MTNR1A chr4:69590353-190872778 23145 121282426 3rs293433 rs12646565 315.633 0 MTNR1A chr11:42185849-126756938 1545184571090 1 rs4375424 rs10750356 36.99 0 MTNR1B chr11:81251505-1032347294842 21983225 3 rs7935238 rs1913462 26.176 0 MTNR1Bchr11:84128537-120941583 7678 36813047 1 rs488925 rs4643089 29.271 0MTNR1B chr11:21723471-131521797 20508 109798327 1 rs11828478 rs251289827.565 0 MTNR1B chr11:23168804-106781292 16332 83612489 1 rs11027007rs7103285 49.747 0 MTNR1B chr11:74545378-134940416 14496 60395039 3rs512780 rs11224228 527.758 0 MTNR1B chr21:14601415-48084989 824933483575 3 rs2775537 rs2839378 12047.211 0 MX1 chr21:14601415-480849898249 33483575 3 rs2775537 rs2839378 41.154 0 MX1 chr21:14768343-480849898193 33316647 3 rs2257224 rs2839378 5021.076 0 MX1chr21:14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0MX1 chr21:14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.3630 MX1 chr21:10708231-47970581 8807 37262351 3 rs4044122 rs2255397 73.1880 MX1 chr8:30757798-142750969 20699 111993172 1 rs10101203 rs642102534.223 0 MYC chr8:60424884-145286483 17030 84861600 3 rs1401422rs9720889 8.858 0 MYC chr8:23218101-146274708 23020 123056608 1rs7010362 rs7822726 38.828 0 MYC chr8:66822030-144791126 16557 779690973 rs6472235 rs10100154 251.068 0 MYC chr12:10113083-116370432 20594106257350 1 rs2012504 rs7958254 35.157 0 MYF5 chr12:59512781-12774493913469 68232159 3 rs908394 rs7966946 20.62 0 MYF5chr12:10020267-129866293 23654 119846027 1 rs1597097 rs2170504 45.428 0MYF5 chr12:39967134-84174413 8879 44207280 1 rs11172661 rs1111603939.568 0 MYF5 chr12:50855195-133778796 17748 82923602 3 rs4351895rs7975069 159.589 0 MYF5 chr12:10113083-116370432 20594 106257350 1rs2012504 rs7958254 35.157 0 MYF6 chr12:59512781-127744939 1346968232159 3 rs908394 rs7966946 20.62 0 MYF6 chr12:10020267-12986629323654 119846027 1 rs1597097 rs2170504 45.428 0 MYF6chr12:39967134-84174413 8879 44207280 1 rs11172661 rs11116039 39.568 0MYF6 chr12:50855195-133778796 17748 82923602 3 rs4351895 rs7975069159.589 0 MYF6 chr3:13878889-149737330 24723 135858442 1 rs12634112rs2007869 55.663 0 MYLK chr3:33409611-170735099 23775 137325489 1rs3915062 rs11924032 26.867 0 MYLK chr3:102240202-195550366 1731893310165 1 rs1620217 rs11711870 41.031 0 MYLK chr3:103140700-1448831728539 41742473 1 rs4314176 rs6797159 44.122 0 MYLKchr3:83075971-196935657 21465 113859687 1 rs9872858 rs34729751 44.35 0MYLK chr3:114889454-177826047 12700 62936594 3 rs6795297 rs7628308102.526 0 MYLK chr5:141659-19010008 4662 18868350 3 rs11741126 rs464237050.124 0 MYO10 chr5:4872310-180709915 35876 175837606 3 rs816467rs10071993 179.394 0 MYO10 chr6:64844594-169078546 21567 104233953 1rs4710465 rs601639 46.524 0 MYO6 chr6:66609532-147053632 15315 804441013 rs9354335 rs4896886 44.941 0 MYO6 chr6:73120320-165130872 1871592010553 1 rs9442780 rs10946016 76.383 0 MYO6 chr6:26922906-9357835919746 66655454 1 rs9348738 rs9363009 27.061 0 MYO6chr6:66541198-162520133 19344 95978936 1 rs2000382 rs6901071 27.509 0MYO6 chr6:62697746-94090076 6391 31392331 1 rs6455128 rs3799807 108.85 0MYO6 chr6:67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.4980 MYO6 chr6:75600804-78928379 602 3327576 3 rs7743423 rs1416055 49.19 0MYO6 chr11:42185849-126756938 15451 84571090 1 rs4375424 rs1075035636.99 0 MYO7A chr11:21723471-131521797 20508 109798327 1 rs11828478rs2512898 27.565 0 MYO7A chr11:23168804-106781292 16332 83612489 1rs11027007 rs7103285 49.747 0 MYO7A chr11:74545378-134940416 1449660395039 3 rs512780 rs11224228 527.758 0 MYO7A chr19:266034-180615093100 17795476 3 rs2312724 rs7250332 19.51 0 MYO9B chr19:288246-5911062811009 58822383 3 rs10409452 cnvi0009466 100.582 0 MYO9Bchr1:64114301-245591329 29842 181477029 1 rs11208257 rs1173850 37.504 0MYOC chr1:75098453-243531649 27360 168433197 1 rs12117493 rs1092700232.113 0 MYOC chr1:79710545-188898319 17303 109187775 1 rs417181rs16829637 45.89 0 MYOC chr1:109645793-194560463 12025 84914671 3cnvi0008281 rs10921616 63.121 0 MYOC chr11:211482-66910826 1381366699345 3 rs2293168 rs4375446 30.249 0 MYOD1 chr1:64114301-24559132929842 181477029 1 rs11208257 rs1173850 37.504 0 MYOGchr1:178626526-244159143 13064 65532618 3 rs2761477 rs479338 11.373 0MYOG chr1:75098453-243531649 27360 168433197 1 rs12117493 rs1092700232.113 0 MYOG chr1:188850774-235423607 10060 46572834 1 rs16829466rs12409696 43.25 0 MYOG chr1:191875752-235423607 9517 43547856 1rs9427811 rs12409696 62.01 0 MYOG chr1:189128124-227340790 7927 382126671 rs7515205 rs12752546 167.428 0 MYOG chr1:174219398-247422297 1598673202900 1 rs16846809 rs4642922 35.258 0 MYOG chr1:197187605-2264044576316 29216853 3 rs10922187 rs3008192 130.989 0 MYOGchr5:84830796-171903310 16642 87072515 1 rs300657 rs10042482 42.208 0MYOT chr5:57343495-171903310 21683 114559816 1 rs10940593 rs1004248261.169 0 MYOT chr5:98442871-150317237 9828 51874367 1 rs1447379rs7710790 38.687 0 MYOT chr5:4872310-180709915 35876 175837606 3rs816467 rs10071993 179.394 0 MYOT chr2:18856-41136833 9721 41117978 3rs11901199 rs10187704 191.638 0 MYT1L chr12:10113083-116370432 20594106257350 1 rs2012504 rs7958254 35.157 0 NACA chr12:10020267-12986629323654 119846027 1 rs1597097 rs2170504 45.428 0 NACAchr12:39967134-84174413 8879 44207280 1 rs11172661 rs11116039 39.568 0NACA chr12:50855195-133778796 17748 82923602 3 rs4351895 rs7975069159.589 0 NACA chr9:1989033-107532317 18263 105543285 1 rs7864828rs10820726 39.824 0 NANS chr9:2522475-140068342 25719 137545868 3rs10966757 rs4074426 93.386 0 NANS chr9:33180228-132003792 1469198823565 1 rs7854765 rs9408988 28.69 0 NANS chr9:100158052-1390773439815 38919292 3 rs1020884 rs4842126 470.601 0 NANSchr8:30757798-142750969 20699 111993172 1 rs10101203 rs6421025 34.223 0NCALD chr8:60424884-145286483 17030 84861600 3 rs1401422 rs9720889 8.8580 NCALD chr8:23218101-146274708 23020 123056608 1 rs7010362 rs782272638.828 0 NCALD chr8:76354446-113652365 6767 37297920 1 rs830783rs16883889 127.023 0 NCALD chr8:66822030-144791126 16557 77969097 3rs6472235 rs10100154 251.068 0 NCALD chr7:11855636-156148608 26852144292973 1 rs6947930 rs6945016 36.446 0 NCF1C chr7:8872727-15638335927773 147510633 1 rs917038 rs878717 32.336 0 NCF1Cchr7:8794418-119068130 23484 110273713 1 rs2189621 rs6977904 70.867 0NCF1C chr7:60392-84158180 19095 84097789 3 rs12670102 rs2715048 208.3080 NCF1C chr3:13878889-149737330 24723 135858442 1 rs12634112 rs200786955.663 0 NCK1 chr3:33409611-170735099 23775 137325489 1 rs3915062rs11924032 26.867 0 NCK1 chr3:102240202-195550366 17318 93310165 1rs1620217 rs11711870 41.031 0 NCK1 chr3:103140700-144883172 853941742473 1 rs4314176 rs6797159 44.122 0 NCK1 chr3:83075971-19693565721465 113859687 1 rs9872858 rs34729751 44.35 0 NCK1chr3:114889454-177826047 12700 62936594 3 rs6795297 rs7628308 102.526 0NCK1 chr2:34870277-241929621 37755 207059345 3 rs13422005 rs1020527646.946 0 NCL chr2:38101137-241482099 36812 203380963 1 rs879321rs7576043 52.099 0 NCL chr2:193255360-242529978 10289 49274619 3rs1351905 cnvi0010399 93.244 0 NCL chr12:59512781-127744939 1346968232159 3 rs908394 rs7966946 20.62 0 NCOR2 chr12:10020267-12986629323654 119846027 1 rs1597097 rs2170504 45.428 0 NCOR2chr12:112610714-133708729 5366 21098016 3 rs11066188 rs11147249 695.45 0NCOR2 chr12:50855195-133778796 17748 82923602 3 rs4351895 rs7975069159.589 0 NCOR2 chr2:12056323-227979775 39094 215923453 1 rs966391rs1922020 31.384 0 NEUROD1 chr2:34870277-241929621 37755 207059345 3rs13422005 rs10205276 46.946 0 NEUROD1 chr2:38101137-241482099 36812203380963 1 rs879321 rs7576043 52.099 0 NEUROD1 chr2:77041264-19476375421140 117722491 1 rs2102827 rs16835406 94.091 0 NEUROD1chr2:180138805-193144041 2298 13005237 3 rs6746115 rs2592243 132.36 0NEUROD1 chr22:16871137-51184393 9245 34313257 3 rs131538 rs7284680209.79 0 NF2 chr1:64114301-245591329 29842 181477029 1 rs11208257rs1173850 37.504 0 NFASC chr1:178626526-244159143 13064 65532618 3rs2761477 rs479338 11.373 0 NFASC chr1:75098453-243531649 27360168433197 1 rs12117493 rs10927002 32.113 0 NFASCchr1:188850774-235423607 10060 46572834 1 rs16829466 rs12409696 43.25 0NFASC chr1:191875752-235423607 9517 43547856 1 rs9427811 rs1240969662.01 0 NFASC chr1:189128124-227340790 7927 38212667 1 rs7515205rs12752546 167.428 0 NFASC chr1:174219398-247422297 15986 73202900 1rs16846809 rs4642922 35.258 0 NFASC chr1:197187605-226404457 631629216853 3 rs10922187 rs3008192 130.989 0 NFASC chr18:44788908-780151808492 33226273 3 rs9944807 rs12960632 579.2 0 NFATC1chr20:13712393-55093901 8218 41381509 1 rs6033810 rs6999 41.237 0 NFATC2chr20:7869025-62424661 11941 54555637 3 rs2294306 rs6010652 9.732 0NFATC2 chr20:4591715-58420336 11753 53828622 1 rs6139494 rs141638840.922 0 NFATC2 chr20:236802-54845796 12646 54608995 3 rs448294rs6064362 286.151 0 NFATC2 chr10:7188484-134205354 26672 127016871 1rs1977295 rs3923858 50.772 0 NFKB2 chr10:58385643-124973104 1362566587462 1 rs7920235 rs17663304 36.18 0 NFKB2 chr10:57671424-13334922316243 75677800 1 rs11005106 rs4301710 37.114 0 NFKB2chr10:55492162-117205017 13465 61712856 1 rs6481032 rs1933664 62.56 0NFKB2 chr10:53602190-135522754 19167 81920565 3 rs12247820 rs10909028139.373 0 NFKB2 chr14:26018408-44486343 3682 18467936 3 rs10138454rs9323093 17.669 0 NFKBIA chr14:35760062-35886955 27 126894 4 rs17536892rs2415290 5.425 0 NFKBIA chr14:35433187-35884639 78 451453 3 rs2273154rs1012919 170.85 0 NFKBIA chr14:26898958-104436931 17396 77537974 1rs1245195 rs11851097 57.233 0 NFKBIA chr14:19917123-65327288 1028645410166 3 rs2495197 rs9323455 270.291 0 NFKBIA chr19:31569338-537809663788 22211629 1 rs2867544 rs10407424 33.9 0 NFKBIB chr19:288246-5911062811009 58822383 3 rs10409452 cnvi0009466 100.582 0 NFKBIBchr6:26922906-93578359 19746 66655454 1 rs9348738 rs9363009 27.061 0NFKBIE chr6:31289284-56929863 15402 25640580 3 rs9265170 cnvi001543725.647 0 NFKBIE chr6:32968276-73449742 15442 40481467 3 rs2395300rs4235869 415.87 0 NFKBIE chr14:26898958-104436931 17396 77537974 1rs1245195 rs11851097 57.233 0 NGB chr14:65405722-103799039 8979 383933183 rs11623705 rs11628472 266.153 0 NGB chr22:16871137-51184393 924534313257 3 rs131538 rs7284680 209.79 0 NHP2L1 chr2:12056323-22797977539094 215923453 1 rs966391 rs1922020 31.384 0 NMIchr2:34870277-241929621 37755 207059345 3 rs13422005 rs10205276 46.946 0NMI chr2:38101137-241482099 36812 203380963 1 rs879321 rs7576043 52.0990 NMI chr2:77041264-194763754 21140 117722491 1 rs2102827 rs1683540694.091 0 NMI chr2:83383702-175194550 16291 91810849 3 rs12469609rs11891208 154.4 0 NMI chr12:59512781-127744939 13469 68232159 3rs908394 rs7966946 20.62 0 NOS1 chr12:10020267-129866293 23654 1198460271 rs1597097 rs2170504 45.428 0 NOS1 chr12:112610714-133708729 536621098016 3 rs11066188 rs11147249 695.45 0 NOS1 chr12:50855195-13377879617748 82923602 3 rs4351895 rs7975069 159.589 0 NOS1chr2:110829655-110982530 15 152876 1 rs163667 rs13386516 42.435 0 NPHP1chr2:12056323-227979775 39094 215923453 1 rs966391 rs1922020 31.384 0NPHP1 chr2:34870277-241929621 37755 207059345 3 rs13422005 rs1020527646.946 0 NPHP1 chr2:110829655-110982530 15 152876 3 rs163667 rs1338651633.513 0 NPHP1 chr2:110829655-110929964 12 100310 3 rs163667 rs674770118.706 0 NPHP1 chr2:110829655-110934723 13 105069 3 rs163667 rs115465210.443 0 NPHP1 chr2:38101137-241482099 36812 203380963 1 rs879321rs7576043 52.099 0 NPHP1 chr2:110871665-110983050 21 111386 1 rs17842653rs10173717 83.324 0 NPHP1 chr2:110834186-111144295 30 310110 3 rs163660rs2117529 40.53 0 NPHP1 chr2:110891433-111068787 18 177355 3 rs1588327rs339216 20.575 0 NPHP1 chr2:77041264-194763754 21140 117722491 1rs2102827 rs16835406 94.091 0 NPHP1 chr2:110857243-111068787 24 211545 3rs6716800 rs339216 35.798 0 NPHP1 chr2:110732676-111068787 32 336112 3rs12467706 rs339216 109.625 0 NPHP1 chr2:83383702-175194550 1629191810849 3 rs12469609 rs11891208 154.4 0 NPHP1 chr4:31222833-18054807624457 149325244 1 rs7662351 rs3849606 36.162 0 NPY2Rchr4:137206602-158430547 3577 21223946 3 rs1597600 rs12507865 83.533 0NPY2R chr4:68173959-185767176 20235 117593218 1 rs6552083 rs486242861.893 0 NPY2R chr4:22401728-188608857 28456 166207130 1 rs4697297rs7687115 35.717 0 NPY2R chr4:63726348-173015421 19817 109289074 1rs17082970 rs2131002 30.251 0 NPY2R chr4:126374899-162380016 616636005118 1 rs4834042 rs17041092 33.404 0 NPY2R chr4:155739051-1658498541997 10110804 1 rs7691720 rs10005938 26.215 0 NPY2Rchr4:69590353-190872778 23145 121282426 3 rs293433 rs12646565 315.633 0NPY2R chr2:12056323-227979775 39094 215923453 1 rs966391 rs192202031.384 0 NRBP1 chr2:27260469-27667297 33 406829 1 rs1124649 rs480315.064 0 NRBP1 chr2:18856-41136833 9721 41117978 3 rs11901199 rs10187704191.638 0 NRBP1 chr11:42185849-126756938 15451 84571090 1 rs4375424rs10750356 36.99 0 NRGN chr11:21723471-131521797 20508 109798327 1rs11828478 rs2512898 27.565 0 NRGN chr11:74545378-134940416 1449660395039 3 rs512780 rs11224228 527.758 0 NRGN chr19:31569338-537809663788 22211629 1 rs2867544 rs10407424 33.9 0 NUCB1chr19:43257015-55294329 −7309 12037315 3 rs7246152 rs2569676 21.402 0NUCB1 chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466100.582 0 NUCB1 chr1:1005806-105612342 19173 104606537 3 rs3934834rs1584633 44.152 0 NUDC chr1:2006108-109527861 22130 107521754 3rs2254669 rs839879 162.269 0 NUDC chr1:64114301-245591329 29842181477029 1 rs11208257 rs1173850 37.504 0 OBSCN chr1:178626526-24415914313064 65532618 3 rs2761477 rs479338 11.373 0 OBSCNchr1:75098453-243531649 27360 168433197 1 rs12117493 rs10927002 32.113 0OBSCN chr1:188850774-235423607 10060 46572834 1 rs16829466 rs1240969643.25 0 OBSCN chr1:191875752-235423607 9517 43547856 1 rs9427811rs12409696 62.01 0 OBSCN chr1:174219398-247422297 15986 73202900 1rs16846809 rs4642922 35.258 0 OBSCN chr1:226536645-236803753 260010267109 3 rs874583 rs10925178 100.109 0 OBSCN chr3:179527-11463064123879 114451115 3 rs4684741 rs1587972 207.852 0 OGG1chr1:1005806-105612342 19173 104606537 3 rs3934834 rs1584633 44.152 0OPRD1 chr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879162.269 0 OPRD1 chr8:30757798-142750969 20699 111993172 1 rs10101203rs6421025 34.223 0 OPRK1 chr8:23218101-146274708 23020 123056608 1rs7010362 rs7822726 38.828 0 OPRK1 chr8:53908875-54088142 47 179268 1rs360974 rs2194910 15.819 50134 OPRK1 chr8:43235525-66712108 363223476584 3 rs10091311 rs7001138 58.838 0 OPRK1 chr6:64844594-16907854621567 104233953 1 rs4710465 rs601639 46.524 0 OPRM1chr6:151495387-165969396 3761 14474010 3 rs9322304 rs1022180 22.826 0OPRM1 chr6:73120320-165130872 18715 92010553 1 rs9442780 rs1094601676.383 0 OPRM1 chr6:66541198-162520133 19344 95978936 1 rs2000382rs6901071 27.509 0 OPRM1 chr6:94117546-165103679 15579 70986134 1rs3799792 rs9347902 34.066 0 OPRM1 chr6:100082983-170909002 1639370826020 3 rs594231 rs12213906 261.313 0 OPRM1 chr3:152392877-15261388331 221007 3 rs9828639 rs2872090 1.227 0 P2RY1 chr3:145967173-1738998904912 27932718 3 rs9863647 rs7618997 46.396 0 P2RY1chr3:33409611-170735099 23775 137325489 1 rs3915062 rs11924032 26.867 0P2RY1 chr3:102240202-195550366 17318 93310165 1 rs1620217 rs1171187041.031 0 P2RY1 chr3:83075971-196935657 21465 113859687 1 rs9872858rs34729751 44.35 0 P2RY1 chr3:114889454-177826047 12700 62936594 3rs6795297 rs7628308 102.526 0 P2RY1 chr12:10113083-116370432 20594106257350 1 rs2012504 rs7958254 35.157 0 PA2G4 chr12:10020267-12986629323654 119846027 1 rs1597097 rs2170504 45.428 0 PA2G4chr12:39967134-84174413 8879 44207280 1 rs11172661 rs11116039 39.568 0PA2G4 chr12:50855195-133778796 17748 82923602 3 rs4351895 rs7975069159.589 0 PA2G4 chr1:1005806-105612342 19173 104606537 3 rs3934834rs1584633 44.152 0 PABPC4 chr1:2006108-109527861 22130 107521754 3rs2254669 rs839879 162.269 0 PABPC4 chr9:2522475-140068342 25719137545868 3 rs10966757 rs4074426 93.386 0 PAEP chr9:100158052-1390773439815 38919292 3 rs1020884 rs4842126 470.601 0 PAEP chr17:108420-266107695548 26502350 3 rs12452527 rs658591 82.699 0 PAFAH1B1chr19:31569338-53780966 3788 22211629 1 rs2867544 rs10407424 33.9 0PAFAH1B3 chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466100.582 0 PAFAH1B3 chr5:84830796-171903310 16642 87072515 1 rs300657rs10042482 42.208 0 PAM chr5:93678849-103794722 1632 10115874 3 rs160270rs2963216 3.838 0 PAM chr5:57343495-171903310 21683 114559816 1rs10940593 rs10042482 61.169 0 PAM chr5:98442871-150317237 9828 518743671 rs1447379 rs7710790 38.687 0 PAM chr5:84160703-104650005 3339 204893031 rs6860783 rs560688 92.914 0 PAM chr5:80735161-125293366 8499 445582061 rs1541830 rs327816 52.167 0 PAM chr5:4872310-180709915 35876 1758376063 rs816467 rs10071993 179.394 0 PAM chr16:59854720-89273883 760929419164 3 rs1373880 rs8046156 31.884 0 PARD6A chr16:64107047-829207374544 18813691 1 rs2319723 rs918661 28.887 0 PARD6Achr16:67634786-67780829 11 146044 1 cnvi0008013 rs9925393 12.023 0PARD6A chr16:50219449-89544756 10324 39325308 3 rs6500298 rs3803681108.108 0 PARD6A chr20:13712393-55093901 8218 41381509 1 rs6033810rs6999 41.237 0 PARD6B chr20:7869025-62424661 11941 54555637 3 rs2294306rs6010652 9.732 0 PARD6B chr20:4591715-58420336 11753 53828622 1rs6139494 rs1416388 40.922 0 PARD6B chr20:236802-54845796 12646 546089953 rs448294 rs6064362 286.151 0 PARD6B chr18:44788908-78015180 849233226273 3 rs9944807 rs12960632 579.2 0 PARD6G chr12:10113083-11637043220594 106257350 1 rs2012504 rs7958254 35.157 0 PAWRchr12:59512781-127744939 13469 68232159 3 rs908394 rs7966946 20.62 0PAWR chr12:10020267-129866293 23654 119846027 1 rs1597097 rs217050445.428 0 PAWR chr12:39967134-84174413 8879 44207280 1 rs11172661rs11116039 39.568 0 PAWR chr12:79291372-80266372 130 975001 1 rs1551847rs2698261 34.672 0 PAWR chr12:50855195-133778796 17748 82923602 3rs4351895 rs7975069 159.589 0 PAWR chr2:12056323-227979775 39094215923453 1 rs966391 rs1922020 31.384 0 PCBP1 chr2:34870277-24192962137755 207059345 3 rs13422005 rs10205276 46.946 0 PCBP1chr2:69979290-70389900 49 410611 3 rs10177224 rs11677137 16.309 0 PCBP1chr2:38101137-241482099 36812 203380963 1 rs879321 rs7576043 52.099 0PCBP1 chr2:41212010-82396211 9721 41184202 3 rs12614285 rs934310 396.3960 PCBP1 chr21:44839153-47856106 674 3016954 1 rs2838302 rs2236616 38.1580 PCBP3 chr21:14601415-48084989 8249 33483575 3 rs2775537 rs283937812047.211 0 PCBP3 chr21:14601415-48084989 8249 33483575 3 rs2775537rs2839378 41.154 0 PCBP3 chr21:47091361-47226895 18 135535 1 rs2838973rs2839002 14.709 0 PCBP3 chr21:14768343-48084989 8193 33316647 3rs2257224 rs2839378 5021.076 0 PCBP3 chr21:14601415-48084989 824933483575 3 rs2775537 rs2839378 4787.438 0 PCBP3 chr21:14595264-480849898781 33489726 3 rs2847443 rs2839378 1871.363 0 PCBP3chr21:46381900-48098560 448 1716661 1 rs8132265 cnvi0019195 712.68 0PCBP3 chr21:10708231-47970581 8807 37262351 3 rs4044122 rs2255397 73.1880 PCBP3 chr5:84830796-171903310 16642 87072515 1 rs300657 rs1004248242.208 0 PCDHA4 chr5:57343495-171903310 21683 114559816 1 rs10940593rs10042482 61.169 0 PCDHA4 chr5:98442871-150317237 9828 51874367 1rs1447379 rs7710790 38.687 0 PCDHA4 chr5:4872310-180709915 35876175837606 3 rs816467 rs10071993 179.394 0 PCDHA4 chr6:64844594-16907854621567 104233953 1 rs4710465 rs601639 46.524 0 PCMT1chr6:73120320-165130872 18715 92010553 1 rs9442780 rs10946016 76.383 0PCMT1 chr6:66541198-162520133 19344 95978936 1 rs2000382 rs690107127.509 0 PCMT1 chr6:94117546-165103679 15579 70986134 1 rs3799792rs9347902 34.066 0 PCMT1 chr6:100082983-170909002 16393 70826020 3rs594231 rs12213906 261.313 0 PCMT1 chr21:44839153-47856106 674 30169541 rs2838302 rs2236616 38.158 0 PCNT chr21:14601415-48084989 824933483575 3 rs2775537 rs2839378 12047.211 0 PCNT chr21:14601415-480849898249 33483575 3 rs2775537 rs2839378 41.154 0 PCNTchr21:14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0PCNT chr21:14601415-48084989 8249 33483575 3 rs2775537 rs28393784787.438 0 PCNT chr21:14595264-48084989 8781 33489726 3 rs2847443rs2839378 1871.363 0 PCNT chr21:46381900-48098560 448 1716661 1rs8132265 cnvi0019195 712.68 0 PCNT chr21:10708231-47970581 880737262351 3 rs4044122 rs2255397 73.188 0 PCNT chr21:14601415-480849898249 33483575 3 rs2775537 rs2839378 12047.211 0 PCP4chr21:14601415-48084989 8249 33483575 3 rs2775537 rs2839378 41.154 0PCP4 chr21:14768343-48084989 8193 33316647 3 rs2257224 rs28393785021.076 0 PCP4 chr21:14601415-48084989 8249 33483575 3 rs2775537rs2839378 4787.438 0 PCP4 chr21:14595264-48084989 8781 33489726 3rs2847443 rs2839378 1871.363 0 PCP4 chr21:10708231-47970581 880737262351 3 rs4044122 rs2255397 73.188 0 PCP4 chr1:64114301-24559132929842 181477029 1 rs11208257 rs1173850 37.504 0 PDCchr1:178626526-244159143 13064 65532618 3 rs2761477 rs479338 11.373 0PDC chr1:75098453-243531649 27360 168433197 1 rs12117493 rs1092700232.113 0 PDC chr1:79710545-188898319 17303 109187775 1 rs417181rs16829637 45.89 0 PDC chr1:174219398-247422297 15986 73202900 1rs16846809 rs4642922 35.258 0 PDC chr1:109645793-194560463 1202584914671 3 cnvi0008281 rs10921616 63.121 0 PDC chr19:31569338-537809663788 22211629 1 rs2867544 rs10407424 33.9 0 PDCD5 chr19:288246-5911062811009 58822383 3 rs10409452 cnvi0009466 100.582 0 PDCD5chr9:2522475-140068342 25719 137545868 3 rs10966757 rs4074426 93.386 0PDCL chr9:33180228-132003792 14691 98823565 1 rs7854765 rs9408988 28.690 PDCL chr9:100158052-139077343 9815 38919292 3 rs1020884 rs4842126470.601 0 PDCL chr2:12056323-227979775 39094 215923453 1 rs966391rs1922020 31.384 0 PDE1A chr2:34870277-241929621 37755 207059345 3rs13422005 rs10205276 46.946 0 PDE1A chr2:38101137-241482099 36812203380963 1 rs879321 rs7576043 52.099 0 PDE1A chr2:77041264-19476375421140 117722491 1 rs2102827 rs16835406 94.091 0 PDE1Achr2:180138805-193144041 2298 13005237 3 rs6746115 rs2592243 132.36 0PDE1A chr12:10113083-116370432 20594 106257350 1 rs2012504 rs795825435.157 0 PDE1B chr12:10020267-129866293 23654 119846027 1 rs1597097rs2170504 45.428 0 PDE1B chr12:39967134-84174413 8879 44207280 1rs11172661 rs11116039 39.568 0 PDE1B chr12:50855195-133778796 1774882923602 3 rs4351895 rs7975069 159.589 0 PDE1B chr7:11855636-15614860826852 144292973 1 rs6947930 rs6945016 36.446 0 PDE1Cchr7:7724805-53845684 11772 46120880 3 rs10263415 rs6948633 42.007 0PDE1C chr7:8872727-156383359 27773 147510633 1 rs917038 rs878717 32.3360 PDE1C chr7:8794418-119068130 23484 110273713 1 rs2189621 rs697790470.867 0 PDE1C chr7:60392-84158180 19095 84097789 3 rs12670102 rs2715048208.308 0 PDE1C chr1:64114301-245591329 29842 181477029 1 rs11208257rs1173850 37.504 0 PDE4DIP chr1:75098453-243531649 27360 168433197 1rs12117493 rs10927002 32.113 0 PDE4DIP chr1:121171208-145073750 11223902543 3 rs4844616 rs634953 101.367 0 PDE4DIP chr1:79710545-18889831917303 109187775 1 rs417181 rs16829637 45.89 0 PDE4DIPchr1:109645793-194560463 12025 84914671 3 cnvi0008281 rs10921616 63.1210 PDE4DIP chr2:34870277-241929621 37755 207059345 3 rs13422005rs10205276 46.946 0 PDE6D chr2:38101137-241482099 36812 203380963 1rs879321 rs7576043 52.099 0 PDE6D chr2:193255360-242529978 1028949274619 3 rs1351905 cnvi0010399 93.244 0 PDE6D chr17:44458950-81047708−8195 36588759 1 cnvi0016818 rs35680231 35.591 0 PDE6Gchr17:62662507-81047708 −11496 18385202 3 rs6504246 rs35680231 56.048 0PDE6G chr16:176743-50013967 8328 49837225 3 rs2562164 rs12597023 174.3920 PDIA2 chr5:161172541-179954615 4271 18782075 3 rs4921415 rs100594336.291 0 PDLIM7 chr5:4872310-180709915 35876 175837606 3 rs816467rs10071993 179.394 0 PDLIM7 chr16:176743-50013967 8328 49837225 3rs2562164 rs12597023 174.392 0 PDPK1 chr1:64114301-245591329 29842181477029 1 rs11208257 rs1173850 37.504 0 PEA15 chr1:75098453-24353164927360 168433197 1 rs12117493 rs10927002 32.113 0 PEA15chr1:79710545-188898319 17303 109187775 1 rs417181 rs16829637 45.89 0PEA15 chr1:109645793-194560463 12025 84914671 3 cnvi0008281 rs1092161663.121 0 PEA15 chr5:39526068-67275356 4441 27749289 1 rs16869031rs999826 77.848 0 PELO chr5:49952847-89853069 7268 39900223 3 rs12188654rs42467 26.225 0 PELO chr5:4872310-180709915 35876 175837606 3 rs816467rs10071993 179.394 0 PELO chr5:84830796-171903310 16642 87072515 1rs300657 rs10042482 42.208 0 PFDN1 chr5:57343495-171903310 21683114559816 1 rs10940593 rs10042482 61.169 0 PFDN1 chr5:98442871-1503172379828 51874367 1 rs1447379 rs7710790 38.687 0 PFDN1chr5:4872310-180709915 35876 175837606 3 rs816467 rs10071993 179.394 0PFDN1 chr20:13712393-55093901 8218 41381509 1 rs6033810 rs6999 41.237 0PFDN4 chr20:7869025-62424661 11941 54555637 3 rs2294306 rs6010652 9.7320 PFDN4 chr20:4591715-58420336 11753 53828622 1 rs6139494 rs141638840.922 0 PFDN4 chr20:236802-54845796 12646 54608995 3 rs448294 rs6064362286.151 0 PFDN4 chr12:10113083-116370432 20594 106257350 1 rs2012504rs7958254 35.157 0 PFDN5 chr12:10020267-129866293 23654 119846027 1rs1597097 rs2170504 45.428 0 PFDN5 chr12:39967134-84174413 8879 442072801 rs11172661 rs11116039 39.568 0 PFDN5 chr12:50855195-133778796 1774882923602 3 rs4351895 rs7975069 159.589 0 PFDN5 chr1:64114301-24559132929842 181477029 1 rs11208257 rs1173850 37.504 0 PFKFB2chr1:178626526-244159143 13064 65532618 3 rs2761477 rs479338 11.373 0PFKFB2 chr1:75098453-243531649 27360 168433197 1 rs12117493 rs1092700232.113 0 PFKFB2 chr1:188850774-235423607 10060 46572834 1 rs16829466rs12409696 43.25 0 PFKFB2 chr1:191875752-235423607 9517 43547856 1rs9427811 rs12409696 62.01 0 PFKFB2 chr1:189128124-227340790 792738212667 1 rs7515205 rs12752546 167.428 0 PFKFB2chr1:174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0PFKFB2 chr1:197187605-226404457 6316 29216853 3 rs10922187 rs3008192130.989 0 PFKFB2 chr17:108420-26610769 5548 26502350 3 rs12452527rs658591 82.699 0 PFN1 chr1:64114301-245591329 29842 181477029 1rs11208257 rs1173850 37.504 0 PGM1 chr1:1005806-105612342 19173104606537 3 rs3934834 rs1584633 44.152 0 PGM1 chr1:2006108-10952786122130 107521754 3 rs2254669 rs839879 162.269 0 PGM1chr16:176743-50013967 8328 49837225 3 rs2562164 rs12597023 174.392 0PHKB chr7:11855636-156148608 26852 144292973 1 rs6947930 rs694501636.446 0 PHKG1 chr7:8872727-156383359 27773 147510633 1 rs917038rs878717 32.336 0 PHKG1 chr7:8794418-119068130 23484 110273713 1rs2189621 rs6977904 70.867 0 PHKG1 chr7:56147898-56348924 35 201027 3cnvi0001044 rs940494 33.6 0 PHKG1 chr7:60392-84158180 19095 84097789 3rs12670102 rs2715048 208.308 0 PHKG1 chr16:29441284-33923125 585 44818423 rs7206789 rs4043755 42.437 0 PHKG2 chr16:176743-50013967 8328 498372253 rs2562164 rs12597023 174.392 0 PHKG2 chr19:266034-18061509 310017795476 3 rs2312724 rs7250332 19.51 0 PIAS4 chr19:629303-4119012 7093489710 1 rs2283575 rs350887 26.758 0 PIAS4 chr19:288246-59110628 1100958822383 3 rs10409452 cnvi0009466 100.582 0 PIAS4chr22:16871137-51184393 9245 34313257 3 rs131538 rs7284680 209.79 0PICK1 chr18:25388300-75954881 11539 50566582 1 rs11083228 rs187602139.235 0 PIK3C3 chr18:1583633-58142042 11490 56558410 3 rs9945988rs1560399 3.736 0 PIK3C3 chr18:26550830-63713914 8241 37163085 1rs16945738 rs2715304 17.922 0 PIK3C3 chr18:26162481-67193217 925541030737 1 rs12458903 rs9961907 31.327 0 PIK3C3 chr18:30929223-447206642910 13791442 3 rs10775453 rs9304343 535.348 0 PIK3C3chr3:166503411-190576461 4854 24073051 1 rs11925936 rs1393054 31.414 0PIK3CA chr3:102240202-195550366 17318 93310165 1 rs1620217 rs1171187041.031 0 PIK3CA chr3:164955741-191742104 5741 26786364 1 rs2218152rs9835019 52.438 0 PIK3CA chr3:83075971-196935657 21465 113859687 1rs9872858 rs34729751 44.35 0 PIK3CA chr3:177912894-197551411 412919638518 3 rs9290640 rs1273562 185.507 0 PIK3CA chr7:11855636-15614860826852 144292973 1 rs6947930 rs6945016 36.446 0 PIK3CGchr7:78621315-155831817 13678 77210503 3 rs1006818 rs6969015 123.319 0PIK3CG chr7:8872727-156383359 27773 147510633 1 rs917038 rs878717 32.3360 PIK3CG chr7:8794418-119068130 23484 110273713 1 rs2189621 rs697790470.867 0 PIK3CG chr7:84302877-110993169 5183 26690293 3 rs4338048rs10254893 203.09 0 PIK3CG chr5:49952847-89853069 7268 39900223 3rs12188654 rs42467 26.225 0 PIK3R1 chr5:57343495-171903310 21683114559816 1 rs10940593 rs10042482 61.169 0 PIK3R1 chr5:4872310-18070991535876 175837606 3 rs816467 rs10071993 179.394 0 PIK3R1chr6:26922906-93578359 19746 66655454 1 rs9348738 rs9363009 27.061 0PLA2G7 chr6:31289284-56929863 15402 25640580 3 rs9265170 cnvi001543725.647 0 PLA2G7 chr6:32968276-73449742 15442 40481467 3 rs2395300rs4235869 415.87 0 PLA2G7 chr20:7869025-62424661 11941 54555637 3rs2294306 rs6010652 9.732 0 PLCB1 chr20:4591715-58420336 11753 538286221 rs6139494 rs1416388 40.922 0 PLCB1 chr20:236802-54845796 1264654608995 3 rs448294 rs6064362 286.151 0 PLCB1 chr15:29325866-560441895303 26718324 3 rs4779705 rs2414433 21.732 0 PLCB2chr15:32939946-43104406 2544 10164461 3 rs12594777 rs13380301 32.942 0PLCB2 chr11:42185849-126756938 15451 84571090 1 rs4375424 rs1075035636.99 0 PLCB3 chr11:21723471-131521797 20508 109798327 1 rs11828478rs2512898 27.565 0 PLCB3 chr11:23168804-106781292 16332 83612489 1rs11027007 rs7103285 49.747 0 PLCB3 chr11:211482-66910826 13813 666993453 rs2293168 rs4375446 30.249 0 PLCB3 chr3:13878889-149737330 24723135858442 1 rs12634112 rs2007869 55.663 0 PLCD1 chr3:33409611-17073509923775 137325489 1 rs3915062 rs11924032 26.867 0 PLCD1chr3:179527-114630641 23879 114451115 3 rs4684741 rs1587972 207.852 0PLCD1 chr16:59854720-89273883 7609 29419164 3 rs1373880 rs8046156 31.8840 PLCG2 chr16:64107047-82920737 4544 18813691 1 rs2319723 rs91866128.887 0 PLCG2 chr16:50219449-89544756 10324 39325308 3 rs6500298rs3803681 108.108 0 PLCG2 chr3:166503411-190576461 4854 24073051 1rs11925936 rs1393054 31.414 0 PLD1 chr3:145967173-173899890 491227932718 3 rs9863647 rs7618997 46.396 0 PLD1 chr3:102240202-19555036617318 93310165 1 rs1620217 rs11711870 41.031 0 PLD1chr3:164955741-191742104 5741 26786364 1 rs2218152 rs9835019 52.438 0PLD1 chr3:83075971-196935657 21465 113859687 1 rs9872858 rs3472975144.35 0 PLD1 chr3:114889454-177826047 12700 62936594 3 rs6795297rs7628308 102.526 0 PLD1 chr17:108420-26610769 5548 26502350 3rs12452527 rs658591 82.699 0 PLD2 chr19:31569338-53780966 3788 222116291 rs2867544 rs10407424 33.9 0 PLEKHA4 chr19:43257015-55294329 −730912037315 3 rs7246152 rs2569676 21.402 0 PLEKHA4 chr19:288246-5911062811009 58822383 3 rs10409452 cnvi0009466 100.582 0 PLEKHA4chr16:176743-50013967 8328 49837225 3 rs2562164 rs12597023 174.392 0PLK1 chr11:42185849-126756938 15451 84571090 1 rs4375424 rs1075035636.99 0 POLA2 chr11:21723471-131521797 20508 109798327 1 rs11828478rs2512898 27.565 0 POLA2 chr11:23168804-106781292 16332 83612489 1rs11027007 rs7103285 49.747 0 POLA2 chr11:211482-66910826 13813 666993453 rs2293168 rs4375446 30.249 0 POLA2 chr8:30757798-142750969 20699111993172 1 rs10101203 rs6421025 34.223 0 POLB chr8:41983076-50280013418 8296938 1 rs12544318 rs12677656 39.988 0 POLBchr8:23218101-146274708 23020 123056608 1 rs7010362 rs7822726 38.828 0POLB chr8:25304020-43159151 3371 17855132 3 rs10503771 cnvi0018779263.504 0 POLB chr16:50219449-89544756 10324 39325308 3 rs6500298rs3803681 108.108 0 POLR2C chr20:13712393-55093901 8218 41381509 1rs6033810 rs6999 41.237 0 POLR3F chr20:7869025-62424661 11941 54555637 3rs2294306 rs6010652 9.732 0 POLR3F chr20:4591715-58420336 11753 538286221 rs6139494 rs1416388 40.922 0 POLR3F chr20:18389203-18575485 42 1862831 rs4814744 rs6045492 14.642 0 POLR3F chr20:236802-54845796 1264654608995 3 rs448294 rs6064362 286.151 0 POLR3F chr22:43483242-511780902461 7694849 3 rs8141749 rs2285395 30.687 0 PPARAchr22:16871137-51184393 9245 34313257 3 rs131538 rs7284680 209.79 0PPARA chr4:31222833-180548076 24457 149325244 1 rs7662351 rs384960636.162 0 PPEF2 chr4:68173959-185767176 20235 117593218 1 rs6552083rs4862428 61.893 0 PPEF2 chr4:22401728-188608857 28456 166207130 1rs4697297 rs7687115 35.717 0 PPEF2 chr4:63726348-173015421 19817109289074 1 rs17082970 rs2131002 30.251 0 PPEF2 chr4:29179713-11703830715513 87858595 1 rs1507441 rs1068807 71.6 0 PPEF2chr4:69590353-190872778 23145 121282426 3 rs293433 rs12646565 315.633 0PPEF2 chr1:1005806-105612342 19173 104606537 3 rs3934834 rs158463344.152 0 PPIH chr1:2006108-109527861 22130 107521754 3 rs2254669rs839879 162.269 0 PPIH chr14:26898958-104436931 17396 77537974 1rs1245195 rs11851097 57.233 0 PPM1A chr14:19917123-65327288 1028645410166 3 rs2495197 rs9323455 270.291 0 PPM1A chr14:80818058-1053485525492 24530495 3 rs6574553 rs2028416 15.874 0 PPP1R13Bchr14:26898958-104436931 17396 77537974 1 rs1245195 rs11851097 57.233 0PPP1R13B chr14:103847274-107188715 464 3341442 3 rs8020912 rs4280141104.64 0 PPP1R13B chr19:31569338-53780966 3788 22211629 1 rs2867544rs10407424 33.9 0 PPP1R14A chr19:288246-59110628 11009 58822383 3rs10409452 cnvi0009466 100.582 0 PPP1R14A chr19:31569338-53780966 378822211629 1 rs2867544 rs10407424 33.9 0 PPP2R1A chr19:52365654-54612628524 2246975 3 rs4514789 rs254262 59.657 0 PPP2R1Achr19:43257015-55294329 −7309 12037315 3 rs7246152 rs2569676 21.402 0PPP2R1A chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466100.582 0 PPP2R1A chr4:31222833-180548076 24457 149325244 1 rs7662351rs3849606 36.162 0 PPP3CA chr4:89603085-113991140 4018 24388056 3rs2972038 rs2279892 28.405 0 PPP3CA chr4:68173959-185767176 20235117593218 1 rs6552083 rs4862428 61.893 0 PPP3CA chr4:102178963-10240710919 228147 1 rs2850965 rs1863575 20.006 0 PPP3CA chr4:22401728-18860885728456 166207130 1 rs4697297 rs7687115 35.717 0 PPP3CAchr4:63726348-173015421 19817 109289074 1 rs17082970 rs2131002 30.251 0PPP3CA chr4:29179713-117038307 15513 87858595 1 rs1507441 rs1068807 71.60 PPP3CA chr4:69590353-190872778 23145 121282426 3 rs293433 rs12646565315.633 0 PPP3CA chr10:7188484-134205354 26672 127016871 1 rs1977295rs3923858 50.772 0 PPYR1 chr10:734229-69155636 14859 68421408 3rs1769236 rs2394375 72.104 0 PPYR1 chr10:46990728-47670202 87 679475 3rs7898282 rs12774812 148.333 0 PPYR1 chr10:46928388-47703613 103 7752263 rs7915055 rs4128664 211.228 0 PPYR1 chr10:47020220-47121726 9 101507 3rs4434936 rs6599598 18.769 0 PPYR1 chr10:46565132-49372024 398 2806893 3cnvi0015902 rs1111323 101.866 0 PPYR1 chr10:46961667-47703613 102 7419473 rs506372 rs4128664 61.091 0 PPYR1 chr10:47020220-47121726 9 101507 3rs4434936 rs6599598 15.584 0 PPYR1 chr10:46928388-52437780 1060 55093933 rs7915055 rs3001866 425.826 0 PPYR1 chr10:46691610-49246290 3672554681 3 rs2611445 rs1058785 74.315 0 PPYR1 chr10:46961667-47748912 104787246 3 rs506372 rs3013867 198.089 0 PPYR1 chr10:46928388-49059803 3332131416 3 rs7915055 rs4926101 51.799 0 PPYR1 chr10:46961667-47670202 88708536 3 rs506372 rs12774812 112.263 0 PPYR1 chr10:46961667-47748912 104787246 3 rs506372 rs3013867 124.114 0 PPYR1 chr10:46961667-49059803 3322098137 3 rs506372 rs4926101 252.089 0 PPYR1 chr10:47020220-47748912 102728693 3 rs4434936 rs3013867 217.507 0 PPYR1 chr10:46928388-49059803 3332131416 3 rs7915055 rs4926101 32.715 0 PPYR1 chr10:46961667-47748912 104787246 3 rs506372 rs3013867 139.094 0 PPYR1 chr10:46961667-47748912 104787246 3 rs506372 rs3013867 156.17 0 PPYR1 chr10:46769902-49047366 3482277465 1 cnvi0015917 cnvi0022253 48.528 0 PPYR1 chr10:46928388-470889689 160581 3 rs7915055 rs28702886 7.159 0 PPYR1 chr10:46961667-47748912104 787246 3 rs506372 rs3013867 97.267 0 PPYR1 chr10:46928388-4714911713 220730 3 rs7915055 rs4979753 20.682 0 PPYR1 chr10:46961667-4712172611 160060 3 rs506372 rs6599598 15.813 0 PPYR1 chr10:46961667-47748912104 787246 3 rs506372 rs3013867 124.017 0 PPYR1 chr10:46961667-470889688 127302 3 rs506372 rs28702886 21.05 0 PPYR1 chr10:46928388-49201964 3342273577 3 rs7915055 rs3013936 217.279 0 PPYR1 chr10:47041592-47164700 10123109 3 rs4593952 cnvi0019847 26.227 0 PPYR1 chr10:47020220-47121726 9101507 3 rs4434936 rs6599598 19.555 0 PPYR1 chr10:46928388-47121726 12193339 3 rs7915055 rs6599598 17.084 0 PPYR1 chr10:46961667-47748912 104787246 3 rs506372 rs3013867 72.604 0 PPYR1 chr10:46961667-47149117 12187451 3 rs506372 rs4979753 25.412 0 PPYR1 chr10:46961667-47099529 9137863 3 rs506372 rs4481963 14.479 0 PPYR1 chr10:46961667-47099529 9137863 3 rs506372 rs4481963 5.516 0 PPYR1 chr10:46961667-47121726 11160060 3 rs506372 rs6599598 17.522 0 PPYR1 chr10:46961667-47121726 11160060 3 rs506372 rs6599598 8.359 0 PPYR1 chr10:46928388-47748912 105820525 3 rs7915055 rs3013867 115.204 0 PPYR1 chr10:46961667-47121726 11160060 3 rs506372 rs6599598 21.039 0 PPYR1 chr10:47020220-47121726 9101507 3 rs4434936 rs6599598 11.163 0 PPYR1 chr10:46892172-47149117 15256946 3 cnvi0015924 rs4979753 35.314 0 PPYR1 chr10:46961667-47121726 11160060 3 rs506372 rs6599598 13.506 0 PPYR1 chr10:46961667-47121726 11160060 3 rs506372 rs6599598 21.312 0 PPYR1 chr10:46961667-47121726 11160060 3 rs506372 rs6599598 15.771 0 PPYR1 chr10:46990728-47748912 103758185 3 rs7898282 rs3013867 14.294 0 PPYR1 chr10:46961667-47748912 104787246 3 rs506372 rs3013867 164.218 0 PPYR1 chr10:46961667-47121726 11160060 3 rs506372 rs6599598 12.386 0 PPYR1 chr10:46961667-47121726 11160060 3 rs506372 rs6599598 11.748 0 PPYR1 chr10:46990728-47703613 101712886 3 rs7898282 rs4128664 119.651 0 PPYR1 chr10:88874-53366180 1285353277307 3 cnvi0015449 rs10998465 319.021 0 PPYR1 chr1:1005806-10561234219173 104606537 3 rs3934834 rs1584633 44.152 0 PRDX1chr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879 162.269 0PRDX1 chr11:42185849-126756938 15451 84571090 1 rs4375424 rs1075035636.99 0 PRG2 chr11:21723471-131521797 20508 109798327 1 rs11828478rs2512898 27.565 0 PRG2 chr11:23168804-106781292 16332 83612489 1rs11027007 rs7103285 49.747 0 PRG2 chr11:211482-66910826 13813 666993453 rs2293168 rs4375446 30.249 0 PRG2 chr19:266034-18061509 3100 177954763 rs2312724 rs7250332 19.51 0 PRKACA chr19:288246-59110628 1100958822383 3 rs10409452 cnvi0009466 100.582 0 PRKACAchr17:44458950-81047708 −8195 36588759 1 cnvi0016818 rs35680231 35.591 0PRKCA chr17:21685812-67308196 12365 45622385 1 rs34864328 rs1768685250.018 0 PRKCA chr17:61016209-66240093 890 5223885 1 rs1588368rs11658645 37.309 0 PRKCA chr17:59314257-66170047 1135 6855791 1rs758467 rs4558468 71.379 0 PRKCA chr17:62662507-81047708 −1149618385202 3 rs6504246 rs35680231 56.048 0 PRKCA chr3:13878889-14973733024723 135858442 1 rs12634112 rs2007869 55.663 0 PRKCDchr3:53033796-53274602 48 240807 3 rs12635298 rs2306569 0.826 0 PRKCDchr3:33409611-170735099 23775 137325489 1 rs3915062 rs11924032 26.867 0PRKCD chr3:179527-114630641 23879 114451115 3 rs4684741 rs1587972207.852 0 PRKCD chr19:53533161-54743217 317 1210057 3 rs2870438rs17239607 11.393 0 PRKCG chr19:52365654-54612628 524 2246975 3rs4514789 rs254262 59.657 0 PRKCG chr19:43257015-55294329 −7309 120373153 rs7246152 rs2569676 21.402 0 PRKCG chr19:288246-59110628 1100958822383 3 rs10409452 cnvi0009466 100.582 0 PRKCGchr3:166503411-190576461 4854 24073051 1 rs11925936 rs1393054 31.414 0PRKCI chr3:145967173-173899890 4912 27932718 3 rs9863647 rs761899746.396 0 PRKCI chr3:33409611-170735099 23775 137325489 1 rs3915062rs11924032 26.867 0 PRKCI chr3:102240202-195550366 17318 93310165 1rs1620217 rs11711870 41.031 0 PRKCI chr3:164955741-191742104 574126786364 1 rs2218152 rs9835019 52.438 0 PRKCI chr3:83075971-19693565721465 113859687 1 rs9872858 rs34729751 44.35 0 PRKCIchr3:114889454-177826047 12700 62936594 3 rs6795297 rs7628308 102.526 0PRKCI chr1:1005806-105612342 19173 104606537 3 rs3934834 rs158463344.152 0 PRKCZ chr1:1229770-2378046 167 1148277 1 rs6669227 rs3424177344.903 0 PRKCZ chr1:2113565-2379248 78 265684 1 rs262688 rs1158154872.771 0 PRKCZ chr1:1911558-2218100 55 306543 1 rs28645431 rs1211947041.757 0 PRKCZ chr1:1201632-2182470 109 980839 1 rs12402622 rs26051227.748 0 PRKCZ chr1:1254841-3342804 386 2087964 1 rs10907179 rs87017139.259 0 PRKCZ chr1:2006108-109527861 22130 107521754 3 rs2254669rs839879 162.269 0 PRKCZ chr10:7188484-134205354 26672 127016871 1rs1977295 rs3923858 50.772 0 PRKG1 chr10:734229-69155636 14859 684214083 rs1769236 rs2394375 72.104 0 PRKG1 chr10:53679060-53826682 70 147623 1rs1937683 rs10824010 27.553 0 PRKG1 chr10:53602190-135522754 1916781920565 3 rs12247820 rs10909028 139.373 0 PRKG1 chr10:88874-5336618012853 53277307 3 cnvi0015449 rs10998465 319.021 0 PRKG1chr10:7188484-134205354 26672 127016871 1 rs1977295 rs3923858 50.772 0PRLHR chr10:58385643-124973104 13625 66587462 1 rs7920235 rs1766330436.18 0 PRLHR chr10:57671424-133349223 16243 75677800 1 rs11005106rs4301710 37.114 0 PRLHR chr10:53602190-135522754 19167 81920565 3rs12247820 rs10909028 139.373 0 PRLHR chr19:31569338-53780966 378822211629 1 rs2867544 rs10407424 33.9 0 PRMT1 chr19:43257015-55294329−7309 12037315 3 rs7246152 rs2569676 21.402 0 PRMT1chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466 100.582 0PRMT1 chr17:44458950-81047708 −8195 36588759 1 cnvi0016818 rs3568023135.591 0 PRPSAP1 chr17:62662507-81047708 −11496 18385202 3 rs6504246rs35680231 56.048 0 PRPSAP1 chr9:1989033-107532317 18263 105543285 1rs7864828 rs10820726 39.824 0 PSAT1 chr9:2522475-140068342 25719137545868 3 rs10966757 rs4074426 93.386 0 PSAT1 chr9:33180228-13200379214691 98823565 1 rs7854765 rs9408988 28.69 0 PSAT1 chr9:46587-9433529017484 94288704 3 rs10814410 rs9409606 762.393 0 PSAT1chr14:26898958-104436931 17396 77537974 1 rs1245195 rs11851097 57.233 0PSEN1 chr14:65405722-103799039 8979 38393318 3 rs11623705 rs11628472266.153 0 PSEN1 chr1:64114301-245591329 29842 181477029 1 rs11208257rs1173850 37.504 0 PSEN2 chr1:178626526-244159143 13064 65532618 3rs2761477 rs479338 11.373 0 PSEN2 chr1:75098453-243531649 27360168433197 1 rs12117493 rs10927002 32.113 0 PSEN2chr1:188850774-235423607 10060 46572834 1 rs16829466 rs12409696 43.25 0PSEN2 chr1:191875752-235423607 9517 43547856 1 rs9427811 rs1240969662.01 0 PSEN2 chr1:189128124-227340790 7927 38212667 1 rs7515205rs12752546 167.428 0 PSEN2 chr1:174219398-247422297 15986 73202900 1rs16846809 rs4642922 35.258 0 PSEN2 chr1:226423572-227452700 215 10291291 rs6605032 rs1969230 24.875 0 PSEN2 chr1:226536645-236803753 260010267109 3 rs874583 rs10925178 100.109 0 PSEN2 chr19:31569338-537809663788 22211629 1 rs2867544 rs10407424 33.9 0 PSG9 chr19:43257015-55294329−7309 12037315 3 rs7246152 rs2569676 21.402 0 PSG9chr19:43318068-43774853 60 456786 3 rs10410612 rs11672322 88.945 0 PSG9chr19:43663086-43840088 54 177003 1 rs12460930 rs2159134 65.237 0 PSG9chr19:43465816-43774853 41 309038 3 rs17345014 rs11672322 25.803 0 PSG9chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466 100.582 0PSG9 chr11:345515-17408630 4247 17063116 3 rs11246094 rs5215 30.474 0PSMA1 chr11:211482-66910826 13813 66699345 3 rs2293168 rs4375446 30.2490 PSMA1 chr7:11855636-156148608 26852 144292973 1 rs6947930 rs694501636.446 0 PSMA2 chr7:7724805-53845684 11772 46120880 3 rs10263415rs6948633 42.007 0 PSMA2 chr7:8872727-156383359 27773 147510633 1rs917038 rs878717 32.336 0 PSMA2 chr7:8794418-119068130 23484 1102737131 rs2189621 rs6977904 70.867 0 PSMA2 chr7:60392-84158180 19095 840977893 rs12670102 rs2715048 208.308 0 PSMA2 chr14:80818058-105348552 549224530495 3 rs6574553 rs2028416 15.874 0 PSMC1 chr14:90716051-90836365 22120315 1 rs11159958 rs11626241 15.241 0 PSMC1 chr14:26898958-10443693117396 77537974 1 rs1245195 rs11851097 57.233 0 PSMC1chr14:65405722-103799039 8979 38393318 3 rs11623705 rs11628472 266.153 0PSMC1 chr2:231927569-232035793 10 108225 1 rs3815844 rs2032953 14.229 0PSMD1 chr2:34870277-241929621 37755 207059345 3 rs13422005 rs1020527646.946 0 PSMD1 chr2:38101137-241482099 36812 203380963 1 rs879321rs7576043 52.099 0 PSMD1 chr2:193255360-242529978 10289 49274619 3rs1351905 cnvi0010399 93.244 0 PSMD1 chr17:21685812-67308196 1236545622385 1 rs34864328 rs17686852 50.018 0 PSMD11 chr17:26648492-589550845831 32306593 3 rs1981512 rs8068776 15.642 0 PSMD11chr11:211482-66910826 13813 66699345 3 rs2293168 rs4375446 30.249 0PSMD13 chr3:166503411-190576461 4854 24073051 1 rs11925936 rs139305431.414 0 PSMD2 chr3:102240202-195550366 17318 93310165 1 rs1620217rs11711870 41.031 0 PSMD2 chr3:164955741-191742104 5741 26786364 1rs2218152 rs9835019 52.438 0 PSMD2 chr3:83075971-196935657 21465113859687 1 rs9872858 rs34729751 44.35 0 PSMD2 chr3:177912894-1975514114129 19638518 3 rs9290640 rs1273562 185.507 0 PSMD2chr3:13878889-149737330 24723 135858442 1 rs12634112 rs2007869 55.663 0PSMD6 chr3:33409611-170735099 23775 137325489 1 rs3915062 rs1192403226.867 0 PSMD6 chr3:179527-114630641 23879 114451115 3 rs4684741rs1587972 207.852 0 PSMD6 chr14:22513116-32242747 1997 9729632 1rs4982546 rs17098165 31.673 0 PSME1 chr14:22349686-25012115 755 26624301 rs994827 rs7142675 27.602 0 PSME1 chr14:19917123-65327288 1028645410166 3 rs2495197 rs9323455 270.291 0 PSME1 chr13:20211434-2037744813 166015 3 rs11617480 rs9508901 22.015 0 PSPC1 chr13:19584477-8120408813265 61619612 3 rs1334954 rs1176297 22.162 0 PSPC1chr13:20338643-20442879 14 104237 1 rs4769903 rs9552026 14.251 0 PSPC1chr13:19771535-20664819 93 893285 1 rs9511997 rs9509033 30.263 0 PSPC1chr13:19121741-63373781 10326 44252041 3 rs9578050 rs9539575 82.761 0PSPC1 chr19:31569338-53780966 3788 22211629 1 rs2867544 rs10407424 33.90 PTGIR chr19:43257015-55294329 −7309 12037315 3 rs7246152 rs256967621.402 0 PTGIR chr19:288246-59110628 11009 58822383 3 rs10409452cnvi0009466 100.582 0 PTGIR chr6:26922906-93578359 19746 66655454 1rs9348738 rs9363009 27.061 0 PTP4A1 chr6:62697746-94090076 6391 313923311 rs6455128 rs3799807 108.85 0 PTP4A1 chr6:62697746-67410283 787 47125381 rs6455128 rs9294717 74.311 0 PTP4A1 chr6:32968276-73449742 1544240481467 3 rs2395300 rs4235869 415.87 0 PTP4A1 chr8:30757798-14275096920699 111993172 1 rs10101203 rs6421025 34.223 0 PTP4A3chr8:60424884-145286483 17030 84861600 3 rs1401422 rs9720889 8.858 0PTP4A3 chr8:23218101-146274708 23020 123056608 1 rs7010362 rs782272638.828 0 PTP4A3 chr8:66822030-144791126 16557 77969097 3 rs6472235rs10100154 251.068 0 PTP4A3 chr12:10113083-116370432 20594 106257350 1rs2012504 rs7958254 35.157 0 PTPN11 chr12:59512781-127744939 1346968232159 3 rs908394 rs7966946 20.62 0 PTPN11 chr12:10020267-12986629323654 119846027 1 rs1597097 rs2170504 45.428 0 PTPN11chr12:112610714-133708729 5366 21098016 3 rs11066188 rs11147249 695.45 0PTPN11 chr12:50855195-133778796 17748 82923602 3 rs4351895 rs7975069159.589 0 PTPN11 chr7:11855636-156148608 26852 144292973 1 rs6947930rs6945016 36.446 0 PTPN12 chr7:8872727-156383359 27773 147510633 1rs917038 rs878717 32.336 0 PTPN12 chr7:8794418-119068130 23484 1102737131 rs2189621 rs6977904 70.867 0 PTPN12 chr7:60392-84158180 19095 840977893 rs12670102 rs2715048 208.308 0 PTPN12 chr12:207886-50770291 1156550562406 3 rs868249 rs4477515 43.892 0 PTPN6 chr20:2882947-3055513 33172567 1 rs6138938 rs4813627 15.318 0 PTPRA chr20:236802-54845796 1264654608995 3 rs448294 rs6064362 286.151 0 PTPRA chr11:42185849-12675693815451 84571090 1 rs4375424 rs10750356 36.99 0 PTPRJchr11:21723471-131521797 20508 109798327 1 rs11828478 rs2512898 27.565 0PTPRJ chr11:23168804-106781292 16332 83612489 1 rs11027007 rs710328549.747 0 PTPRJ chr11:211482-66910826 13813 66699345 3 rs2293168rs4375446 30.249 0 PTPRJ chr19:266034-18061509 3100 17795476 3 rs2312724rs7250332 19.51 0 PTPRS chr19:288246-59110628 11009 58822383 3rs10409452 cnvi0009466 100.582 0 PTPRS chr1:1005806-105612342 19173104606537 3 rs3934834 rs1584633 44.152 0 PTPRU chr1:2006108-10952786122130 107521754 3 rs2254669 rs839879 162.269 0 PTPRUchr12:59512781-127744939 13469 68232159 3 rs908394 rs7966946 20.62 0 PXNchr12:10020267-129866293 23654 119846027 1 rs1597097 rs2170504 45.428 0PXN chr12:112610714-133708729 5366 21098016 3 rs11066188 rs11147249695.45 0 PXN chr12:50855195-133778796 17748 82923602 3 rs4351895rs7975069 159.589 0 PXN chr14:26898958-104436931 17396 77537974 1rs1245195 rs11851097 57.233 0 PYGL chr14:19917123-65327288 1028645410166 3 rs2495197 rs9323455 270.291 0 PYGL chr11:42185849-12675693815451 84571090 1 rs4375424 rs10750356 36.99 0 PYGMchr11:21723471-131521797 20508 109798327 1 rs11828478 rs2512898 27.565 0PYGM chr11:23168804-106781292 16332 83612489 1 rs11027007 rs710328549.747 0 PYGM chr11:211482-66910826 13813 66699345 3 rs2293168 rs437544630.249 0 PYGM chr17:44458950-81047708 −8195 36588759 1 cnvi0016818rs35680231 35.591 0 QRICH2 chr17:62662507-81047708 −11496 18385202 3rs6504246 rs35680231 56.048 0 QRICH2 chr15:29325866-56044189 530326718324 3 rs4779705 rs2414433 21.732 0 RAB27A chr15:51688996-10239806011030 50709065 1 rs2459396 rs7181527 36.939 0 RAB27Achr15:53775670-96810867 9973 43035198 1 rs657495 rs2589238 49.204 0RAB27A chr15:43392075-66051345 4963 22659271 3 rs8028608 rs649453759.842 0 RAB27A chr1:1005806-105612342 19173 104606537 3 rs3934834rs1584633 44.152 0 RAB3B chr1:2006108-109527861 22130 107521754 3rs2254669 rs839879 162.269 0 RAB3B chr3:13878889-149737330 24723135858442 1 rs12634112 rs2007869 55.663 0 RAB5A chr3:179527-11463064123879 114451115 3 rs4684741 rs1587972 207.852 0 RAB5Achr15:51688996-102398060 11030 50709065 1 rs2459396 rs7181527 36.939 0RAB8B chr15:53775670-96810867 9973 43035198 1 rs657495 rs2589238 49.2040 RAB8B chr15:43392075-66051345 4963 22659271 3 rs8028608 rs649453759.842 0 RAB8B chr19:42462788-42637232 14 174445 1 rs1075728 rs382670519.764 0 RABAC1 chr19:31569338-53780966 3788 22211629 1 rs2867544rs10407424 33.9 0 RABAC1 chr19:288246-59110628 11009 58822383 3rs10409452 cnvi0009466 100.582 0 RABAC1 chr7:60392-84158180 1909584097789 3 rs12670102 rs2715048 208.308 0 RAC1 chr12:10113083-11637043220594 106257350 1 rs2012504 rs7958254 35.157 0 RACGAP1chr12:10020267-129866293 23654 119846027 1 rs1597097 rs2170504 45.428 0RACGAP1 chr12:39967134-84174413 8879 44207280 1 rs11172661 rs1111603939.568 0 RACGAP1 chr12:207886-50770291 11565 50562406 3 rs868249rs4477515 43.892 0 RACGAP1 chr3:179527-114630641 23879 114451115 3rs4684741 rs1587972 207.852 0 RAF1 chr7:11855636-156148608 26852144292973 1 rs6947930 rs6945016 36.446 0 RALA chr7:7724805-5384568411772 46120880 3 rs10263415 rs6948633 42.007 0 RALAchr7:8872727-156383359 27773 147510633 1 rs917038 rs878717 32.336 0 RALAchr7:8794418-119068130 23484 110273713 1 rs2189621 rs6977904 70.867 0RALA chr7:60392-84158180 19095 84097789 3 rs12670102 rs2715048 208.308 0RALA chr2:12056323-227979775 39094 215923453 1 rs966391 rs1922020 31.3840 RALB chr2:34870277-241929621 37755 207059345 3 rs13422005 rs1020527646.946 0 RALB chr2:38101137-241482099 36812 203380963 1 rs879321rs7576043 52.099 0 RALB chr2:77041264-194763754 21140 117722491 1rs2102827 rs16835406 94.091 0 RALB chr2:83383702-175194550 1629191810849 3 rs12469609 rs11891208 154.4 0 RALB chr22:19601238-20241160201 639923 3 rs8135473 rs1567871 11.687 0 RANBP1 chr22:18907405-21465780610 2558376 3 rs9618419 rs11703181 1799.961 0 RANBP1chr22:18877787-21462353 613 2584567 1 rs2543958 rs140392 772.063 0RANBP1 chr22:18877787-21462353 512 2584567 1 rs2543958 rs140392 1596.6870 RANBP1 chr22:16871137-51184393 9245 34313257 3 rs131538 rs7284680209.79 0 RANBP1 chr13:36707502-103656104 13622 66948603 1 rs3827890rs1952590 38.726 0 RAP2A chr13:87746779-104646511 3908 16899733 3rs9301986 rs17414312 27.724 0 RAP2A chr13:23742931-115064482 1982991321552 1 rs4770401 rs7999630 44.074 0 RAP2A chr13:90018392-1051908024136 15172411 1 rs7335222 rs11841281 42.954 0 RAP2Achr13:65193124-115053155 12025 49860032 3 rs9598811 rs7327124 78.057 0RAP2A chr3:13878889-149737330 24723 135858442 1 rs12634112 rs200786955.663 0 RASSF1 chr3:33409611-170735099 23775 137325489 1 rs3915062rs11924032 26.867 0 RASSF1 chr3:179527-114630641 23879 114451115 3rs4684741 rs1587972 207.852 0 RASSF1 chr14:22513116-32242747 19979729632 1 rs4982546 rs17098165 31.673 0 RBM23 chr14:22513116-24480333636 1967218 1 rs4982546 rs4982844 28.02 0 RBM23 chr14:22349686-25012115755 2662430 1 rs994827 rs7142675 27.602 0 RBM23 chr14:19917123-6532728810286 45410166 3 rs2495197 rs9323455 270.291 0 RBM23chr3:13878889-149737330 24723 135858442 1 rs12634112 rs2007869 55.663 0RBM5 chr3:33409611-170735099 23775 137325489 1 rs3915062 rs1192403226.867 0 RBM5 chr3:50028385-50132131 12 103747 1 rs4688758 rs262483412.939 0 RBM5 chr3:179527-114630641 23879 114451115 3 rs4684741rs1587972 207.852 0 RBM5 chr1:1005806-105612342 19173 104606537 3rs3934834 rs1584633 44.152 0 RCC1 chr1:2006108-109527861 22130 1075217543 rs2254669 rs839879 162.269 0 RCC1 chr1:1005806-105612342 19173104606537 3 rs3934834 rs1584633 44.152 0 RCC2 chr1:2006108-10952786122130 107521754 3 rs2254669 rs839879 162.269 0 RCC2chr17:108420-26610769 5548 26502350 3 rs12452527 rs658591 82.699 0 RCVRNchr2:12056323-227979775 39094 215923453 1 rs966391 rs1922020 31.384 0REL chr2:34870277-241929621 37755 207059345 3 rs13422005 rs1020527646.946 0 REL chr2:38101137-241482099 36812 203380963 1 rs879321rs7576043 52.099 0 REL chr2:41212010-82396211 9721 41184202 3 rs12614285rs934310 396.396 0 REL chr11:42185849-126756938 15451 84571090 1rs4375424 rs10750356 36.99 0 RELA chr11:21723471-131521797 20508109798327 1 rs11828478 rs2512898 27.565 0 RELA chr11:23168804-10678129216332 83612489 1 rs11027007 rs7103285 49.747 0 RELAchr11:211482-66910826 13813 66699345 3 rs2293168 rs4375446 30.249 0 RELAchr19:31569338-53780966 3788 22211629 1 rs2867544 rs10407424 33.9 0 RELBchr19:43257015-55294329 −7309 12037315 3 rs7246152 rs2569676 21.402 0RELB chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466100.582 0 RELB chr12:59512781-127744939 13469 68232159 3 rs908394rs7966946 20.62 0 RFC5 chr12:10020267-129866293 23654 119846027 1rs1597097 rs2170504 45.428 0 RFC5 chr12:112610714-133708729 536621098016 3 rs11066188 rs11147249 695.45 0 RFC5 chr12:50855195-13377879617748 82923602 3 rs4351895 rs7975069 159.589 0 RFC5chr10:7188484-134205354 26672 127016871 1 rs1977295 rs3923858 50.772 0RGS10 chr10:58385643-124973104 13625 66587462 1 rs7920235 rs1766330436.18 0 RGS10 chr10:57671424-133349223 16243 75677800 1 rs11005106rs4301710 37.114 0 RGS10 chr10:53602190-135522754 19167 81920565 3rs12247820 rs10909028 139.373 0 RGS10 chr4:179131-68998153 1349568819023 3 rs7686948 rs7687396 625.133 0 RGS12 chr1:64114301-24559132929842 181477029 1 rs11208257 rs1173850 37.504 0 RGS13chr1:178626526-244159143 13064 65532618 3 rs2761477 rs479338 11.373 0RGS13 chr1:75098453-243531649 27360 168433197 1 rs12117493 rs1092700232.113 0 RGS13 chr1:188850774-235423607 10060 46572834 1 rs16829466rs12409696 43.25 0 RGS13 chr1:191875752-235423607 9517 43547856 1rs9427811 rs12409696 62.01 0 RGS13 chr1:189128124-227340790 792738212667 1 rs7515205 rs12752546 167.428 0 RGS13 chr1:174219398-24742229715986 73202900 1 rs16846809 rs4642922 35.258 0 RGS13chr1:109645793-194560463 12025 84914671 3 cnvi0008281 rs10921616 63.1210 RGS13 chr5:161172541-179954615 4271 18782075 3 rs4921415 rs100594336.291 0 RGS14 chr5:4872310-180709915 35876 175837606 3 rs816467rs10071993 179.394 0 RGS14 chr1:64114301-245591329 29842 181477029 1rs11208257 rs1173850 37.504 0 RGS16 chr1:178626526-244159143 1306465532618 3 rs2761477 rs479338 11.373 0 RGS16 chr1:75098453-24353164927360 168433197 1 rs12117493 rs10927002 32.113 0 RGS16chr1:79710545-188898319 17303 109187775 1 rs417181 rs16829637 45.89 0RGS16 chr1:174219398-247422297 15986 73202900 1 rs16846809 rs464292235.258 0 RGS16 chr1:109645793-194560463 12025 84914671 3 cnvi0008281rs10921616 63.121 0 RGS16 chr1:64114301-245591329 29842 181477029 1rs11208257 rs1173850 37.504 0 RGS18 chr1:178626526-244159143 1306465532618 3 rs2761477 rs479338 11.373 0 RGS18 chr1:75098453-24353164927360 168433197 1 rs12117493 rs10927002 32.113 0 RGS18chr1:191636974-191875752 41 238779 1 rs12118448 rs9427811 14.635 251840RGS18 chr1:191772972-192059022 49 286051 1 rs9427526 rs10921078 19.19968570 RGS18 chr1:188850774-235423607 10060 46572834 1 rs16829466rs12409696 43.25 0 RGS18 chr1:191875752-235423607 9517 43547856 1rs9427811 rs12409696 62.01 0 RGS18 chr1:189128124-227340790 792738212667 1 rs7515205 rs12752546 167.428 0 RGS18 chr1:174219398-24742229715986 73202900 1 rs16846809 rs4642922 35.258 0 RGS18chr1:191640296-191788524 25 148229 1 rs10920990 rs17402518 14.942 339068RGS18 chr1:109645793-194560463 12025 84914671 3 cnvi0008281 rs1092161663.121 0 RGS18 chr20:54870769-62912463 2390 8041695 3 rs6069696rs6062363 249.708 0 RGS19 chr1:64114301-245591329 29842 181477029 1rs11208257 rs1173850 37.504 0 RGS2 chr1:178626526-244159143 1306465532618 3 rs2761477 rs479338 11.373 0 RGS2 chr1:75098453-24353164927360 168433197 1 rs12117493 rs10927002 32.113 0 RGS2chr1:188850774-235423607 10060 46572834 1 rs16829466 rs12409696 43.25 0RGS2 chr1:191875752-235423607 9517 43547856 1 rs9427811 rs12409696 62.010 RGS2 chr1:189128124-227340790 7927 38212667 1 rs7515205 rs12752546167.428 0 RGS2 chr1:174219398-247422297 15986 73202900 1 rs16846809rs4642922 35.258 0 RGS2 chr1:109645793-194560463 12025 84914671 3cnvi0008281 rs10921616 63.121 0 RGS2 chr1:64114301-245591329 29842181477029 1 rs11208257 rs1173850 37.504 0 RGS4 chr1:75098453-24353164927360 168433197 1 rs12117493 rs10927002 32.113 0 RGS4chr1:79710545-188898319 17303 109187775 1 rs417181 rs16829637 45.89 0RGS4 chr1:162920811-163351718 112 430908 1 rs2343490 rs3010344 311.918 0RGS4 chr1:109645793-194560463 12025 84914671 3 cnvi0008281 rs1092161663.121 0 RGS4 chr1:64114301-245591329 29842 181477029 1 rs11208257rs1173850 37.504 0 RGS5 chr1:75098453-243531649 27360 168433197 1rs12117493 rs10927002 32.113 0 RGS5 chr1:79710545-188898319 17303109187775 1 rs417181 rs16829637 45.89 0 RGS5 chr1:162920811-163351718112 430908 1 rs2343490 rs3010344 311.918 0 RGS5 chr1:109645793-19456046312025 84914671 3 cnvi0008281 rs10921616 63.121 0 RGS5chr1:64114301-245591329 29842 181477029 1 rs11208257 rs1173850 37.504 0RGS7 chr1:178626526-244159143 13064 65532618 3 rs2761477 rs479338 11.3730 RGS7 chr1:75098453-243531649 27360 168433197 1 rs12117493 rs1092700232.113 0 RGS7 chr1:238655362-242087644 1078 3432283 3 rs2392861rs4658565 806.215 0 RGS7 chr1:174219398-247422297 15986 73202900 1rs16846809 rs4642922 35.258 0 RGS7 chr1:236848751-249219320 329312370570 3 rs819666 cnvi0018731 920.725 0 RGS7 chr3:13878889-14973733024723 135858442 1 rs12634112 rs2007869 55.663 0 RHOchr3:33409611-170735099 23775 137325489 1 rs3915062 rs11924032 26.867 0RHO chr3:102240202-195550366 17318 93310165 1 rs1620217 rs1171187041.031 0 RHO chr3:103140700-144883172 8539 41742473 1 rs4314176rs6797159 44.122 0 RHO chr3:83075971-196935657 21465 113859687 1rs9872858 rs34729751 44.35 0 RHO chr3:114889454-177826047 12700 629365943 rs6795297 rs7628308 102.526 0 RHO chr3:13878889-149737330 24723135858442 1 rs12634112 rs2007869 55.663 0 RHOA chr3:33409611-17073509923775 137325489 1 rs3915062 rs11924032 26.867 0 RHOAchr3:179527-114630641 23879 114451115 3 rs4684741 rs1587972 207.852 0RHOA chr4:31222833-180548076 24457 149325244 1 rs7662351 rs384960636.162 0 RHOH chr4:39472311-63464732 3456 23992422 3 rs2687975 rs4403080120.672 0 RHOH chr4:22401728-188608857 28456 166207130 1 rs4697297rs7687115 35.717 0 RHOH chr4:29179713-117038307 15513 87858595 1rs1507441 rs1068807 71.6 0 RHOH chr4:179131-68998153 13495 68819023 3rs7686948 rs7687396 625.133 0 RHOH chr11:211482-66910826 13813 666993453 rs2293168 rs4375446 30.249 0 RIC8A chr12:10113083-116370432 20594106257350 1 rs2012504 rs7958254 35.157 0 RIC8B chr12:59512781-12774493913469 68232159 3 rs908394 rs7966946 20.62 0 RIC8Bchr12:10020267-129866293 23654 119846027 1 rs1597097 rs2170504 45.428 0RIC8B chr12:50855195-133778796 17748 82923602 3 rs4351895 rs7975069159.589 0 RIC8B chr2:12056323-227979775 39094 215923453 1 rs966391rs1922020 31.384 0 RIF1 chr2:34870277-241929621 37755 207059345 3rs13422005 rs10205276 46.946 0 RIF1 chr2:38101137-241482099 36812203380963 1 rs879321 rs7576043 52.099 0 RIF1 chr2:77041264-19476375421140 117722491 1 rs2102827 rs16835406 94.091 0 RIF1chr2:83383702-175194550 16291 91810849 3 rs12469609 rs11891208 154.4 0RIF1 chr18:1583633-58142042 11490 56558410 3 rs9945988 rs1560399 3.736 0RIOK3 chr18:10274-30780701 6393 30770428 3 cnvi0008694 rs271534 338.7770 RIOK3 chr6:2681610-31453618 81 28772009 3 rs1131896 rs9267212 428.1770 RIPK1 chr6:1171596-29895228 43 28723633 0 rs3128994 rs9259831 53.123 0RIPK1 chr6:1171596-29899147 47 28727552 0 rs3128994 rs2394704 80.695 0RIPK1 chr6:1177990-29899147 39 28721158 0 rs2428530 rs2394704 44.381 0RIPK1 chr6:1175965-29899147 43 28723183 0 rs1611522 rs2394704 52.089 0RIPK1 chr6:2585208-31281876 −2 28696669 1 rs1634746 rs1634747 31.615 0RIPK1 chr6:1171596-29899147 47 28727552 0 rs3128994 rs2394704 63.572 0RIPK1 chr6:2584569-31286381 8 28701813 1 rs9391764 rs9265057 34.598 0RIPK1 chr6:2681610-31453618 81 28772009 3 rs1131896 rs9267212 390.234 0RIPK1 chr6:1171596-29892436 39 28720841 1 rs3128994 rs9259806 31.699 0RIPK1 chr6:1171596-29895228 43 28723633 0 rs3128994 rs9259831 43.568 0RIPK1 chr6:181089-30430875 1806 30249787 3 rs1535053 rs35792611 80.394 0RIPK1 chr8:89855372-90385087 98 529716 1 rs10504865 rs4458917 376.728384888 RIPK2 chr8:30757798-142750969 20699 111993172 1 rs10101203rs6421025 34.223 0 RIPK2 chr8:60424884-145286483 17030 84861600 3rs1401422 rs9720889 8.858 0 RIPK2 chr8:23218101-146274708 23020123056608 1 rs7010362 rs7822726 38.828 0 RIPK2 chr8:89499072-90708428202 1209357 3 rs7832310 rs6981616 372.548 61547 RIPK2chr8:76354446-113652365 6767 37297920 1 rs830783 rs16883889 127.023 0RIPK2 chr8:66822030-144791126 16557 77969097 3 rs6472235 rs10100154251.068 0 RIPK2 chr1:64114301-245591329 29842 181477029 1 rs11208257rs1173850 37.504 0 RIT1 chr1:75098453-243531649 27360 168433197 1rs12117493 rs10927002 32.113 0 RIT1 chr1:79710545-188898319 17303109187775 1 rs417181 rs16829637 45.89 0 RIT1 chr1:109645793-19456046312025 84914671 3 cnvi0008281 rs10921616 63.121 0 RIT1chr18:25388300-75954881 11539 50566582 1 rs11083228 rs1876021 39.235 0RIT2 chr18:1583633-58142042 11490 56558410 3 rs9945988 rs1560399 3.736 0RIT2 chr18:40271967-40472219 29 200253 1 rs1430916 rs656134 18.041 0RIT2 chr18:26550830-63713914 8241 37163085 1 rs16945738 rs2715304 17.9220 RIT2 chr18:26162481-67193217 9255 41030737 1 rs12458903 rs996190731.327 0 RIT2 chr18:30929223-44720664 2910 13791442 3 rs10775453rs9304343 535.348 0 RIT2 chr12:59512781-127744939 13469 68232159 3rs908394 rs7966946 20.62 0 RNF10 chr12:10020267-129866293 23654119846027 1 rs1597097 rs2170504 45.428 0 RNF10 chr12:112610714-1337087295366 21098016 3 rs11066188 rs11147249 695.45 0 RNF10chr12:50855195-133778796 17748 82923602 3 rs4351895 rs7975069 159.589 0RNF10 chr1:51547424-51719315 12 171892 1 rs11205809 rs6701572 18.548 0RNF11 chr1:1005806-105612342 19173 104606537 3 rs3934834 rs158463344.152 0 RNF11 chr1:2006108-109527861 22130 107521754 3 rs2254669rs839879 162.269 0 RNF11 chr1:1005806-105612342 19173 104606537 3rs3934834 rs1584633 44.152 0 RPA2 chr1:2006108-109527861 22130 1075217543 rs2254669 rs839879 162.269 0 RPA2 chr9:2522475-140068342 25719137545868 3 rs10966757 rs4074426 93.386 0 RPL12 chr9:33180228-13200379214691 98823565 1 rs7854765 rs9408988 28.69 0 RPL12chr9:100158052-139077343 9815 38919292 3 rs1020884 rs4842126 470.601 0RPL12 chr2:12056323-227979775 39094 215923453 1 rs966391 rs192202031.384 0 RPL37A chr2:34870277-241929621 37755 207059345 3 rs13422005rs10205276 46.946 0 RPL37A chr2:38101137-241482099 36812 203380963 1rs879321 rs7576043 52.099 0 RPL37A chr2:193255360-242529978 1028949274619 3 rs1351905 cnvi0010399 93.244 0 RPL37A chr11:345515-174086304247 17063116 3 rs11246094 rs5215 30.474 0 RPLP2 chr11:211482-6691082613813 66699345 3 rs2293168 rs4375446 30.249 0 RPLP2chr20:13712393-55093901 8218 41381509 1 rs6033810 rs6999 41.237 0 RPN2chr20:7869025-62424661 11941 54555637 3 rs2294306 rs6010652 9.732 0 RPN2chr20:4591715-58420336 11753 53828622 1 rs6139494 rs1416388 40.922 0RPN2 chr20:236802-54845796 12646 54608995 3 rs448294 rs6064362 286.151 0RPN2 chr5:84830796-171903310 16642 87072515 1 rs300657 rs10042482 42.2080 RPS14 chr5:57343495-171903310 21683 114559816 1 rs10940593 rs1004248261.169 0 RPS14 chr5:98442871-150317237 9828 51874367 1 rs1447379rs7710790 38.687 0 RPS14 chr5:4872310-180709915 35876 175837606 3rs816467 rs10071993 179.394 0 RPS14 chr16:59854720-89273883 760929419164 3 rs1373880 rs8046156 31.884 0 RRAD chr16:64107047-829207374544 18813691 1 rs2319723 rs918661 28.887 0 RRAD chr16:50219449-8954475610324 39325308 3 rs6500298 rs3803681 108.108 0 RRADchr11:3906740-4201641 55 294902 1 rs11600857 rs2044138 27.361 0 RRM1chr11:345515-17408630 4247 17063116 3 rs11246094 rs5215 30.474 0 RRM1chr11:211482-66910826 13813 66699345 3 rs2293168 rs4375446 30.249 0 RRM1chr2:12056323-227979775 39094 215923453 1 rs966391 rs1922020 31.384 0RTN4 chr2:34870277-241929621 37755 207059345 3 rs13422005 rs1020527646.946 0 RTN4 chr2:38101137-241482099 36812 203380963 1 rs879321rs7576043 52.099 0 RTN4 chr2:55031023-55437014 143 405992 1 rs17345167rs17039586 453.996 0 RTN4 chr2:41212010-82396211 9721 41184202 3rs12614285 rs934310 396.396 0 RTN4 chr19:31569338-53780966 3788 222116291 rs2867544 rs10407424 33.9 0 RUVBL2 chr19:43257015-55294329 −730912037315 3 rs7246152 rs2569676 21.402 0 RUVBL2 chr19:288246-5911062811009 58822383 3 rs10409452 cnvi0009466 100.582 0 RUVBL2chr19:31569338-53780966 3788 22211629 1 rs2867544 rs10407424 33.9 0 RYR1chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466 100.582 0RYR1 chr1:237570457-237675464 37 105008 1 rs4659495 rs2618721 15.007 0RYR2 chr1:64114301-245591329 29842 181477029 1 rs11208257 rs117385037.504 0 RYR2 chr1:178626526-244159143 13064 65532618 3 rs2761477rs479338 11.373 0 RYR2 chr1:75098453-243531649 27360 168433197 1rs12117493 rs10927002 32.113 0 RYR2 chr1:174219398-247422297 1598673202900 1 rs16846809 rs4642922 35.258 0 RYR2 chr1:237584925-23790487086 319946 1 rs4593814 rs10925504 31.95 0 RYR2 chr1:236848751-2492193203293 12370570 3 rs819666 cnvi0018731 920.725 0 RYR2chr1:64114301-245591329 29842 181477029 1 rs11208257 rs1173850 37.504 0S100A6 chr1:75098453-243531649 27360 168433197 1 rs12117493 rs1092700232.113 0 S100A6 chr1:79710545-188898319 17303 109187775 1 rs417181rs16829637 45.89 0 S100A6 chr1:109645793-194560463 12025 84914671 3cnvi0008281 rs10921616 63.121 0 S100A6 chr1:64114301-245591329 29842181477029 1 rs11208257 rs1173850 37.504 0 S100A8 chr1:75098453-24353164927360 168433197 1 rs12117493 rs10927002 32.113 0 S100A8chr1:79710545-188898319 17303 109187775 1 rs417181 rs16829637 45.89 0S100A8 chr1:109645793-194560463 12025 84914671 3 cnvi0008281 rs1092161663.121 0 S100A8 chr13:19584477-81204088 13265 61619612 3 rs1334954rs1176297 22.162 0 SACS chr13:23742931-115064482 19829 91321552 1rs4770401 rs7999630 44.074 0 SACS chr13:19121741-63373781 10326 442520413 rs9578050 rs9539575 82.761 0 SACS chr1:64114301-245591329 29842181477029 1 rs11208257 rs1173850 37.504 0 SARS chr1:75098453-24353164927360 168433197 1 rs12117493 rs10927002 32.113 0 SARSchr1:79710545-188898319 17303 109187775 1 rs417181 rs16829637 45.89 0SARS chr1:109645793-194560463 12025 84914671 3 cnvi0008281 rs1092161663.121 0 SARS chr12:10113083-116370432 20594 106257350 1 rs2012504rs7958254 35.157 0 SCN8A chr12:10020267-129866293 23654 119846027 1rs1597097 rs2170504 45.428 0 SCN8A chr12:39967134-84174413 8879 442072801 rs11172661 rs11116039 39.568 0 SCN8A chr12:50855195-133778796 1774882923602 3 rs4351895 rs7975069 159.589 0 SCN8A chr2:12056323-22797977539094 215923453 1 rs966391 rs1922020 31.384 0 SCTRchr2:34870277-241929621 37755 207059345 3 rs13422005 rs10205276 46.946 0SCTR chr2:38101137-241482099 36812 203380963 1 rs879321 rs7576043 52.0990 SCTR chr2:77041264-194763754 21140 117722491 1 rs2102827 rs1683540694.091 0 SCTR chr2:83383702-175194550 16291 91810849 3 rs12469609rs11891208 154.4 0 SCTR chr2:12056323-227979775 39094 215923453 1rs966391 rs1922020 31.384 0 SDC1 chr2:18856-41136833 9721 41117978 3rs11901199 rs10187704 191.638 0 SDC1 chr8:30757798-142750969 20699111993172 1 rs10101203 rs6421025 34.223 0 SDC2 chr8:60424884-14528648317030 84861600 3 rs1401422 rs9720889 8.858 0 SDC2chr8:23218101-146274708 23020 123056608 1 rs7010362 rs7822726 38.828 0SDC2 chr8:76354446-113652365 6767 37297920 1 rs830783 rs16883889 127.0230 SDC2 chr8:66822030-144791126 16557 77969097 3 rs6472235 rs10100154251.068 0 SDC2 chr1:1005806-105612342 19173 104606537 3 rs3934834rs1584633 44.152 0 SDC3 chr1:2006108-109527861 22130 107521754 3rs2254669 rs839879 162.269 0 SDC3 chr20:13712393-55093901 8218 413815091 rs6033810 rs6999 41.237 0 SDC4 chr20:7869025-62424661 11941 54555637 3rs2294306 rs6010652 9.732 0 SDC4 chr20:4591715-58420336 11753 53828622 1rs6139494 rs1416388 40.922 0 SDC4 chr20:236802-54845796 12646 54608995 3rs448294 rs6064362 286.151 0 SDC4 chr8:30757798-142750969 20699111993172 1 rs10101203 rs6421025 34.223 0 SDCBP chr8:23218101-14627470823020 123056608 1 rs7010362 rs7822726 38.828 0 SDCBPchr8:43235525-66712108 3632 23476584 3 rs10091311 rs7001138 58.838 0SDCBP chr20:236802-54845796 12646 54608995 3 rs448294 rs6064362 286.1510 SDCBP2 chr2:12056323-227979775 39094 215923453 1 rs966391 rs192202031.384 0 SDPR chr2:34870277-241929621 37755 207059345 3 rs13422005rs10205276 46.946 0 SDPR chr2:38101137-241482099 36812 203380963 1rs879321 rs7576043 52.099 0 SDPR chr2:77041264-194763754 21140 1177224911 rs2102827 rs16835406 94.091 0 SDPR chr2:185050218-212752193 458327701976 1 rs1526196 rs6727114 45.31 0 SDPR chr2:180138805-1931440412298 13005237 3 rs6746115 rs2592243 132.36 0 SDPRchr1:64114301-245591329 29842 181477029 1 rs11208257 rs1173850 37.504 0SELE chr1:169556446-171300348 340 1743903 1 rs9332480 rs7541160 32.81 0SELE chr1:75098453-243531649 27360 168433197 1 rs12117493 rs1092700232.113 0 SELE chr1:79710545-188898319 17303 109187775 1 rs417181rs16829637 45.89 0 SELE chr1:109645793-194560463 12025 84914671 3cnvi0008281 rs10921616 63.121 0 SELE chr1:64114301-245591329 29842181477029 1 rs11208257 rs1173850 37.504 0 SELENBP1chr1:75098453-243531649 27360 168433197 1 rs12117493 rs10927002 32.113 0SELENBP1 chr1:79710545-188898319 17303 109187775 1 rs417181 rs1682963745.89 0 SELENBP1 chr1:109645793-194560463 12025 84914671 3 cnvi0008281rs10921616 63.121 0 SELENBP1 chr20:13712393-55093901 8218 41381509 1rs6033810 rs6999 41.237 0 SEMG1 chr20:7869025-62424661 11941 54555637 3rs2294306 rs6010652 9.732 0 SEMG1 chr20:4591715-58420336 11753 538286221 rs6139494 rs1416388 40.922 0 SEMG1 chr20:236802-54845796 1264654608995 3 rs448294 rs6064362 286.151 0 SEMG1 chr20:13712393-550939018218 41381509 1 rs6033810 rs6999 41.237 0 SEMG2 chr20:7869025-6242466111941 54555637 3 rs2294306 rs6010652 9.732 0 SEMG2chr20:4591715-58420336 11753 53828622 1 rs6139494 rs1416388 40.922 0SEMG2 chr20:236802-54845796 12646 54608995 3 rs448294 rs6064362 286.1510 SEMG2 chr6:2681610-31453618 81 28772009 3 rs1131896 rs9267212 428.1770 SERPINB9 chr6:1171596-29895228 43 28723633 0 rs3128994 rs925983153.123 0 SERPINB9 chr6:1171596-29899147 47 28727552 0 rs3128994rs2394704 80.695 0 SERPINB9 chr6:1177990-29899147 39 28721158 0rs2428530 rs2394704 44.381 0 SERPINB9 chr6:1175965-29899147 43 287231830 rs1611522 rs2394704 52.089 0 SERPINB9 chr6:2585208-31281876 −228696669 1 rs1634746 rs1634747 31.615 0 SERPINB9 chr6:1171596-2989914747 28727552 0 rs3128994 rs2394704 63.572 0 SERPINB9chr6:2584569-31286381 8 28701813 1 rs9391764 rs9265057 34.598 0 SERPINB9chr6:2681610-31453618 81 28772009 3 rs1131896 rs9267212 390.234 0SERPINB9 chr6:1171596-29892436 39 28720841 1 rs3128994 rs9259806 31.6990 SERPINB9 chr6:1171596-29895228 43 28723633 0 rs3128994 rs925983143.568 0 SERPINB9 chr6:181089-30430875 1806 30249787 3 rs1535053rs35792611 80.394 0 SERPINB9 chr9:2522475-140068342 25719 137545868 3rs10966757 rs4074426 93.386 0 SET chr9:33180228-132003792 14691 988235651 rs7854765 rs9408988 28.69 0 SET chr9:100158052-139077343 9815 389192923 rs1020884 rs4842126 470.601 0 SET chr21:36927793-37647438 142 719646 3rs2205031 rs9980084 187.28 0 SETD4 chr21:14601415-48084989 8249 334835753 rs2775537 rs2839378 12047.211 0 SETD4 chr21:14601415-48084989 824933483575 3 rs2775537 rs2839378 41.154 0 SETD4 chr21:14768343-480849898193 33316647 3 rs2257224 rs2839378 5021.076 0 SETD4chr21:14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0SETD4 chr21:14595264-48084989 8781 33489726 3 rs2847443 rs28393781871.363 0 SETD4 chr21:10708231-47970581 8807 37262351 3 rs4044122rs2255397 73.188 0 SETD4 chr1:64114301-245591329 29842 181477029 1rs11208257 rs1173850 37.504 0 SETDB1 chr1:75098453-243531649 27360168433197 1 rs12117493 rs10927002 32.113 0 SETDB1chr1:79710545-188898319 17303 109187775 1 rs417181 rs16829637 45.89 0SETDB1 chr1:109645793-194560463 12025 84914671 3 cnvi0008281 rs1092161663.121 0 SETDB1 chr2:12056323-227979775 39094 215923453 1 rs966391rs1922020 31.384 0 SF3B14 chr2:18856-41136833 9721 41117978 3 rs11901199rs10187704 191.638 0 SF3B14 chr3:13878889-149737330 24723 135858442 1rs12634112 rs2007869 55.663 0 SGOL1 chr3:179527-114630641 23879114451115 3 rs4684741 rs1587972 207.852 0 SGOL1 chr2:12056323-22797977539094 215923453 1 rs966391 rs1922020 31.384 0 SGOL2chr2:34870277-241929621 37755 207059345 3 rs13422005 rs10205276 46.946 0SGOL2 chr2:38101137-241482099 36812 203380963 1 rs879321 rs757604352.099 0 SGOL2 chr2:185050218-212752193 4583 27701976 1 rs1526196rs6727114 45.31 0 SGOL2 chr2:193255360-242529978 10289 49274619 3rs1351905 cnvi0010399 93.244 0 SGOL2 chr12:10113083-116370432 20594106257350 1 rs2012504 rs7958254 35.157 0 SH2B3 chr12:59512781-12774493913469 68232159 3 rs908394 rs7966946 20.62 0 SH2B3chr12:10020267-129866293 23654 119846027 1 rs1597097 rs2170504 45.428 0SH2B3 chr12:50855195-133778796 17748 82923602 3 rs4351895 rs7975069159.589 0 SH2B3 chr19:31569338-53780966 3788 22211629 1 rs2867544rs10407424 33.9 0 SHANK1 chr19:43257015-55294329 −7309 12037315 3rs7246152 rs2569676 21.402 0 SHANK1 chr19:288246-59110628 11009 588223833 rs10409452 cnvi0009466 100.582 0 SHANK1 chr17:108420-26610769 554826502350 3 rs12452527 rs658591 82.699 0 SHBG chr1:64114301-24559132929842 181477029 1 rs11208257 rs1173850 37.504 0 SHC1chr1:154752736-154944156 62 191421 3 rs10908440 rs12076073 65.821 0 SHC1chr1:75098453-243531649 27360 168433197 1 rs12117493 rs10927002 32.113 0SHC1 chr1:79710545-188898319 17303 109187775 1 rs417181 rs16829637 45.890 SHC1 chr1:109645793-194560463 12025 84914671 3 cnvi0008281 rs1092161663.121 0 SHC1 chr16:176743-50013967 8328 49837225 3 rs2562164 rs12597023174.392 0 SIAH1 chr19:31569338-53780966 3788 22211629 1 rs2867544rs10407424 33.9 0 SIRT2 chr19:288246-59110628 11009 58822383 3rs10409452 cnvi0009466 100.582 0 SIRT2 chr9:1989033-107532317 18263105543285 1 rs7864828 rs10820726 39.824 0 SLC1A1 chr9:2522475-14006834225719 137545868 3 rs10966757 rs4074426 93.386 0 SLC1A1chr9:46587-94335290 17484 94288704 3 rs10814410 rs9409606 762.393 0SLC1A1 chr1:1005806-105612342 19173 104606537 3 rs3934834 rs158463344.152 0 SLC2A1 chr1:2006108-109527861 22130 107521754 3 rs2254669rs839879 162.269 0 SLC2A1 chr5:141659-19010008 4662 18868350 3rs11741126 rs4642370 50.124 0 SLC6A3 chr5:506051-4746181 1345 4240131 3rs6864158 rs7716294 447.942 0 SLC6A3 chr1:1005806-105612342 19173104606537 3 rs3934834 rs1584633 44.152 0 SLC6A9 chr1:2006108-10952786122130 107521754 3 rs2254669 rs839879 162.269 0 SLC6A9chr17:44458950-81047708 −8195 36588759 1 cnvi0016818 rs35680231 35.591 0SLC9A3R1 chr17:62662507-81047708 −11496 18385202 3 rs6504246 rs3568023156.048 0 SLC9A3R1 chr15:51688996-102398060 11030 50709065 1 rs2459396rs7181527 36.939 0 SMAD3 chr15:53775670-96810867 9973 43035198 1rs657495 rs2589238 49.204 0 SMAD3 chr15:66108544-102427006 8615 363184633 cnvi0007613 rs11632620 159.164 0 SMAD3 chr5:84830796-171903310 1664287072515 1 rs300657 rs10042482 42.208 0 SMAD5 chr5:57343495-17190331021683 114559816 1 rs10940593 rs10042482 61.169 0 SMAD5chr5:98442871-150317237 9828 51874367 1 rs1447379 rs7710790 38.687 0SMAD5 chr5:4872310-180709915 35876 175837606 3 rs816467 rs10071993179.394 0 SMAD5 chr5:49952847-89853069 7268 39900223 3 rs12188654rs42467 26.225 0 SMN2 chr5:57343495-171903310 21683 114559816 1rs10940593 rs10042482 61.169 0 SMN2 chr5:69323596-70398523 189 1074928 1cnvi0017237 cnvi0017343 91.012 0 SMN2 chr5:69268538-70308861 189 10403243 cnvi0017230 cnvi0023254 49.308 0 SMN2 chr5:69243138-69405204 46 1620673 cnvi0023208 cnvi0023221 30.078 0 SMN2 chr5:69677532-70379466 127701935 3 cnvi0017312 cnvi0023557 34.65 0 SMN2 chr5:69283377-70251701 177968325 1 cnvi0023548 cnvi0021172 83.517 0 SMN2 chr5:69291141-70271505180 980365 1 cnvi0017232 cnvi0021174 88.653 0 SMN2chr5:69279340-70251701 179 972362 1 cnvi0017231 cnvi0021172 78.887 0SMN2 chr5:69323596-70275720 177 952125 1 cnvi0017237 cnvi0017327 103.4840 SMN2 chr5:69268538-70251701 181 983164 3 cnvi0017230 cnvi002117260.056 0 SMN2 chr5:69328641-70291250 177 962610 1 cnvi0023210cnvi0017323 62.594 0 SMN2 chr5:69688350-70369397 124 681048 1cnvi0017249 cnvi0018714 25.677 0 SMN2 chr5:69243138-70291250 191 10481131 cnvi0023208 cnvi0017323 65.988 0 SMN2 chr5:68835256-70379466 2541544211 1 cnvi0017190 cnvi0023557 55.77 0 SMN2 chr5:69291141-70251701176 960561 1 cnvi0017232 cnvi0021172 46.783 0 SMN2chr5:69283377-70275720 182 992344 1 cnvi0023548 cnvi0017327 79.66 0 SMN2chr5:69243138-70488200 217 1245063 1 cnvi0023208 cnvi0021181 90.718 0SMN2 chr5:68976129-70599000 267 1622872 3 cnvi0017227 cnvi0017334 64.2290 SMN2 chr5:68835256-70450158 262 1614903 3 cnvi0017190 cnvi001734949.942 0 SMN2 chr5:69440806-70593467 185 1152662 1 cnvi0017247cnvi0026040 53.84 0 SMN2 chr5:69688350-70379466 126 691117 3 cnvi0017249cnvi0023557 32.967 0 SMN2 chr5:69174834-70636542 245 1461709 3cnvi0017202 cnvi0017338 140.179 0 SMN2 chr5:68894461-70636542 2831742082 3 cnvi0017213 cnvi0017338 68.289 0 SMN2 chr5:4872310-18070991535876 175837606 3 rs816467 rs10071993 179.394 0 SMN2chr16:59854720-89273883 7609 29419164 3 rs1373880 rs8046156 31.884 0SMPD3 chr16:64107047-82920737 4544 18813691 1 rs2319723 rs918661 28.8870 SMPD3 chr16:50219449-89544756 10324 39325308 3 rs6500298 rs3803681108.108 0 SMPD3 chr15:29325866-56044189 5303 26718324 3 rs4779705rs2414433 21.732 0 SNAP23 chr15:32939946-43104406 2544 10164461 3rs12594777 rs13380301 32.942 0 SNAP23 chr20:7869025-62424661 1194154555637 3 rs2294306 rs6010652 9.732 0 SNAP25 chr20:4591715-5842033611753 53828622 1 rs6139494 rs1416388 40.922 0 SNAP25chr20:236802-54845796 12646 54608995 3 rs448294 rs6064362 286.151 0SNAP25 chr6:64844594-169078546 21567 104233953 1 rs4710465 rs60163946.524 0 SNAP91 chr6:66609532-147053632 15315 80444101 3 rs9354335rs4896886 44.941 0 SNAP91 chr6:73120320-165130872 18715 92010553 1rs9442780 rs10946016 76.383 0 SNAP91 chr6:26922906-93578359 1974666655454 1 rs9348738 rs9363009 27.061 0 SNAP91 chr6:66541198-16252013319344 95978936 1 rs2000382 rs6901071 27.509 0 SNAP91chr6:84250330-84391540 19 141211 1 rs7741310 rs1454130 14.57 0 SNAP91chr6:62697746-94090076 6391 31392331 1 rs6455128 rs3799807 108.85 0SNAP91 chr6:67621368-147709180 16188 80087813 1 rs6919455 rs773931452.498 0 SNAP91 chr6:79198069-99893938 4062 20695870 3 rs1321584rs4504482 200.961 0 SNAP91 chr4:31222833-180548076 24457 149325244 1rs7662351 rs3849606 36.162 0 SNCA chr4:89603085-113991140 4018 243880563 rs2972038 rs2279892 28.405 0 SNCA chr4:68173959-185767176 20235117593218 1 rs6552083 rs4862428 61.893 0 SNCA chr4:22401728-18860885728456 166207130 1 rs4697297 rs7687115 35.717 0 SNCAchr4:90618264-90784528 33 166265 1 rs17286290 rs2736994 16.242 0 SNCAchr4:63726348-173015421 19817 109289074 1 rs17082970 rs2131002 30.251 0SNCA chr4:29179713-117038307 15513 87858595 1 rs1507441 rs1068807 71.6 0SNCA chr4:69590353-190872778 23145 121282426 3 rs293433 rs12646565315.633 0 SNCA chr20:13712393-55093901 8218 41381509 1 rs6033810 rs699941.237 0 SNRPB2 chr20:7869025-62424661 11941 54555637 3 rs2294306rs6010652 9.732 0 SNRPB2 chr20:4591715-58420336 11753 53828622 1rs6139494 rs1416388 40.922 0 SNRPB2 chr20:236802-54845796 12646 546089953 rs448294 rs6064362 286.151 0 SNRPB2 chr20:13712393-55093901 821841381509 1 rs6033810 rs6999 41.237 0 SNTA1 chr20:7869025-62424661 1194154555637 3 rs2294306 rs6010652 9.732 0 SNTA1 chr20:4591715-5842033611753 53828622 1 rs6139494 rs1416388 40.922 0 SNTA1chr20:236802-54845796 12646 54608995 3 rs448294 rs6064362 286.151 0SNTA1 chr15:20058438-32544679 2394 12486242 3 rs12591240 cnvi0018163296.82 0 SNURF chr15:22267462-32461463 2232 10194002 3 rs4123826rs286103 218.215 0 SNURF chr18:25388300-75954881 11539 50566582 1rs11083228 rs1876021 39.235 0 SOCS6 chr18:64480206-70125971 1534 56457663 rs10516001 rs1347013 65.248 0 SOCS6 chr18:46516210-68441007 508821924798 1 rs7229153 rs1282652 51.891 0 SOCS6 chr18:65585580-692815101074 3695931 1 rs11875790 rs8090683 111.579 0 SOCS6chr18:62041997-76047493 3846 14005497 1 rs1421538 rs8085865 33.212 0SOCS6 chr18:44788908-78015180 8492 33226273 3 rs9944807 rs12960632 579.20 SOCS6 chr17:21685812-67308196 12365 45622385 1 rs34864328 rs1768685250.018 0 SOCS7 chr17:26648492-58955084 5831 32306593 3 rs1981512rs8068776 15.642 0 SOCS7 chr15:29325866-56044189 5303 26718324 3rs4779705 rs2414433 21.732 0 SORD chr15:44763598-47394943 502 2631346 3rs7172106 rs4095484 142.088 0 SORD chr15:43392075-66051345 4963 226592713 rs8028608 rs6494537 59.842 0 SORD chr6:10123365-31221039 −313521097675 1 rs2181334 rs4416711 318.459 0 SOX4 chr6:2681610-31453618 8128772009 3 rs1131896 rs9267212 428.177 0 SOX4 chr6:3760708-31957364 806228196657 3 rs2187825 cnvi0006380 39.016 0 SOX4 chr6:1171596-29895228 4328723633 0 rs3128994 rs9259831 53.123 0 SOX4 chr6:19044000-31286381−6774 12242382 1 rs6922929 rs9265057 31.384 0 SOX4 chr6:1171596-2989914747 28727552 0 rs3128994 rs2394704 80.695 0 SOX4 chr6:1177990-29899147 3928721158 0 rs2428530 rs2394704 44.381 0 SOX4 chr6:1175965-29899147 4328723183 0 rs1611522 rs2394704 52.089 0 SOX4 chr6:2585208-31281876 −228696669 1 rs1634746 rs1634747 31.615 0 SOX4 chr6:1171596-29899147 4728727552 0 rs3128994 rs2394704 63.572 0 SOX4 chr6:2584569-31286381 828701813 1 rs9391764 rs9265057 34.598 0 SOX4 chr6:2681610-31453618 8128772009 3 rs1131896 rs9267212 390.234 0 SOX4 chr6:1171596-29892436 3928720841 1 rs3128994 rs9259806 31.699 0 SOX4 chr6:1171596-29895228 4328723633 0 rs3128994 rs9259831 43.568 0 SOX4 chr6:19044000-31286381−6774 12242382 0 rs6922929 rs9265057 33.119 0 SOX4 chr6:181089-304308751806 30249787 3 rs1535053 rs35792611 80.394 0 SOX4chr8:30757798-142750969 20699 111993172 1 rs10101203 rs6421025 34.223 0SPAG1 chr8:60424884-145286483 17030 84861600 3 rs1401422 rs9720889 8.8580 SPAG1 chr8:23218101-146274708 23020 123056608 1 rs7010362 rs782272638.828 0 SPAG1 chr8:76354446-113652365 6767 37297920 1 rs830783rs16883889 127.023 0 SPAG1 chr8:66822030-144791126 16557 77969097 3rs6472235 rs10100154 251.068 0 SPAG1 chr16:88780175-89789898 143 10097241 rs4782321 rs6500437 27.339 0 SPG7 chr4:31222833-180548076 24457149325244 1 rs7662351 rs3849606 36.162 0 SPP1 chr4:68173959-18576717620235 117593218 1 rs6552083 rs4862428 61.893 0 SPP1chr4:22401728-188608857 28456 166207130 1 rs4697297 rs7687115 35.717 0SPP1 chr4:63726348-173015421 19817 109289074 1 rs17082970 rs213100230.251 0 SPP1 chr4:29179713-117038307 15513 87858595 1 rs1507441rs1068807 71.6 0 SPP1 chr4:69590353-190872778 23145 121282426 3 rs293433rs12646565 315.633 0 SPP1 chr2:12056323-227979775 39094 215923453 1rs966391 rs1922020 31.384 0 SPTBN1 chr2:34870277-241929621 37755207059345 3 rs13422005 rs10205276 46.946 0 SPTBN1chr2:38101137-241482099 36812 203380963 1 rs879321 rs7576043 52.099 0SPTBN1 chr2:41212010-82396211 9721 41184202 3 rs12614285 rs934310396.396 0 SPTBN1 chr5:161172541-179954615 4271 18782075 3 rs4921415rs10059433 6.291 0 SQSTM1 chr5:4872310-180709915 35876 175837606 3rs816467 rs10071993 179.394 0 SQSTM1 chr20:35942718-36175566 43 232849 3rs6104528 rs4810841 2.708 0 SRC chr20:13712393-55093901 8218 41381509 1rs6033810 rs6999 41.237 0 SRC chr20:7869025-62424661 11941 54555637 3rs2294306 rs6010652 9.732 0 SRC chr20:4591715-58420336 11753 53828622 1rs6139494 rs1416388 40.922 0 SRC chr20:236802-54845796 12646 54608995 3rs448294 rs6064362 286.151 0 SRC chr3:179527-114630641 23879 114451115 3rs4684741 rs1587972 207.852 0 SRGAP3 chr13:19584477-81204088 1326561619612 3 rs1334954 rs1176297 22.162 0 STARD13 chr13:23742931-11506448219829 91321552 1 rs4770401 rs7999630 44.074 0 STARD13chr13:19121741-63373781 10326 44252041 3 rs9578050 rs9539575 82.761 0STARD13 chr20:13712393-55093901 8218 41381509 1 rs6033810 rs6999 41.2370 STAU1 chr20:7869025-62424661 11941 54555637 3 rs2294306 rs60106529.732 0 STAU1 chr20:4591715-58420336 11753 53828622 1 rs6139494rs1416388 40.922 0 STAU1 chr20:236802-54845796 12646 54608995 3 rs448294rs6064362 286.151 0 STAU1 chr5:161172541-179954615 4271 18782075 3rs4921415 rs10059433 6.291 0 STC2 chr5:4872310-180709915 35876 1758376063 rs816467 rs10071993 179.394 0 STC2 chr12:10113083-116370432 20594106257350 1 rs2012504 rs7958254 35.157 0 STRAP chr12:8171838-325358635853 24364026 3 rs11609309 rs7963182 23.697 0 STRAPchr12:10020267-129866293 23654 119846027 1 rs1597097 rs2170504 45.428 0STRAP chr12:207886-50770291 11565 50562406 3 rs868249 rs4477515 43.892 0STRAP chr2:12056323-227979775 39094 215923453 1 rs966391 rs192202031.384 0 STRN chr2:34870277-241929621 37755 207059345 3 rs13422005rs10205276 46.946 0 STRN chr2:18856-41136833 9721 41117978 3 rs11901199rs10187704 191.638 0 STRN chr19:31569338-53780966 3788 22211629 1rs2867544 rs10407424 33.9 0 STRN4 chr19:43257015-55294329 −7309 120373153 rs7246152 rs2569676 21.402 0 STRN4 chr19:288246-59110628 1100958822383 3 rs10409452 cnvi0009466 100.582 0 STRN4 chr1:1005806-10561234219173 104606537 3 rs3934834 rs1584633 44.152 0 STX12chr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879 162.269 0STX12 chr16:29441284-33923125 585 4481842 3 rs7206789 rs4043755 42.437 0STX4 chr16:176743-50013967 8328 49837225 3 rs2562164 rs12597023 174.3920 STX4 chr11:42185849-126756938 15451 84571090 1 rs4375424 rs1075035636.99 0 STX5 chr11:21723471-131521797 20508 109798327 1 rs11828478rs2512898 27.565 0 STX5 chr11:23168804-106781292 16332 83612489 1rs11027007 rs7103285 49.747 0 STX5 chr11:211482-66910826 13813 666993453 rs2293168 rs4375446 30.249 0 STX5 chr9:2522475-140068342 25719137545868 3 rs10966757 rs4074426 93.386 0 STXBP1 chr9:33180228-13200379214691 98823565 1 rs7854765 rs9408988 28.69 0 STXBP1chr9:100158052-139077343 9815 38919292 3 rs1020884 rs4842126 470.601 0STXBP1 chr1:64114301-245591329 29842 181477029 1 rs11208257 rs117385037.504 0 STXBP3 chr1:75098453-243531649 27360 168433197 1 rs12117493rs10927002 32.113 0 STXBP3 chr1:79710545-188898319 17303 109187775 1rs417181 rs16829637 45.89 0 STXBP3 chr1:2006108-109527861 22130107521754 3 rs2254669 rs839879 162.269 0 STXBP3 chr4:31222833-18054807624457 149325244 1 rs7662351 rs3849606 36.162 0 SULT1E1chr4:68173959-185767176 20235 117593218 1 rs6552083 rs4862428 61.893 0SULT1E1 chr4:22401728-188608857 28456 166207130 1 rs4697297 rs768711535.717 0 SULT1E1 chr4:63726348-173015421 19817 109289074 1 rs17082970rs2131002 30.251 0 SULT1E1 chr4:29179713-117038307 15513 87858595 1rs1507441 rs1068807 71.6 0 SULT1E1 chr4:69590353-190872778 23145121282426 3 rs293433 rs12646565 315.633 0 SULT1E1chr6:64844594-169078546 21567 104233953 1 rs4710465 rs601639 46.524 0SUMO4 chr6:73120320-165130872 18715 92010553 1 rs9442780 rs1094601676.383 0 SUMO4 chr6:66541198-162520133 19344 95978936 1 rs2000382rs6901071 27.509 0 SUMO4 chr6:94117546-165103679 15579 70986134 1rs3799792 rs9347902 34.066 0 SUMO4 chr6:100082983-170909002 1639370826020 3 rs594231 rs12213906 261.313 0 SUMO4 chr9:1989033-10753231718263 105543285 1 rs7864828 rs10820726 39.824 0 SYKchr9:2522475-140068342 25719 137545868 3 rs10966757 rs4074426 93.386 0SYK chr9:33180228-132003792 14691 98823565 1 rs7854765 rs9408988 28.69 0SYK chr9:46587-94335290 17484 94288704 3 rs10814410 rs9409606 762.393 0SYK chr12:10113083-116370432 20594 106257350 1 rs2012504 rs795825435.157 0 SYT1 chr12:59512781-127744939 13469 68232159 3 rs908394rs7966946 20.62 0 SYT1 chr12:10020267-129866293 23654 119846027 1rs1597097 rs2170504 45.428 0 SYT1 chr12:39967134-84174413 8879 442072801 rs11172661 rs11116039 39.568 0 SYT1 chr12:79291372-80266372 130 9750011 rs1551847 rs2698261 34.672 0 SYT1 chr12:50855195-133778796 1774882923602 3 rs4351895 rs7975069 159.589 0 SYT1 chr11:345515-17408630 424717063116 3 rs11246094 rs5215 30.474 0 SYT9 chr11:211482-66910826 1381366699345 3 rs2293168 rs4375446 30.249 0 SYT9 chr2:12056323-22797977539094 215923453 1 rs966391 rs1922020 31.384 0 TANC1chr2:34870277-241929621 37755 207059345 3 rs13422005 rs10205276 46.946 0TANC1 chr2:38101137-241482099 36812 203380963 1 rs879321 rs757604352.099 0 TANC1 chr2:77041264-194763754 21140 117722491 1 rs2102827rs16835406 94.091 0 TANC1 chr2:83383702-175194550 16291 91810849 3rs12469609 rs11891208 154.4 0 TANC1 chr2:12056323-227979775 39094215923453 1 rs966391 rs1922020 31.384 0 TANK chr2:34870277-24192962137755 207059345 3 rs13422005 rs10205276 46.946 0 TANKchr2:38101137-241482099 36812 203380963 1 rs879321 rs7576043 52.099 0TANK chr2:77041264-194763754 21140 117722491 1 rs2102827 rs1683540694.091 0 TANK chr2:83383702-175194550 16291 91810849 3 rs12469609rs11891208 154.4 0 TANK chr16:29441284-33923125 585 4481842 3 rs7206789rs4043755 42.437 0 TAOK2 chr16:176743-50013967 8328 49837225 3 rs2562164rs12597023 174.392 0 TAOK2 chr5:49952847-89853069 7268 39900223 3rs12188654 rs42467 26.225 0 TBCA chr5:57343495-171903310 21683 1145598161 rs10940593 rs10042482 61.169 0 TBCA chr5:4872310-180709915 35876175837606 3 rs816467 rs10071993 179.394 0 TBCA chr17:44458950-81047708−8195 36588759 1 cnvi0016818 rs35680231 35.591 0 TBCDchr17:62662507-81047708 −11496 18385202 3 rs6504246 rs35680231 56.048 0TBCD chr1:64114301-245591329 29842 181477029 1 rs11208257 rs117385037.504 0 TBCE chr1:178626526-244159143 13064 65532618 3 rs2761477rs479338 11.373 0 TBCE chr1:75098453-243531649 27360 168433197 1rs12117493 rs10927002 32.113 0 TBCE chr1:174219398-247422297 1598673202900 1 rs16846809 rs4642922 35.258 0 TBCE chr1:226536645-2368037532600 10267109 3 rs874583 rs10925178 100.109 0 TBCEchr12:10113083-116370432 20594 106257350 1 rs2012504 rs7958254 35.157 0TBK1 chr12:59512781-127744939 13469 68232159 3 rs908394 rs7966946 20.620 TBK1 chr12:10020267-129866293 23654 119846027 1 rs1597097 rs217050445.428 0 TBK1 chr12:39967134-84174413 8879 44207280 1 rs11172661rs11116039 39.568 0 TBK1 chr12:50855195-133778796 17748 82923602 3rs4351895 rs7975069 159.589 0 TBK1 chr19:266034-18061509 3100 17795476 3rs2312724 rs7250332 19.51 0 TBXA2R chr19:629303-4119012 709 3489710 1rs2283575 rs350887 26.758 0 TBXA2R chr19:288246-59110628 11009 588223833 rs10409452 cnvi0009466 100.582 0 TBXA2R chr19:1130986-2128054 143997069 1 rs10413074 rs1017084 25.799 0 TCF3 chr19:859214-1650134 121790921 1 rs1683564 rs1860661 36.427 0 TCF3 chr19:266034-18061509 310017795476 3 rs2312724 rs7250332 19.51 0 TCF3 chr19:629303-4119012 7093489710 1 rs2283575 rs350887 26.758 0 TCF3 chr19:1351916-1716865 58364950 1 rs11670805 rs11878765 31.586 0 TCF3 chr19:288246-59110628 1100958822383 3 rs10409452 cnvi0009466 100.582 0 TCF3 chr18:25388300-7595488111539 50566582 1 rs11083228 rs1876021 39.235 0 TCF4chr18:1583633-58142042 11490 56558410 3 rs9945988 rs1560399 3.736 0 TCF4chr18:46516210-68441007 5088 21924798 1 rs7229153 rs1282652 51.891 0TCF4 chr18:26550830-63713914 8241 37163085 1 rs16945738 rs2715304 17.9220 TCF4 chr18:26162481-67193217 9255 41030737 1 rs12458903 rs996190731.327 0 TCF4 chr18:44788908-78015180 8492 33226273 3 rs9944807rs12960632 579.2 0 TCF4 chr6:64844594-169078546 21567 104233953 1rs4710465 rs601639 46.524 0 TCP1 chr6:151495387-165969396 3761 144740103 rs9322304 rs1022180 22.826 0 TCP1 chr6:73120320-165130872 1871592010553 1 rs9442780 rs10946016 76.383 0 TCP1 chr6:66541198-16252013319344 95978936 1 rs2000382 rs6901071 27.509 0 TCP1chr6:94117546-165103679 15579 70986134 1 rs3799792 rs9347902 34.066 0TCP1 chr6:100082983-170909002 16393 70826020 3 rs594231 rs12213906261.313 0 TCP1 chr3:13878889-149737330 24723 135858442 1 rs12634112rs2007869 55.663 0 TDGF1 chr3:33409611-170735099 23775 137325489 1rs3915062 rs11924032 26.867 0 TDGF1 chr3:179527-114630641 23879114451115 3 rs4684741 rs1587972 207.852 0 TDGF1 chr6:26922906-9357835919746 66655454 1 rs9348738 rs9363009 27.061 0 TEAD3chr6:31289284-56929863 15402 25640580 3 rs9265170 cnvi0015437 25.647 0TEAD3 chr6:32968276-73449742 15442 40481467 3 rs2395300 rs4235869 415.870 TEAD3 chr14:19917123-65327288 10286 45410166 3 rs2495197 rs9323455270.291 0 TEP1 chr5:141659-19010008 4662 18868350 3 rs11741126 rs464237050.124 0 TERT chr5:830376-1276121 128 445746 3 rs12657470 cnvi00125725.026 0 TERT chr5:506051-4746181 1345 4240131 3 rs6864158 rs7716294447.942 0 TERT chr10:7188484-134205354 26672 127016871 1 rs1977295rs3923858 50.772 0 TFAM chr10:734229-69155636 14859 68421408 3 rs1769236rs2394375 72.104 0 TFAM chr10:58385643-124973104 13625 66587462 1rs7920235 rs17663304 36.18 0 TFAM chr10:57671424-133349223 1624375677800 1 rs11005106 rs4301710 37.114 0 TFAM chr10:55492162-11720501713465 61712856 1 rs6481032 rs1933664 62.56 0 TFAMchr10:53602190-135522754 19167 81920565 3 rs12247820 rs10909028 139.3730 TFAM chr2:12056323-227979775 39094 215923453 1 rs966391 rs192202031.384 0 TGFA chr2:34870277-241929621 37755 207059345 3 rs13422005rs10205276 46.946 0 TGFA chr2:38101137-241482099 36812 203380963 1rs879321 rs7576043 52.099 0 TGFA chr2:41212010-82396211 9721 41184202 3rs12614285 rs934310 396.396 0 TGFA chr20:13712393-55093901 8218 413815091 rs6033810 rs6999 41.237 0 TGM2 chr20:7869025-62424661 11941 54555637 3rs2294306 rs6010652 9.732 0 TGM2 chr20:4591715-58420336 11753 53828622 1rs6139494 rs1416388 40.922 0 TGM2 chr20:236802-54845796 12646 54608995 3rs448294 rs6064362 286.151 0 TGM2 chr21:14601415-48084989 8249 334835753 rs2775537 rs2839378 12047.211 0 TIAM1 chr21:14601415-48084989 824933483575 3 rs2775537 rs2839378 41.154 0 TIAM1 chr21:14768343-480849898193 33316647 3 rs2257224 rs2839378 5021.076 0 TIAM1chr21:14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0TIAM1 chr21:14595264-48084989 8781 33489726 3 rs2847443 rs28393781871.363 0 TIAM1 chr21:10708231-47970581 8807 37262351 3 rs4044122rs2255397 73.188 0 TIAM1 chr15:29325866-56044189 5303 26718324 3rs4779705 rs2414433 21.732 0 TJP1 chr15:29659013-30239328 126 580316 1rs4779618 rs12905328 41.602 0 TJP1 chr15:20058438-32544679 2394 124862423 rs12591240 cnvi0018163 296.82 0 TJP1 chr15:22267462-32461463 223210194002 3 rs4123826 rs286103 218.215 0 TJP1 chr17:75730493-79302149 8803571657 3 rs7210773 rs2864474 14.319 0 TK1 chr17:44458950-81047708 −819536588759 1 cnvi0016818 rs35680231 35.591 0 TK1 chr17:62662507-81047708−11496 18385202 3 rs6504246 rs35680231 56.048 0 TK1chr4:31222833-180548076 24457 149325244 1 rs7662351 rs3849606 36.162 0TLR10 chr4:22401728-188608857 28456 166207130 1 rs4697297 rs768711535.717 0 TLR10 chr4:29179713-117038307 15513 87858595 1 rs1507441rs1068807 71.6 0 TLR10 chr4:179131-68998153 13495 68819023 3 rs7686948rs7687396 625.133 0 TLR10 chr3:13878889-149737330 24723 135858442 1rs12634112 rs2007869 55.663 0 TM4SF1 chr3:145967173-173899890 491227932718 3 rs9863647 rs7618997 46.396 0 TM4SF1 chr3:33409611-17073509923775 137325489 1 rs3915062 rs11924032 26.867 0 TM4SF1chr3:102240202-195550366 17318 93310165 1 rs1620217 rs11711870 41.031 0TM4SF1 chr3:83075971-196935657 21465 113859687 1 rs9872858 rs3472975144.35 0 TM4SF1 chr3:114889454-177826047 12700 62936594 3 rs6795297rs7628308 102.526 0 TM4SF1 chr1:1005806-105612342 19173 104606537 3rs3934834 rs1584633 44.152 0 TNFRSF14 chr1:1254841-3342804 386 2087964 1rs10907179 rs870171 39.259 0 TNFRSF14 chr1:2006108-109527861 22130107521754 3 rs2254669 rs839879 162.269 0 TNFRSF14 chr12:207886-5077029111565 50562406 3 rs868249 rs4477515 43.892 0 TNFRSF1Achr1:1005806-105612342 19173 104606537 3 rs3934834 rs1584633 44.152 0TNFRSF1B chr1:2006108-109527861 22130 107521754 3 rs2254669 rs839879162.269 0 TNFRSF1B chr3:166503411-190576461 4854 24073051 1 rs11925936rs1393054 31.414 0 TNIK chr3:145967173-173899890 4912 27932718 3rs9863647 rs7618997 46.396 0 TNIK chr3:102240202-195550366 1731893310165 1 rs1620217 rs11711870 41.031 0 TNIK chr3:164955741-1917421045741 26786364 1 rs2218152 rs9835019 52.438 0 TNIKchr3:83075971-196935657 21465 113859687 1 rs9872858 rs34729751 44.35 0TNIK chr3:114889454-177826047 12700 62936594 3 rs6795297 rs7628308102.526 0 TNIK chr4:179131-68998153 13495 68819023 3 rs7686948 rs7687396625.133 0 TNIP2 chr11:345515-17408630 4247 17063116 3 rs11246094 rs521530.474 0 TNNI2 chr11:211482-66910826 13813 66699345 3 rs2293168rs4375446 30.249 0 TNNI2 chr19:288246-59110628 11009 58822383 3rs10409452 cnvi0009466 100.582 0 TNNI3 chr1:64114301-245591329 29842181477029 1 rs11208257 rs1173850 37.504 0 TNNT2 chr1:178626526-24415914313064 65532618 3 rs2761477 rs479338 11.373 0 TNNT2chr1:75098453-243531649 27360 168433197 1 rs12117493 rs10927002 32.113 0TNNT2 chr1:188850774-235423607 10060 46572834 1 rs16829466 rs1240969643.25 0 TNNT2 chr1:191875752-235423607 9517 43547856 1 rs9427811rs12409696 62.01 0 TNNT2 chr1:189128124-227340790 7927 38212667 1rs7515205 rs12752546 167.428 0 TNNT2 chr1:174219398-247422297 1598673202900 1 rs16846809 rs4642922 35.258 0 TNNT2 chr1:197187605-2264044576316 29216853 3 rs10922187 rs3008192 130.989 0 TNNT2chr1:64114301-245591329 29842 181477029 1 rs11208257 rs1173850 37.504 0TOMM20 chr1:178626526-244159143 13064 65532618 3 rs2761477 rs47933811.373 0 TOMM20 chr1:75098453-243531649 27360 168433197 1 rs12117493rs10927002 32.113 0 TOMM20 chr1:188850774-235423607 10060 46572834 1rs16829466 rs12409696 43.25 0 TOMM20 chr1:191875752-235423607 951743547856 1 rs9427811 rs12409696 62.01 0 TOMM20 chr1:174219398-24742229715986 73202900 1 rs16846809 rs4642922 35.258 0 TOMM20chr1:226536645-236803753 2600 10267109 3 rs874583 rs10925178 100.109 0TOMM20 chr17:38388040-38909192 55 521153 3 rs9916782 rs2109217 3.141 0TOP2A chr17:21685812-67308196 12365 45622385 1 rs34864328 rs1768685250.018 0 TOP2A chr17:26648492-58955084 5831 32306593 3 rs1981512rs8068776 15.642 0 TOP2A chr17:108420-26610769 5548 26502350 3rs12452527 rs658591 82.699 0 TP53 chr12:207886-50770291 11565 50562406 3rs868249 rs4477515 43.892 0 TPI1 chr16:59854720-89273883 7609 29419164 3rs1373880 rs8046156 31.884 0 TRADD chr16:64107047-82920737 4544 188136911 rs2319723 rs918661 28.887 0 TRADD chr16:50219449-89544756 1032439325308 3 rs6500298 rs3803681 108.108 0 TRADD chr9:2522475-14006834225719 137545868 3 rs10966757 rs4074426 93.386 0 TRAF1chr9:33180228-132003792 14691 98823565 1 rs7854765 rs9408988 28.69 0TRAF1 chr9:100158052-139077343 9815 38919292 3 rs1020884 rs4842126470.601 0 TRAF1 chr9:2522475-140068342 25719 137545868 3 rs10966757rs4074426 93.386 0 TRAF2 chr9:139492789-140913833 196 1421045 1rs28485548 cnvi0002661 28.211 0 TRAF2 chr9:139492789-140212642 109719854 3 rs28485548 rs13295516 12.464 0 TRAF2 chr9:139725120-14017625050 451131 1 rs2811750 rs28576426 24.435 0 TRAF2 chr11:24610019-424145663388 17804548 3 rs1858156 rs7127426 27.914 0 TRAF6chr11:21723471-131521797 20508 109798327 1 rs11828478 rs2512898 27.565 0TRAF6 chr11:23168804-106781292 16332 83612489 1 rs11027007 rs710328549.747 0 TRAF6 chr11:211482-66910826 13813 66699345 3 rs2293168rs4375446 30.249 0 TRAF6 chr4:31222833-180548076 24457 149325244 1rs7662351 rs3849606 36.162 0 TRIM2 chr4:137206602-158430547 357721223946 3 rs1597600 rs12507865 83.533 0 TRIM2 chr4:68173959-18576717620235 117593218 1 rs6552083 rs4862428 61.893 0 TRIM2chr4:22401728-188608857 28456 166207130 1 rs4697297 rs7687115 35.717 0TRIM2 chr4:63726348-173015421 19817 109289074 1 rs17082970 rs213100230.251 0 TRIM2 chr4:126374899-162380016 6166 36005118 1 rs4834042rs17041092 33.404 0 TRIM2 chr4:69590353-190872778 23145 121282426 3rs293433 rs12646565 315.633 0 TRIM2 chr11:42185849-126756938 1545184571090 1 rs4375424 rs10750356 36.99 0 TRIM29 chr11:84128537-1209415837678 36813047 1 rs488925 rs4643089 29.271 0 TRIM29chr11:21723471-131521797 20508 109798327 1 rs11828478 rs2512898 27.565 0TRIM29 chr11:98062720-121890280 5422 23827561 1 rs6589308 rs194446529.075 0 TRIM29 chr11:74545378-134940416 14496 60395039 3 rs512780rs11224228 527.758 0 TRIM29 chr5:141659-19010008 4662 18868350 3rs11741126 rs4642370 50.124 0 TRIO chr5:13798559-14174106 121 375548 3rs795544 rs32571 239.534 0 TRIO chr5:4872310-180709915 35876 175837606 3rs816467 rs10071993 179.394 0 TRIO chr11:42185849-126756938 1545184571090 1 rs4375424 rs10750356 36.99 0 TRMT112 chr11:21723471-13152179720508 109798327 1 rs11828478 rs2512898 27.565 0 TRMT112chr11:23168804-106781292 16332 83612489 1 rs11027007 rs7103285 49.747 0TRMT112 chr11:211482-66910826 13813 66699345 3 rs2293168 rs437544630.249 0 TRMT112 chr3:13878889-149737330 24723 135858442 1 rs12634112rs2007869 55.663 0 TRPC1 chr3:33409611-170735099 23775 137325489 1rs3915062 rs11924032 26.867 0 TRPC1 chr3:102240202-195550366 1731893310165 1 rs1620217 rs11711870 41.031 0 TRPC1 chr3:103140700-1448831728539 41742473 1 rs4314176 rs6797159 44.122 0 TRPC1chr3:83075971-196935657 21465 113859687 1 rs9872858 rs34729751 44.35 0TRPC1 chr3:114889454-177826047 12700 62936594 3 rs6795297 rs7628308102.526 0 TRPC1 chr4:31222833-180548076 24457 149325244 1 rs7662351rs3849606 36.162 0 TRPC3 chr4:117433230-126039335 1532 8606106 3rs11734105 rs3956574 31.166 0 TRPC3 chr4:68173959-185767176 20235117593218 1 rs6552083 rs4862428 61.893 0 TRPC3 chr4:22401728-18860885728456 166207130 1 rs4697297 rs7687115 35.717 0 TRPC3chr4:63726348-173015421 19817 109289074 1 rs17082970 rs2131002 30.251 0TRPC3 chr4:69590353-190872778 23145 121282426 3 rs293433 rs12646565315.633 0 TRPC3 chr13:36707502-103656104 13622 66948603 1 rs3827890rs1952590 38.726 0 TRPC4 chr13:19584477-81204088 13265 61619612 3rs1334954 rs1176297 22.162 0 TRPC4 chr13:23742931-115064482 1982991321552 1 rs4770401 rs7999630 44.074 0 TRPC4 chr13:19121741-6337378110326 44252041 3 rs9578050 rs9539575 82.761 0 TRPC4chr17:108420-26610769 5548 26502350 3 rs12452527 rs658591 82.699 0 TRPV1chr12:10113083-116370432 20594 106257350 1 rs2012504 rs7958254 35.157 0TRPV4 chr12:59512781-127744939 13469 68232159 3 rs908394 rs7966946 20.620 TRPV4 chr12:10020267-129866293 23654 119846027 1 rs1597097 rs217050445.428 0 TRPV4 chr12:50855195-133778796 17748 82923602 3 rs4351895rs7975069 159.589 0 TRPV4 chr7:11855636-156148608 26852 144292973 1rs6947930 rs6945016 36.446 0 TRPV6 chr7:78621315-155831817 1367877210503 3 rs1006818 rs6969015 123.319 0 TRPV6 chr7:8872727-15638335927773 147510633 1 rs917038 rs878717 32.336 0 TRPV6chr7:120061880-143606234 4616 23544355 3 rs12531689 rs10247493 18.96 0TRPV6 chr7:11855636-156148608 26852 144292973 1 rs6947930 rs694501636.446 0 TSC22D4 chr7:78621315-155831817 13678 77210503 3 rs1006818rs6969015 123.319 0 TSC22D4 chr7:8872727-156383359 27773 147510633 1rs917038 rs878717 32.336 0 TSC22D4 chr7:8794418-119068130 23484110273713 1 rs2189621 rs6977904 70.867 0 TSC22D4 chr7:84302877-1109931695183 26690293 3 rs4338048 rs10254893 203.09 0 TSC22D4chr14:80818058-105348552 5492 24530495 3 rs6574553 rs2028416 15.874 0TSHR chr14:26898958-104436931 17396 77537974 1 rs1245195 rs1185109757.233 0 TSHR chr14:65405722-103799039 8979 38393318 3 rs11623705rs11628472 266.153 0 TSHR chr6:26922906-93578359 19746 66655454 1rs9348738 rs9363009 27.061 0 TTBK1 chr6:31289284-56929863 15402 256405803 rs9265170 cnvi0015437 25.647 0 TTBK1 chr6:32968276-73449742 1544240481467 3 rs2395300 rs4235869 415.87 0 TTBK1 chr5:84830796-17190331016642 87072515 1 rs300657 rs10042482 42.208 0 TTC1chr5:57343495-171903310 21683 114559816 1 rs10940593 rs10042482 61.169 0TTC1 chr5:4872310-180709915 35876 175837606 3 rs816467 rs10071993179.394 0 TTC1 chr6:64844594-169078546 21567 104233953 1 rs4710465rs601639 46.524 0 TTK chr6:66609532-147053632 15315 80444101 3 rs9354335rs4896886 44.941 0 TTK chr6:73120320-165130872 18715 92010553 1rs9442780 rs10946016 76.383 0 TTK chr6:26922906-93578359 19746 666554541 rs9348738 rs9363009 27.061 0 TTK chr6:66541198-162520133 1934495978936 1 rs2000382 rs6901071 27.509 0 TTK chr6:62697746-94090076 639131392331 1 rs6455128 rs3799807 108.85 0 TTK chr6:67621368-14770918016188 80087813 1 rs6919455 rs7739314 52.498 0 TTK chr6:79198069-998939384062 20695870 3 rs1321584 rs4504482 200.961 0 TTKchr2:12056323-227979775 39094 215923453 1 rs966391 rs1922020 31.384 0TTN chr2:34870277-241929621 37755 207059345 3 rs13422005 rs1020527646.946 0 TTN chr2:38101137-241482099 36812 203380963 1 rs879321rs7576043 52.099 0 TTN chr2:77041264-194763754 21140 117722491 1rs2102827 rs16835406 94.091 0 TTN chr2:175243501-180024167 926 4780667 3rs2305292 rs17454311 283.917 0 TTN chr11:345515-17408630 4247 17063116 3rs11246094 rs5215 30.474 0 TUB chr11:211482-66910826 13813 66699345 3rs2293168 rs4375446 30.249 0 TUB chr12:10113083-116370432 20594106257350 1 rs2012504 rs7958254 35.157 0 TUBA1A chr12:10020267-12986629323654 119846027 1 rs1597097 rs2170504 45.428 0 TUBA1Achr12:39967134-84174413 8879 44207280 1 rs11172661 rs11116039 39.568 0TUBA1A chr12:207886-50770291 11565 50562406 3 rs868249 rs4477515 43.8920 TUBA1A chr12:10113083-116370432 20594 106257350 1 rs2012504 rs795825435.157 0 TUBA1B chr12:10020267-129866293 23654 119846027 1 rs1597097rs2170504 45.428 0 TUBA1B chr12:39967134-84174413 8879 44207280 1rs11172661 rs11116039 39.568 0 TUBA1B chr12:207886-50770291 1156550562406 3 rs868249 rs4477515 43.892 0 TUBA1B chr22:16871137-511843939245 34313257 3 rs131538 rs7284680 209.79 0 TUBA8 chr6:10123365-31221039−3135 21097675 1 rs2181334 rs4416711 318.459 0 TUBBchr6:26922906-93578359 19746 66655454 1 rs9348738 rs9363009 27.061 0TUBB chr6:2681610-31453618 81 28772009 3 rs1131896 rs9267212 428.177 0TUBB chr6:3760708-31957364 8062 28196657 3 rs2187825 cnvi0006380 39.0160 TUBB chr6:19044000-31286381 −6774 12242382 1 rs6922929 rs926505731.384 0 TUBB chr6:2585208-31281876 −2 28696669 1 rs1634746 rs163474731.615 0 TUBB chr6:24697388-31341340 −8293 6643953 1 rs2092404 rs926651538.794 0 TUBB chr6:26430981-31878433 −8001 5447453 1 rs2893848 rs51941755.651 0 TUBB chr6:2584569-31286381 8 28701813 1 rs9391764 rs926505734.598 0 TUBB chr6:2681610-31453618 81 28772009 3 rs1131896 rs9267212390.234 0 TUBB chr6:29253756-32671521 2267 3417766 1 rs9468508 rs927543951.553 0 TUBB chr6:19044000-31286381 −6774 12242382 0 rs6922929rs9265057 33.119 0 TUBB chr6:30475431-32449411 −7687 1973981 3cnvi0005997 rs1964995 153.275 0 TUBB chr17:21685812-67308196 1236545622385 1 rs34864328 rs17686852 50.018 0 TUBG1 chr17:26648492-589550845831 32306593 3 rs1981512 rs8068776 15.642 0 TUBG1chr9:2522475-140068342 25719 137545868 3 rs10966757 rs4074426 93.386 0TXN chr9:33180228-132003792 14691 98823565 1 rs7854765 rs9408988 28.69 0TXN chr9:100158052-139077343 9815 38919292 3 rs1020884 rs4842126 470.6010 TXN chr18:10274-30780701 6393 30770428 3 cnvi0008694 rs271534 338.7770 TYMS chr8:30757798-142750969 20699 111993172 1 rs10101203 rs642102534.223 0 UBE2V2 chr8:49046707-49170958 16 124252 1 rs4433176 rs455293012.646 72253 UBE2V2 chr8:41983076-50280013 418 8296938 1 rs12544318rs12677656 39.988 0 UBE2V2 chr8:23218101-146274708 23020 123056608 1rs7010362 rs7822726 38.828 0 UBE2V2 chr8:43235525-66712108 3632 234765843 rs10091311 rs7001138 58.838 0 UBE2V2 chr1:64114301-245591329 29842181477029 1 rs11208257 rs1173850 37.504 0 UBQLN4 chr1:75098453-24353164927360 168433197 1 rs12117493 rs10927002 32.113 0 UBQLN4chr1:79710545-188898319 17303 109187775 1 rs417181 rs16829637 45.89 0UBQLN4 chr1:109645793-194560463 12025 84914671 3 cnvi0008281 rs1092161663.121 0 UBQLN4 chr4:31222833-180548076 24457 149325244 1 rs7662351rs3849606 36.162 0 UCHL1 chr4:39472311-63464732 3456 23992422 3rs2687975 rs4403080 120.672 0 UCHL1 chr4:22401728-188608857 28456166207130 1 rs4697297 rs7687115 35.717 0 UCHL1 chr4:29179713-11703830715513 87858595 1 rs1507441 rs1068807 71.6 0 UCHL1 chr4:179131-6899815313495 68819023 3 rs7686948 rs7687396 625.133 0 UCHL1chr12:131894274-133778796 308 1884523 1 rs10848373 rs7975069 29.931 0ULK1 chr12:131564183-133161346 306 1597164 1 rs2141189 rs11208 31.414 0ULK1 chr12:112610714-133708729 5366 21098016 3 rs11066188 rs11147249695.45 0 ULK1 chr12:132378017-133778796 190 1400780 1 rs11246867rs7975069 39.951 0 ULK1 chr12:50855195-133778796 17748 82923602 3rs4351895 rs7975069 159.589 0 ULK1 chr16:176743-50013967 8328 49837225 3rs2562164 rs12597023 174.392 0 USP7 chr19:266034-18061509 3100 177954763 rs2312724 rs7250332 19.51 0 VAV1 chr19:6812891-7000401 66 187511 3rs2174759 rs11665875 138.272 0 VAV1 chr19:288246-59110628 11009 588223833 rs10409452 cnvi0009466 100.582 0 VAV1 chr10:7188484-134205354 26672127016871 1 rs1977295 rs3923858 50.772 0 VCL chr10:58385643-12497310413625 66587462 1 rs7920235 rs17663304 36.18 0 VCLchr10:57671424-133349223 16243 75677800 1 rs11005106 rs4301710 37.114 0VCL chr10:55492162-117205017 13465 61712856 1 rs6481032 rs1933664 62.560 VCL chr10:53602190-135522754 19167 81920565 3 rs12247820 rs10909028139.373 0 VCL chr5:84830796-171903310 16642 87072515 1 rs300657rs10042482 42.208 0 VDAC1 chr5:57343495-171903310 21683 114559816 1rs10940593 rs10042482 61.169 0 VDAC1 chr5:98442871-150317237 982851874367 1 rs1447379 rs7710790 38.687 0 VDAC1 chr5:4872310-18070991535876 175837606 3 rs816467 rs10071993 179.394 0 VDAC1chr3:179527-114630641 23879 114451115 3 rs4684741 rs1587972 207.852 0VHL chr10:7188484-134205354 26672 127016871 1 rs1977295 rs3923858 50.7720 VIM chr10:734229-69155636 14859 68421408 3 rs1769236 rs2394375 72.1040 VIM chr10:88874-53366180 12853 53277307 3 cnvi0015449 rs10998465319.021 0 VIM chr3:13878889-149737330 24723 135858442 1 rs12634112rs2007869 55.663 0 VIPR1 chr3:33409611-170735099 23775 137325489 1rs3915062 rs11924032 26.867 0 VIPR1 chr3:179527-114630641 23879114451115 3 rs4684741 rs1587972 207.852 0 VIPR1 chr17:21685812-6730819612365 45622385 1 rs34864328 rs17686852 50.018 0 VTNchr17:26648492-58955084 5831 32306593 3 rs1981512 rs8068776 15.642 0 VTNchr19:31569338-53780966 3788 22211629 1 rs2867544 rs10407424 33.9 0WDR62 chr19:288246-59110628 11009 58822383 3 rs10409452 cnvi0009466100.582 0 WDR62 chr7:11855636-156148608 26852 144292973 1 rs6947930rs6945016 36.446 0 WDR91 chr7:78621315-155831817 13678 77210503 3rs1006818 rs6969015 123.319 0 WDR91 chr7:8872727-156383359 27773147510633 1 rs917038 rs878717 32.336 0 WDR91 chr7:134696740-135170448 89473709 1 rs4329203 rs2696888 28.6 0 WDR91 chr7:120061880-143606234 461623544355 3 rs12531689 rs10247493 18.96 0 WDR91 chr5:84830796-17190331016642 87072515 1 rs300657 rs10042482 42.208 0 WWC1chr5:161172541-179954615 4271 18782075 3 rs4921415 rs10059433 6.291 0WWC1 chr5:57343495-171903310 21683 114559816 1 rs10940593 rs1004248261.169 0 WWC1 chr5:4872310-180709915 35876 175837606 3 rs816467rs10071993 179.394 0 WWC1 chr20:13712393-55093901 8218 41381509 1rs6033810 rs6999 41.237 0 YWHAB chr20:7869025-62424661 11941 54555637 3rs2294306 rs6010652 9.732 0 YWHAB chr20:4591715-58420336 11753 538286221 rs6139494 rs1416388 40.922 0 YWHAB chr20:236802-54845796 1264654608995 3 rs448294 rs6064362 286.151 0 YWHAB chr17:108420-26610769 554826502350 3 rs12452527 rs658591 82.699 0 YWHAE chr7:11855636-15614860826852 144292973 1 rs6947930 rs6945016 36.446 0 YWHAGchr7:8872727-156383359 27773 147510633 1 rs917038 rs878717 32.336 0YWHAG chr7:8794418-119068130 23484 110273713 1 rs2189621 rs697790470.867 0 YWHAG chr7:60392-84158180 19095 84097789 3 rs12670102 rs2715048208.308 0 YWHAG chr2:18856-41136833 9721 41117978 3 rs11901199rs10187704 191.638 0 YWHAQ chr8:30757798-142750969 20699 111993172 1rs10101203 rs6421025 34.223 0 YWHAZ chr8:60424884-145286483 1703084861600 3 rs1401422 rs9720889 8.858 0 YWHAZ chr8:23218101-14627470823020 123056608 1 rs7010362 rs7822726 38.828 0 YWHAZchr8:76354446-113652365 6767 37297920 1 rs830783 rs16883889 127.023 0YWHAZ chr8:66822030-144791126 16557 77969097 3 rs6472235 rs10100154251.068 0 YWHAZ chr2:12056323-227979775 39094 215923453 1 rs966391rs1922020 31.384 0 ZAP70 chr2:34870277-241929621 37755 207059345 3rs13422005 rs10205276 46.946 0 ZAP70 chr2:38101137-241482099 36812203380963 1 rs879321 rs7576043 52.099 0 ZAP70 chr2:77041264-19476375421140 117722491 1 rs2102827 rs16835406 94.091 0 ZAP70chr2:83383702-175194550 16291 91810849 3 rs12469609 rs11891208 154.4 0ZAP70 chr18:25388300-75954881 11539 50566582 1 rs11083228 rs187602139.235 0 ZNF24 chr18:1583633-58142042 11490 56558410 3 rs9945988rs1560399 3.736 0 ZNF24 chr18:32722154-33260373 96 538220 3 rs13512rs508284 245.257 0 ZNF24 chr18:26550830-63713914 8241 37163085 1rs16945738 rs2715304 17.922 0 ZNF24 chr18:26162481-67193217 925541030737 1 rs12458903 rs9961907 31.327 0 ZNF24 chr18:30929223-447206642910 13791442 3 rs10775453 rs9304343 535.348 0 ZNF24

What is claimed is:
 1. A method of treating anxiety disorder in asubject, comprising administering an effective amount of fasoracetam toa subject, wherein fasoracetam is administered at a dose of 50-400 mg,100-400 mg, or 200-400 mg, and wherein the dose is administered once,twice, or three times daily.
 2. The method of claim 1, wherein thesubject has at least one genetic alteration in an mGluR network gene. 3.The method of claim 2, wherein the genetic alteration is a copy numbervariation (CNV) or single nucleotide variation (SNV).
 4. The method ofclaim 3, wherein the genetic alteration is a CNV.
 5. The method of claim4, wherein the CNV is a duplication or deletion.
 6. The method of claim1, wherein fasoracetam is fasoracetam monohydrate (NS-105 or NFC-1). 7.The method of claim 1, wherein fasoracetam is administered at a dose of50 mg, 100 mg, 150 mg, 200 mg, 250 mg, 300 mg, 350 mg, or 400 mg.
 8. Themethod of claim 1, wherein the fasoracetam is administered at a dose of200-400 mg, such as 200 mg, 300 mg, or 400 mg, and wherein the dose isadministered twice daily.
 9. The method of claim 4, wherein the subjecthas a CNV in at least 2, 3, 4, 5, 6, 7, 8, 9, or 10 mGluR network genes.10. The method of claim 1, wherein the subject does not have a CNV inone or more of GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, or GRM8. 11.The method of claim 1, wherein the anxiety disorder is one or more ofgeneralized anxiety disorder, phobia, social anxiety disorder, socialphobia, panic disorder, panic attack, post-traumatic stress disorders,separation anxiety disorder, selective mutism, agoraphobia, or ananxiety disorder induced by a substance/medication or due to anothermedical condition.
 12. The method of claim 1, wherein the subject is apediatric, adolescent, or adult subject.
 13. The method of claim 1,wherein the fasoracetam is administered in combination with ananxiolytic agent.
 14. The method of claim 13, wherein the anxiolyticagent is a benzodiazepine, an antidepressant, pregabalin, or abeta-blocker.
 15. The method of claim 1, wherein anxiety symptoms arereduced in the subject following at least 1 week, such as at least 2weeks, such as at least 3 weeks, such as at least 4 weeks of treatmentwith fasoracetam.
 16. The method of claim 1, wherein symptoms ofinattentiveness, hyperactivity, and/or impulsiveness are reduced in thesubject following at least 1 week, such as at least 2 weeks, such as atleast 3 weeks, such as at least 4 weeks of treatment with fasoracetam.17. The method of claim 1, wherein the subject has anxiety disorder aswell as one or more of attention-deficit hyperactivity disorder (ADHD),oppositional defiant disorder (ODD), conduct disorder, Tourette'ssyndrome, phobia, obsessive compulsive disorder (OCD), difficultycontrolling anger, disruptive behaviors, dermatillomania, adevelopmental disorder, a mood disorder, a movement disorder, ordepression.
 18. The method of claim 1, wherein the subject does not haveany of ADHD, ODD, conduct disorder, Tourette's syndrome, phobia,obsessive compulsive disorder (OCD), difficulty controlling anger,disruptive behaviors, dermatillomania, a developmental disorder, a mooddisorder, a movement disorder, or depression.
 19. The method of claim 1,wherein fear symptoms, anxiety symptoms, panic attacks, and/ordisruptive behavior are reduced in frequency and/or severity in thesubject after at least 1 week, such as at least 2 weeks, at least 3weeks, or at least 4 weeks of treatment with the activator.